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Aliases for FAM133B Gene

Aliases for FAM133B Gene

  • Family With Sequence Similarity 133 Member B 2 3 5
  • Family With Sequence Similarity 133, Member B 2

External Ids for FAM133B Gene

Previous GeneCards Identifiers for FAM133B Gene

  • GC07M092029
  • GC07M092190
  • GC07M086799

Summaries for FAM133B Gene

GeneCards Summary for FAM133B Gene

FAM133B (Family With Sequence Similarity 133 Member B) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FAM133A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM133B Gene

Genomics for FAM133B Gene

Regulatory Elements for FAM133B Gene

Enhancers for FAM133B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F092527 1.2 FANTOM5 ENCODE 46.3 +62.0 62023 2.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RBM48 FAM133B PEX1 GATAD1 ENSG00000243107 CDK6 GC07M092508
GH07F092829 1.1 FANTOM5 ENCODE 23 -243.8 -243790 9.6 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FAM133B GATAD1 ENSG00000243107 CDK6 MTERF1 SAMD9 LOC101927497 RNU6-10P GC07M092702
GH07F092178 0.2 ENCODE 15.8 +411.2 411185 1.5 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GLIS2 ZNF143 ZNF263 KAT8 CYP51A1 ENSG00000243107 FAM133B GATAD1 MTERF1 ERVW-1 KRIT1 LRRD1
GH07F093231 0.6 ENCODE 14.1 -641.7 -641678 2.0 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 SAMD9L LOC105375403 FAM133B GATAD1 RPS27P17 VPS50 HEPACAM2
GH07F092588 1.1 ENCODE 13.8 +0.5 524 2.3 HDGF CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 GATAD1 ENSG00000243107 RBM48 FAM133B ERVW-1 PEX1 GC07P092561
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM133B on UCSC Golden Path with GeneCards custom track

Promoters for FAM133B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000630237 294 2200 HDGF CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for FAM133B Gene

Chromosome:
7
Start:
92,560,758 bp from pter
End:
92,590,394 bp from pter
Size:
29,637 bases
Orientation:
Minus strand

Genomic View for FAM133B Gene

Genes around FAM133B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM133B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM133B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM133B Gene

Proteins for FAM133B Gene

  • Protein details for FAM133B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BKY9-F133B_HUMAN
    Recommended name:
    Protein FAM133B
    Protein Accession:
    Q5BKY9
    Secondary Accessions:
    • B2R994
    • Q05D67
    • Q6P5S6
    • Q8N0W8

    Protein attributes for FAM133B Gene

    Size:
    247 amino acids
    Molecular mass:
    28385 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM133B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM133B Gene

Post-translational modifications for FAM133B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM133B Gene

Domains & Families for FAM133B Gene

Protein Domains for FAM133B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM133B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5BKY9

UniProtKB/Swiss-Prot:

F133B_HUMAN :
  • Belongs to the FAM133 family.
Family:
  • Belongs to the FAM133 family.
genes like me logo Genes that share domains with FAM133B: view

No data available for Gene Families for FAM133B Gene

Function for FAM133B Gene

Gene Ontology (GO) - Molecular Function for FAM133B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with FAM133B: view

Phenotypes for FAM133B Gene

GenomeRNAi human phenotypes for FAM133B:
genes like me logo Genes that share phenotypes with FAM133B: view

Animal Model Products

miRNA for FAM133B Gene

miRTarBase miRNAs that target FAM133B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM133B Gene

Localization for FAM133B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM133B Gene COMPARTMENTS Subcellular localization image for FAM133B gene
Compartment Confidence
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM133B Gene

Pathways & Interactions for FAM133B Gene

SuperPathways for FAM133B Gene

No Data Available

Interacting Proteins for FAM133B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000398401%0d%0a9606.ENSP00000260983%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000398401 Q5BKY9-F133B_HUMAN for FAM133B Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM133B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM133B Gene

Transcripts for FAM133B Gene

Unigene Clusters for FAM133B Gene

Family with sequence similarity 133, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM133B Gene

No ASD Table

Relevant External Links for FAM133B Gene

GeneLoc Exon Structure for
FAM133B
ECgene alternative splicing isoforms for
FAM133B

Expression for FAM133B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM133B Gene

Protein differential expression in normal tissues from HIPED for FAM133B Gene

This gene is overexpressed in Liver, secretome (53.0) and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM133B Gene



Protein tissue co-expression partners for FAM133B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM133B Gene:

FAM133B

SOURCE GeneReport for Unigene cluster for FAM133B Gene:

Hs.18564
genes like me logo Genes that share expression patterns with FAM133B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM133B Gene

Orthologs for FAM133B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM133B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM133B 34
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia FAM133B 35
  • 97 (a)
OneToOne
LOC100856224 34
  • 93.61 (n)
cow
(Bos Taurus)
Mammalia FAM133B 34
  • 95.41 (n)
mouse
(Mus musculus)
Mammalia Fam133b 34 16 35
  • 85.45 (n)
rat
(Rattus norvegicus)
Mammalia Fam133b 34
  • 85.13 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM133B 35
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20455 34
zebrafish
(Danio rerio)
Actinopterygii fam133b 35
  • 60 (a)
OneToMany
Dr.14852 34
Species where no ortholog for FAM133B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM133B Gene

ENSEMBL:
Gene Tree for FAM133B (if available)
TreeFam:
Gene Tree for FAM133B (if available)

Paralogs for FAM133B Gene

Paralogs for FAM133B Gene

(2) SIMAP similar genes for FAM133B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM133B: view

Variants for FAM133B Gene

Sequence variations from dbSNP and Humsavar for FAM133B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10226732 -- 92,573,703(+) TAATC(A/G)TTCTG intron-variant
rs10230853 -- 92,574,890(+) ctggg(C/T)gacag intron-variant
rs10231849 -- 92,562,599(+) TTAAC(A/G)TAACT intron-variant, utr-variant-3-prime
rs10248055 -- 92,572,159(+) ACAGA(A/G)AAATG intron-variant
rs10250762 -- 92,576,038(+) TACTC(C/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM133B Gene

Variant ID Type Subtype PubMed ID
esv3398419 CNV insertion 20981092
nsv966860 CNV duplication 23825009

Variation tolerance for FAM133B Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM133B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM133B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM133B Gene

Disorders for FAM133B Gene

Relevant External Links for FAM133B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM133B

No disorders were found for FAM133B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM133B Gene

Publications for FAM133B Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3 64

Products for FAM133B Gene

Sources for FAM133B Gene

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