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Aliases for FAM13C Gene

Aliases for FAM13C Gene

  • Family With Sequence Similarity 13 Member C 2 3 5
  • Family With Sequence Similarity 13, Member C1 2 3
  • Family With Sequence Similarity 13, Member C 2 3
  • FAM13C1 3 4

External Ids for FAM13C Gene

Previous HGNC Symbols for FAM13C Gene

  • FAM13C1

Previous GeneCards Identifiers for FAM13C Gene

  • GC10M060676
  • GC10M061005
  • GC10M054996

Summaries for FAM13C Gene

GeneCards Summary for FAM13C Gene

FAM13C (Family With Sequence Similarity 13 Member C) is a Protein Coding gene. An important paralog of this gene is FAM13B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM13C Gene

Genomics for FAM13C Gene

Regulatory Elements for FAM13C Gene

Promoters for FAM13C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM13C on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM13C Gene

Chromosome:
10
Start:
59,246,129 bp from pter
End:
59,363,181 bp from pter
Size:
117,053 bases
Orientation:
Minus strand

Genomic View for FAM13C Gene

Genes around FAM13C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM13C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM13C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM13C Gene

Proteins for FAM13C Gene

  • Protein details for FAM13C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE31-FA13C_HUMAN
    Recommended name:
    Protein FAM13C
    Protein Accession:
    Q8NE31
    Secondary Accessions:
    • B7ZB77
    • Q5T631
    • Q6P2M3
    • Q99787

    Protein attributes for FAM13C Gene

    Size:
    585 amino acids
    Molecular mass:
    65727 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI15709.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM13C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM13C Gene

Proteomics data for FAM13C Gene at MOPED

Post-translational modifications for FAM13C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM13C Gene

Domains & Families for FAM13C Gene

Protein Domains for FAM13C Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NE31

UniProtKB/Swiss-Prot:

FA13C_HUMAN :
  • Belongs to the FAM13 family.
Family:
  • Belongs to the FAM13 family.
genes like me logo Genes that share domains with FAM13C: view

No data available for Gene Families for FAM13C Gene

Function for FAM13C Gene

Phenotypes for FAM13C Gene

genes like me logo Genes that share phenotypes with FAM13C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM13C Gene

Localization for FAM13C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM13C Gene COMPARTMENTS Subcellular localization image for FAM13C gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM13C Gene

Pathways & Interactions for FAM13C Gene

SuperPathways for FAM13C Gene

No Data Available

Interacting Proteins for FAM13C Gene

Gene Ontology (GO) - Biological Process for FAM13C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM13C Gene

Drugs & Compounds for FAM13C Gene

No Compound Related Data Available

Transcripts for FAM13C Gene

Unigene Clusters for FAM13C Gene

Family with sequence similarity 13, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM13C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - - - - - -
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - - - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - - - -
SP13:
SP14:

Relevant External Links for FAM13C Gene

GeneLoc Exon Structure for
FAM13C
ECgene alternative splicing isoforms for
FAM13C

Expression for FAM13C Gene

mRNA expression in normal human tissues for FAM13C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM13C Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.0).

SOURCE GeneReport for Unigene cluster for FAM13C Gene Hs.607594

genes like me logo Genes that share expression patterns with FAM13C: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM13C Gene

Orthologs for FAM13C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM13C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM13C 35
  • 88.79 (n)
  • 87.24 (a)
FAM13C 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM13C 35
  • 90.7 (n)
  • 88.18 (a)
FAM13C 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam13c 35
  • 84.25 (n)
  • 84.48 (a)
Fam13c 16
Fam13c 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM13C 35
  • 99.32 (n)
  • 98.8 (a)
FAM13C 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam13c 35
  • 82.51 (n)
  • 82.7 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM13C 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM13C 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM13C 35
  • 69.84 (n)
  • 63.95 (a)
FAM13C 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 7 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730440 35
  • 64.57 (n)
  • 62.8 (a)
Str.13599 35
zebrafish
(Danio rerio)
Actinopterygii LOC100537056 35
  • 57.09 (n)
  • 51.13 (a)
FAM13C (1 of 10) 36
  • 7 (a)
OneToMany
FAM13C (10 of 10) 36
  • 39 (a)
OneToMany
FAM13C (2 of 10) 36
  • 7 (a)
OneToMany
FAM13C (3 of 10) 36
  • 6 (a)
OneToMany
FAM13C (4 of 10) 36
  • 5 (a)
OneToMany
FAM13C (5 of 10) 36
  • 6 (a)
OneToMany
FAM13C (6 of 10) 36
  • 11 (a)
OneToMany
FAM13C (7 of 10) 36
  • 13 (a)
OneToMany
FAM13C (8 of 10) 36
  • 12 (a)
OneToMany
FAM13C (9 of 10) 36
  • 12 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6424 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
OneToMany
Species with no ortholog for FAM13C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM13C Gene

ENSEMBL:
Gene Tree for FAM13C (if available)
TreeFam:
Gene Tree for FAM13C (if available)

Paralogs for FAM13C Gene

Paralogs for FAM13C Gene

(1) SIMAP similar genes for FAM13C Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM13C: view

Variants for FAM13C Gene

Sequence variations from dbSNP and Humsavar for FAM13C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs17853626 - 59,352,349(+) TGCTG(A/C/G/T)GTCGC reference, missense, utr-variant-5-prime
rs371468 -- 59,363,288(-) GGAGC(C/T)GAGCT upstream-variant-2KB
rs373304 -- 59,301,747(+) CTACT(A/G)TGAGG intron-variant
rs376619 -- 59,304,129(-) actcc(A/G)tcgct intron-variant
rs284577 -- 59,341,465(+) GGCGG(A/G)TCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM13C Gene

Variant ID Type Subtype PubMed ID
nsv831888 CNV Gain 17160897
nsv528505 CNV Loss 19592680
nsv507558 CNV Insertion 20534489
nsv467289 CNV Loss 19166990
esv269602 CNV Insertion 20981092
esv273164 CNV Insertion 20981092
esv4266 CNV Deletion 18987735
esv2737429 CNV Deletion 23290073

Variation tolerance for FAM13C Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM13C Gene

HapMap Linkage Disequilibrium report
FAM13C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM13C Gene

Disorders for FAM13C Gene

Relevant External Links for FAM13C

Genetic Association Database (GAD)
FAM13C
Human Genome Epidemiology (HuGE) Navigator
FAM13C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM13C

No disorders were found for FAM13C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM13C Gene

Publications for FAM13C Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  5. Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study. (PMID: 20200953) Karasik D. … Demissie S. (J. Bone Miner. Res. 2010) 3

Products for FAM13C Gene

Sources for FAM13C Gene

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