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FAM13A Gene

protein-coding   GIFtS: 55
GCID: GC04M089647

Family With Sequence Similarity 13, Member A

(Previous names: family with sequence similarity 13, member A1)
(Previous symbol: FAM13A1)
  See FAM13A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 13, Member A1 2     ARHGAP482
FAM13A11 2 3 5     FAM13A1_v2 Protein2
Family With Sequence Similarity 13, Member A11 2     Protein FAM13A2
KIAA09143 5     

External Ids:    HGNC: 193671   Entrez Gene: 101442   Ensembl: ENSG000001386407   OMIM: 6132995   UniProtKB: O949883   

Export aliases for FAM13A gene to outside databases

Previous GC identifers: GC04M089866 GC04M085399


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM13A Gene:
FAM13A (family with sequence similarity 13, member A) is a protein-coding gene. Diseases associated with FAM13A include idiopathic pulmonary fibrosis. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is FAM13B.

Gene Wiki entry for FAM13A (Family with sequence similarity 13, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM13A gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   HNF-3beta   Meis-1b   RORalpha1   Nkx3-1 v2   Nkx3-1 v3   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM13A promoter sequence
   Search Chromatin IP Primers for FAM13A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM13A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22.1

FAM13A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM13A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M089647:  view genomic region     (about GC identifiers)

Start:
89,647,106 bp from pter      End:
90,032,549 bp from pter
Size:
385,444 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FA13A_HUMAN, O94988 (See protein sequence)
Recommended Name: Protein FAM13A  
Size: 1023 amino acids; 116932 Da
Sequence caution: Sequence=BAA74937.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAC03636.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B4DLC1 Q24JP0 Q5PR21 Q8NBA3
Alternative splicing: 5 isoforms:  O94988-4   O94988-1   O94988-3   O94988-5   O94988-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM13A: NX_O94988

Explore proteomics data for FAM13A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM13A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001015045.1  NP_001252507.1  NP_001252508.1  NP_001252509.1  NP_055698.2  

    ENSEMBL proteins: 
     ENSP00000378450   ENSP00000264344   ENSP00000427189   ENSP00000421914   ENSP00000421562  
     ENSP00000423252   ENSP00000427077   ENSP00000425784   ENSP00000423800   ENSP00000426517  
     ENSP00000422345   ENSP00000421269  
    Reactome Protein details: O94988

    FAM13A Human Recombinant Protein Products:

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    Novus Biologicals FAM13A Protein
    Novus Biologicals FAM13A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAM13A

     
    Search eBioscience for Proteins for FAM13A 

     
    antibodies-online proteins for FAM13A 

     
    Search antibodies-online for peptides for FAM13A

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    antibodies-online antibodies for FAM13A 

    FAM13A Assay Products:

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    Cloud-Clone Corp. ELISAs for FAM13A
    Cloud-Clone Corp. CLIAs for FAM13A
    Search eBioscience for ELISAs for FAM13A 
    antibodies-online kits for FAM13A (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGAP: Rho GTPase activating proteins

    2 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry O94988

    ProtoNet protein and cluster: O94988

    UniProtKB/Swiss-Prot: FA13A_HUMAN, O94988
    Similarity: Belongs to the FAM13 family
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with FAM13A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
         
    Find genes that share ontologies with FAM13A           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM13A

    miRNA
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    miRTarBase miRNAs that target FAM13A:
    hsa-mir-10b-5p (MIRT047429), hsa-mir-615-3p (MIRT039722)

    Block miRNA regulation of human, mouse, rat FAM13A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM13A (see all 61):
    hsa-miR-582-3p hsa-miR-607 hsa-miR-106a hsa-miR-485-3p hsa-miR-4305 hsa-miR-30d hsa-miR-301a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidFAM13A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM13A

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    GenScript: all cDNA clones in your preferred vector (see all 2): FAM13A (NM_001015045)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM13A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM13A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM13A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with FAM13A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FAM13A About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with FAM13A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for FAM13A
        Rho GTPase cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM13A
    Interactions:

        Search GeneGlobe Interaction Network for FAM13A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for FAM13A (O949883 ENSP000002643444) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF2P153363I2D: score=2 
    JUNP054123I2D: score=2 
    MEF2CQ064133I2D: score=2 
    RAPGEF2Q9Y4G83I2D: score=2 
    MAP3K10Q027793I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with FAM13A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM13A (FA13A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM13A gene (5 alternative transcripts): 
    NM_001015045.2  NM_001265578.1  NM_001265579.1  NM_001265580.1  NM_014883.3  

    Unigene Cluster for FAM13A:

    Family with sequence similarity 13, member A
    Hs.97270  [show with all ESTs]
    Unigene Representative Sequence: NM_014883
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000395002(uc003hsa.1 uc003hsb.1 uc003hsd.1 uc003hsc.1 uc011cdq.1 uc010ikr.1)
    ENST00000264344(uc011cdp.1 uc003hse.1 uc003hsf.1) ENST00000509478
    ENST00000511573 ENST00000503556 ENST00000511976 ENST00000508369 ENST00000513837
    ENST00000506433 ENST00000504229 ENST00000502811 ENST00000504836(uc003hsg.1)
    ENST00000508360 ENST00000511623 ENST00000507352 ENST00000515155 ENST00000502914
    ENST00000502459(uc003hsh.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat FAM13A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM13A (see all 61):
    hsa-miR-582-3p hsa-miR-607 hsa-miR-106a hsa-miR-485-3p hsa-miR-4305 hsa-miR-30d hsa-miR-301a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidFAM13A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM13A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM13A
    Clone
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    OriGene clones in human, mouse for FAM13A (see all 13)
    OriGene ORF clones in mouse, rat for FAM13A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM13A (NM_001015045)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM13A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM13A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM13A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM13A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM13A
      QuantiFast Probe-based Assays in human, mouse, rat FAM13A

    Additional mRNA sequence: 

    AB020721.2 AF009202.1 AK027138.1 AK091328.1 AK091787.1 AK091881.1 AK123724.1 AK296932.1 
    AK298262.1 BC033006.1 BC041029.1 BC053569.1 BC058029.1 BC063126.1 BC086875.1 BX647410.1 

    Selected DOTS entries (see all 27):

    DT.91852767  DT.100785857  DT.121257620  DT.91753707  DT.100020622  DT.95079716  DT.454578  DT.91753709 
    DT.121257545  DT.75135814  DT.100020547  DT.91750420  DT.101983381  DT.91721242  DT.100679264  DT.100735515 
    DT.99932895  DT.121257630  DT.121257618  DT.121257518  DT.121257629  DT.40218134  DT.40278706  DT.65286087 

    Selected AceView cDNA sequences (see all 210):

    Z45451 BP373366 Z41156 CB134242 AI804851 BC053569 F01608 BQ012433 
    AI269099 BC063126 F05350 BM787723 AA480339 D62906 CD244795 BX647410 
    BU682121 AI878808 BU741924 T34354 CD677419 AA324372 BC041029 CR615111 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM13A (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a ·
    SP1:                                                              -                 -     -     -                                                               
    SP2:                          -                                   -                 -     -     -                                                               
    SP3:                                                              -                 -     -     -                                                               
    SP4:                          -                                   -                 -                                                                           
    SP5:                                                              -     -           -     -     -                                                               

    ExUns: 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b
    SP1:                                                                    -     -                           
    SP2:                                                                    -     -                           
    SP3:                                            -     -                 -     -                           
    SP4:                                            -     -                 -     -                           
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for FAM13A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM13A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAGTCTGT
    FAM13A Expression
    About this image


    FAM13A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Thyroid (Endocrine System)
     
     Adipose (Muscoskeletal System)
    FAM13A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM13A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97270

    UniProtKB/Swiss-Prot: FA13A_HUMAN, O94988
    Tissue specificity: Isoform 1 is widely expressed, with highest expression in skeletal muscle, thymus, brain and
    lung. Isoform 3 is less abundant than isoform 1 and predominantly expressed in kidney, pancreas,liver, lung and
    thymus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM13A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM13A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam13a5 family with sequence similarity 13, member A   --   6 (27.93 cM) 58932090 
    chicken
    (Gallus gallus)
    Aves FAM13A1 family with sequence similarity 13, member A 74.4(n)
    77.2(a)
      422515  XM_004941028.1  XP_004941085.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM13A6
    family with sequence similarity 13, member A
    72(a)
    1 ↔ 1
    5(45888336-46040429)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam13a1 family with sequence similarity 13, member A 67.08(n)
    68.08(a)
      100488957  XM_002938631.2  XP_002938677.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fam13a1 family with sequence similarity 13, member A 61.22(n)
    58.45(a)
      559330  XM_005160105.1  XP_005160162.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64246
    --
    21(a)
    1 → many
    2R(13590840-13606832)


    ENSEMBL Gene Tree for FAM13A (if available)
    TreeFam Gene Tree for FAM13A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM13A gene
    FAM13B2  FAM13C2  
    Selected SIMAP similar genes for FAM13A using alignment to 9 protein entries:     FA13A_HUMAN (see all proteins) (see all similar genes):
    FAM13B    ARHGAP1    ARHGAP20    ARHGAP22    ARHGAP31    ABR
    ARHGAP25    ARHGAP32    ARHGAP8    KIAA0053    ARHGAP24    ARHGAP33
    SNX26    ARAP1    PRR5-ARHGAP8    CHN1    ARHGAP9    ARHGAP27

    Find genes that share paralogs with FAM13A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM13A (see all 6297)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30678071,2
    C--85613368(+) CTTAG-/GAA   
       
    /GGAA
    ATTGT
    2 -- int1 cds11NA 2
    rs672123881,2
    C--85628375(+) ACACA-/TAGTCTG 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs567107051,2
    C--85698317(+) TTTTT-/T/TTT 
     TTTTTTT
    GAGAC
    1 -- int11NA 2
    rs1931957621,2
    --89651785(+) TAATCC/TACCCT 5 -- int10--------
    rs1428662011,2
    --89651823(+) CAGGCA/GTGAGC 5 -- int10--------
    rs1510725101,2
    --89651967(+) TTTTAC/TTTAGA 5 -- int10--------
    rs1409244841,2
    --89652111(+) CGGCCA/GCTTGG 5 -- int10--------
    rs76626801,2
    C,F--89652128(+) TCTAGC/TTTCTT 5 -- int13Minor allele frequency- T:0.22WA NA EA 358
    rs76874351,2
    C--89652146(+) AAGCGC/TTGGTG 5 -- int10--------
    rs1855482041,2
    --89652248(+) CATTAA/GTCTTG 5 -- int10--------

    HapMap Linkage Disequilibrium report for FAM13A (89647106 - 89897106 bp, first 250kb of FAM13A)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM13A (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2647176CNV Deletion19546169
    esv2727954CNV Deletion23290073
    esv1054095CNV Deletion17803354
    esv2660897CNV Deletion23128226
    esv2669940CNV Deletion23128226
    esv1378129CNV Deletion17803354
    esv1010735CNV Deletion20482838
    esv2727955CNV Deletion23290073
    esv1980466CNV Deletion18987734
    esv2589450CNV Deletion19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM13A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM13A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613299    OMIM disorders: --

    1 disease for FAM13A:    
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    idiopathic pulmonary fibrosis

    1 disease from the University of Copenhagen DISEASES database for FAM13A:
    Chronic obstructive pulmonary disease

    Find genes that share disorders with FAM13A           About GenesLikeMe

    Genetic Association Database (GAD): FAM13A
    Human Genome Epidemiology (HuGE) Navigator: FAM13A (8 documents)

    Export disorders for FAM13A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM13A gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with FAM13A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (PubMed id 22080838)1, 4 Cho M.H.... . (Hum. Mol. Genet. 2012)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. (PubMed id 20010835)1, 4 Hancock D.B....London S.J. (Nat. Genet. 2010)
    5. Variants in FAM13A are associated with chronic obstructive pulmonary disease. (PubMed id 20173748)1, 4 Cho M.H....Silverman E.K. (Nat. Genet. 2010)
    6. Genomewide association study of movement-related adverse antipsychotic effects. (PubMed id 19875103)1, 4 Aberg K....van den Oord E.J. (Biol. Psychiatry 2010)
    7. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    8. Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. (PubMed id 20656943)1, 4 Pillai S.G....Silverman E.K. (Am. J. Respir. Crit. Care Med. 2010)
    9. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    10. Cloning and characterization of FAM13A1--a gene near a milk protein QTL on BTA6: evidence for population-wide linkage disequilibrium in Israeli Holsteins. (PubMed id 15234000)1, 2 Cohen M.... Seroussi E. (Genomics 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10144 HGNC: 19367 AceView: FAM13A1 Ensembl:ENSG00000138640 euGenes: HUgn10144
    ECgene: FAM13A H-InvDB: FAM13A

    (According to HUGE)
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    HUGE: KIAA0914

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM13A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM13A gene:
    Search GeneIP for patents involving FAM13A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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