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FAM133A Gene

protein-coding   GIFtS: 40
GCID: GC0XP092929

Family With Sequence Similarity 133, Member A

  Search for FAM133A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 133, Member A1 2
Cancer/Testis Antigen 1151 2
CT1152
Protein FAM133A2

External Ids:    HGNC: 267481   Entrez Gene: 2864992   Ensembl: ENSG000001790837   UniProtKB: Q8N9E03   

Export aliases for FAM133A gene to outside databases

Previous GC identifers: GC0XP092815 GC0XP082751


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM133A Gene:
FAM133A (family with sequence similarity 133, member A) is a protein-coding gene. An important paralog of this gene is FAM133B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM133A gene promoter:
         TBP   Bach1   GCNF   STAT5A   GATA-1   IRF-2   GCNF-1   GCNF-2   RSRFC4   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM133A promoter sequence
   Search Chromatin IP Primers for FAM133A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM133A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.32   Ensembl cytogenetic band:  Xq21.32   HGNC cytogenetic band: Xq21.32

FAM133A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM133A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP092929:  view genomic region     (about GC identifiers)

Start:
92,929,012 bp from pter      End:
92,967,273 bp from pter
Size:
38,262 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F133A_HUMAN, Q8N9E0 (See protein sequence)
Recommended Name: Protein FAM133A  
Size: 248 amino acids; 28941 Da

Explore the universe of human proteins at neXtProt for FAM133A: NX_Q8N9E0

Explore proteomics data for FAM133A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM133A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001164580.1  NP_001164581.1  NP_001164582.1  NP_775969.1  

    ENSEMBL proteins: 
     ENSP00000362169   ENSP00000441389   ENSP00000348067   ENSP00000318974  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026766 Fam133

    Graphical View of Domain Structure for InterPro Entry Q8N9E0

    ProtoNet protein and cluster: Q8N9E0

    UniProtKB/Swiss-Prot: F133A_HUMAN, Q8N9E0
    Similarity: Belongs to the FAM133 family


    FAM133A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FAM133A:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM133A
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    Selected qRT-PCR Assays for microRNAs that regulate FAM133A (see all 38):
    hsa-miR-411* hsa-miR-548j hsa-miR-4307 hsa-miR-379* hsa-miR-199a-3p hsa-miR-30d hsa-miR-374a* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidFAM133A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    mitochondrion2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM133A
    Interactions:

        Search GeneGlobe Interaction Network for FAM133A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM133A (F133A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM133A gene (4 alternative transcripts): 
    NM_001171109.1  NM_001171110.1  NM_001171111.1  NM_173698.2  

    Unigene Cluster for FAM133A:

    Family with sequence similarity 133, member A
    Hs.110069  [show with all ESTs]
    Unigene Representative Sequence: NM_001171110
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332647 ENST00000538690(uc022bzu.1) ENST00000355813(uc004efr.2 uc022bzv.1)
    ENST00000322139(uc022bzw.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FAM133A (see all 38):
    hsa-miR-411* hsa-miR-548j hsa-miR-4307 hsa-miR-379* hsa-miR-199a-3p hsa-miR-30d hsa-miR-374a* hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidFAM133A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM133A
      QuantiFast Probe-based Assays in human, mouse, rat FAM133A

    Additional mRNA sequence: 

    AK094978.1 BC113385.1 BC113387.1 

    4 DOTS entries:

    DT.206553  DT.100747128  DT.121298687  DT.121298737 

    Selected AceView cDNA sequences (see all 28):

    W78711 BQ438275 W92970 BX095621 NM_173698 AI962308 AI127575 AI655800 
    BU194152 W92969 AI339405 AK094978 AW629391 BX092755 W80479 AA625803 
    AA909330 BE073134 AA609774 BF968643 AI653208 AI864183 AW236582 BE073127 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM133A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACCTGAA
    FAM133A Expression
    About this image

    FAM133A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM133A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.110069
        Custom PCR Arrays for FAM133A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM133A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM133A gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia FAM133A1 family with sequence similarity 133, member A 86.61(n)
    89.04(a)
      608953  XM_005641547.1  XP_005641604.1 
    chicken
    (Gallus gallus)
    Aves FAM133B6
    Gallus gallus family with sequence similarity 133,...
    70(a)
    1 → many
    2(22812393-22826798)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    6(21302197-21313668)
    zebrafish
    (Danio rerio)
    Actinopterygii fam133b6
    family with sequence similarity 133, member B
    58(a)
    1 → many
    19(41295613-41308285) ENSDARG00000013863


    ENSEMBL Gene Tree for FAM133A (if available)
    TreeFam Gene Tree for FAM133A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM133A gene
    FAM133B2  
    2 SIMAP similar genes for FAM133A using alignment to 1 protein entry:     F133A_HUMAN:
    MGC40405    FAM133B

    FAM133A for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for FAM133A (see all 6)
    PGOHUM00000238809 PGOHUM00000239375 PGOHUM00000244464 PGOHUM00000259731 PGOHUM00000240399


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM133A (see all 516)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10456951,2
    H--92891588(-) TAGACT/CGGAGA 4 -- us2k15Minor allele frequency- C:0.00MN NS EA 590
    rs1390211451,2
    C,F--92891782(+) CATCCG/AACAAG 4 -- us2k11Minor allele frequency- A:0.00NA 4468
    rs1427236511,2
    C,F--92891799(+) AGAATG/CGGCTC 4 -- us2k11Minor allele frequency- C:0.01NA 4440
    rs1470621731,2
    C,F--92891811(+) TCATAC/GTTCTG 4 -- us2k11Minor allele frequency- G:0.00NA 4414
    rs1460577481,2
    C,F--92891878(+) TGCCTT/CTAGGG 4 -- us2k11Minor allele frequency- C:0.00NA 4428
    rs2018490671,2
    --92891884(+) TAGGGA/TCTTCT 4 -- us2k10--------
    rs1885681391,2
    C--92891931(+) ACACTA/GTCCTG 4 -- us2k10--------
    rs1390422521,2
    C--92891998(+) CCTCTA/C/GTTGCT 4 -- us2k10--------
    rs1809724881,2
    C--92892032(+) CTTTAA/CCTGGG 4 -- us2k10--------
    rs2012928231,2
    --92892054(+) GGATCC/TTCTTT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM133A (92929012 - 92967273 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM133A: --
    Locus Specific Mutation Databases (LSDB): FAM133A

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM133A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM133A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    FAM133A for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM133A

    Export disorders for FAM133A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM133A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM133A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 286499 HGNC: 26748 AceView: FLJ37659 Ensembl:ENSG00000179083 euGenes: HUgn286499
    ECgene: FAM133A H-InvDB: FAM133A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM133A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM133A gene:
    Search GeneIP for patents involving FAM133A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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