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Aliases for FAM132A Gene

Aliases for FAM132A Gene

  • Family With Sequence Similarity 132 Member A 2 3 5
  • Adipose-Derived Insulin-Sensitizing Factor 2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 12 3 4
  • C1q Domain Containing 2 2 3
  • Adipolin 2 3
  • C1QDC2 3 4
  • CTRP12 3 4
  • Family With Sequence Similarity 132, Member A 2
  • C1q/TNF-Related Protein 12 3
  • Protein FAM132A 3
  • C1QTNF12 3

External Ids for FAM132A Gene

Previous HGNC Symbols for FAM132A Gene

  • C1QDC2

Previous GeneCards Identifiers for FAM132A Gene

  • GC01M001168

Summaries for FAM132A Gene

GeneCards Summary for FAM132A Gene

FAM132A (Family With Sequence Similarity 132 Member A) is a Protein Coding gene. GO annotations related to this gene include hormone activity. An important paralog of this gene is ERFE.

UniProtKB/Swiss-Prot for FAM132A Gene

  • Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM132A Gene

Genomics for FAM132A Gene

Regulatory Elements for FAM132A Gene

Enhancers for FAM132A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F001127 1.7 FANTOM5 Ensembl ENCODE 11.9 +118.0 117977 4.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 TTLL10 TTLL10-AS1 SDF4 B3GALT6 FAM132A UBE2J2 C1orf159 AGRN VWA1 GC01M001125
GH01F001131 1.3 Ensembl ENCODE 11.9 +112.1 112138 6.5 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ZNF207 TTLL10 TTLL10-AS1 SDF4 B3GALT6 FAM132A UBE2J2 C1orf159 LINC01342 GC01M001125
GH01F001189 1 FANTOM5 12 +57.8 57827 0.3 MLX ZFP64 ARID4B DMAP1 RAD21 THRB YY1 RARA GATA4 THAP11 SDF4 B3GALT6 MIR429 MIR200B MIR200A UBE2J2 LINC01786 FAM132A SLC35E2 TNFRSF18
GH01F001249 1.2 Ensembl ENCODE 0.8 -3.5 -3483 1.8 HDGF PKNOX1 ATF1 ZNF143 REST TBX21 SMARCA4 MYNN NBN CTCF B3GALT6 ANKRD65 ATAD3B ENSG00000260179 FAM132A
GH01F001243 0.8 Ensembl 0.8 +0.5 549 6.2 BCOR CTCF ZNF223 ZMYM3 BCL11B HIC1 ZFHX2 GLIS2 SCRT2 ZNF600 B3GALT6 ANKRD65 SCNN1D SDF4 ENSG00000237094 ATAD3B ENSG00000230092 FAM132A PIR44892
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM132A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM132A Gene

Chromosome:
1
Start:
1,242,446 bp from pter
End:
1,247,218 bp from pter
Size:
4,773 bases
Orientation:
Minus strand

Genomic View for FAM132A Gene

Genes around FAM132A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM132A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM132A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM132A Gene

Proteins for FAM132A Gene

  • Protein details for FAM132A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7M4-ADIPL_HUMAN
    Recommended name:
    Adipolin
    Protein Accession:
    Q5T7M4
    Secondary Accessions:
    • Q5EBL5

    Protein attributes for FAM132A Gene

    Size:
    302 amino acids
    Molecular mass:
    32416 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked. May interact with ERFE (By similarity).

neXtProt entry for FAM132A Gene

Post-translational modifications for FAM132A Gene

Other Protein References for FAM132A Gene

No data available for DME Specific Peptides for FAM132A Gene

Domains & Families for FAM132A Gene

Gene Families for FAM132A Gene

Protein Domains for FAM132A Gene

Suggested Antigen Peptide Sequences for FAM132A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7M4

UniProtKB/Swiss-Prot:

ADIPL_HUMAN :
  • Contains 1 C1q domain.
  • Belongs to the adipolin/erythroferrone family.
Domain:
  • Contains 1 C1q domain.
Family:
  • Belongs to the adipolin/erythroferrone family.
genes like me logo Genes that share domains with FAM132A: view

Function for FAM132A Gene

Molecular function for FAM132A Gene

UniProtKB/Swiss-Prot Function:
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (By similarity).
UniProtKB/Swiss-Prot Induction:
By insulin in subcutaneous adipose tissue.

Gene Ontology (GO) - Molecular Function for FAM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity ISS --
genes like me logo Genes that share ontologies with FAM132A: view

Phenotypes for FAM132A Gene

genes like me logo Genes that share phenotypes with FAM132A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM132A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM132A Gene

Localization for FAM132A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM132A Gene

Adipolin fCTRP12: Secreted.
Adipolin gCTRP12: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM132A gene
Compartment Confidence
extracellular 5
plasma membrane 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FAM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with FAM132A: view

Pathways & Interactions for FAM132A Gene

SuperPathways for FAM132A Gene

No Data Available

Interacting Proteins for FAM132A Gene

Gene Ontology (GO) - Biological Process for FAM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010906 regulation of glucose metabolic process IEA --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0045721 negative regulation of gluconeogenesis IEA --
GO:0046324 regulation of glucose import IEA,ISS --
GO:0046326 positive regulation of glucose import IEA --
genes like me logo Genes that share ontologies with FAM132A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM132A Gene

Transcripts for FAM132A Gene

mRNA/cDNA for FAM132A Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM132A Gene

Family with sequence similarity 132, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM132A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3:

Relevant External Links for FAM132A Gene

GeneLoc Exon Structure for
FAM132A
ECgene alternative splicing isoforms for
FAM132A

Expression for FAM132A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM132A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM132A Gene

This gene is overexpressed in Colon - Transverse (x6.5), Small Intestine - Terminal Ileum (x5.2), and Skin - Not Sun Exposed (Suprapubic) (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of FAM132A Gene:

FAM132A

SOURCE GeneReport for Unigene cluster for FAM132A Gene:

Hs.197613

mRNA Expression by UniProt/SwissProt for FAM132A Gene:

Q5T7M4-ADIPL_HUMAN
Tissue specificity: Predominantly expressed by adipose tissues.
genes like me logo Genes that share expression patterns with FAM132A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FAM132A Gene

Orthologs for FAM132A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM132A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FAM132A 34 35
  • 79.07 (n)
cow
(Bos Taurus)
Mammalia FAM132A 34 35
  • 76.11 (n)
rat
(Rattus norvegicus)
Mammalia Fam132a 34
  • 75 (n)
mouse
(Mus musculus)
Mammalia Fam132a 34 16 35
  • 74.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM132A 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM132A 34 35
  • 62.21 (n)
lizard
(Anolis carolinensis)
Reptilia FAM132A 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam132a 34
  • 58.19 (n)
Str.12517 34
zebrafish
(Danio rerio)
Actinopterygii fam132a 34 35
  • 58.7 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12580 34
Species where no ortholog for FAM132A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM132A Gene

ENSEMBL:
Gene Tree for FAM132A (if available)
TreeFam:
Gene Tree for FAM132A (if available)

Paralogs for FAM132A Gene

Paralogs for FAM132A Gene

(1) SIMAP similar genes for FAM132A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM132A: view

Variants for FAM132A Gene

Sequence variations from dbSNP and Humsavar for FAM132A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10047044 -- 1,243,285(+) AGGCC(A/C)GGCGT intron-variant
rs10047210 -- 1,243,286(+) GGCCA(A/G)GCGTG intron-variant
rs111422263 -- 1,244,782(+) TCCCC(C/T)ACTCA intron-variant
rs111517457 -- 1,246,407(+) AGGGC(A/G)ACCCG intron-variant
rs111528198 -- 1,244,175(+) GGGCA(A/C/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM132A Gene

Variant ID Type Subtype PubMed ID
nsv950452 CNV deletion 24416366
nsv544965 CNV loss 21841781
nsv544964 CNV loss 21841781
nsv544947 CNV loss 21841781
nsv517709 CNV gain+loss 19592680
nsv482937 CNV loss 15286789
nsv470680 CNV loss 18288195
nsv469848 CNV gain 16826518
nsv455661 CNV loss 19166990
nsv1160772 CNV duplication 26073780
nsv1074016 CNV deletion 25765185
nsv10161 CNV gain+loss 18304495
nsv1003578 CNV gain 25217958
esv3584991 CNV gain 21293372
dgv2n67 CNV gain 20364138
dgv10n106 CNV deletion 24896259

Variation tolerance for FAM132A Gene

Gene Damage Index Score: 8.31; 85.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM132A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM132A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM132A Gene

Disorders for FAM132A Gene

Relevant External Links for FAM132A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM132A

No disorders were found for FAM132A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM132A Gene

Publications for FAM132A Gene

  1. Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex vivo effects. (PMID: 24492466) Tan B.K. … Randeva H.S. (J. Endocrinol. 2014) 3 4 64
  2. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. (PMID: 21849507) Enomoto T. … Ouchi N. (J. Biol. Chem. 2011) 2 3 64
  3. Circulatory changes of the novel adipokine adipolin/CTRP12 in response to metformin treatment and an oral glucose challenge in humans. (PMID: 24612181) Tan B.K. … Randeva H.S. (Clin. Endocrinol. (Oxf) 2014) 3 64
  4. Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line. (PMID: 22736092) Conde J. … Gualillo O. (Ann. Rheum. Dis. 2013) 3 64
  5. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. (PMID: 22942287) Wei Z. … Wong G.W. (J. Biol. Chem. 2012) 3 64

Products for FAM132A Gene

Sources for FAM132A Gene

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