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Aliases for FAM13C Gene

Aliases for FAM13C Gene

  • Family With Sequence Similarity 13 Member C 2 3 5
  • Family With Sequence Similarity 13, Member C1 2 3
  • FAM13C1 3 4
  • Family With Sequence Similarity 13, Member C 2
  • Protein FAM13C 3

External Ids for FAM13C Gene

Previous HGNC Symbols for FAM13C Gene

  • FAM13C1

Previous GeneCards Identifiers for FAM13C Gene

  • GC10M060676
  • GC10M061005
  • GC10M054996

Summaries for FAM13C Gene

GeneCards Summary for FAM13C Gene

FAM13C (Family With Sequence Similarity 13 Member C) is a Protein Coding gene. An important paralog of this gene is FAM13A.

Additional gene information for FAM13C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM13C Gene

Genomics for FAM13C Gene

Regulatory Elements for FAM13C Gene

Enhancers for FAM13C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H059322 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +39.9 39941 2.2 FOXA2 ARID4B RAD21 RARA YY1 ATF7 MIXL1 REST MIER2 PPARG FAM13C ENSG00000236556 LOC102724778 GC10M059343
GH10H058967 1.5 FANTOM5 ENCODE dbSUPER 10.8 +395.4 395358 1.2 ELF3 TBP FOXA2 ARID4B DNMT3B THRB ZSCAN9 RAD21 RARA SCRT2 PHYHIPL FAM13C GC10M058913 GC10P058898
GH10H058963 1.4 FANTOM5 ENCODE dbSUPER 10.3 +398.9 398862 2.1 SOX13 CTCF FOXA2 SAP130 EBF1 RAD21 ZIC2 ZNF644 THRB TEAD3 PHYHIPL FAM13C GC10M058913 GC10P058898
GH10H059386 0.8 Ensembl ENCODE 17.1 -24.8 -24831 2.4 CTCF JUND POLR2A HLF HNF4A NFE2 EZH2 FAM13C GC10M059378 GC10M059444
GH10H059266 0.8 FANTOM5 dbSUPER 16.8 +98.0 97960 0.3 ZNF740 MAX MIER2 REST FAM13C PHYHIPL SLC16A9 ENSG00000236556 GC10M059173
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM13C on UCSC Golden Path with GeneCards custom track

Promoters for FAM13C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000028428 481 1400 ZSCAN4 KLF17 ZNF2 RAD21 GLIS2 FOS KLF7 REST ZEB2 ZNF843

Genomic Locations for FAM13C Gene

Genomic Locations for FAM13C Gene
chr10:59,246,129-59,363,181
(GRCh38/hg38)
Size:
117,053 bases
Orientation:
Minus strand
chr10:61,005,889-61,122,939
(GRCh37/hg19)

Genomic View for FAM13C Gene

Genes around FAM13C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM13C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM13C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM13C Gene

Proteins for FAM13C Gene

  • Protein details for FAM13C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE31-FA13C_HUMAN
    Recommended name:
    Protein FAM13C
    Protein Accession:
    Q8NE31
    Secondary Accessions:
    • B7ZB77
    • Q5T631
    • Q6P2M3
    • Q99787

    Protein attributes for FAM13C Gene

    Size:
    585 amino acids
    Molecular mass:
    65727 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI15709.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM13C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM13C Gene

Post-translational modifications for FAM13C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM13C Gene

Domains & Families for FAM13C Gene

Gene Families for FAM13C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM13C Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NE31

UniProtKB/Swiss-Prot:

FA13C_HUMAN :
  • Belongs to the FAM13 family.
Family:
  • Belongs to the FAM13 family.
genes like me logo Genes that share domains with FAM13C: view

Function for FAM13C Gene

Phenotypes From GWAS Catalog for FAM13C Gene

Gene Ontology (GO) - Molecular Function for FAM13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM13C: view

Phenotypes for FAM13C Gene

genes like me logo Genes that share phenotypes with FAM13C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM13C Gene

Localization for FAM13C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM13C gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM13C Gene

Pathways & Interactions for FAM13C Gene

SuperPathways for FAM13C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM13C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM13C Gene

Drugs & Compounds for FAM13C Gene

No Compound Related Data Available

Transcripts for FAM13C Gene

mRNA/cDNA for FAM13C Gene

Unigene Clusters for FAM13C Gene

Family with sequence similarity 13, member C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM13C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - - - - - -
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - - - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - - - -
SP13:
SP14:

Relevant External Links for FAM13C Gene

GeneLoc Exon Structure for
FAM13C
ECgene alternative splicing isoforms for
FAM13C

Expression for FAM13C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM13C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM13C Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of FAM13C Gene:

FAM13C

SOURCE GeneReport for Unigene cluster for FAM13C Gene:

Hs.607594

Evidence on tissue expression from TISSUES for FAM13C Gene

  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with FAM13C: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM13C Gene

Orthologs for FAM13C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM13C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM13C 33 34
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia FAM13C 33 34
  • 90.7 (n)
cow
(Bos Taurus)
Mammalia FAM13C 33 34
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Fam13c 33 16 34
  • 84.25 (n)
rat
(Rattus norvegicus)
Mammalia Fam13c 33
  • 82.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM13C 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM13C 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM13C 33 34
  • 69.84 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
OneToMany
-- 34
  • 7 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730440 33
  • 64.57 (n)
Str.13599 33
zebrafish
(Danio rerio)
Actinopterygii LOC100537056 33
  • 57.09 (n)
FAM13C (10 of 10) 34
  • 39 (a)
OneToMany
FAM13C (7 of 10) 34
  • 13 (a)
OneToMany
FAM13C (8 of 10) 34
  • 12 (a)
OneToMany
FAM13C (9 of 10) 34
  • 12 (a)
OneToMany
FAM13C (6 of 10) 34
  • 11 (a)
OneToMany
FAM13C (1 of 10) 34
  • 7 (a)
OneToMany
FAM13C (2 of 10) 34
  • 7 (a)
OneToMany
FAM13C (3 of 10) 34
  • 6 (a)
OneToMany
FAM13C (5 of 10) 34
  • 6 (a)
OneToMany
FAM13C (4 of 10) 34
  • 5 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6424 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 7 (a)
OneToMany
Species where no ortholog for FAM13C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM13C Gene

ENSEMBL:
Gene Tree for FAM13C (if available)
TreeFam:
Gene Tree for FAM13C (if available)

Paralogs for FAM13C Gene

Paralogs for FAM13C Gene

(1) SIMAP similar genes for FAM13C Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FAM13C: view

Variants for FAM13C Gene

Sequence variations from dbSNP and Humsavar for FAM13C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs193920897 Uncertain significance 59,252,904(-) CCACC(A/T)CACCT reference, missense
rs1000029602 -- 59,313,734(+) CTGTG(A/C)AGGAT intron-variant
rs1000061792 -- 59,304,695(+) AAACC(C/G)GCATG intron-variant
rs1000090949 -- 59,262,779(+) GGGCA(A/G)CGGCA intron-variant
rs1000171782 -- 59,306,782(+) AGGCA(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM13C Gene

Variant ID Type Subtype PubMed ID
nsv551149 CNV loss 21841781
nsv831888 CNV gain 17160897
nsv551148 CNV loss 21841781
nsv528505 CNV loss 19592680
nsv507558 OTHER sequence alteration 20534489
nsv477953 CNV novel sequence insertion 20440878
nsv467289 CNV loss 19166990
nsv1115395 CNV duplication 24896259
esv4266 CNV loss 18987735
esv3386762 CNV insertion 20981092
esv3360999 CNV insertion 20981092
esv3305324 CNV mobile element insertion 20981092
esv2737429 CNV deletion 23290073

Variation tolerance for FAM13C Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM13C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM13C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM13C Gene

Disorders for FAM13C Gene

Relevant External Links for FAM13C

Genetic Association Database (GAD)
FAM13C
Human Genome Epidemiology (HuGE) Navigator
FAM13C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM13C

No disorders were found for FAM13C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM13C Gene

Publications for FAM13C Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for FAM13C Gene

Sources for FAM13C Gene

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