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Aliases for FAM132B Gene

Aliases for FAM132B Gene

  • Family With Sequence Similarity 132 Member B 2 3 5
  • Myonectin 2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 15 3 4
  • Family With Sequence Similarity 132, Member B 2 3
  • C1QTNF15 3 4
  • CTRP15 3 4
  • Protein FAM132B 3
  • ERFE 4

External Ids for FAM132B Gene

Previous GeneCards Identifiers for FAM132B Gene

  • GC02P238732
  • GC02P239067
  • GC02P230863

Summaries for FAM132B Gene

GeneCards Summary for FAM132B Gene

FAM132B (Family With Sequence Similarity 132 Member B) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and hormone activity. An important paralog of this gene is FAM132A.

UniProtKB/Swiss-Prot for FAM132B Gene

  • Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM132B Gene

Genomics for FAM132B Gene

Regulatory Elements for FAM132B Gene

Enhancers for FAM132B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM132B on UCSC Golden Path with GeneCards custom track

Promoters for FAM132B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM132B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM132B Gene

Chromosome:
2
Start:
238,158,982 bp from pter
End:
238,168,900 bp from pter
Size:
9,919 bases
Orientation:
Plus strand

Genomic View for FAM132B Gene

Genes around FAM132B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM132B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM132B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM132B Gene

Proteins for FAM132B Gene

  • Protein details for FAM132B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0M1-ERFE_HUMAN
    Recommended name:
    Erythroferrone
    Protein Accession:
    Q4G0M1
    Secondary Accessions:
    • W8S2M9

    Protein attributes for FAM132B Gene

    Size:
    354 amino acids
    Molecular mass:
    37279 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form heteromeric complexes with C1QTNF2 and FAM132A and, to a lesser extent, with C1QTNF5 and C1QTNF10 (By similarity).

neXtProt entry for FAM132B Gene

Proteomics data for FAM132B Gene at MOPED

Post-translational modifications for FAM132B Gene

Other Protein References for FAM132B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM132B Gene

Domains & Families for FAM132B Gene

Protein Domains for FAM132B Gene

Suggested Antigen Peptide Sequences for FAM132B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0M1

UniProtKB/Swiss-Prot:

ERFE_HUMAN :
  • Contains 1 C1q domain.
  • Belongs to the adipolin/erythroferrone family.
Domain:
  • Contains 1 C1q domain.
Family:
  • Belongs to the adipolin/erythroferrone family.
genes like me logo Genes that share domains with FAM132B: view

No data available for Gene Families for FAM132B Gene

Function for FAM132B Gene

Molecular function for FAM132B Gene

UniProtKB/Swiss-Prot Function:
Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity).

Phenotypes for FAM132B Gene

genes like me logo Genes that share phenotypes with FAM132B: view

Animal Models for FAM132B Gene

MGI Knock Outs for FAM132B:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM132B

miRNA for FAM132B Gene

miRTarBase miRNAs that target FAM132B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM132B Gene

Localization for FAM132B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM132B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM132B Gene COMPARTMENTS Subcellular localization image for FAM132B gene
Compartment Confidence
extracellular 5
mitochondrion 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FAM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with FAM132B: view

Pathways & Interactions for FAM132B Gene

SuperPathways for FAM132B Gene

No Data Available

Interacting Proteins for FAM132B Gene

Gene Ontology (GO) - Biological Process for FAM132B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000193 positive regulation of fatty acid transport IEA --
genes like me logo Genes that share ontologies with FAM132B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM132B Gene

Drugs & Compounds for FAM132B Gene

No Compound Related Data Available

Transcripts for FAM132B Gene

mRNA/cDNA for FAM132B Gene

(2) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FAM132B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3: - -

Relevant External Links for FAM132B Gene

GeneLoc Exon Structure for
FAM132B
ECgene alternative splicing isoforms for
FAM132B

Expression for FAM132B Gene

mRNA expression in normal human tissues for FAM132B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM132B Gene

This gene is overexpressed in Muscle - Skeletal (x11.3), Testis (x6.4), Brain - Cerebellar Hemisphere (x4.3), and Brain - Cerebellum (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM132B Gene



SOURCE GeneReport for Unigene cluster for FAM132B Gene Hs.24951

genes like me logo Genes that share expression patterns with FAM132B: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM132B Gene

Orthologs for FAM132B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM132B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM132B 35
  • 75.82 (n)
  • 70.59 (a)
FAM132B 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam132b 35
  • 76.19 (n)
  • 75.71 (a)
Fam132b 16
Fam132b 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM132B 35
  • 98.58 (n)
  • 96.7 (a)
FAM132B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam132b 35
  • 82.07 (n)
  • 84.81 (a)
dog
(Canis familiaris)
Mammalia FAM132B 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM132B 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM132B 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM132B 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FAM132B 36
  • 35 (a)
OneToOne
Species with no ortholog for FAM132B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM132B Gene

ENSEMBL:
Gene Tree for FAM132B (if available)
TreeFam:
Gene Tree for FAM132B (if available)

Paralogs for FAM132B Gene

Paralogs for FAM132B Gene

(1) SIMAP similar genes for FAM132B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM132B: view

Variants for FAM132B Gene

Sequence variations from dbSNP and Humsavar for FAM132B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6747952 -- 238,161,285(+) CAGTA(C/T)GGGGA intron-variant
rs3795905 -- 238,167,171(-) GTGTG(A/G)GCAGA utr-variant-3-prime
rs3820817 -- 238,167,294(-) TTCTT(C/T)CCTGG utr-variant-3-prime
rs11689193 -- 238,166,024(+) GGGAC(C/T)GGTGC intron-variant
rs6760421 -- 238,164,405(+) TCGGC(C/G/T)TCCAC intron-variant

Variation tolerance for FAM132B Gene

Gene Damage Index Score: 3.89; 59.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FAM132B Gene

Disorders for FAM132B Gene

Relevant External Links for FAM132B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM132B

No disorders were found for FAM132B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM132B Gene

Publications for FAM132B Gene

  1. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. (PMID: 22351773) Seldin M.M. … Wong G.W. (J. Biol. Chem. 2012) 2 3 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM132B Gene

Sources for FAM132B Gene

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