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Aliases for FAM135A Gene

Aliases for FAM135A Gene

  • Family With Sequence Similarity 135, Member A 2 3
  • KIAA1411 2 3 4
  • Protein FAM135A 3

External Ids for FAM135A Gene

Previous HGNC Symbols for FAM135A Gene

  • KIAA1411

Previous GeneCards Identifiers for FAM135A Gene

  • GC06P071179
  • GC06P068321
  • GC06P071122

Summaries for FAM135A Gene

GeneCards Summary for FAM135A Gene

FAM135A (Family With Sequence Similarity 135, Member A) is a Protein Coding gene. An important paralog of this gene is FAM135B.

Gene Wiki entry for FAM135A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM135A Gene

Genomics for FAM135A Gene

Regulatory Elements for FAM135A Gene

Genomic Location for FAM135A Gene

Start:
70,412,941 bp from pter
End:
70,561,174 bp from pter
Size:
148,234 bases
Orientation:
Plus strand

Genomic View for FAM135A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM135A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM135A Gene

Proteins for FAM135A Gene

  • Protein details for FAM135A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2D6-F135A_HUMAN
    Recommended name:
    Protein FAM135A
    Protein Accession:
    Q9P2D6
    Secondary Accessions:
    • A2RRQ5
    • Q3C0H3
    • Q5JXK0
    • Q5JXK1
    • Q68DW0
    • Q6P081
    • Q9H0F2
    • Q9NU48
    • Q9NUQ5
    • Q9NXL5

    Protein attributes for FAM135A Gene

    Size:
    1515 amino acids
    Molecular mass:
    169840 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH65767.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAA90995.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAA92649.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66754.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI42417.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM135A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM135A Gene

Proteomics data for FAM135A Gene at MOPED

Post-translational modifications for FAM135A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM135A Gene

Domains for FAM135A Gene

Protein Domains for FAM135A Gene

Suggested Antigen Peptide Sequences for FAM135A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2D6

UniProtKB/Swiss-Prot:

F135A_HUMAN :
  • Q9P2D6
Family:
  • Belongs to the FAM135 family.
genes like me logo Genes that share domains with FAM135A: view

No data available for Gene Families for FAM135A Gene

Function for FAM135A Gene

Gene Ontology (GO) - Molecular Function for FAM135A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008374 O-acyltransferase activity --
GO:0016788 hydrolase activity, acting on ester bonds --
genes like me logo Genes that share ontologies with FAM135A: view

Phenotypes for FAM135A Gene

GenomeRNAi human phenotypes for FAM135A:
genes like me logo Genes that share phenotypes with FAM135A: view

miRNA for FAM135A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM135A Gene

Localization for FAM135A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM135A Gene COMPARTMENTS Subcellular localization image for FAM135A gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM135A Gene

Pathways for FAM135A Gene

SuperPathways for FAM135A Gene

No Data Available

Interacting Proteins for FAM135A Gene

Selected Interacting proteins: Q9P2D6-F135A_HUMAN for FAM135A Gene via MINT I2D

Symbol External ID(s) Details
PCBD1
--

Gene Ontology (GO) - Biological Process for FAM135A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006505 GPI anchor metabolic process --
GO:0006629 lipid metabolic process --
GO:0006886 intracellular protein transport --
genes like me logo Genes that share ontologies with FAM135A: view

No data available for Pathways by source for FAM135A Gene

Transcripts for FAM135A Gene

Unigene Clusters for FAM135A Gene

Family with sequence similarity 135, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM135A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21a ·
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6:
SP7:
SP8:

ExUns: 21b ^ 22a · 22b ^ 23a · 23b
SP1: -
SP2: -
SP3:
SP4: -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for FAM135A Gene

GeneLoc Exon Structure for
FAM135A
ECgene alternative splicing isoforms for
FAM135A

Expression for FAM135A Gene

mRNA expression in normal human tissues for FAM135A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM135A Gene

This gene is overexpressed in Esophagus - Mucosa (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FAM135A Gene

SOURCE GeneReport for Unigene cluster for FAM135A Gene Hs.211700

mRNA Expression by UniProt/SwissProt for FAM135A Gene

Q9P2D6-F135A_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with FAM135A: view

Orthologs for FAM135A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM135A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM135A 35
  • 99.63 (n)
  • 99.47 (a)
FAM135A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM135A 35
  • 89.52 (n)
  • 88.31 (a)
FAM135A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM135A 35
  • 93.49 (n)
  • 91.22 (a)
FAM135A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam135a 35
  • 87.39 (n)
  • 84.37 (a)
Fam135a 16
Fam135a 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM135A 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM135A 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam135a 35
  • 85.79 (n)
  • 82.05 (a)
chicken
(Gallus gallus)
Aves FAM135A 35
  • 75.69 (n)
  • 72.46 (a)
FAM135A 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM135A 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam135a 35
  • 68.7 (n)
  • 64.63 (a)
zebrafish
(Danio rerio)
Actinopterygii fam135a 36
  • 57 (a)
OneToOne
LOC566435 35
  • 62.32 (n)
  • 62.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32333 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C09D4.4 35
  • 45.38 (n)
  • 30 (a)
C09D4.4 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
Species with no ortholog for FAM135A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM135A Gene

ENSEMBL:
Gene Tree for FAM135A (if available)
TreeFam:
Gene Tree for FAM135A (if available)

Paralogs for FAM135A Gene

Paralogs for FAM135A Gene

Selected SIMAP similar genes for FAM135A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM135A: view

Variants for FAM135A Gene

Sequence variations from dbSNP and Humsavar for FAM135A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs747454 -- 70,420,627(+) GCTTG(A/G)TATTC intron-variant
rs976538 -- 70,560,528(+) TGCCT(A/T)TTAAA utr-variant-3-prime
rs997350 -- 70,504,498(-) AAAAA(C/T)GGCTA intron-variant
rs1124059 -- 70,421,702(+) TATGA(A/C)CCAGT intron-variant
rs1208471 -- 70,552,609(+) gatta(C/T)aggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM135A Gene

Variant ID Type Subtype PubMed ID
nsv886142 CNV Gain 21882294
nsv524328 CNV Gain 19592680
nsv886144 CNV Gain 21882294
nsv886145 CNV Loss 21882294
nsv886146 CNV Loss 21882294

Relevant External Links for FAM135A Gene

HapMap Linkage Disequilibrium report
FAM135A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM135A Gene

Disorders for FAM135A Gene

Relevant External Links for FAM135A

Genetic Association Database (GAD)
FAM135A
Human Genome Epidemiology (HuGE) Navigator
FAM135A
genes like me logo Genes that share disorders with FAM135A: view

No data available for UniProtKB/Swiss-Prot for FAM135A Gene

Publications for FAM135A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T. … Zhu X. (Hum. Genet. 2010) 3 48

Products for FAM135A Gene

Sources for FAM135A Gene

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