FAM136A Gene
protein-coding GIFtS: 44
GCID: GC02M070523
|
|
family with sequence similarity 136, member A
| |
Aliases for FAM136A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 136, Member A1 2 | | FLJ146681 | | Protein FAM136A2 |
Export aliases for FAM136A gene to outside databasesPrevious GC identifers: GC02M070376 GC02M070259 |
Summaries for FAM136A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for FAM136A
|
Genomic Views for FAM136A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM136A gene promoter: AhR AML1a HSF1 (long) Arnt CREB AREB6 deltaCREB FOXJ2 (long isoform) HSF1short FOXJ2 Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM136A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM136A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13.3 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p14FAM136A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M070523: view genomic region
(about GC identifiers)
Start:
|
70,523,107 bp from pter |
End:
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70,529,222 bp from pter |
Size:
|
6,116 bases |
Orientation:
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minus strand |
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Proteins for FAM136A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: F136A_HUMAN, Q96C01 (See
protein sequence)Recommended Name: Protein FAM136A Size: 138 amino acids; 15641 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: Q96SS3Explore the universe of human proteins at neXtProt for FAM136A: NX_Q96C01
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96C01 FAM136A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116211.2 ENSEMBL proteins: ENSP00000037869 ENSP00000391468 ENSP00000397269 ENSP00000390840 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FAM136A for ontologies About GeneDecksing
FAM136A Antibody Products: Assay Products for FAM136A: |
Protein
Domains / Families for FAM136A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM136A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96C01ProtoNet protein and cluster: Q96C01 UniProtKB/Swiss-Prot: F136A_HUMAN, Q96C01Similarity: Belongs to the FAM136 family |
Function for FAM136A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM136A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM136A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM136A (NM_032822) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM136A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM136A  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM136A |
|
Pathways & Interactions for FAM136A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM136A
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 2 Interacting proteins for FAM136A (Q96C011, 3 ENSP000000378694) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for FAM136A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for FAM136A Search CenterWatch for drugs/clinical trials and news about FAM136A / F136A 
|
Transcripts for FAM136A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for FAM136A gene: NM_032822.2 Unigene Cluster for FAM136A: Family with sequence similarity 136, member A Hs.516077 [show with all ESTs]Unigene Representative Sequence: BC0262936 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000037869(uc002sgq.4) ENST00000460307(uc010fdp.3) ENST00000450256 ENST00000430566 ENST00000438759 ENST00000498665
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM136A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM136A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM136A (NM_032822) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM136A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM136A  |
Additional cDNA sequence: AK027574.1 AK225148.1 AK225151.1 AK309543.1 AK315877.1 AL833147.1 BC014975.1 BC026293.1 13 DOTS entries: DT.87016833 DT.91654094 DT.100881002 DT.100881001 DT.121036153 DT.121036162 DT.91753367 DT.100881000 DT.100881003 DT.102829400 DT.91753366 DT.100027867 DT.100880999 24/247 AceView cDNA sequences (see all 247): CR596266 CB853567 CD722831 AI335655 BM852112 BC014975 BM790525 AA613781 CR612968 CA437889 BP367848 BU186527 CR613530 AA523988 CB108776 CR595145 CR623290 AI373082 CR599147 CB139815 AI915144 AI401201 AI521663 CA431421 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM136A About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | |
| SP1: | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for FAM136A
|
Expression for FAM136A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM136A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCACCTTATT
About this image See FAM136A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM136A
SOURCE GeneReport for Unigene cluster: Hs.516077 SABiosciences Custom PCR Arrays for FAM136A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM136A Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM136A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM136A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM136A | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM136A |
Orthologs for FAM136A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FAM136A gene from 8/23 species (see all 23) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Fam136a5 |
family with sequence similarity 136, member A |
-- |
  |
6 (37.69 cM) 86365683 |
chicken (Gallus gallus) |
Aves |
FAM136A6 |
Uncharacterized protein |
57(a) |
1 ↔ 1 |
22(2894384-2899996) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.149962 |
Xenopus laevis transcribed sequence with weak similarity more |
74.98(n) |
  |
BX847204.1 |
zebrafish (Danio rerio) |
Actinopterygii |
wufb72f052 |
Danio rerio cDNA clone MGC73247 IMAGE4199156, complete more |
78.25(n) |
  |
BC059586.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG53231 |
CG5323 |
54.17(n) 41.18(a) |
  |
37137 NM_137502.4 NP_611346.1 |
worm (Caenorhabditis elegans) |
Secernentea |
CELE_ZK637.21 |
Protein ZK637.2 |
49.47(n) 38.89(a) |
  |
176252 NM_066560.4 NP_498961.2 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT2G437206AT1G057406(see all 4) |
uncharacterized protein(see all 4) |
22(a)20(a)(see all 4) |
many → 1many → 1(see all 4) |
2(18123267-18124338) 1(1720674-1721309) |
rice (Oryza sativa) |
Liliopsida |
-- |
expressed protein |
22(a) |
1 ↔ 1 |
11(8437826-8440689) |
ENSEMBL Gene Tree for FAM136A (if available) TreeFam Gene Tree for FAM136A (if available)  |
Paralogs for FAM136A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for FAM136A gene
FAM136A for paralogs About GeneDecksing
5/13 Pseudogenes.org Pseudogenes for FAM136A (see all 13) PGOHUM00000237144 PGOHUM00000246352 PGOHUM00000240071 PGOHUM00000250294 PGOHUM00000235496
|
Genomic Variants for FAM136A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM136A (70523107 - 70529222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FAM136A: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM136A |
|
Disorders
/ Diseases for FAM136A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM136A for disorders About MalaCards
FAM136A for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: FAM136A (1 document) Export disorders for FAM136A gene to outside databases
|
Publications for FAM136A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM136A gene, integrated from 9 sources (see all 18): (articles sorted by number of sources associating them with FAM136A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
|
External Searches for FAM136A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FAM136A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM136A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM136A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for FAM136A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM136A gene: Search GeneIP for patents involving FAM136A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for FAM136A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM136A | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM136A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM136A | | OriGene Protein Over-expression Lysate for FAM136A | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for FAM136A | | OriGene 3'-UTR Clone for FAM136A | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM136A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM136A | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for FAM136A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for FAM136A | | OriGene Custom Protein Services for FAM136A | | OriGene Custom Immunoassay Development | | |
| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM136A | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM136A | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM136A | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM136A | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM136A | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM136A |
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 |  |  |  | |
| | | Search Tocris compounds for FAM136A |
| |  |  |  |  | | | | |
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 | | FAM136A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM136A |
|  |  |  | | | ThermoFisher Antibodies for FAM136A |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM136A |
|
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