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Aliases for FAM13A Gene

Aliases for FAM13A Gene

  • Family With Sequence Similarity 13 Member A 2 3 5
  • Family With Sequence Similarity 13, Member A1 2 3
  • Family With Sequence Similarity 13, Member A 2 3
  • FAM13A1 3 4
  • FAM13A1_v2 Protein 3
  • ARHGAP48 3
  • KIAA0914 4

External Ids for FAM13A Gene

Previous HGNC Symbols for FAM13A Gene

  • FAM13A1

Previous GeneCards Identifiers for FAM13A Gene

  • GC04M089866
  • GC04M089647
  • GC04M085399

Summaries for FAM13A Gene

GeneCards Summary for FAM13A Gene

FAM13A (Family With Sequence Similarity 13 Member A) is a Protein Coding gene. Diseases associated with FAM13A include Pulmonary Fibrosis, Idiopathic. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is FAM13B.

Gene Wiki entry for FAM13A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM13A Gene

Genomics for FAM13A Gene

Regulatory Elements for FAM13A Gene

Enhancers for FAM13A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM13A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM13A Gene

88,725,954 bp from pter
89,111,398 bp from pter
385,445 bases
Minus strand

Genomic View for FAM13A Gene

Genes around FAM13A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM13A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM13A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM13A Gene

Proteins for FAM13A Gene

  • Protein details for FAM13A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM13A
    Protein Accession:
    Secondary Accessions:
    • B4DLC1
    • Q24JP0
    • Q5PR21
    • Q8NBA3

    Protein attributes for FAM13A Gene

    1023 amino acids
    Molecular mass:
    116932 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74937.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC03636.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM13A Gene


neXtProt entry for FAM13A Gene

Proteomics data for FAM13A Gene at MOPED

Post-translational modifications for FAM13A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM13A Gene

Domains & Families for FAM13A Gene

Gene Families for FAM13A Gene

Protein Domains for FAM13A Gene

Suggested Antigen Peptide Sequences for FAM13A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rho-GAP domain.
  • Belongs to the FAM13 family.
  • Contains 1 Rho-GAP domain.
  • Belongs to the FAM13 family.
genes like me logo Genes that share domains with FAM13A: view

Function for FAM13A Gene

genes like me logo Genes that share phenotypes with FAM13A: view

Human Phenotype Ontology for FAM13A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM13A Gene

Localization for FAM13A Gene

Subcellular locations from

Jensen Localization Image for FAM13A Gene COMPARTMENTS Subcellular localization image for FAM13A gene
Compartment Confidence
cytosol 5
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM13A Gene

Pathways & Interactions for FAM13A Gene

genes like me logo Genes that share pathways with FAM13A: view

Pathways by source for FAM13A Gene

3 Reactome pathways for FAM13A Gene

Interacting Proteins for FAM13A Gene

Gene Ontology (GO) - Biological Process for FAM13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with FAM13A: view

No data available for SIGNOR curated interactions for FAM13A Gene

Drugs & Compounds for FAM13A Gene

(1) Drugs for FAM13A Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Antagonist 990
genes like me logo Genes that share compounds with FAM13A: view

Transcripts for FAM13A Gene

Unigene Clusters for FAM13A Gene

Family with sequence similarity 13, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM13A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a ·
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP9: - - - - - - - - - - - - - - - - - - - -
SP10: - - - -
SP11: - -
SP12: - - -
SP13: -

ExUns: 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b
SP1: - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP6: - - - -
SP8: - -

Relevant External Links for FAM13A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM13A Gene

mRNA expression in normal human tissues for FAM13A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM13A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.3) and Plasma (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM13A Gene

SOURCE GeneReport for Unigene cluster for FAM13A Gene Hs.97270

mRNA Expression by UniProt/SwissProt for FAM13A Gene

Tissue specificity: Isoform 1 is widely expressed, with highest expression in skeletal muscle, thymus, brain and lung. Isoform 3 is less abundant than isoform 1 and predominantly expressed in kidney, pancreas,liver, lung and thymus.
genes like me logo Genes that share expression patterns with FAM13A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM13A Gene

Orthologs for FAM13A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM13A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM13A 35
  • 89.11 (n)
  • 88.36 (a)
FAM13A 36
  • 87 (a)
(Pan troglodytes)
Mammalia FAM13A1 35
  • 99.71 (n)
  • 99.71 (a)
FAM13A1 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
FAM13A 36
  • 88 (a)
(Monodelphis domestica)
Mammalia FAM13A 36
  • 70 (a)
(Mus musculus)
Mammalia Fam13a 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
(Gallus gallus)
Aves FAM13A 35
  • 74.4 (n)
  • 77.2 (a)
FAM13A 36
  • 77 (a)
(Anolis carolinensis)
Reptilia FAM13A 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam13a 35
  • 67.08 (n)
  • 68.08 (a)
(Danio rerio)
Actinopterygii fam13a 35
  • 61.22 (n)
  • 58.45 (a)
fam13a 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6424 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
Species with no ortholog for FAM13A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM13A Gene

Gene Tree for FAM13A (if available)
Gene Tree for FAM13A (if available)

Paralogs for FAM13A Gene

Paralogs for FAM13A Gene

genes like me logo Genes that share paralogs with FAM13A: view

Variants for FAM13A Gene

Sequence variations from dbSNP and Humsavar for FAM13A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs7657817 - 88,747,708(+) TTCAA(C/T)ACTGG reference, missense
rs874147 -- 89,077,107(-) GCCTA(G/T)ATTTC intron-variant
rs874148 -- 89,077,014(-) CTCCC(A/G)CTTCT intron-variant
rs987469 -- 88,785,492(-) TTTCT(C/G)TTTTA intron-variant
rs898073 -- 88,807,616(+) CATTC(A/G)ATGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM13A Gene

Variant ID Type Subtype PubMed ID
nsv461576 CNV Gain 19166990
nsv470051 CNV Gain 18288195
esv2589450 CNV Deletion 19546169
esv2660897 CNV Deletion 23128226
esv1980466 CNV Deletion 18987734
esv2727954 CNV Deletion 23290073
esv1010735 CNV Deletion 20482838
esv1378129 CNV Deletion 17803354
esv2647176 CNV Deletion 19546169
nsv4416 CNV Insertion 18451855
esv2669940 CNV Deletion 23128226
esv2664903 CNV Deletion 23128226
dgv5642n71 CNV Loss 21882294
esv2671485 CNV Deletion 23128226
esv2727955 CNV Deletion 23290073
esv1054095 CNV Deletion 17803354
nsv461577 CNV Gain 19166990
esv270228 CNV Insertion 20981092
esv274118 CNV Insertion 20981092
nsv822638 CNV Gain 20364138

Variation tolerance for FAM13A Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM13A Gene

Disorders for FAM13A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM13A Gene - From: Orphanet

Disorder Aliases PubMed IDs
pulmonary fibrosis, idiopathic
  • idiopathic pulmonary fibrosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM13A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM13A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM13A Gene

Publications for FAM13A Gene

  1. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (PMID: 22080838) Cho M.H. … . (Hum. Mol. Genet. 2012) 3 48 67
  2. IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. (PMID: 25101718) Lee J.H. … Silverman E.K. (Am. J. Respir. Cell Mol. Biol. 2015) 3
  3. Identification of FAM13A gene associated with the ratio of FEV1 to FVC in Korean population by genome-wide association studies including gene-environment interactions. (PMID: 25608829) Kim S. … Shin C. (J. Hum. Genet. 2015) 3
  4. Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt. (PMID: 25609086) Jin Z. … Yang J. (Mol. Biol. Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for FAM13A Gene

Sources for FAM13A Gene