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Aliases for FAM132B Gene

Aliases for FAM132B Gene

  • Family With Sequence Similarity 132, Member B 2 3
  • Myonectin 2 3 4
  • CTRP15 3 4 6
  • Complement C1q Tumor Necrosis Factor-Related Protein 15 3 4
  • C1QTNF15 3 4
  • Protein FAM132B 3
  • Erythroferrone 3
  • ERFE 4

External Ids for FAM132B Gene

Summaries for FAM132B Gene

GeneCards Summary for FAM132B Gene

FAM132B (Family With Sequence Similarity 132, Member B) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is FAM132A.

UniProtKB/Swiss-Prot for FAM132B Gene

  • Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM132B Gene

Genomics for FAM132B Gene

Genomic Location for FAM132B Gene

Start:
238,158,982 bp from pter
End:
238,168,900 bp from pter
Size:
9,919 bases
Orientation:
Plus strand

Genomic View for FAM132B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM132B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM132B Gene

Regulatory Elements for FAM132B Gene

Proteins for FAM132B Gene

  • Protein details for FAM132B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0M1-ERFE_HUMAN
    Recommended name:
    Erythroferrone
    Protein Accession:
    Q4G0M1
    Secondary Accessions:
    • W8S2M9

    Protein attributes for FAM132B Gene

    Size:
    354 amino acids
    Molecular mass:
    37279 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form heteromeric complexes with C1QTNF2 and FAM132A and, to a lesser extent, with C1QTNF5 and C1QTNF10 (By similarity).

neXtProt entry for FAM132B Gene

Proteomics data for FAM132B Gene at MOPED

Post-translational modifications for FAM132B Gene

Other Protein References for FAM132B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM132B Gene

Domains for FAM132B Gene

Protein Domains for FAM132B Gene

UniProtKB/Swiss-Prot:

ERFE_HUMAN
Domain:
  • Contains 1 C1q domain.:
    • Q4G0M1
Family:
  • Belongs to the adipolin/erythroferrone family.:
    • Q4G0M1
genes like me logo Genes that share domains with FAM132B: view

No data available for Gene Families for FAM132B Gene

Function for FAM132B Gene

Molecular function for FAM132B Gene

UniProtKB/Swiss-Prot Function: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity).

Gene Ontology (GO) - Molecular Function for FAM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity ISS --
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with FAM132B: view

miRNA for FAM132B Gene

miRTarBase miRNAs that target FAM132B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM132B Gene

Localization for FAM132B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM132B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM132B Gene COMPARTMENTS Subcellular localization image for FAM132B gene
Compartment Confidence
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FAM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with FAM132B: view

Pathways for FAM132B Gene

SuperPathways for FAM132B Gene

No Data Available

Interacting Proteins for FAM132B Gene

Gene Ontology (GO) - Biological Process for FAM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis ISS --
GO:0019217 regulation of fatty acid metabolic process IEA --
GO:2000193 positive regulation of fatty acid transport IEA --
genes like me logo Genes that share ontologies with FAM132B: view

No data available for Pathways by source for FAM132B Gene

Transcripts for FAM132B Gene

mRNA/cDNA for FAM132B Gene

(2) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FAM132B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3: - -

Relevant External Links for FAM132B Gene

GeneLoc Exon Structure for
FAM132B
ECgene alternative splicing isoforms for
FAM132B

Expression for FAM132B Gene

mRNA expression in normal human tissues for FAM132B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM132B Gene

This gene is overexpressed in Muscle - Skeletal (11.3), Testis (6.4), Brain - Cerebellar Hemisphere (4.3), and Brain - Cerebellum (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FAM132B Gene

SOURCE GeneReport for Unigene cluster for FAM132B Gene Hs.24951

genes like me logo Genes that share expressions with FAM132B: view

Orthologs for FAM132B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM132B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM132B 36
  • 98.58 (n)
  • 96.7 (a)
FAM132B 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM132B 36
  • 75.82 (n)
  • 70.59 (a)
FAM132B 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM132B 37
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam132b 36
  • 76.19 (n)
  • 75.71 (a)
Fam132b 16
Fam132b 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM132B 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM132B 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam132b 36
  • 82.07 (n)
  • 84.81 (a)
lizard
(Anolis carolinensis)
Reptilia FAM132B 37
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FAM132B 37
  • 35 (a)
OneToOne
Species with no ortholog for FAM132B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM132B Gene

ENSEMBL:
Gene Tree for FAM132B (if available)
TreeFam:
Gene Tree for FAM132B (if available)

Paralogs for FAM132B Gene

Paralogs for FAM132B Gene

Selected SIMAP similar genes for FAM132B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM132B: view

Variants for FAM132B Gene

Sequence variations from dbSNP and Humsavar for FAM132B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs935418 -- 238,157,147(+) GTGGT(A/G)TGATC upstream-variant-2KB
rs1982338 -- 238,157,738(+) GGAAC(C/T)TGGCC upstream-variant-2KB
rs1982339 -- 238,158,041(+) GATAG(C/T)CAAAA upstream-variant-2KB
rs2166538 -- 238,158,918(+) CTCGG(A/G)CGAGG upstream-variant-2KB
rs3795905 -- 238,167,171(-) GTGTG(A/G)GCAGA utr-variant-3-prime

Relevant External Links for FAM132B Gene

HapMap Linkage Disequilibrium report
FAM132B

No data available for Structural Variations from Database of Genomic Variants (DGV) for FAM132B Gene

Disorders for FAM132B Gene

No disorders were found for FAM132B Gene.

No data available for UniProtKB/Swiss-Prot for FAM132B Gene

Publications for FAM132B Gene

  1. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. (PMID: 22351773) Seldin M.M. … Wong G.W. (J. Biol. Chem. 2012) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  4. Identification of erythroferrone as an erythroid regulator of iron metabolism. (PMID: 24880340) Kautz L. … Ganz T. (Nat. Genet. 2014) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM132B Gene

Sources for FAM132B Gene

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