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Aliases for FAM136A Gene

Aliases for FAM136A Gene

  • Family With Sequence Similarity 136 Member A 2 3 5
  • Family With Sequence Similarity 136, Member A 2
  • Hypothetical Protein FLJ14668 2

External Ids for FAM136A Gene

Previous GeneCards Identifiers for FAM136A Gene

  • GC02M070376
  • GC02M070523
  • GC02M070259

Summaries for FAM136A Gene

GeneCards Summary for FAM136A Gene

FAM136A (Family With Sequence Similarity 136 Member A) is a Protein Coding gene. Diseases associated with FAM136A include meniere's disease and labyrinthine disease.

Gene Wiki entry for FAM136A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM136A Gene

Genomics for FAM136A Gene

Regulatory Elements for FAM136A Gene

Promoters for FAM136A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM136A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM136A Gene

Chromosome:
2
Start:
70,295,975 bp from pter
End:
70,302,090 bp from pter
Size:
6,116 bases
Orientation:
Minus strand

Genomic View for FAM136A Gene

Genes around FAM136A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM136A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM136A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM136A Gene

Proteins for FAM136A Gene

  • Protein details for FAM136A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C01-F136A_HUMAN
    Recommended name:
    Protein FAM136A
    Protein Accession:
    Q96C01
    Secondary Accessions:
    • Q96SS3

    Protein attributes for FAM136A Gene

    Size:
    138 amino acids
    Molecular mass:
    15641 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM136A Gene

Proteomics data for FAM136A Gene at MOPED

Post-translational modifications for FAM136A Gene

  • Ubiquitination at Lys 48
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM136A Gene

No data available for DME Specific Peptides for FAM136A Gene

Domains & Families for FAM136A Gene

Protein Domains for FAM136A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM136A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C01

UniProtKB/Swiss-Prot:

F136A_HUMAN :
  • Belongs to the FAM136 family.
Family:
  • Belongs to the FAM136 family.
genes like me logo Genes that share domains with FAM136A: view

No data available for Gene Families for FAM136A Gene

Function for FAM136A Gene

genes like me logo Genes that share phenotypes with FAM136A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM136A Gene

Localization for FAM136A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM136A Gene COMPARTMENTS Subcellular localization image for FAM136A gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM136A Gene

Pathways & Interactions for FAM136A Gene

SuperPathways for FAM136A Gene

No Data Available

Interacting Proteins for FAM136A Gene

Gene Ontology (GO) - Biological Process for FAM136A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM136A Gene

Drugs & Compounds for FAM136A Gene

No Compound Related Data Available

Transcripts for FAM136A Gene

Unigene Clusters for FAM136A Gene

Family with sequence similarity 136, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM136A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for FAM136A Gene

GeneLoc Exon Structure for
FAM136A
ECgene alternative splicing isoforms for
FAM136A

Expression for FAM136A Gene

mRNA expression in normal human tissues for FAM136A Gene

Protein differential expression in normal tissues from HIPED for FAM136A Gene

This gene is overexpressed in Nasal epithelium (24.4), Peripheral blood mononuclear cells (8.4), and Liver (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM136A Gene



SOURCE GeneReport for Unigene cluster for FAM136A Gene Hs.516077

genes like me logo Genes that share expression patterns with FAM136A: view

Protein tissue co-expression partners for FAM136A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM136A Gene

Orthologs for FAM136A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM136A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100688076 35
  • 91.06 (n)
  • 91.3 (a)
-- 36
  • 83 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam136a 35
  • 89.61 (n)
  • 89.86 (a)
Fam136a 16
Fam136a 36
  • 90 (a)
OneToMany
Fam136b-ps 36
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FAM136A 35
  • 99.76 (n)
  • 100 (a)
FAM136A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam136a 35
  • 88.41 (n)
  • 89.13 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
FAM136A 36
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FAM136A 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC426296 35
  • 68.14 (n)
  • 61.03 (a)
FAM136A 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10079 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14996 35
zebrafish
(Danio rerio)
Actinopterygii wufb72f05 35
fam136a 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4968 35
fruit fly
(Drosophila melanogaster)
Insecta CG5327 35
  • 51.13 (n)
  • 35.34 (a)
CG12661 36
  • 31 (a)
OneToMany
CG5323 36
  • 36 (a)
OneToMany
CG5327 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK637.2 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5803 36
  • 32 (a)
OneToOne
Species with no ortholog for FAM136A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM136A Gene

ENSEMBL:
Gene Tree for FAM136A (if available)
TreeFam:
Gene Tree for FAM136A (if available)

Paralogs for FAM136A Gene

genes like me logo Genes that share paralogs with FAM136A: view

No data available for Paralogs for FAM136A Gene

Variants for FAM136A Gene

Sequence variations from dbSNP and Humsavar for FAM136A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3860 -- 70,296,268(+) TTCCT(G/T)TTGCC utr-variant-3-prime
rs7459 -- 70,296,009(+) TTAAA(A/G)TCAAA utr-variant-3-prime
rs14234 -- 70,297,010(+) GGGGA(A/G)AGCCT utr-variant-3-prime
rs1058256 -- 70,296,840(+) TTTTG(A/T)TTCAC utr-variant-3-prime
rs2169836 -- 70,296,684(+) TCCAC(A/T)AGGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM136A Gene

Variant ID Type Subtype PubMed ID
nsv518294 CNV Loss 19592680

Variation tolerance for FAM136A Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.48; 82.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM136A Gene

HapMap Linkage Disequilibrium report
FAM136A
Human Gene Mutation Database (HGMD)
FAM136A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM136A Gene

Disorders for FAM136A Gene

MalaCards: The human disease database

(4) MalaCards diseases for FAM136A Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
meniere's disease
  • meniere disease
labyrinthine disease
  • labyrinthine dysfunction
motion sickness
  • motion sickness nos
peripheral vertigo
  • vertigo, peripheral
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM136A

Genetic Association Database (GAD)
FAM136A
Human Genome Epidemiology (HuGE) Navigator
FAM136A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM136A
genes like me logo Genes that share disorders with FAM136A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM136A Gene

Publications for FAM136A Gene

  1. Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease. (PMID: 25305078) Requena T. … Lopez-Escamez J.A. (Hum. Mol. Genet. 2014) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for FAM136A Gene

Sources for FAM136A Gene

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