FAM135B Gene
protein-coding GIFtS : 50
GCID: GC08 M139213
family with sequence similarity 135, member B
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Aliasesfor FAM135B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 135, Member B 1 2 C8ORFK321 2 Protein FAM135B2 C8orfK323
Export aliases for FAM135B gene to outside databases Previous GC identifer: GC08M134457
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Summariesfor FAM135B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for FAM135B
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Genomic Viewsfor FAM135B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_008046.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM135B gene promoter: TBP USF1 Elk-1 AP-1 Lmo2 E47 AREB6 S8 Other transcription factors Search SABiosciences Chromatin IP Primers for FAM135B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM135B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q24.23 Ensembl cytogenetic band: 8q24.23 HGNC cytogenetic band: 8q24.23 FAM135B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M139213: view genomic region
(about GC identifiers )
Start:
139,142,266 bp from pter
End:
139,509,065 bp from pter
Size:
366,800 bases
Orientation:
minus strand
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Proteinsfor FAM135B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F135B_HUMAN, Q49AJ0 (See
protein sequence )Recommended Name: Protein FAM135B Size : 1406 amino acids; 155770 Da
Secondary accessions : B5MDB3 O95879 Q2WGJ7 Q3KP46Alternative splicing : 4 isoforms : Q49AJ0-1 Q49AJ0-2 Q49AJ0-3 Q49AJ0-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM135B: NX_Q49AJ0 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q49AJ0 FAM135B Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_056996.2 ENSEMBL proteins: ENSP00000378710 ENSP00000429874 ENSP00000276737 ENSP00000430088 ENSP00000160713 ENSP00000428017 Human Recombinant Protein Products for FAM135B: FAM135B Antibody Products: Assay Products for FAM135B:
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Protein
Domains / Familiesfor FAM135B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM135B for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q49AJ0 ProtoNet protein and cluster: Q49AJ0
UniProtKB/Swiss-Prot: F135B_HUMAN, Q49AJ0 Similarity : Belongs to the FAM135 family
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Functionfor FAM135B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Phenotypes: 3 GenomeRNAi human phenotypes for FAM135B :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM135B (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM135BOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM135B (NM_015912 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM135B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM135B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM135B
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Pathways & Interactionsfor FAM135B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM135B STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for FAM135B (Q49AJ0 2 , 3 ENSP00000276737 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor FAM135B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM135B Search CenterWatch for drugs/clinical trials and news about FAM135B / F135B
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Transcriptsfor FAM135B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM135B gene: NM_015912.3 Unigene Cluster for FAM135B:
Family with sequence similarity 135, member B Hs.126024 [show with all ESTs ] Unigene Representative Sequence: NM_015912 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000395297 (uc003yux.3 uc003yuy.3 uc003yuz.3 ) ENST00000482951 (uc003yva.3 )ENST00000276737 (uc003yvb.3 ) ENST00000467365 ENST00000395295 ENST00000160713 ENST00000517849 ENST00000520380 ENST00000520954 ENST00000520283 ENST00000523049 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM135B (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM135BOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM135B (NM_015912 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM135B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM135B
Additional cDNA sequence: AF131744.1 AK091433.1 BC037288.1 BC106912.1 BC106913.1 CR457147.1 CR936831.1
6 DOTS entries : DT.404306 DT.120639918
DT.111400 DT.120639894 DT.120639893 DT.40119184 24/36 AceView cDNA sequences (see all 36 ):
BX110118 BP360024 AL045573 AA890163 AI684585 CR457147 AF131744 BC038357 AA972109 AK091433 NM_015912 BP360050 AI187420 AI150379 AL041122 AL704920 BM353291 BF510654 AI651264 AA394187 AX746980 AL041121 BI459784 AA405916 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM135B About this scheme ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c SP1 :     -   -       -         SP2 :     -         -         SP3 :                    
ECgene alternative splicing isoforms for FAM135B
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Expression for FAM135B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM135B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCTCATTTGAAbout this image FAM135B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Testis Seminiferous Tubules Spermatid Germ Cells, Male Gametocytes Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM135B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM135B SOURCE GeneReport for Unigene cluster: Hs.126024 SABiosciences Custom PCR Arrays for FAM135B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM135BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat FAM135B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM135B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM135B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM135B
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Orthologsfor FAM135B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for FAM135B gene from 8/23 species (see all 23 ) About this table
ENSEMBL Gene Tree for FAM135B (if available)TreeFam Gene Tree for FAM135B (if available)
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Paralogsfor FAM135B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM135B gene FAM135A 2 1 SIMAP similar gene for FAM135B using alignment to 5 protein entries: F135B_HUMAN (see all proteins ):FAM135A
FAM135B for paralogs About GeneDecksing
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Genomic Variantsfor FAM135B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 8 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM135B (139142266 - 139392266 bp, first 250kb of FAM135B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for FAM135B 1 CNV : 70445 3 Indels : 95727 82795 13130
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM135B
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Disorders
/ Diseasesfor FAM135B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM135B for disorders About GeneDecksing 3 diseases for FAM135B : About MalaCards extrapulmonary tuberculosis pulmonary tuberculosis tuberculosis 1 disease from the University of Copenhagen DISEASES database for FAM135B :Extrapulmonary tuberculosis Human Genome Epidemiology (HuGE) Navigator: FAM135B (1 document)Export disorders for FAM135B gene to outside databases
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Publicationsfor FAM135B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM135B gene integrated from 9 sources : (articles sorted by number of sources associating them with FAM135B) Utopia : connect your pdf to the dynamic world of online information
Large-scale concatenation cDNA sequencing. (PubMed id 9110174) 1 , 3 Yu W.... Gibbs R.A. (1997) A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474) 1 , 3 Andersson B.... Gibbs R.A. (1996) A genome-wide association study of inflammatory biomar ker changes in response to fenofibrate treatment in the Genetics of Lipid Loweri ng Drug and Diet Network. (PubMed id 22228203) 1 Aslibekyan S....Arnett D.K. (2012) Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193) 1 Cirulli E.T....Goldstein D.B. (2010) DNA sequence and analysis of human chromosome 8. (PubMed id 16421571) 2 Nusbaum C....Lander E.S. (2006) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for FAM135B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM135B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM135B gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM135B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM135B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM135B gene: Search GeneIP for patents involving FAM135B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM135B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM135B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM135B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM135B Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM135B OriGene 3'-UTR Clone for FAM135B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM135B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM135B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM135B OriGene Custom Protein Services for FAM135B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM135B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM135B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM135B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM135B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM135B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM135B
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