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Aliases for FAM134A Gene

Aliases for FAM134A Gene

  • Family With Sequence Similarity 134 Member A 2 3 5
  • C2orf17 3 4
  • Family With Sequence Similarity 134, Member A 2
  • Chromosome 2 Open Reading Frame 17 2
  • Metastasis Associated Gene-2 3
  • Protein FAM134A 3
  • MAG-2 3

External Ids for FAM134A Gene

Previous HGNC Symbols for FAM134A Gene

  • C2orf17

Previous GeneCards Identifiers for FAM134A Gene

  • GC02P219752
  • GC02P220040
  • GC02P211896

Summaries for FAM134A Gene

GeneCards Summary for FAM134A Gene

FAM134A (Family With Sequence Similarity 134 Member A) is a Protein Coding gene. An important paralog of this gene is FAM134C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM134A Gene

Genomics for FAM134A Gene

Regulatory Elements for FAM134A Gene

Enhancers for FAM134A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F218962 1.7 FANTOM5 Ensembl ENCODE 11.1 -212.5 -212516 2.4 ATF1 PKNOX1 MLX ARID4B SIN3A ZNF48 ZNF2 ETS1 SLC30A9 GLIS2 FAM134A CDK5R2 FEV PTPRN STK36 USP37 GC02P218963 LINC00608
GH02F219541 1.4 Ensembl ENCODE 11.1 +368.0 367965 5.1 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ASIC4 OBSL1 INHA FAM134A ENSG00000268896 CHPF
GH02F219121 1.2 Ensembl ENCODE 10.3 -51.1 -51087 7.3 ATF1 ARID4B YBX1 FOS SP5 KAT8 SREBF1 MIER3 ETV4 RCOR2 SLC23A3 NHEJ1 IHH LOC100129175 MIR375 FEV CRYBA2 LINC00608 CNPPD1 FAM134A
GH02F218443 1.1 ENCODE 11.1 -730.4 -730390 4.1 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS CNOT9 PLCD4 FAM134A USP37 VIL1 RN7SKP38
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM134A on UCSC Golden Path with GeneCards custom track

Promoters for FAM134A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000607773 1475 3401 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 ZNF207

Genomic Location for FAM134A Gene

219,176,225 bp from pter
219,185,479 bp from pter
9,255 bases
Plus strand

Genomic View for FAM134A Gene

Genes around FAM134A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM134A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM134A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM134A Gene

Proteins for FAM134A Gene

  • Protein details for FAM134A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM134A
    Protein Accession:
    Secondary Accessions:
    • Q6P1P5
    • Q9H0K7

    Protein attributes for FAM134A Gene

    543 amino acids
    Molecular mass:
    57830 Da
    Quaternary structure:
    • Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1.

neXtProt entry for FAM134A Gene

Post-translational modifications for FAM134A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM134A Gene

Domains & Families for FAM134A Gene

Protein Domains for FAM134A Gene


Suggested Antigen Peptide Sequences for FAM134A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The LIR motif interacts with ATG8 family proteins.
  • Belongs to the FAM134 family.
  • The LIR motif interacts with ATG8 family proteins.
  • Belongs to the FAM134 family.
genes like me logo Genes that share domains with FAM134A: view

No data available for Gene Families for FAM134A Gene

Function for FAM134A Gene

Phenotypes for FAM134A Gene

genes like me logo Genes that share phenotypes with FAM134A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM134A Gene

Localization for FAM134A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM134A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM134A gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM134A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with FAM134A: view

Pathways & Interactions for FAM134A Gene

SuperPathways for FAM134A Gene

No Data Available

Interacting Proteins for FAM134A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8NC44-F134A_HUMAN ENSP00000395249 for FAM134A Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for FAM134A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM134A Gene

Transcripts for FAM134A Gene

Unigene Clusters for FAM134A Gene

Family with sequence similarity 134, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM134A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP2: -
SP3: -
SP4: - - - - -

Relevant External Links for FAM134A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM134A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM134A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM134A Gene

This gene is overexpressed in Adrenal (17.2) and Testis (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM134A Gene

Protein tissue co-expression partners for FAM134A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM134A Gene:


SOURCE GeneReport for Unigene cluster for FAM134A Gene:

genes like me logo Genes that share expression patterns with FAM134A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM134A Gene

Orthologs for FAM134A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM134A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM134A 34 35
  • 99.51 (n)
(Bos Taurus)
Mammalia FAM134A 34
  • 90.49 (n)
C2ORF17 35
  • 89 (a)
(Canis familiaris)
Mammalia FAM134A 34 35
  • 89.62 (n)
(Rattus norvegicus)
Mammalia Fam134a 34
  • 88.64 (n)
(Mus musculus)
Mammalia Fam134a 34 16 35
  • 87.69 (n)
(Monodelphis domestica)
Mammalia FAM134A 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 31 (a)
(Gallus gallus)
Aves FAM134A 34 35
  • 67.43 (n)
(Anolis carolinensis)
Reptilia FAM134A 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam134a 34
  • 61.87 (n)
Str.17191 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13426 34
(Danio rerio)
Actinopterygii fam134a 34 35
  • 61.88 (n)
Species where no ortholog for FAM134A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM134A Gene

Gene Tree for FAM134A (if available)
Gene Tree for FAM134A (if available)

Paralogs for FAM134A Gene

Paralogs for FAM134A Gene

(1) SIMAP similar genes for FAM134A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM134A: view

Variants for FAM134A Gene

Sequence variations from dbSNP and Humsavar for FAM134A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10170226 -- 219,177,892(+) GTTGA(C/G)GGTTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10170244 -- 219,177,953(+) CTACC(A/G)GGGAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10191168 -- 219,184,824(+) TTGTG(G/T)GTTTT downstream-variant-500B, utr-variant-3-prime
rs10193576 -- 219,177,905(+) TGAGT(A/C)ATGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10548905 -- 219,176,501(+) GGTCC(-/AT)AGAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM134A Gene

Variant ID Type Subtype PubMed ID
nsv508200 CNV deletion 20534489
nsv3170 CNV deletion 18451855
esv3893555 CNV loss 25118596

Variation tolerance for FAM134A Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.39; 88.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM134A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM134A Gene

Disorders for FAM134A Gene

Relevant External Links for FAM134A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM134A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM134A Gene

Publications for FAM134A Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for FAM134A Gene

Sources for FAM134A Gene

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