FAM134C Gene
protein-coding GIFtS: 44
GCID: GC17M040731
|
|
family with sequence similarity 134, member C
| |
Aliases
for FAM134C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Family With Sequence Similarity 134, Member C1 2 | | DKFZp686B10361 | | FLJ338061 | | Protein FAM134C2 |
| External Ids: | HGNC: 272581 | Entrez Gene: 1624272 | Ensembl: ENSG000001416997 | UniProtKB: Q86VR23 | | ORGUL members: | |
|---|
| NONCODE:n407229 n333902 | |
Export aliases for FAM134C gene to outside databasesPrevious GC identifers: GC17M037986 GC17M036496
|---|
Summaries
for FAM134C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for FAM134C
|
Genomic Views
for FAM134C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM134C gene promoter:
NF-1 NF-1/L AML1a Tal-1beta GATA-1 COMP1 Zic1 ZIC2/Zic2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM134C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM134C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2FAM134C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M040731: view genomic region
(about GC identifiers)
Start:
|
40,731,526 bp from pter |
End:
|
40,762,641 bp from pter |
Size:
|
31,116 bases |
Orientation:
|
minus strand |
ORGUL member locations:
Legend (see complete legend)
40731525 40746485 40761445 chr17
|
Proteins
for FAM134C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F134C_HUMAN, Q86VR2 (See
protein sequence)Recommended Name: Protein FAM134C Size: 466 amino acids; 51396 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for FAM134C: NX_Q86VR2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86VR2
FAM134C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_835227.1
ENSEMBL proteins: ENSP00000467157 ENSP00000309432 ENSP00000467847 ENSP00000466925 ENSP00000466145 ENSP00000465016 ENSP00000465004 ENSP00000467332 ENSP00000466482 ENSP00000446235
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FAM134C for ontologies About GeneDecksing
FAM134C Antibody Products:
Assay Products for FAM134C: |
Protein
Domains /
Families
for FAM134C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86VR2 UniProtKB/Swiss-Prot: F134C_HUMAN, Q86VR2Similarity: Belongs to the FAM134 family |
Function
for FAM134C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM134C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM134C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM134C (NM_178126) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM134C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM134C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM134C |
Animal Models:
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fam134c):
FAM134C for phenotypes About GeneDecksing
|
Pathways & Interactions
for FAM134C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM134C
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for FAM134C (Q86VR23 ENSP000003094324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM134C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM134C
Search CenterWatch for drugs/clinical trials and news about FAM134C / F134C
|
Transcripts
for FAM134C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM134C gene: NM_178126.3 Unigene Cluster for FAM134C: Family with sequence similarity 134, member C Hs.632262 [show with all ESTs]Unigene Representative Sequence: AK09112513 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000589797 ENST00000309428(uc002ial.2 uc010wgq.1 uc002iam.1 uc010cyk.1)
ENST00000585894 ENST00000586870 ENST00000589007 ENST00000590035 ENST00000585726
ENST00000591547 ENST00000593251 ENST00000588423 ENST00000586796 ENST00000590541
ENST00000543197
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM134C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM134C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM134C (NM_178126) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM134C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM134C |
Additional cDNA sequence: AK057409.1 AK091125.1 AK225797.1 AK294791.1 AK308288.1 BC024980.1 BC049370.1 BX647175.1 BX648069.1 L38937.1 NR_026697.1 19 DOTS entries: DT.92425637 DT.436336 DT.100698957 DT.100762577 DT.120999061 DT.120999088 DT.95254386 DT.97812316 DT.100645290 DT.120999097 DT.92047323 DT.95265695 DT.95265696 DT.102838254 DT.120999002 DT.120999038 DT.120999106 DT.95164442 DT.95164443 24/255 AceView cDNA sequences (see all 255): BM708480 AI630234 BP871662 BE670114 BQ420342 AA744513 N92551 BM674535 CR599112 BU624442 AI762685 T30238 R27994 BM969256 AA725292 AA303178 BU681339 AI823769 BP872503 C01956 BF376169 BU194783 L38935 BQ231218
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for FAM134C (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | - | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM134C
|
Expression
for FAM134C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM134C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTGTGCGCT
About this image
See FAM134C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM134C
SOURCE GeneReport for Unigene cluster: Hs.632262
SABiosciences Custom PCR Arrays for FAM134C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM134C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM134C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM134C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM134C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM134C |
Orthologs
for FAM134C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM134C gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAM134C1 |
family with sequence similarity 134, member C |
70.43(n)
70.82(a) |
|
772215 XM_001234117.2 XP_001234118.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM134C6 |
-- |
67(a) |
1 ↔ 1 |
6(61787331-61796246) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.309592 |
Xenopus laevis transcribed sequences |
77.11(n) |
|
48034962 |
zebrafish
(Danio rerio) |
Actinopterygii |
fam134c1 |
family with sequence similarity 134, member C |
61.11(n)
57.53(a) |
|
566014 XM_689279.4 XP_694371.1 |
ENSEMBL Gene Tree for FAM134C (if available)
TreeFam Gene Tree for FAM134C (if available) |
Paralogs
for FAM134C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM134C gene
- FAM134A2 FAM134B2
2 SIMAP similar genes for FAM134C using alignment to 10 protein entries: F134C_HUMAN (see all proteins):FAM134B FAM134A
FAM134C for paralogs About GeneDecksing
|
Genomic Variants
for FAM134C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM134C (40731526 - 40762641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM134C
1 Indel: 40181 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM134C |
|
Disorders
/ Diseases
for FAM134C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM134C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM134C gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FAM134C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for FAM134C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM134C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM134C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM134C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM134C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM134C gene:
Search GeneIP for patents involving FAM134C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM134C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM134C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM134C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM134C | | | OriGene Protein Over-expression Lysate for FAM134C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM134C | | OriGene 3'-UTR Clone for FAM134C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM134C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM134C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM134C | | OriGene Custom Protein Services for FAM134C | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM134C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM134C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM134C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM134C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM134C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM134C |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM134C |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM134C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM134C |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM134C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM134C |
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