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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM132A Gene

protein-coding GIFtS: 40
GCID: GC01M001168

family with sequence similarity 132, member A

(Previous name: C1q domain containing 2 )
(Previous symbol: C1QDC2)

Search for FAM132A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 132, Member A¹ ²		MGC105127¹
C1QDC2¹ ² ³		Adipolin¹
C1QTNF12¹ ²		Adipose-Derived Insulin-Sensitizing Factor²
CTRP12¹ ²		C1q/TNF-Related Protein 12²
C1q Domain Containing 2¹ ²		Protein FAM132A²

External Ids:	HGNC: 32308¹	Entrez Gene: 388581²	Ensembl: ENSG00000184163⁷	UniProtKB: Q5T7M4³

Export aliases for FAM132A gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004350.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM132A gene promoter:
STAT5B STAT1 STAT4 STAT6 STAT1beta STAT5A STAT1alpha STAT2 STAT3 ZID
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FAM132A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM132A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33

FAM132A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM132A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M001168: view genomic region (about GC identifiers)

Start:	1,177,826 bp from pter	End:	1,182,102 bp from pter
Size:	4,277 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F132A_HUMAN, Q5T7M4 (See protein sequence)

Recommended Name: Protein FAM132A precursor

Size: 302 amino acids; 32416 Da

Subcellular location: Secreted (Potential)

Secondary accessions: Q5EBL5

Explore the universe of human proteins at neXtProt for FAM132A: NX_Q5T7M4

FAM132A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001014980.1

ENSEMBL proteins:

ENSP00000329137

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IEA	--

FAM132A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM132A for domains About GeneDecksing

1 InterPro domain/family:

IPR008983 Tumour_necrosis_fac-like_dom

Graphical View of Domain Structure for InterPro Entry Q5T7M4

ProtoNet protein and cluster: Q5T7M4

UniProtKB/Swiss-Prot: F132A_HUMAN, Q5T7M4

Similarity: Belongs to the FAM132 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for FAM132A:

Increased TP53 protein express

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM132A

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/19 Interacting proteins for FAM132A (ENSP00000329137⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGEF10L	ENSP00000355060⁴	STRING: ENSP00000355060
ATPAF1	ENSP00000361005⁴	STRING: ENSP00000361005
C1orf146	ENSP00000359401⁴	STRING: ENSP00000359401
CRYZ	ENSP00000339399⁴	STRING: ENSP00000339399
FAM163A	ENSP00000354891⁴	STRING: ENSP00000354891

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010906	regulation of glucose metabolic process	--	--
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA	--
GO:0045721	negative regulation of gluconeogenesis	IEA	--
GO:0046326	positive regulation of glucose import	IEA	--
GO:0046628	positive regulation of insulin receptor signaling pathway	IEA	--

FAM132A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM132A
Search CenterWatch for drugs/clinical trials and news about FAM132A / F132A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for FAM132A gene:

NM_001014980.2

Unigene Cluster for FAM132A:

Family with sequence similarity 132, member A

Hs.197613 [show with all ESTs]

Unigene Representative Sequence: BC089443

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000462849 ENST00000478606 ENST00000330388(uc001adl.2) ENST00000468365

ENST00000486627

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Additional cDNA sequence: BC089443.1

3 DOTS entries:

DT.101961684 DT.70105502 DT.100012665

12 AceView cDNA sequences:

CA394474 CF131018 AW873053 BX119870 BU621109 AI660577 BE906672 AI634846

AW008561 AI241049 BQ711062 BF589994

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM132A About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:													-
SP2:
SP3:

ECgene alternative splicing isoforms for FAM132A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM132A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTCCAGGC

About this image

FAM132A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM132A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM132A

SOURCE GeneReport for Unigene cluster: Hs.197613

SABiosciences Custom PCR Arrays for FAM132A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM132A gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Fam132a^{1 , 5}	family with sequence similarity 132, member A^{1, 5}	74.55(n)¹ 72.64(a)¹	4 (87.66 cM)⁵ 67389¹ NM_026125.3¹ NP_080401.1¹ 155962318⁵
chicken (Gallus gallus)	Aves	FAM132A¹	family with sequence similarity 132, member A	62.82(n) 60.65(a)	419422 XM_417583.3 XP_417583.1
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12517²	Transcribed sequence with weak similarity to protein more	72.39(n)	BX714430.1
zebrafish (Danio rerio)	Actinopterygii	fam132a¹	family with sequence similarity 132, member A	59.23(n) 52.7(a)	790933 NM_001080078.1 NP_001073547.1

ENSEMBL Gene Tree for FAM132A (if available)
TreeFam Gene Tree for FAM132A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM132A gene

FAM132B²

1 SIMAP similar gene for FAM132A using alignment to 1 protein entry: F132A_HUMAN:

FAM132B

FAM132A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147252342^1,2		--	1177339(+)	`CTGGGC/TGCACC`	1	--	int¹		0	--	--	--	--
rs2297863^1,2	C,F,A,	--	1177474(+)	`TCCCGA/GGGGCC`	1	--	int¹		4		EA WA NA	1842
rs2297864^1,2	C,F,A,H,	--	1177630(+)	`GGGCTA/GCCAGG`	1	--	int¹		19		NS EA NA CSA WA	2341
rs79861994^1,2	F,	--	1177773(+)	`GCCGAC/GCTCGG`	1	--	int¹		1		WA	118
rs113022812^1,2		--	1177795(+)	`CCACCC/TCCAGT`	1	--	int¹		1		CSA	2
rs58080375^1,2		--	1177821(+)	`CACTCA/GAAGGC`	1	--	int¹		0	--	--	--	--
rs12095691^1,2	C,	--	1177886(+)	`GTCCCC/TGGGAT`	1	--	ut3¹ ese³		2		CSA WA	119
rs12410680^1,2	C,F,H,	--	1177893(+)	`GGATCC/TGGCGG`	1	--	ut3¹ ese³		1		NA	6
rs114544631^1,2	C,F,	--	1177896(+)	`TCCGGC/TGGCAG`	1	--	ut3¹		1		WA	118
rs3835300^1,2	C,	--	1177919(+)	`CCCCCT/-GGGCG`	1	--	ut3¹		1		CSA	2

HapMap Linkage Disequilibrium report for FAM132A (1177826 - 1182102 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM132A
2 CNVs: 0001 30362

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM132A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM132A)

Utopia: connect your pdf to the dynamic
world of online information

Adipolin/C1qdc2/CTRP12 protein functions as an adipok ine that improves glucose metabolism. (PubMed id 21849507)^{1, 3} Enomoto T....Ouchi N. (2011)
Endopeptidase cleavage generates a functionally distin ct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an alte red oligomeric state and signaling specificity. (PubMed id 22942287)¹ Wei Z....Wong G.W. (2012)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 388581	HGNC: 32308	AceView: LOC388581	Ensembl:ENSG00000184163	euGenes: HUgn388581
ECgene: FAM132A	H-InvDB: FAM132A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM132A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM132A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM132A gene:
Search GeneIP for patents involving FAM132A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM132A gene at Home site.

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FAM132A Gene

family with sequence similarity 132, member A

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Export list of displayed genes

FAM132A Gene

family with sequence similarity 132, member A

Aliasesfor FAM132A gene

Summariesfor FAM132A gene

Genomic Viewsfor FAM132A gene

Proteinsfor FAM132A gene

Protein Domains /Familiesfor FAM132A gene

Functionfor FAM132A gene

Pathways & Interactionsfor FAM132A gene

Drugs & Compoundsfor FAM132A gene

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Expression for FAM132A gene

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Disorders / Diseasesfor FAM132A gene

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External Searches for FAM132A gene

Genome Databases showing FAM132A gene

Other Databases showing FAM132A gene

Specialized Databases showing FAM132A gene

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Productsfor FAM132A gene

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Aliases
for FAM132A gene

Summaries
for FAM132A gene

Genomic Views
for FAM132A gene

Proteins
for FAM132A gene

Protein Domains /
Families
for FAM132A gene

Function
for FAM132A gene

Pathways & Interactions
for FAM132A gene

Drugs & Compounds
for FAM132A gene

Transcripts
for FAM132A gene

Expression
for FAM132A gene

Orthologs
for FAM132A gene

Paralogs
for FAM132A gene

Genomic Variants
for FAM132A gene

Disorders / Diseases
for FAM132A gene

Publications
for FAM132A gene

Intellectual Property
for FAM132A gene

Products
for FAM132A gene