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Aliases for FAM135A Gene

Aliases for FAM135A Gene

  • Family With Sequence Similarity 135 Member A 2 3 5
  • KIAA1411 2 3 4
  • Family With Sequence Similarity 135, Member A 2
  • Protein FAM135A 3

External Ids for FAM135A Gene

Previous HGNC Symbols for FAM135A Gene

  • KIAA1411

Previous GeneCards Identifiers for FAM135A Gene

  • GC06P071179
  • GC06P068321
  • GC06P071122

Summaries for FAM135A Gene

GeneCards Summary for FAM135A Gene

FAM135A (Family With Sequence Similarity 135 Member A) is a Protein Coding gene. Diseases associated with FAM135A include Retinitis Pigmentosa. GO annotations related to this gene include hydrolase activity, acting on ester bonds and O-acyltransferase activity. An important paralog of this gene is FAM135B.

Gene Wiki entry for FAM135A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM135A Gene

Genomics for FAM135A Gene

Regulatory Elements for FAM135A Gene

Enhancers for FAM135A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F070474 0.4 ENCODE 10.9 +62.0 62032 0.2 RAD51 JUND FAM135A LOC105377849 GC06P070515
GH06F070838 0.5 FANTOM5 2.5 +426.0 426018 0.1 ZNF584 THRB FAM135A PIR55092 GC06M070817
GH06F070231 0.4 FANTOM5 2.5 -181.2 -181224 0.0 PKNOX1 FAM135A ENSG00000253809 GC06M070247
GH06F070410 1.1 ENCODE 0.8 +0.7 686 5.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 EVADR SDHAF4 FAM135A LOC105377849
GH06F070880 0.3 FANTOM5 1.6 +467.6 467570 0.3 FAM135A PIR60398 PIR60782
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM135A on UCSC Golden Path with GeneCards custom track

Promoters for FAM135A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM135A Gene

70,412,941 bp from pter
70,561,174 bp from pter
148,234 bases
Plus strand

Genomic View for FAM135A Gene

Genes around FAM135A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM135A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM135A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM135A Gene

Proteins for FAM135A Gene

  • Protein details for FAM135A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM135A
    Protein Accession:
    Secondary Accessions:
    • A2RRQ5
    • Q3C0H3
    • Q5JXK0
    • Q5JXK1
    • Q68DW0
    • Q6P081
    • Q9H0F2
    • Q9NU48
    • Q9NUQ5
    • Q9NXL5

    Protein attributes for FAM135A Gene

    1515 amino acids
    Molecular mass:
    169840 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH65767.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAA90995.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAA92649.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66754.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI42417.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM135A Gene


neXtProt entry for FAM135A Gene

Post-translational modifications for FAM135A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM135A Gene

Domains & Families for FAM135A Gene

Protein Domains for FAM135A Gene

Suggested Antigen Peptide Sequences for FAM135A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM135 family.
  • Belongs to the FAM135 family.
genes like me logo Genes that share domains with FAM135A: view

No data available for Gene Families for FAM135A Gene

Function for FAM135A Gene

Gene Ontology (GO) - Molecular Function for FAM135A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052689 carboxylic ester hydrolase activity IBA --
genes like me logo Genes that share ontologies with FAM135A: view

Phenotypes for FAM135A Gene

genes like me logo Genes that share phenotypes with FAM135A: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM135A Gene

Localization for FAM135A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM135A gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM135A Gene

Pathways & Interactions for FAM135A Gene

SuperPathways for FAM135A Gene

No Data Available

Interacting Proteins for FAM135A Gene

Selected Interacting proteins: Q9P2D6-F135A_HUMAN for FAM135A Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM135A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044255 cellular lipid metabolic process IBA --
genes like me logo Genes that share ontologies with FAM135A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM135A Gene

Transcripts for FAM135A Gene

Unigene Clusters for FAM135A Gene

Family with sequence similarity 135, member A:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM135A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21a ·
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -

ExUns: 21b ^ 22a · 22b ^ 23a · 23b
SP1: -
SP2: -
SP4: -
SP5: - -

Relevant External Links for FAM135A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM135A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM135A Gene

mRNA differential expression in normal tissues according to GTEx for FAM135A Gene

This gene is overexpressed in Esophagus - Mucosa (x4.8).

Protein differential expression in normal tissues from HIPED for FAM135A Gene

This gene is overexpressed in Testis (58.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM135A Gene

Protein tissue co-expression partners for FAM135A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM135A Gene:


SOURCE GeneReport for Unigene cluster for FAM135A Gene:


mRNA Expression by UniProt/SwissProt for FAM135A Gene:

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with FAM135A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FAM135A Gene

Orthologs for FAM135A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM135A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM135A 34 35
  • 99.63 (n)
(Canis familiaris)
Mammalia FAM135A 34 35
  • 93.49 (n)
(Bos Taurus)
Mammalia FAM135A 34 35
  • 89.52 (n)
(Mus musculus)
Mammalia Fam135a 34 16 35
  • 87.39 (n)
(Rattus norvegicus)
Mammalia Fam135a 34
  • 85.79 (n)
(Monodelphis domestica)
Mammalia FAM135A 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FAM135A 35
  • 77 (a)
(Gallus gallus)
Aves FAM135A 34 35
  • 75.69 (n)
(Anolis carolinensis)
Reptilia FAM135A 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam135a 34
  • 68.7 (n)
(Danio rerio)
Actinopterygii LOC566435 34
  • 62.32 (n)
fam135a 35
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32333 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea C09D4.4 34 35
  • 45.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
-- 35
  • 31 (a)
Species where no ortholog for FAM135A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM135A Gene

Gene Tree for FAM135A (if available)
Gene Tree for FAM135A (if available)

Paralogs for FAM135A Gene

Paralogs for FAM135A Gene

(1) SIMAP similar genes for FAM135A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM135A: view

Variants for FAM135A Gene

Sequence variations from dbSNP and Humsavar for FAM135A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs748520978 Likely benign 70,477,264(+) GATTA(C/T)TTCCA reference, synonymous-codon, utr-variant-5-prime
rs10080714 -- 70,425,744(+) acatg(C/G)acaca intron-variant
rs10214776 -- 70,416,176(+) CTTGA(A/G)AAGCA intron-variant, upstream-variant-2KB
rs10214805 -- 70,535,423(+) cagga(A/G)cactg intron-variant
rs10434814 -- 70,530,447(+) AAATT(C/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM135A Gene

Variant ID Type Subtype PubMed ID
esv3609438 CNV loss 21293372
esv3609439 CNV loss 21293372
nsv1027049 CNV gain 25217958
nsv1027161 CNV loss 25217958
nsv1032876 CNV loss 25217958
nsv524328 CNV gain 19592680

Variation tolerance for FAM135A Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.18; 93.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM135A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM135A Gene

Disorders for FAM135A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM135A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM135A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM135A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM135A Gene

Publications for FAM135A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T. … Zhu X. (Hum. Genet. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for FAM135A Gene

Sources for FAM135A Gene

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