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Aliases for FAM135B Gene

Aliases for FAM135B Gene

  • Family With Sequence Similarity 135 Member B 2 3 5
  • C8ORFK32 3 4
  • Family With Sequence Similarity 135, Member B 2
  • Protein FAM135B 3

External Ids for FAM135B Gene

Previous GeneCards Identifiers for FAM135B Gene

  • GC08M139213
  • GC08M134457

Summaries for FAM135B Gene

GeneCards Summary for FAM135B Gene

FAM135B (Family With Sequence Similarity 135 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds. An important paralog of this gene is FAM135A.

Gene Wiki entry for FAM135B Gene

Additional gene information for FAM135B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM135B Gene

Genomics for FAM135B Gene

GeneHancer (GH) Regulatory Elements for FAM135B Gene

Promoters and enhancers for FAM135B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I138496 Promoter 0.6 EPDnew 550.8 0.0 -43 0.1 EZH2 FAM135B GC08M138509
GH08I138432 Promoter 0.5 EPDnew 550.2 +64.0 63951 0.1 GC08P138434 FAM135B LOC401478
GH08I138258 Enhancer 0.8 ENCODE 0.1 +236.9 236853 3.1 FOXA2 MLX ARID4B DMAP1 RAD21 RARA CREM MIXL1 HMG20B RXRA LOC401478 GC08P138434 FAM135B
GH08I138262 Enhancer 0.7 ENCODE 0.1 +234.4 234401 0.1 SOX13 FOXA2 MAX ZNF644 RAD21 RARA YY1 LCORL HNF4G MIXL1 LOC401478 GC08P138434 FAM135B
GH08I138275 Enhancer 0.6 ENCODE 0.1 +220.4 220443 1.8 FOXA2 RXRA MAX REST RAD21 FOXA1 YY1 JUND ATF3 HNF4A GC08P138434 LOC401478 FAM135B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM135B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM135B gene promoter:

Genomic Locations for FAM135B Gene

Genomic Locations for FAM135B Gene
366,800 bases
Minus strand

Genomic View for FAM135B Gene

Genes around FAM135B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM135B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM135B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM135B Gene

Proteins for FAM135B Gene

  • Protein details for FAM135B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM135B
    Protein Accession:
    Secondary Accessions:
    • B5MDB3
    • O95879
    • Q2WGJ7
    • Q3KP46

    Protein attributes for FAM135B Gene

    1406 amino acids
    Molecular mass:
    155770 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM135B Gene


neXtProt entry for FAM135B Gene

Post-translational modifications for FAM135B Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM135B Gene

Domains & Families for FAM135B Gene

Gene Families for FAM135B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM135B Gene

Suggested Antigen Peptide Sequences for FAM135B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM135 family.
  • Belongs to the FAM135 family.
genes like me logo Genes that share domains with FAM135B: view

Function for FAM135B Gene

Phenotypes From GWAS Catalog for FAM135B Gene

Gene Ontology (GO) - Molecular Function for FAM135B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052689 carboxylic ester hydrolase activity IBA --
genes like me logo Genes that share ontologies with FAM135B: view
genes like me logo Genes that share phenotypes with FAM135B: view

Animal Model Products

CRISPR Products

miRNA for FAM135B Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM135B Gene

Localization for FAM135B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM135B gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM135B Gene

Pathways & Interactions for FAM135B Gene

SuperPathways for FAM135B Gene

No Data Available

Interacting Proteins for FAM135B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q49AJ0-F135B_HUMAN ENSP00000378710 for FAM135B Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM135B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044255 cellular lipid metabolic process IBA --
genes like me logo Genes that share ontologies with FAM135B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM135B Gene

Drugs & Compounds for FAM135B Gene

No Compound Related Data Available

Transcripts for FAM135B Gene

Unigene Clusters for FAM135B Gene

Family with sequence similarity 135, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM135B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - -

Relevant External Links for FAM135B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM135B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM135B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM135B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.6), Brain - Cerebellum (x5.5), Brain - Frontal Cortex (BA9) (x4.8), Testis (x4.7), Brain - Cortex (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for FAM135B Gene

This gene is overexpressed in Cervix (42.2), Cerebrospinal fluid (15.3), and Pancreas (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM135B Gene

Protein tissue co-expression partners for FAM135B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM135B Gene:


SOURCE GeneReport for Unigene cluster for FAM135B Gene:


Evidence on tissue expression from TISSUES for FAM135B Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with FAM135B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM135B Gene

Orthologs for FAM135B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAM135B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC464414 33
  • 99.38 (n)
FAM135B 34
  • 99 (a)
(Bos Taurus)
Mammalia -- 34
  • 87 (a)
-- 34
  • 84 (a)
(Canis familiaris)
Mammalia FAM135B 33 34
  • 86.65 (n)
(Mus musculus)
Mammalia Fam135b 33 16 34
  • 82 (n)
(Rattus norvegicus)
Mammalia Fam135b 33
  • 81.69 (n)
(Monodelphis domestica)
Mammalia FAM135B 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia FAM135B 34
  • 49 (a)
(Gallus gallus)
Aves FAM135B 33 34
  • 67.67 (n)
(Anolis carolinensis)
Reptilia FAM135B 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam135b 33
  • 63.89 (n)
(Danio rerio)
Actinopterygii LOC100003594 33
  • 66.09 (n)
FAM135B 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32333 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea C09D4.4 34
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LPL1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
-- 34
  • 27 (a)
Species where no ortholog for FAM135B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM135B Gene

Gene Tree for FAM135B (if available)
Gene Tree for FAM135B (if available)

Paralogs for FAM135B Gene

Paralogs for FAM135B Gene

(1) SIMAP similar genes for FAM135B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM135B: view

Variants for FAM135B Gene

Sequence variations from dbSNP and Humsavar for FAM135B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000011556 -- 138,337,660(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000021880 -- 138,499,074(-) T/A upstream_transcript_variant
rs1000023605 -- 138,190,860(-) A/G intron_variant
rs1000029613 -- 138,176,277(-) C/A/G intron_variant
rs1000032525 -- 138,273,626(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM135B Gene

Variant ID Type Subtype PubMed ID
dgv1311e199 CNV deletion 23128226
esv1671280 CNV insertion 17803354
esv24380 CNV loss 19812545
esv2737691 CNV deletion 23290073
esv2764108 CNV loss 21179565
esv3369978 CNV duplication 20981092
esv3573014 CNV loss 25503493
esv3576609 CNV gain 25503493
esv3618984 CNV loss 21293372
esv3618985 CNV loss 21293372
nsv1030981 CNV gain 25217958
nsv1137407 CNV deletion 24896259
nsv395932 CNV deletion 16902084
nsv465939 CNV loss 19166990
nsv476396 CNV novel sequence insertion 20440878
nsv477310 CNV novel sequence insertion 20440878
nsv478821 CNV novel sequence insertion 20440878
nsv509281 CNV insertion 20534489
nsv525300 CNV loss 19592680
nsv612532 CNV loss 21841781
nsv6418 CNV insertion 18451855
nsv831477 CNV loss 17160897
nsv831478 CNV gain 17160897

Variation tolerance for FAM135B Gene

Residual Variation Intolerance Score: 4.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM135B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM135B Gene

Disorders for FAM135B Gene

Additional Disease Information for FAM135B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM135B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM135B Gene

Publications for FAM135B Gene

  1. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S … Arnett DK (Pharmacogenetics and genomics 2012) 3 44 58
  2. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli ET … Goldstein DB (European journal of human genetics : EJHG 2010) 3 44 58
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FAM135B Gene

Sources for FAM135B Gene

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