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Aliases for FAM135B Gene

Aliases for FAM135B Gene

  • Family With Sequence Similarity 135, Member B 2 3
  • C8ORFK32 3 4
  • Protein FAM135B 3

External Ids for FAM135B Gene

Previous GeneCards Identifiers for FAM135B Gene

  • GC08M139213
  • GC08M134457

Summaries for FAM135B Gene

GeneCards Summary for FAM135B Gene

FAM135B (Family With Sequence Similarity 135, Member B) is a Protein Coding gene. Diseases associated with FAM135B include extrapulmonary tuberculosis. An important paralog of this gene is FAM135A.

Gene Wiki entry for FAM135B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM135B Gene

Genomics for FAM135B Gene

Regulatory Elements for FAM135B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM135B Gene

138,130,023 bp from pter
138,496,822 bp from pter
366,800 bases
Minus strand

Genomic View for FAM135B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM135B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM135B Gene

Proteins for FAM135B Gene

  • Protein details for FAM135B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM135B
    Protein Accession:
    Secondary Accessions:
    • B5MDB3
    • O95879
    • Q2WGJ7
    • Q3KP46

    Protein attributes for FAM135B Gene

    1406 amino acids
    Molecular mass:
    155770 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM135B Gene


neXtProt entry for FAM135B Gene

Proteomics data for FAM135B Gene at MOPED

Post-translational modifications for FAM135B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM135B Gene

No data available for DME Specific Peptides for FAM135B Gene

Domains for FAM135B Gene

Protein Domains for FAM135B Gene

Suggested Antigen Peptide Sequences for FAM135B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM135 family.
  • Belongs to the FAM135 family.
genes like me logo Genes that share domains with FAM135B: view

No data available for Gene Families for FAM135B Gene

Function for FAM135B Gene

Gene Ontology (GO) - Molecular Function for FAM135B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016788 hydrolase activity, acting on ester bonds --
genes like me logo Genes that share ontologies with FAM135B: view
genes like me logo Genes that share phenotypes with FAM135B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM135B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM135B Gene

Localization for FAM135B Gene

Subcellular locations from

Jensen Localization Image for FAM135B Gene COMPARTMENTS Subcellular localization image for FAM135B gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM135B Gene

Pathways for FAM135B Gene

SuperPathways for FAM135B Gene

No Data Available

Interacting Proteins for FAM135B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q49AJ0-F135B_HUMAN ENSP00000378710 for FAM135B Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for FAM135B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006505 GPI anchor metabolic process --
GO:0006886 intracellular protein transport --
genes like me logo Genes that share ontologies with FAM135B: view

No data available for Pathways by source for FAM135B Gene

Transcripts for FAM135B Gene

Unigene Clusters for FAM135B Gene

Family with sequence similarity 135, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM135B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM135B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - -

Relevant External Links for FAM135B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM135B Gene

mRNA expression in normal human tissues for FAM135B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM135B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.6), Brain - Cerebellum (5.5), Brain - Frontal Cortex (BA9) (4.8), Testis (4.7), Brain - Cortex (4.2), and Brain - Anterior cingulate cortex (BA24) (4.2).

Protein differential expression in normal tissues for FAM135B Gene

This gene is overexpressed in Cervix (42.2), Cerebrospinal fluid (15.3), and Pancreas (10.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM135B Gene

SOURCE GeneReport for Unigene cluster for FAM135B Gene Hs.126024

genes like me logo Genes that share expressions with FAM135B: view

Expression partners for FAM135B Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM135B Gene

Orthologs for FAM135B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAM135B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM135B 35
  • 86.65 (n)
  • 85.41 (a)
FAM135B 36
  • 83 (a)
(Mus musculus)
Mammalia Fam135b 35
  • 82 (n)
  • 81.46 (a)
Fam135b 16
Fam135b 36
  • 80 (a)
(Pan troglodytes)
Mammalia LOC464414 35
  • 99.38 (n)
  • 99.16 (a)
FAM135B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam135b 35
  • 81.69 (n)
  • 81.1 (a)
(Bos Taurus)
Mammalia -- 36
  • 87 (a)
-- 36
  • 84 (a)
(Monodelphis domestica)
Mammalia FAM135B 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia FAM135B 36
  • 49 (a)
(Gallus gallus)
Aves FAM135B 35
  • 67.67 (n)
  • 65.69 (a)
FAM135B 36
  • 60 (a)
(Anolis carolinensis)
Reptilia FAM135B 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam135b 35
  • 63.89 (n)
  • 62.83 (a)
(Danio rerio)
Actinopterygii LOC100003594 35
  • 66.09 (n)
  • 67.53 (a)
FAM135B 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32333 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea C09D4.4 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
-- 36
  • 40 (a)
Species with no ortholog for FAM135B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM135B Gene

Gene Tree for FAM135B (if available)
Gene Tree for FAM135B (if available)

Paralogs for FAM135B Gene

Paralogs for FAM135B Gene

(1) SIMAP similar genes for FAM135B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM135B: view

Variants for FAM135B Gene

Sequence variations from dbSNP and Humsavar for FAM135B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs340704 -- 138,364,563(+) TCCTT(A/G)AAACC intron-variant
rs340712 -- 138,371,082(+) ggcct(A/G)aagac intron-variant
rs340713 -- 138,371,516(+) GGTGC(A/C)AGTTT intron-variant
rs754155 -- 138,131,333(-) TAAAG(G/T)AAGCC utr-variant-3-prime
rs869522 -- 138,241,254(-) CAGCA(C/G)ATAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM135B Gene

Variant ID Type Subtype PubMed ID
nsv831477 CNV Loss 17160897
nsv891511 CNV Gain 21882294
esv24380 CNV Loss 19812545
nsv509281 CNV Insertion 20534489
nsv891512 CNV Gain 21882294
nsv395932 CNV Loss 16902084
esv2737691 CNV Deletion 23290073
nsv465939 CNV Loss 19166990
nsv831478 CNV Gain 17160897
esv1671280 CNV Insertion 17803354
nsv6418 CNV Insertion 18451855
dgv1311e199 CNV Deletion 23128226
nsv525300 CNV Loss 19592680
nsv891513 CNV Loss 21882294

Relevant External Links for FAM135B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM135B Gene

Disorders for FAM135B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FAM135B Gene in MalaCards »

(1) Disease for FAM135B Gene

(1) University of Copenhagen DISEASES for FAM135B Gene

Relevant External Links for FAM135B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FAM135B: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FAM135B Gene

Publications for FAM135B Gene

  1. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S. … Arnett D.K. (Pharmacogenet. Genomics 2012) 3 48
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 48
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM135B Gene

Sources for FAM135B Gene

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