FAM13B Gene
protein-coding GIFtS: 49
GCID: GC05M137303
|
|
family with sequence similarity 13, member B(Previous names: chromosome 5 open reading frame 5, family with sequence...)
(Previous symbols: C5orf5, FAM13B1)
| |
Aliases
for FAM13B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 13, Member B1 2 | | N611 2 | | C5orf51 2 3 | | Family With Sequence Similarity 13, Member B11 2 | | FAM13B11 2 3 | | GAP-Like Protein N612 3 | | ARHGAP491 2 | | Chromosome 5 Open Reading Frame 51 | | KHCHP1 2 | | Protein FAM13B2 |
Export aliases for FAM13B gene to outside databasesPrevious GC identifer: GC05M132465 |
Summaries
for FAM13B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM13B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM13B gene promoter:
AML1a COUP Pax-2 FOXD3 Nkx2-5 Pax-2a PPAR-alpha COUP-TF E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM13B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM13B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31FAM13B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M137303: view genomic region
(about GC identifiers)
Start:
|
137,273,638 bp from pter |
End:
|
137,387,650 bp from pter |
Size:
|
114,013 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM13B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA13B_HUMAN, Q9NYF5 (See
protein sequence)Recommended Name: Protein FAM13B Size: 915 amino acids; 104543 Da
Sequence caution: Sequence=AAF67482.1; Type=Frameshift; Positions=734; Sequence=AAF67482.1; Type=Miscellaneousdiscrepancy;
Secondary accessions: D3DQB5 G3V0H9 Q3ZCR0 Q6PGQ2 Q9P0I7Alternative splicing: 3 isoforms: Q9NYF5-1 Q9NYF5-2 Q9NYF5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM13B: NX_Q9NYF5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYF5
FAM13B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001095270.1 NP_001095271.1 NP_057687.2
ENSEMBL proteins: ENSP00000033079 ENSP00000394669 ENSP00000388521 ENSP00000425326 ENSP00000424785 ENSP00000422311 ENSP00000426863 ENSP00000422673 Reactome Protein details: Q9NYF5
Human Recombinant Protein Products for FAM13B:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FAM13B for ontologies About GeneDecksing
FAM13B Antibody Products:
Assay Products for FAM13B: |
Protein
Domains /
Families
for FAM13B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM13B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NYF5ProtoNet protein and cluster: Q9NYF5 1 Blocks protein family: IPB000198 RhoGAP domain
UniProtKB/Swiss-Prot: FA13B_HUMAN, Q9NYF5Similarity: Belongs to the FAM13 familySimilarity: Contains 1 Rho-GAP domain |
Function
for FAM13B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IEA | -- |
FAM13B for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for FAM13B:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM13B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM13B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FAM13B (NM_001101801) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM13B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM13B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM13B |
|
Pathways & Interactions
for FAM13B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for FAM13B
FAM13B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM13B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/40 Interacting proteins for FAM13B (Q9NYF53 ENSP000000330794) via UniProtKB, MINT, STRING, and/or I2D (see all 40)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
-- | -- | | GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
TAS | -- |
FAM13B for ontologies About GeneDecksing
|
Drugs & Compounds
for FAM13B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM13B
Search CenterWatch for drugs/clinical trials and news about FAM13B / FA13B
|
Transcripts
for FAM13B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM13B gene (3 alternative transcripts): NM_001101800.1 NM_001101801.1 NM_016603.2 Unigene Cluster for FAM13B: Family with sequence similarity 13, member B Hs.567453 [show with all ESTs]Unigene Representative Sequence: NM_01660311 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000033079(uc003lbz.2 uc003lcb.2 uc003lca.2) ENST00000425075
ENST00000420893 ENST00000513640 ENST00000505281 ENST00000514310 ENST00000502471
ENST00000509596 ENST00000508403 ENST00000505961 ENST00000510804
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM13B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM13B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FAM13B (NM_001101801) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM13B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM13B |
Additional cDNA sequence: AF157316.1 AF251038.1 AK314224.1 AL833699.1 BC041335.1 BC048965.1 BC056887.1 14 DOTS entries: DT.100778867 DT.443259 DT.100840763 DT.97857426 DT.111548 DT.100778868 DT.95376415 DT.101975805 DT.91707936 DT.92031069 DT.100740657 DT.92427593 DT.95375531 DT.40262142 24/135 AceView cDNA sequences (see all 135): BC048965 BU193881 AA815187 AI474530 AW474052 BC056887 AI690987 AF251038 AI217239 CR611121 CA440866 BE222307 AA428681 AA191524 H99220 BG413488 AL833699 AI150076 BQ718292 AA430306 NM_016603 CA437127 CB265547 BQ012187
GeneLoc Exon Structure
|
Expression
for FAM13B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM13B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGCACTTA
About this image
See FAM13B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM13B
SOURCE GeneReport for Unigene cluster: Hs.567453
SABiosciences Custom PCR Arrays for FAM13B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM13B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM13B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM13B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM13B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM13B |
Orthologs
for FAM13B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM13B gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for FAM13B (if available)
TreeFam Gene Tree for FAM13B (if available) |
Paralogs
for FAM13B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM13B gene
- FAM13C2 FAM13A2
6 SIMAP similar genes for FAM13B using alignment to 6 protein entries: FA13B_HUMAN (see all proteins):ARHGAP1 FAM13A ARHGAP24 ARHGAP5 MYO9A ARHGAP28
FAM13B for paralogs About GeneDecksing
|
Genomic Variants
for FAM13B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM13B (137273638 - 137387650 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM13B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM13B |
|
Disorders
/ Diseases
for FAM13B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM13B for disorders About GeneDecksing
OMIM gene information: 609371
OMIM disorders: --
1  disease for FAM13B: About MalaCardskeratitis
Export disorders for FAM13B gene to outside databases
|
Publications
for FAM13B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM13B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM13B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. (PubMed id 11087669)1, 2, 3 Lai F....Le Beau M.M. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). (PubMed id 11161817)1, 3 Lai F.... Le Beau M.M. (2001)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM13B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM13B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM13B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM13B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM13B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM13B gene:
Search GeneIP for patents involving FAM13B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM13B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM13B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM13B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM13B | | | OriGene Protein Over-expression Lysate for FAM13B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM13B | | OriGene 3'-UTR Clone for FAM13B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM13B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM13B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM13B | | OriGene Custom Protein Services for FAM13B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM13B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM13B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM13B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM13B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM13B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM13B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM13B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM13B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM13B |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FAM13B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM13B |
| |  | |
|
|
|
