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FAM133B Gene

protein-coding   GIFtS: 39
GCID: GC07M092190

Family With Sequence Similarity 133, Member B

  Search for FAM133B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 133, Member B1 2
Protein FAM133B2

External Ids:    HGNC: 286291   Entrez Gene: 2574152   Ensembl: ENSG000002345457   UniProtKB: Q5BKY93   

Export aliases for FAM133B gene to outside databases

Previous GC identifers: GC07M092029 GC07M086799


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM133B Gene:
FAM133B (family with sequence similarity 133, member B) is a protein-coding gene. An important paralog of this gene is FAM133A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM133B gene promoter:
         FOXO3   Nkx2-5   Ik-3   FOXO3b   HNF-1   FOXJ2 (long isoform)   FOXO4   Chx10   FOXO3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM133B promoter sequence
   Search Chromatin IP Primers for FAM133B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM133B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.2   Ensembl cytogenetic band:  7q21.2   HGNC cytogenetic band: 7q21.2

FAM133B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM133B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M092190:  view genomic region     (about GC identifiers)

Start:
92,190,072 bp from pter      End:
92,219,708 bp from pter
Size:
29,637 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 91,519,294-91,548,926     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F133B_HUMAN, Q5BKY9 (See protein sequence)
Recommended Name: Protein FAM133B  
Size: 247 amino acids; 28385 Da
Secondary accessions: B2R994 Q05D67 Q6P5S6 Q8N0W8
Alternative splicing: 2 isoforms:  Q5BKY9-1   Q5BKY9-2   

Explore the universe of human proteins at neXtProt for FAM133B: NX_Q5BKY9

Explore proteomics data for FAM133B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM133B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035146.1  NP_001275513.1  NP_690002.2  

    ENSEMBL proteins: 
     ENSP00000389783   ENSP00000398401   ENSP00000389559   ENSP00000402843   ENSP00000446324  
     ENSP00000407458  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026766 Fam133

    Graphical View of Domain Structure for InterPro Entry Q5BKY9

    ProtoNet protein and cluster: Q5BKY9

    UniProtKB/Swiss-Prot: F133B_HUMAN, Q5BKY9
    Similarity: Belongs to the FAM133 family


    FAM133B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044822poly(A) RNA binding IDA--
         
    FAM133B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM133B
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    hsa-miR-4291 hsa-miR-607 hsa-miR-548k hsa-miR-15a hsa-miR-513a-5p hsa-miR-485-3p hsa-miR-128 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidFAM133B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM133B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM133B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    mitochondrion2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM133B
    Interactions:

        Search GeneGlobe Interaction Network for FAM133B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM133B (F133B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM133B gene (3 alternative transcripts): 
    NM_001040057.2  NM_001288584.1  NM_152789.3  

    Unigene Clusters for FAM133B:

    Family with sequence similarity 133, member B
    Hs.18564  [show with all ESTs], Hs.470311  [show with all ESTs], Hs.489105  [show with all ESTs]
    Unigene Representative Sequences: BC157872, NR_034169, NM_001040057
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000438306(uc003umb.3 uc003umc.3 uc022ahf.1) ENST00000445716
    ENST00000415397 ENST00000481407 ENST00000427372 ENST00000494079 ENST00000468931
    ENST00000490747 ENST00000492686 ENST00000480397 ENST00000456502
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FAM133B (see all 58):
    hsa-miR-4291 hsa-miR-607 hsa-miR-548k hsa-miR-15a hsa-miR-513a-5p hsa-miR-485-3p hsa-miR-128 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidFAM133B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM133B
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    OriGene ORF clones in mouse, rat for FAM133B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM133B (NM_152789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM133B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM133B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM133B
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM133B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM133B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM133B
      QuantiFast Probe-based Assays in human, mouse, rat FAM133B

    Additional mRNA sequence: 

    AL833918.2 BC032461.1 BC057771.1 BC073952.1 BC090868.1 

    22 DOTS entries:

    DT.215927  DT.100785994  DT.100024451  DT.95267388  DT.100024450  DT.100687652  DT.95202380  DT.121059337 
    DT.100678167  DT.435678  DT.80101293  DT.99979294  DT.121031302  DT.121059317  DT.101955736  DT.121059378 
    DT.121031303  DT.121059375  DT.121267215  DT.92448784  DT.97777186  DT.97792336 

    Selected AceView cDNA sequences (see all 161):

    BM977184 BQ000276 AI769676 AA354217 BM682394 BE328229 CD671138 AA987485 
    NM_152789 BX380884 BM717863 BM795675 AA485333 AA386192 BQ574913 AW237237 
    BU581155 BC062706 BE468068 BP343695 AA252402 BC073952 CR625691 AK125498 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM133B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGAAACTG
    FAM133B Expression
    About this image

    FAM133B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM133B Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.18564 Hs.470311 Hs.489105
        Custom PCR Arrays for FAM133B
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FAM133B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM133B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM133B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam133b1 , 5 family with sequence similarity 133, member B1, 5 85.45(n)1
    86.85(a)1
      5 (2.22 cM)5
    681521  NM_001042501.11  NP_001035966.11 
     35438445 
    chicken
    (Gallus gallus)
    Aves FAM133B6
    Gallus gallus family with sequence similarity 133,...
    75(a)
    1 → many
    2(22812393-22826798)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    75(a)
    1 → many
    6(21302197-21313668)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.204552 Transcribed sequence with weak similarity to protein more 76.39(n)    141995096 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.148522 Transcribed sequence with weak similarity to protein more 73.97(n)    CF550068.1 


    ENSEMBL Gene Tree for FAM133B (if available)
    TreeFam Gene Tree for FAM133B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM133B gene
    FAM133A2  
    2 SIMAP similar genes for FAM133B using alignment to 5 protein entries:     F133B_HUMAN (see all proteins):
    MGC40405    FAM133A

    FAM133B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM133B (see all 555)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460723971,2
    --92189765(+) TTATAC/TACCTA 2 -- ds50010--------
    rs1387948801,2
    --92189794(+) CTGCAC/TTTCCA 2 -- ds50010--------
    rs1841961671,2
    --92189927(+) AAAGCA/GTACAG 2 -- ds50010--------
    rs1878209791,2
    --92189959(+) CATGCA/GGCTTT 2 -- ds50010--------
    rs560170461,2
    C--92190411(+) AGACAA/GCAAAC 2 -- ut310--------
    rs1418748891,2
    --92190444(+) AGATTC/GTGGCA 2 -- ut310--------
    rs1997341261,2
    C--92190761(+) CCAAT-/CAAT  
            
    GTCTA
    2 -- ut310--------
    rs132252361,2
    A--92191487(+) AATTCC/TAAAAA 2 -- ut310--------
    rs10449201,2
    C--92191509(-) CTAAAA/CTGCAT 2 -- ut313Minor allele frequency- C:0.00NA EU 581
    rs1391944471,2
    --92191641(+) TTCTTC/TTTACT 4 K syn10--------

    HapMap Linkage Disequilibrium report for FAM133B (92190072 - 92219708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM133B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268587CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM133B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM133B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM133B gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with FAM133B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 257415 HGNC: 28629 AceView: MGC40405 Ensembl:ENSG00000234545 euGenes: HUgn257415
    ECgene: FAM133B H-InvDB: FAM133B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM133B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM133B gene:
    Search GeneIP for patents involving FAM133B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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