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Aliases for FAM13B Gene

Aliases for FAM13B Gene

  • Family With Sequence Similarity 13, Member B 2 3
  • Family With Sequence Similarity 13, Member B1 2 3
  • GAP-Like Protein N61 3 4
  • FAM13B1 3 4
  • C5orf5 3 4
  • Chromosome 5 Open Reading Frame 5 2
  • Protein FAM13B 3
  • ARHGAP49 3
  • KHCHP 3
  • N61 3

External Ids for FAM13B Gene

Previous HGNC Symbols for FAM13B Gene

  • C5orf5
  • FAM13B1

Previous GeneCards Identifiers for FAM13B Gene

  • GC05M137303
  • GC05M132465
  • GC05M137273

Summaries for FAM13B Gene

GeneCards Summary for FAM13B Gene

FAM13B (Family With Sequence Similarity 13, Member B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is FAM13A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM13B Gene

Genomics for FAM13B Gene

Regulatory Elements for FAM13B Gene

Genomic Location for FAM13B Gene

Start:
137,937,949 bp from pter
End:
138,051,961 bp from pter
Size:
114,013 bases
Orientation:
Minus strand

Genomic View for FAM13B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM13B Gene

Proteins for FAM13B Gene

  • Protein details for FAM13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYF5-FA13B_HUMAN
    Recommended name:
    Protein FAM13B
    Protein Accession:
    Q9NYF5
    Secondary Accessions:
    • D3DQB5
    • G3V0H9
    • Q3ZCR0
    • Q6PGQ2
    • Q9P0I7

    Protein attributes for FAM13B Gene

    Size:
    915 amino acids
    Molecular mass:
    104543 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF67482.1; Type=Frameshift; Positions=734; Evidence={ECO:0000305}; Sequence=AAF67482.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM13B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM13B Gene

Proteomics data for FAM13B Gene at MOPED

Post-translational modifications for FAM13B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM13B Gene

No data available for DME Specific Peptides for FAM13B Gene

Domains for FAM13B Gene

Gene Families for FAM13B Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for FAM13B Gene

Suggested Antigen Peptide Sequences for FAM13B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYF5

UniProtKB/Swiss-Prot:

FA13B_HUMAN :
  • Q9NYF5
Domain:
  • Contains 1 Rho-GAP domain.
Family:
  • Belongs to the FAM13 family.
genes like me logo Genes that share domains with FAM13B: view

Function for FAM13B Gene

Gene Ontology (GO) - Molecular Function for FAM13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with FAM13B: view

Phenotypes for FAM13B Gene

GenomeRNAi human phenotypes for FAM13B:
genes like me logo Genes that share phenotypes with FAM13B: view

miRNA for FAM13B Gene

miRTarBase miRNAs that target FAM13B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM13B Gene

Localization for FAM13B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM13B Gene COMPARTMENTS Subcellular localization image for FAM13B gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FAM13B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM13B Gene

Pathways for FAM13B Gene

genes like me logo Genes that share pathways with FAM13B: view

Pathways by source for FAM13B Gene

3 Reactome pathways for FAM13B Gene

Gene Ontology (GO) - Biological Process for FAM13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with FAM13B: view

Transcripts for FAM13B Gene

Unigene Clusters for FAM13B Gene

Family with sequence similarity 13, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM13B Gene

No ASD Table

Relevant External Links for FAM13B Gene

GeneLoc Exon Structure for
FAM13B
ECgene alternative splicing isoforms for
FAM13B

Expression for FAM13B Gene

mRNA expression in normal human tissues for FAM13B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM13B Gene

SOURCE GeneReport for Unigene cluster for FAM13B Gene Hs.567453

genes like me logo Genes that share expressions with FAM13B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM13B Gene

Orthologs for FAM13B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM13B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM13B 35
  • 99.71 (n)
  • 99.67 (a)
FAM13B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM13B 35
  • 93.71 (n)
  • 94.42 (a)
FAM13B 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM13B 35
  • 94.61 (n)
  • 95.3 (a)
FAM13B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam13b 35
  • 88.37 (n)
  • 89.77 (a)
Fam13b 16
Fam13b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM13B 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fam13b 35
  • 88.61 (n)
  • 90.39 (a)
chicken
(Gallus gallus)
Aves C5ORF5 35
  • 79.67 (n)
  • 81.27 (a)
FAM13B 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM13B 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam13b 35
  • 69.2 (n)
  • 65.4 (a)
Str.13371 35
zebrafish
(Danio rerio)
Actinopterygii Dr.6589 35
fam13b 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6424 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for FAM13B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM13B Gene

ENSEMBL:
Gene Tree for FAM13B (if available)
TreeFam:
Gene Tree for FAM13B (if available)

Paralogs for FAM13B Gene

Paralogs for FAM13B Gene

Selected SIMAP similar genes for FAM13B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM13B: view

Variants for FAM13B Gene

Sequence variations from dbSNP and Humsavar for FAM13B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1110481 -- 137,963,155(+) ttagc(A/G)tgaaa intron-variant
rs1125979 -- 137,946,019(+) AAGAA(A/C)TTGTC intron-variant
rs1381726 -- 138,034,362(-) CTAGG(A/T)TATAA upstream-variant-2KB, intron-variant
rs1462569 -- 138,031,322(+) ACACA(C/G)GTGTC intron-variant
rs1462570 -- 138,033,478(-) AACCG(A/G)AGTCA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM13B Gene

Variant ID Type Subtype PubMed ID
nsv830501 CNV Gain 17160897
nsv830502 CNV Gain 17160897
esv2730817 CNV Deletion 23290073

Relevant External Links for FAM13B Gene

HapMap Linkage Disequilibrium report
FAM13B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM13B Gene

Disorders for FAM13B Gene

No disorders were found for FAM13B Gene.

No data available for UniProtKB/Swiss-Prot for FAM13B Gene

Publications for FAM13B Gene

  1. cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. (PMID: 11087669) Lai F. … Le Beau M.M. (Genomics 2000) 2 3 4
  2. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). (PMID: 11161817) Lai F. … Le Beau M.M. (Genomics 2001) 2 3
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for FAM13B Gene

Sources for FAM13B Gene

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