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Aliases for FAM134A Gene

Aliases for FAM134A Gene

  • Family With Sequence Similarity 134, Member A 2 3
  • C2orf17 3 4
  • Chromosome 2 Open Reading Frame 17 2

External Ids for FAM134A Gene

Previous HGNC Symbols for FAM134A Gene

  • C2orf17

Previous GeneCards Identifiers for FAM134A Gene

  • GC02P219752
  • GC02P220040
  • GC02P211896

Summaries for FAM134A Gene

GeneCards Summary for FAM134A Gene

FAM134A (Family With Sequence Similarity 134, Member A) is a Protein Coding gene. An important paralog of this gene is FAM134C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM134A Gene

Genomics for FAM134A Gene

Regulatory Elements for FAM134A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM134A Gene

Chromosome:
2
Start:
219,176,225 bp from pter
End:
219,185,479 bp from pter
Size:
9,255 bases
Orientation:
Plus strand

Genomic View for FAM134A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM134A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM134A Gene

Proteins for FAM134A Gene

  • Protein details for FAM134A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC44-F134A_HUMAN
    Recommended name:
    Protein FAM134A
    Protein Accession:
    Q8NC44
    Secondary Accessions:
    • Q6P1P5
    • Q9H0K7

    Protein attributes for FAM134A Gene

    Size:
    543 amino acids
    Molecular mass:
    57830 Da
    Quaternary structure:
    • Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1.

neXtProt entry for FAM134A Gene

Proteomics data for FAM134A Gene at MOPED

Post-translational modifications for FAM134A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM134A Gene

Domains & Families for FAM134A Gene

Protein Domains for FAM134A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM134A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NC44

UniProtKB/Swiss-Prot:

F134A_HUMAN :
  • The LIR motif interacts with ATG8 family proteins.
  • Belongs to the FAM134 family.
Domain:
  • The LIR motif interacts with ATG8 family proteins.
Family:
  • Belongs to the FAM134 family.
genes like me logo Genes that share domains with FAM134A: view

No data available for Gene Families for FAM134A Gene

Function for FAM134A Gene

Phenotypes for FAM134A Gene

GenomeRNAi human phenotypes for FAM134A:
genes like me logo Genes that share phenotypes with FAM134A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM134A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM134A Gene

Localization for FAM134A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM134A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM134A Gene COMPARTMENTS Subcellular localization image for FAM134A gene
Compartment Confidence
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM134A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with FAM134A: view

Pathways & Interactions for FAM134A Gene

SuperPathways for FAM134A Gene

No Data Available

Interacting Proteins for FAM134A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000395249%0d%0a9606.ENSP00000363970%0d%0a
Selected Interacting proteins: Q8NC44-F134A_HUMAN ENSP00000395249 for FAM134A Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for FAM134A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM134A Gene

Drugs & Compounds for FAM134A Gene

No Compound Related Data Available

Transcripts for FAM134A Gene

Unigene Clusters for FAM134A Gene

Family with sequence similarity 134, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM134A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM134A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1:
SP2: -
SP3: -
SP4: - - - - -
SP5:
SP6:

Relevant External Links for FAM134A Gene

GeneLoc Exon Structure for
FAM134A
ECgene alternative splicing isoforms for
FAM134A

Expression for FAM134A Gene

mRNA expression in normal human tissues for FAM134A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM134A Gene

This gene is overexpressed in Adrenal (17.2) and Testis (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM134A Gene



SOURCE GeneReport for Unigene cluster for FAM134A Gene Hs.516707

genes like me logo Genes that share expression patterns with FAM134A: view

Protein tissue co-expression partners for FAM134A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM134A Gene

Orthologs for FAM134A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM134A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM134A 35
  • 90.49 (n)
  • 91.9 (a)
C2ORF17 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM134A 35
  • 89.62 (n)
  • 90.91 (a)
FAM134A 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam134a 35
  • 87.69 (n)
  • 87.83 (a)
Fam134a 16
Fam134a 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM134A 35
  • 99.51 (n)
  • 99.45 (a)
FAM134A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam134a 35
  • 88.64 (n)
  • 89.66 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM134A 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FAM134A 35
  • 67.43 (n)
  • 67.09 (a)
FAM134A 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM134A 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam134a 35
  • 61.87 (n)
  • 59.23 (a)
Str.17191 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13426 35
zebrafish
(Danio rerio)
Actinopterygii fam134a 35
  • 61.88 (n)
  • 59.23 (a)
fam134a 36
  • 45 (a)
OneToOne
Species with no ortholog for FAM134A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM134A Gene

ENSEMBL:
Gene Tree for FAM134A (if available)
TreeFam:
Gene Tree for FAM134A (if available)

Paralogs for FAM134A Gene

Paralogs for FAM134A Gene

(1) SIMAP similar genes for FAM134A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM134A: view

Variants for FAM134A Gene

Sequence variations from dbSNP and Humsavar for FAM134A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7017 -- 219,183,428(+) AGGGT(C/T)AGGAA utr-variant-3-prime
rs1139920 -- 219,183,063(+) TTCTG(C/T)GTTCC utr-variant-3-prime
rs1139921 -- 219,183,079(+) GCTTT(A/G)TTTCC utr-variant-3-prime
rs1139922 -- 219,183,081(+) TTTAT(G/T)TCCCT utr-variant-3-prime
rs2272017 -- 219,181,627(+) TCCTG(C/G)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM134A Gene

Variant ID Type Subtype PubMed ID
nsv875868 CNV Gain 21882294
nsv508200 CNV Loss 20534489
nsv875869 CNV Loss 21882294
nsv3170 CNV Loss 18451855

Variation tolerance for FAM134A Gene

Residual Variation Intolerance Score: 28.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.39; 88.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM134A Gene

HapMap Linkage Disequilibrium report
FAM134A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM134A Gene

Disorders for FAM134A Gene

Relevant External Links for FAM134A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM134A
genes like me logo Genes that share disorders with FAM134A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM134A Gene

Publications for FAM134A Gene

  1. Regulation of endoplasmic reticulum turnover by selective autophagy. (PMID: 26040720) Khaminets A. … Dikic I. (Nature 2015) 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 67
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67

Products for FAM134A Gene

Sources for FAM134A Gene

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