FAM133B Gene
protein-coding GIFtS: 37
GCID: GC07M092190
|
|
family with sequence similarity 133, member B
| |
Aliases
for FAM133B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 133, Member B1 2 | | MGC404051 | | Protein FAM133B2 |
Export aliases for FAM133B gene to outside databasesPrevious GC identifers: GC07M092029 GC07M086799 |
Summaries
for FAM133B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM133B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM133B gene promoter:
FOXO3 Nkx2-5 Ik-3 FOXO3b HNF-1 FOXJ2 (long isoform) FOXO4 Chx10 FOXO3a FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM133B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM133B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.2 Ensembl cytogenetic band: 7q21.2 HGNC cytogenetic band: 7q21.2FAM133B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M092190: view genomic region
(about GC identifiers)
Start:
|
92,190,072 bp from pter |
End:
|
92,219,708 bp from pter |
Size:
|
29,637 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 91,519,294-91,548,926 |
|
Proteins
for FAM133B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F133B_HUMAN, Q5BKY9 (See
protein sequence)Recommended Name: Protein FAM133B Size: 247 amino acids; 28385 Da
Secondary accessions: B2R994 Q05D67 Q6P5S6 Q8N0W8Alternative splicing: 2 isoforms: Q5BKY9-1 Q5BKY9-2 Explore the universe of human proteins at neXtProt for FAM133B: NX_Q5BKY9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5BKY9
FAM133B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001035146.1 NP_690002.2
ENSEMBL proteins: ENSP00000389783 ENSP00000398401 ENSP00000389559 ENSP00000402843 ENSP00000446324 ENSP00000407458
Human Recombinant Protein Products:
FAM133B Antibody Products:
Assay Products for FAM133B: |
Protein
Domains /
Families
for FAM133B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM133B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5BKY9ProtoNet protein and cluster: Q5BKY9 UniProtKB/Swiss-Prot: F133B_HUMAN, Q5BKY9Similarity: Belongs to the FAM133 family |
Function
for FAM133B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM133B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM133B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM133B (NM_152789) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM133B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM133B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM133B |
|
Pathways & Interactions
for FAM133B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM133B
|
Drugs & Compounds
for FAM133B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM133B
Search CenterWatch for drugs/clinical trials and news about FAM133B / F133B
|
Transcripts
for FAM133B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM133B gene (2 alternative transcripts): NM_001040057.1 NM_152789.2 Unigene Clusters for FAM133B: Family with sequence similarity 133, member B Hs.18564 [show with all ESTs], Hs.470311 [show with all ESTs], Hs.489105 [show with all ESTs]Unigene Representative Sequences: BC157872, NR_034169, NM_00104005711 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000438306(uc003umb.3 uc003umc.3 uc022ahf.1) ENST00000445716
ENST00000415397 ENST00000481407 ENST00000427372 ENST00000494079 ENST00000468931
ENST00000490747 ENST00000492686 ENST00000480397 ENST00000456502
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM133B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM133B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM133B (NM_152789) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM133B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM133B |
Additional cDNA sequence: AL833918.2 BC032461.1 BC057771.1 BC073952.1 BC090868.1 21 DOTS entries: DT.215927 DT.100785994 DT.100024451 DT.95267388 DT.100024450 DT.100687652 DT.95202380 DT.121059337 DT.100678167 DT.435678 DT.80101293 DT.99979294 DT.121031302 DT.121059317 DT.101955736 DT.121059378 DT.121031303 DT.121059375 DT.121267215 DT.92448784 DT.97792336 24/161 AceView cDNA sequences (see all 161): AK125498 BC073952 BM795675 BM972602 BQ000276 AI620040 AI769676 BE328229 AA987485 AW510400 AA354217 BE468068 N26424 AW237237 BU688856 BC032461 CD638100 BM750661 AA846659 BC057771 BX380884 AA252402 BE464537 BM977184
GeneLoc Exon Structure
|
Expression
for FAM133B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM133B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGAAACTG
About this image
See FAM133B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM133B
SOURCE GeneReport for Unigene clusters: Hs.18564 Hs.470311 Hs.489105
SABiosciences Custom PCR Arrays for FAM133B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM133B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM133B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM133B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM133B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM133B |
Orthologs
for FAM133B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FAM133B gene from 7/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAM133B1 |
family with sequence similarity 133, member B |
79.37(n)
80.33(a) |
|
420557 NM_001030975.1 NP_001026146.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
76(a) |
1 → many |
6(21302197-21313657) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.204552 |
Transcribed sequence with weak similarity to protein more |
76.39(n) |
|
141995096 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.148522 |
Transcribed sequence with weak similarity to protein more |
73.97(n) |
|
CF550068.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
7(a) |
possible ortholog |
GroupUn.213(12601-14211) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G598006AT2G437956 |
uncharacterized protein |
16(a)14(a) |
many ↔ manymany ↔ many |
3(22094437-22096358) 2(18140944-18142369) |
rice
(Oryza sativa) |
Liliopsida |
-- |
protein FAM133, putative, expressed |
21(a) |
1 → many |
4(24656164-24658572) |
ENSEMBL Gene Tree for FAM133B (if available)
TreeFam Gene Tree for FAM133B (if available) |
Paralogs
for FAM133B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM133B gene
- CIR12 FAM133A2
2 SIMAP similar genes for FAM133B using alignment to 5 protein entries: F133B_HUMAN (see all proteins):MGC40405 FAM133A
FAM133B for paralogs About GeneDecksing
|
Genomic Variants
for FAM133B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM133B (92190072 - 92219708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM133B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM133B |
|
Disorders
/ Diseases
for FAM133B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM133B for disorders About GeneDecksing
1  disease for FAM133B: About MalaCardsmalaria
Export disorders for FAM133B gene to outside databases
|
Publications
for FAM133B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM133B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with FAM133B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for FAM133B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM133B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM133B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM133B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM133B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM133B gene:
Search GeneIP for patents involving FAM133B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM133B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM133B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM133B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM133B | | | OriGene Protein Over-expression Lysate for FAM133B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM133B | | OriGene 3'-UTR Clone for FAM133B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM133B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM133B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM133B | | OriGene Custom Protein Services for FAM133B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM133B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM133B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM133B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM133B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM133B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM133B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM133B |
| |  |  |  |  | | | | |
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 |
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 | | | FAM133B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM133B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM133B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM133B |
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