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Aliases for FAM133B Gene

Aliases for FAM133B Gene

  • Family With Sequence Similarity 133 Member B 2 3 5
  • Family With Sequence Similarity 133, Member B 2

External Ids for FAM133B Gene

Previous GeneCards Identifiers for FAM133B Gene

  • GC07M092029
  • GC07M092190
  • GC07M086799

Summaries for FAM133B Gene

GeneCards Summary for FAM133B Gene

FAM133B (Family With Sequence Similarity 133 Member B) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FAM133A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM133B Gene

Genomics for FAM133B Gene

Regulatory Elements for FAM133B Gene

Enhancers for FAM133B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM133B on UCSC Golden Path with GeneCards custom track

Promoters for FAM133B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM133B Gene

92,560,758 bp from pter
92,590,394 bp from pter
29,637 bases
Minus strand

Genomic View for FAM133B Gene

Genes around FAM133B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM133B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM133B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM133B Gene

Proteins for FAM133B Gene

  • Protein details for FAM133B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM133B
    Protein Accession:
    Secondary Accessions:
    • B2R994
    • Q05D67
    • Q6P5S6
    • Q8N0W8

    Protein attributes for FAM133B Gene

    247 amino acids
    Molecular mass:
    28385 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM133B Gene


neXtProt entry for FAM133B Gene

Post-translational modifications for FAM133B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM133B Gene

No data available for DME Specific Peptides for FAM133B Gene

Domains & Families for FAM133B Gene

Protein Domains for FAM133B Gene


Suggested Antigen Peptide Sequences for FAM133B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM133 family.
  • Belongs to the FAM133 family.
genes like me logo Genes that share domains with FAM133B: view

No data available for Gene Families for FAM133B Gene

Function for FAM133B Gene

Gene Ontology (GO) - Molecular Function for FAM133B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with FAM133B: view

Phenotypes for FAM133B Gene

GenomeRNAi human phenotypes for FAM133B:
genes like me logo Genes that share phenotypes with FAM133B: view

Animal Model Products

CRISPR Products

miRNA for FAM133B Gene

miRTarBase miRNAs that target FAM133B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM133B Gene

Localization for FAM133B Gene

Subcellular locations from

Jensen Localization Image for FAM133B Gene COMPARTMENTS Subcellular localization image for FAM133B gene
Compartment Confidence
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM133B Gene

Pathways & Interactions for FAM133B Gene

SuperPathways for FAM133B Gene

No Data Available

Interacting Proteins for FAM133B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000398401 Q5BKY9-F133B_HUMAN for FAM133B Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM133B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM133B Gene

Drugs & Compounds for FAM133B Gene

No Compound Related Data Available

Transcripts for FAM133B Gene

Unigene Clusters for FAM133B Gene

Family with sequence similarity 133, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM133B Gene

No ASD Table

Relevant External Links for FAM133B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM133B Gene

mRNA expression in normal human tissues for FAM133B Gene

Protein differential expression in normal tissues from HIPED for FAM133B Gene

This gene is overexpressed in Liver, secretome (53.0) and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM133B Gene

Protein tissue co-expression partners for FAM133B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM133B Gene:


SOURCE GeneReport for Unigene cluster for FAM133B Gene:

genes like me logo Genes that share expression patterns with FAM133B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM133B Gene

Orthologs for FAM133B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM133B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM133B 34
  • 95.41 (n)
  • 95.95 (a)
(Canis familiaris)
Mammalia LOC100856224 34
  • 93.61 (n)
  • 95.79 (a)
FAM133B 35
  • 97 (a)
(Mus musculus)
Mammalia Fam133b 34
  • 85.45 (n)
  • 86.85 (a)
Fam133b 16
Fam133b 35
  • 89 (a)
(Pan troglodytes)
Mammalia FAM133B 34
  • 99.87 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam133b 34
  • 85.13 (n)
  • 85.92 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
(Gallus gallus)
Aves FAM133B 35
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20455 34
(Danio rerio)
Actinopterygii Dr.14852 34
fam133b 35
  • 60 (a)
Species where no ortholog for FAM133B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM133B Gene

Gene Tree for FAM133B (if available)
Gene Tree for FAM133B (if available)

Paralogs for FAM133B Gene

Paralogs for FAM133B Gene

(2) SIMAP similar genes for FAM133B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM133B: view

Variants for FAM133B Gene

Sequence variations from dbSNP and Humsavar for FAM133B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs7794389 -- 92,576,044(+) TAAAA(G/T)GATAA intron-variant
rs9656005 -- 92,579,032(+) CTTCT(C/T)CATTT intron-variant
rs10226732 -- 92,573,703(+) TAATC(A/G)TTCTG intron-variant
rs10230853 -- 92,574,890(+) ctggg(C/T)gacag intron-variant
rs10231849 -- 92,562,599(+) TTAAC(A/G)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM133B Gene

Variant ID Type Subtype PubMed ID
esv3398419 CNV insertion 20981092
nsv966860 CNV duplication 23825009

Variation tolerance for FAM133B Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM133B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM133B Gene

Disorders for FAM133B Gene

Relevant External Links for FAM133B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM133B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM133B Gene

Publications for FAM133B Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 65
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3 65

Products for FAM133B Gene

Sources for FAM133B Gene

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