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Aliases for FAM133A Gene

Aliases for FAM133A Gene

  • Family With Sequence Similarity 133 Member A 2 3 5
  • Cancer/Testis Antigen 115 2 3
  • Family With Sequence Similarity 133, Member A 2
  • Protein FAM133A 3
  • CT115 3

External Ids for FAM133A Gene

Previous GeneCards Identifiers for FAM133A Gene

  • GC0XP092815
  • GC0XP092929
  • GC0XP082751

Summaries for FAM133A Gene

GeneCards Summary for FAM133A Gene

FAM133A (Family With Sequence Similarity 133 Member A) is a Protein Coding gene. An important paralog of this gene is FAM133B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM133A Gene

Genomics for FAM133A Gene

Regulatory Elements for FAM133A Gene

Promoters for FAM133A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001490598 -435 2599 ZNF362 PKNOX1 L3MBTL2 ZNF76 NFYC SP2 ZNF384 POLR2A PBX2 ZBTB20

Genomic Location for FAM133A Gene

93,673,736 bp from pter
93,712,274 bp from pter
38,539 bases
Plus strand

Genomic View for FAM133A Gene

Genes around FAM133A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM133A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM133A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM133A Gene

Proteins for FAM133A Gene

  • Protein details for FAM133A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM133A
    Protein Accession:

    Protein attributes for FAM133A Gene

    248 amino acids
    Molecular mass:
    28941 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM133A Gene

Post-translational modifications for FAM133A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM133A Gene

Domains & Families for FAM133A Gene

Protein Domains for FAM133A Gene


Suggested Antigen Peptide Sequences for FAM133A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM133 family.
  • Belongs to the FAM133 family.
genes like me logo Genes that share domains with FAM133A: view

No data available for Gene Families for FAM133A Gene

Function for FAM133A Gene

Gene Ontology (GO) - Molecular Function for FAM133A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM133A: view

Phenotypes for FAM133A Gene

genes like me logo Genes that share phenotypes with FAM133A: view

Animal Model Products

miRNA for FAM133A Gene

miRTarBase miRNAs that target FAM133A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM133A Gene

Localization for FAM133A Gene

Subcellular locations from

Jensen Localization Image for FAM133A Gene COMPARTMENTS Subcellular localization image for FAM133A gene
Compartment Confidence
nucleus 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM133A Gene

Pathways & Interactions for FAM133A Gene

SuperPathways for FAM133A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM133A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM133A Gene

Transcripts for FAM133A Gene

mRNA/cDNA for FAM133A Gene

Unigene Clusters for FAM133A Gene

Family with sequence similarity 133, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM133A Gene

No ASD Table

Relevant External Links for FAM133A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM133A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM133A Gene

mRNA differential expression in normal tissues according to GTEx for FAM133A Gene

This gene is overexpressed in Testis (x6.1), Brain - Hypothalamus (x4.5), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for FAM133A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.8) and Heart (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM133A Gene

Protein tissue co-expression partners for FAM133A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM133A Gene:


SOURCE GeneReport for Unigene cluster for FAM133A Gene:

genes like me logo Genes that share expression patterns with FAM133A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM133A Gene

Orthologs for FAM133A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM133A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM133A 34
  • 86.61 (n)
(Bos Taurus)
Mammalia FAM133A 34 35
  • 86.21 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
(Gallus gallus)
Aves FAM133B 35
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
(Danio rerio)
Actinopterygii fam133b 35
  • 58 (a)
Species where no ortholog for FAM133A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM133A Gene

Gene Tree for FAM133A (if available)
Gene Tree for FAM133A (if available)

Paralogs for FAM133A Gene

Paralogs for FAM133A Gene

(2) SIMAP similar genes for FAM133A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM133A: view

Variants for FAM133A Gene

Sequence variations from dbSNP and Humsavar for FAM133A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs863223375 Benign 93,671,995(-) TAATG(C/G)ATCAT upstream-variant-2KB, reference, missense
rs10126260 -- 93,702,863(+) aaaaa(A/C)aaaaa intron-variant
rs10126690 -- 93,692,673(+) TCCTG(C/T)AGACT intron-variant
rs10127399 -- 93,701,350(+) GGAAC(A/C)TTGTC intron-variant
rs1045684 -- 93,673,378(-) gccac(C/T)CAAGC upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for FAM133A Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM133A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM133A Gene

Disorders for FAM133A Gene

Relevant External Links for FAM133A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM133A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM133A Gene

Publications for FAM133A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 46 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for FAM133A Gene

Sources for FAM133A Gene

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