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Aliases for FAM13C Gene

Aliases for FAM13C Gene

  • Family With Sequence Similarity 13 Member C 2 3 5
  • Family With Sequence Similarity 13, Member C1 2 3
  • FAM13C1 3 4
  • Family With Sequence Similarity 13, Member C 2
  • Protein FAM13C 3

External Ids for FAM13C Gene

Previous HGNC Symbols for FAM13C Gene

  • FAM13C1

Previous GeneCards Identifiers for FAM13C Gene

  • GC10M060676
  • GC10M061005
  • GC10M054996

Summaries for FAM13C Gene

GeneCards Summary for FAM13C Gene

FAM13C (Family With Sequence Similarity 13 Member C) is a Protein Coding gene. An important paralog of this gene is FAM13A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM13C Gene

Genomics for FAM13C Gene

Regulatory Elements for FAM13C Gene

Enhancers for FAM13C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G059322 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +39.9 39941 2.2 FOXA2 ARID4B RAD21 RARA YY1 MIXL1 MIER2 PPARG NR2F2 HNF4A FAM13C ENSG00000236556 LOC102724778 GC10M059343
GH10G058967 1.5 FANTOM5 ENCODE dbSUPER 10.8 +395.4 395358 1.2 FOXA2 ARID4B ZNF48 SP5 MIER2 REST KAT8 MIER3 GLIS1 RCOR2 PHYHIPL FAM13C GC10M058913 GC10P058898
GH10G059266 0.9 FANTOM5 dbSUPER 16.8 +98.0 97960 0.3 CTCF ZNF740 MAX MIER2 REST RAD21 IKZF1 SMC3 KDM1A PCBP1 FAM13C PHYHIPL SLC16A9 ENSG00000236556 GC10M059173
GH10G058963 1.4 FANTOM5 ENCODE dbSUPER 10.3 +398.9 398862 2.1 FOXA2 RAD21 THRB SCRT2 ZNF143 ZNF398 CEBPA KDM1A RBFOX2 CTCF PHYHIPL FAM13C GC10M058913 GC10P058898
GH10G059386 0.8 Ensembl ENCODE 17.1 -24.8 -24831 2.4 CTCF JUND SMARCA4 HLF HNF4A NFE2 EZH2 FAM13C GC10M059378 GC10M059444
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM13C on UCSC Golden Path with GeneCards custom track

Promoters for FAM13C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000028428 481 1400 ZSCAN4 SIN3A KLF17 ZNF2 RAD21 GLIS2 FOS KLF7 REST ZEB2

Genomic Location for FAM13C Gene

Chromosome:
10
Start:
59,246,129 bp from pter
End:
59,363,181 bp from pter
Size:
117,053 bases
Orientation:
Minus strand

Genomic View for FAM13C Gene

Genes around FAM13C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM13C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM13C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM13C Gene

Proteins for FAM13C Gene

  • Protein details for FAM13C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE31-FA13C_HUMAN
    Recommended name:
    Protein FAM13C
    Protein Accession:
    Q8NE31
    Secondary Accessions:
    • B7ZB77
    • Q5T631
    • Q6P2M3
    • Q99787

    Protein attributes for FAM13C Gene

    Size:
    585 amino acids
    Molecular mass:
    65727 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI15709.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM13C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM13C Gene

Post-translational modifications for FAM13C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM13C Gene

Domains & Families for FAM13C Gene

Protein Domains for FAM13C Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NE31

UniProtKB/Swiss-Prot:

FA13C_HUMAN :
  • Belongs to the FAM13 family.
Family:
  • Belongs to the FAM13 family.
genes like me logo Genes that share domains with FAM13C: view

No data available for Gene Families for FAM13C Gene

Function for FAM13C Gene

Gene Ontology (GO) - Molecular Function for FAM13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM13C: view

Phenotypes for FAM13C Gene

genes like me logo Genes that share phenotypes with FAM13C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM13C Gene

Localization for FAM13C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM13C gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM13C Gene

Pathways & Interactions for FAM13C Gene

SuperPathways for FAM13C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM13C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM13C Gene

Drugs & Compounds for FAM13C Gene

No Compound Related Data Available

Transcripts for FAM13C Gene

Unigene Clusters for FAM13C Gene

Family with sequence similarity 13, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM13C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - - - - - -
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - - - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - - - -
SP13:
SP14:

Relevant External Links for FAM13C Gene

GeneLoc Exon Structure for
FAM13C
ECgene alternative splicing isoforms for
FAM13C

Expression for FAM13C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM13C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM13C Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of FAM13C Gene:

FAM13C

SOURCE GeneReport for Unigene cluster for FAM13C Gene:

Hs.607594

Evidence on tissue expression from TISSUES for FAM13C Gene

  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with FAM13C: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM13C Gene

Orthologs for FAM13C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM13C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM13C 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia FAM13C 34 35
  • 90.7 (n)
cow
(Bos Taurus)
Mammalia FAM13C 34 35
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Fam13c 34 16 35
  • 84.25 (n)
rat
(Rattus norvegicus)
Mammalia Fam13c 34
  • 82.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM13C 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM13C 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM13C 34 35
  • 69.84 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
-- 35
  • 7 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730440 34
  • 64.57 (n)
Str.13599 34
zebrafish
(Danio rerio)
Actinopterygii LOC100537056 34
  • 57.09 (n)
FAM13C (10 of 10) 35
  • 39 (a)
OneToMany
FAM13C (7 of 10) 35
  • 13 (a)
OneToMany
FAM13C (8 of 10) 35
  • 12 (a)
OneToMany
FAM13C (9 of 10) 35
  • 12 (a)
OneToMany
FAM13C (6 of 10) 35
  • 11 (a)
OneToMany
FAM13C (1 of 10) 35
  • 7 (a)
OneToMany
FAM13C (2 of 10) 35
  • 7 (a)
OneToMany
FAM13C (3 of 10) 35
  • 6 (a)
OneToMany
FAM13C (5 of 10) 35
  • 6 (a)
OneToMany
FAM13C (4 of 10) 35
  • 5 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6424 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 7 (a)
OneToMany
Species where no ortholog for FAM13C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM13C Gene

ENSEMBL:
Gene Tree for FAM13C (if available)
TreeFam:
Gene Tree for FAM13C (if available)

Paralogs for FAM13C Gene

Paralogs for FAM13C Gene

(1) SIMAP similar genes for FAM13C Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM13C: view

Variants for FAM13C Gene

Sequence variations from dbSNP and Humsavar for FAM13C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs193920897 Uncertain significance 59,252,904(-) CCACC(A/T)CACCT reference, missense
rs1000029602 -- 59,313,734(+) CTGTG(A/C)AGGAT intron-variant
rs1000061792 -- 59,304,695(+) AAACC(C/G)GCATG intron-variant
rs1000090949 -- 59,262,779(+) GGGCA(A/G)CGGCA intron-variant
rs1000171782 -- 59,306,782(+) AGGCA(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM13C Gene

Variant ID Type Subtype PubMed ID
esv2737429 CNV deletion 23290073
esv3305324 CNV mobile element insertion 20981092
esv3360999 CNV insertion 20981092
esv3386762 CNV insertion 20981092
esv4266 CNV loss 18987735
nsv1115395 CNV duplication 24896259
nsv467289 CNV loss 19166990
nsv477953 CNV novel sequence insertion 20440878
nsv507558 OTHER sequence alteration 20534489
nsv528505 CNV loss 19592680
nsv551148 CNV loss 21841781
nsv551149 CNV loss 21841781
nsv831888 CNV gain 17160897

Variation tolerance for FAM13C Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM13C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM13C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM13C Gene

Disorders for FAM13C Gene

Relevant External Links for FAM13C

Genetic Association Database (GAD)
FAM13C
Human Genome Epidemiology (HuGE) Navigator
FAM13C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM13C

No disorders were found for FAM13C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM13C Gene

Publications for FAM13C Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FAM13C Gene

Sources for FAM13C Gene

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