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Aliases for FAM134C Gene

Aliases for FAM134C Gene

  • Family With Sequence Similarity 134 Member C 2 3 5
  • Family With Sequence Similarity 134, Member C 2

External Ids for FAM134C Gene

Previous GeneCards Identifiers for FAM134C Gene

  • GC17M037986
  • GC17M040731
  • GC17M036496

Summaries for FAM134C Gene

GeneCards Summary for FAM134C Gene

FAM134C (Family With Sequence Similarity 134 Member C) is a Protein Coding gene. An important paralog of this gene is FAM134B.

UniProtKB/Swiss-Prot for FAM134C Gene

  • Mediates NRF1-enhanced neurite outgrowth.

Gene Wiki entry for FAM134C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM134C Gene

Genomics for FAM134C Gene

Regulatory Elements for FAM134C Gene

Enhancers for FAM134C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F043322 0.9 Ensembl ENCODE 20.6 -712.5 -712548 1.7 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 ENSG00000267340 ENSG00000267002 ASB16-AS1 HMGN1P29 DHX8 NBR2 LOC108783654 LINC00910 AOC3 ENSG00000260793
GH17F042392 0.2 ENCODE 20.1 +217.6 217631 0.9 HDGF ZNF493 ZFP64 YY1 ZNF302 ZNF354C ZNF138 ZNF202 ZNF680 ZNF654 ENSG00000267340 ENSG00000267002 HMGN1P29 KAT2A LOC108783654 ENSG00000267758 NBR2 P3H4 ENSG00000267765 LINC00910
GH17F043576 1.4 Ensembl ENCODE 20 -966.2 -966219 0.9 ZFP64 ZNF493 ARID4B DMAP1 ZNF48 ZNF2 ZNF121 SLC30A9 ZNF143 KLF7 ENSG00000267340 ASB16-AS1 ENSG00000267002 DHX8 HMGN1P29 NBR2 LINC00910 GPATCH8 FAM134C CNTNAP1
GH17F042997 0.7 Ensembl ENCODE 17.7 -389.3 -389326 5.2 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DHX8 NBR2 ENSG00000267758 LINC00910 HMGN1P29 HMGN2P15 NAGLU ENSG00000267604 RPL27 FAM134C
GH17F042623 1.2 Ensembl ENCODE 13.3 -13.6 -13581 1.9 PKNOX1 ARNT GTF3C2 GATA2 ZNF143 FOS NCOA1 JUNB REST MBD2 DHX8 TUBG2 HMGN1P29 VPS25 FAM134C PSME3 ENSG00000267758 LINC00910 WNK4 ATP5LP7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM134C on UCSC Golden Path with GeneCards custom track

Promoters for FAM134C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001346629 1423 2401 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for FAM134C Gene

Chromosome:
17
Start:
42,579,508 bp from pter
End:
42,610,623 bp from pter
Size:
31,116 bases
Orientation:
Minus strand

Genomic View for FAM134C Gene

Genes around FAM134C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM134C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM134C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM134C Gene

Proteins for FAM134C Gene

  • Protein details for FAM134C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VR2-F134C_HUMAN
    Recommended name:
    Protein FAM134C
    Protein Accession:
    Q86VR2
    Secondary Accessions:
    • B3KR75

    Protein attributes for FAM134C Gene

    Size:
    466 amino acids
    Molecular mass:
    51396 Da
    Quaternary structure:
    • Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1.

    Alternative splice isoforms for FAM134C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM134C Gene

Post-translational modifications for FAM134C Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM134C Gene

Domains & Families for FAM134C Gene

Protein Domains for FAM134C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM134C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VR2

UniProtKB/Swiss-Prot:

F134C_HUMAN :
  • The LIR motif interacts with ATG8 family proteins.
  • Belongs to the FAM134 family.
Domain:
  • The LIR motif interacts with ATG8 family proteins.
Family:
  • Belongs to the FAM134 family.
genes like me logo Genes that share domains with FAM134C: view

No data available for Gene Families for FAM134C Gene

Function for FAM134C Gene

Molecular function for FAM134C Gene

UniProtKB/Swiss-Prot Function:
Mediates NRF1-enhanced neurite outgrowth.

Gene Ontology (GO) - Molecular Function for FAM134C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM134C: view
genes like me logo Genes that share phenotypes with FAM134C: view

Animal Models for FAM134C Gene

MGI Knock Outs for FAM134C:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM134C Gene

Localization for FAM134C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM134C Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM134C Gene COMPARTMENTS Subcellular localization image for FAM134C gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM134C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM134C: view

Pathways & Interactions for FAM134C Gene

SuperPathways for FAM134C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM134C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010976 positive regulation of neuron projection development IEA,IMP 23939472
genes like me logo Genes that share ontologies with FAM134C: view

No data available for Pathways by source and SIGNOR curated interactions for FAM134C Gene

Transcripts for FAM134C Gene

Unigene Clusters for FAM134C Gene

Family with sequence similarity 134, member C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM134C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - -
SP7:
SP8: - - -
SP9: - -

Relevant External Links for FAM134C Gene

GeneLoc Exon Structure for
FAM134C
ECgene alternative splicing isoforms for
FAM134C

Expression for FAM134C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM134C Gene

Protein differential expression in normal tissues from HIPED for FAM134C Gene

This gene is overexpressed in Adipocyte (8.8), Testis (6.6), and Bone (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM134C Gene



Protein tissue co-expression partners for FAM134C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM134C Gene:

FAM134C

SOURCE GeneReport for Unigene cluster for FAM134C Gene:

Hs.632262
genes like me logo Genes that share expression patterns with FAM134C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM134C Gene

Orthologs for FAM134C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM134C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM134C 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia FAM134C 34 35
  • 92.27 (n)
cow
(Bos Taurus)
Mammalia FAM134C 34 35
  • 91.13 (n)
rat
(Rattus norvegicus)
Mammalia Fam134c 34
  • 90.49 (n)
mouse
(Mus musculus)
Mammalia Fam134c 34 16 35
  • 90.34 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM134C 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM134C 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM134C 34 35
  • 70.34 (n)
lizard
(Anolis carolinensis)
Reptilia FAM134C 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam134c 34
  • 66.04 (n)
Str.6330 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.30959 34
zebrafish
(Danio rerio)
Actinopterygii fam134c 34 35
  • 61.19 (n)
Species where no ortholog for FAM134C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM134C Gene

ENSEMBL:
Gene Tree for FAM134C (if available)
TreeFam:
Gene Tree for FAM134C (if available)

Paralogs for FAM134C Gene

Paralogs for FAM134C Gene

genes like me logo Genes that share paralogs with FAM134C: view

Variants for FAM134C Gene

Sequence variations from dbSNP and Humsavar for FAM134C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs398123046 Pathogenic 42,610,535(+) CATCT(A/G)CCTGT upstream-variant-2KB, reference, missense
rs10454087 -- 42,583,623(+) CCCAG(C/T)GTAAA intron-variant
rs1051159 -- 42,579,653(-) GGCAA(A/G)AGGGA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1051166 -- 42,579,570(-) TCTCC(A/C)CTGTG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10537185 -- 42,593,663(+) AAAAA(-/AAAAAAAA)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM134C Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1064012 CNV gain 25217958
nsv1113874 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159

Variation tolerance for FAM134C Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM134C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM134C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM134C Gene

Disorders for FAM134C Gene

Relevant External Links for FAM134C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM134C

No disorders were found for FAM134C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM134C Gene

Publications for FAM134C Gene

  1. Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons. (PMID: 23939472) Wang J.L. … Huang A.M. (Gene 2013) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for FAM134C Gene

Sources for FAM134C Gene

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