|
|
family with sequence similarity 138, member C
| |
Aliases
for FAM138C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): non-coding RNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| Family With Sequence Similarity 138, Member C1 2 | | F3791 2 | | Retina-Specific Protein F3793 |
Export aliases for FAM138C gene to outside databasesPrevious GC identifer: GC09U900868 |
Summaries
for FAM138C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM138C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM138C gene promoter:
S8 AP-1 AML1a POU2F1b POU2F1c NF-kappaB NF-kappaB1 E4BP4 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM138C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM138C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p24.3 Ensembl cytogenetic band: 9p24.3 HGNC cytogenetic band: 9p24.3FAM138C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M000027: view genomic region
(about GC identifiers)
Start:
|
34,394 bp from pter |
End:
|
35,864 bp from pter |
Size:
|
1,471 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM138C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F138A_HUMAN, Q6VEP3 (See
protein sequence)Recommended Name: Protein FAM138A/B/C/F Size: 85 amino acids; 9204 Da
Miscellaneous: Found within a region of subtelomeric DNA that is duplicated in a polymorphic distribution to multiplechromosomes. Contains interchromosomal sequence variation; the polymorphic changes causes amino-acid substitution
Secondary accessions: A6NC04 B2RP05 Q6VEP0 Q6VEP1 Q6VEP4 Q6VEP5 Q8NG00Explore the universe of human proteins at neXtProt for FAM138C: NX_Q6VEP3
FAM138C Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000393278 ENSP00000303458
Human Recombinant Protein Products for FAM138C:
FAM138C Antibody Products:
Assay Products for FAM138C: |
Protein
Domains /
Families
for FAM138C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM138C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6VEP3ProtoNet protein and cluster: Q6VEP3 UniProtKB/Swiss-Prot: F138A_HUMAN, Q6VEP3Similarity: Belongs to the FAM138 family |
Function
for FAM138C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM138C |
|
Pathways & Interactions
for FAM138C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM138C
|
Drugs & Compounds
for FAM138C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM138C
Search CenterWatch for drugs/clinical trials and news about FAM138C 
|
Transcripts
for FAM138C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for FAM138C: Family with sequence similarity 138, member C Hs.744304 Unigene Representative Sequence: AY3419492 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000449442(uc003zfv.3) ENST00000305248
Additional cDNA sequence: AY341949.1 1 DOTS entry: DT.120945077
GeneLoc Exon Structure
|
Expression
for FAM138C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for FAM138C:none
FAM138C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FAM138C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM138C
SOURCE GeneReport for Unigene cluster: Hs.744304
UniProtKB/Swiss-Prot: F138A_HUMAN, Q6VEP3Tissue specificity: Expressed in retina
SABiosciences Custom PCR Arrays for FAM138C
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM138C | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM138C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM138C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM138C |
Orthologs
for FAM138C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for FAM138C (if available)
TreeFam Gene Tree for FAM138C (if available) |
Paralogs
for FAM138C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM138C gene
- FAM138A2
18/56 SIMAP similar genes for FAM138C using alignment to 2 protein entries: F138A_HUMAN (see all proteins)
(see all similar genes):FAM138A FAM138B FAM138F FAM138D ETFA LRRC37A3
NUDT7 RABGEF1 CGRRF1 DNAPTP3 GOSR2 ZNF573
AHSA1 C14orf178 CSTF3 PCTP UBA1 C16orf89
FAM138C for paralogs About GeneDecksing
|
Genomic Variants
for FAM138C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM138C (34394 - 35864 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 30 variations for FAM138C
15/30 CNVs (see all 30): 3753 95783 68173 30360 83989 0675 78021 74277 82833 2041 3274 95782 33061 31460 74275 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FAM138C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM138C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM138C gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM138C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diverse fates of paralogs following segmental duplication of telomeric genes. (PubMed id 15233989)1, 2, 3 Wong A....Ledbetter D.H. (2004)
- Identification of a novel retina-specific gene located in a subtelomeric region with polymorphic distribution among multiple human chromosomes. (PubMed id 11779631)1, 2, 3 Mah N.... Weber B.H.F. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for FAM138C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM138C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM138C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM138C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM138C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM138C gene:
Search GeneIP for patents involving FAM138C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM138C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM138C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM138C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM138C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM138C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM138C | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM138C |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM138C |
| |  |  |  |  | | | | |
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 | | | FAM138C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM138C |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FAM138C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM138C |
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