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Aliases for FAM13B Gene

Aliases for FAM13B Gene

  • Family With Sequence Similarity 13 Member B 2 3 5
  • Family With Sequence Similarity 13, Member B1 2 3
  • Family With Sequence Similarity 13, Member B 2 3
  • GAP-Like Protein N61 3 4
  • FAM13B1 3 4
  • C5orf5 3 4
  • Chromosome 5 Open Reading Frame 5 2
  • ARHGAP49 3
  • KHCHP 3
  • N61 3

External Ids for FAM13B Gene

Previous HGNC Symbols for FAM13B Gene

  • C5orf5
  • FAM13B1

Previous GeneCards Identifiers for FAM13B Gene

  • GC05M137303
  • GC05M132465
  • GC05M137273

Summaries for FAM13B Gene

GeneCards Summary for FAM13B Gene

FAM13B (Family With Sequence Similarity 13 Member B) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is FAM13A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM13B Gene

Genomics for FAM13B Gene

Regulatory Elements for FAM13B Gene

Enhancers for FAM13B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM13B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM13B Gene

137,937,949 bp from pter
138,051,961 bp from pter
114,013 bases
Minus strand

Genomic View for FAM13B Gene

Genes around FAM13B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM13B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM13B Gene

Proteins for FAM13B Gene

  • Protein details for FAM13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM13B
    Protein Accession:
    Secondary Accessions:
    • D3DQB5
    • G3V0H9
    • Q3ZCR0
    • Q6PGQ2
    • Q9P0I7

    Protein attributes for FAM13B Gene

    915 amino acids
    Molecular mass:
    104543 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF67482.1; Type=Frameshift; Positions=734; Evidence={ECO:0000305}; Sequence=AAF67482.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM13B Gene


neXtProt entry for FAM13B Gene

Proteomics data for FAM13B Gene at MOPED

Post-translational modifications for FAM13B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM13B Gene

Domains & Families for FAM13B Gene

Gene Families for FAM13B Gene

Protein Domains for FAM13B Gene

Suggested Antigen Peptide Sequences for FAM13B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rho-GAP domain.
  • Belongs to the FAM13 family.
  • Contains 1 Rho-GAP domain.
  • Belongs to the FAM13 family.
genes like me logo Genes that share domains with FAM13B: view

Function for FAM13B Gene

genes like me logo Genes that share phenotypes with FAM13B: view

Animal Models for FAM13B Gene

MGI Knock Outs for FAM13B:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM13B Gene

Localization for FAM13B Gene

Subcellular locations from

Jensen Localization Image for FAM13B Gene COMPARTMENTS Subcellular localization image for FAM13B gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM13B Gene

Pathways & Interactions for FAM13B Gene

genes like me logo Genes that share pathways with FAM13B: view

Pathways by source for FAM13B Gene

3 Reactome pathways for FAM13B Gene

Gene Ontology (GO) - Biological Process for FAM13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with FAM13B: view

No data available for SIGNOR curated interactions for FAM13B Gene

Drugs & Compounds for FAM13B Gene

No Compound Related Data Available

Transcripts for FAM13B Gene

Unigene Clusters for FAM13B Gene

Family with sequence similarity 13, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM13B Gene

No ASD Table

Relevant External Links for FAM13B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM13B Gene

mRNA expression in normal human tissues for FAM13B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM13B Gene

SOURCE GeneReport for Unigene cluster for FAM13B Gene Hs.567453

genes like me logo Genes that share expression patterns with FAM13B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM13B Gene

Orthologs for FAM13B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM13B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM13B 35
  • 93.71 (n)
  • 94.42 (a)
FAM13B 36
  • 72 (a)
(Canis familiaris)
Mammalia FAM13B 35
  • 94.61 (n)
  • 95.3 (a)
FAM13B 36
  • 95 (a)
(Mus musculus)
Mammalia Fam13b 35
  • 88.37 (n)
  • 89.77 (a)
Fam13b 16
Fam13b 36
  • 91 (a)
(Pan troglodytes)
Mammalia FAM13B 35
  • 99.71 (n)
  • 99.67 (a)
FAM13B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam13b 35
  • 88.61 (n)
  • 90.39 (a)
(Monodelphis domestica)
Mammalia FAM13B 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
-- 36
  • 80 (a)
(Gallus gallus)
Aves C5ORF5 35
  • 79.67 (n)
  • 81.27 (a)
FAM13B 36
  • 81 (a)
(Anolis carolinensis)
Reptilia FAM13B 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam13b 35
  • 69.2 (n)
  • 65.4 (a)
Str.13371 35
(Danio rerio)
Actinopterygii Dr.6589 35
fam13b 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6424 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
Species with no ortholog for FAM13B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM13B Gene

Gene Tree for FAM13B (if available)
Gene Tree for FAM13B (if available)

Paralogs for FAM13B Gene

Paralogs for FAM13B Gene

(6) SIMAP similar genes for FAM13B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM13B: view

Variants for FAM13B Gene

Sequence variations from dbSNP and Humsavar for FAM13B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_049020 -
rs1110481 -- 137,963,155(+) ttagc(A/G)tgaaa intron-variant
rs1125979 -- 137,946,019(+) AAGAA(A/C)TTGTC intron-variant
rs6596412 -- 137,970,946(+) gagca(C/G)ccaga intron-variant
rs6596413 -- 137,971,039(+) caaca(C/T)tagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM13B Gene

Variant ID Type Subtype PubMed ID
nsv830501 CNV Gain 17160897
nsv830502 CNV Gain 17160897
esv2730817 CNV Deletion 23290073

Variation tolerance for FAM13B Gene

Residual Variation Intolerance Score: 6.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM13B Gene

Disorders for FAM13B Gene

Relevant External Links for FAM13B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM13B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM13B Gene

Publications for FAM13B Gene

  1. cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. (PMID: 11087669) Lai F. … Le Beau M.M. (Genomics 2000) 2 3 4 67
  2. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). (PMID: 11161817) Lai F. … Le Beau M.M. (Genomics 2001) 2 3
  3. The eukaryotic elongation factor eEF1A1 interacts with SAMHD1. (PMID: 25423367) Morrissey C. … Webb M. (Biochem. J. 2015) 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3

Products for FAM13B Gene

Sources for FAM13B Gene