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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM132A Gene

protein-coding   GIFtS: 40
GCID: GC01M001168

Family With Sequence Similarity 132, Member A

(Previous name: C1q domain containing 2)
(Previous symbol: C1QDC2)
  Search for FAM132A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 132, Member A1 2     CTRP122 3
C1QDC21 2 3     C1QTNF122
C1q Domain Containing 21 2     C1q/TNF-Related Protein 122
adipolin1 2     Protein FAM132A2
Adipose-Derived Insulin-Sensitizing Factor1 2     

External Ids:    HGNC: 323081   Entrez Gene: 3885812   Ensembl: ENSG000001841637   UniProtKB: Q5T7M43   

Export aliases for FAM132A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM132A Gene: 
FAM132A (family with sequence similarity 132, member A) is a protein-coding gene. An important paralog of this gene is FAM132B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM132A gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   STAT2   STAT3   ZID   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM132A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM132A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

FAM132A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM132A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001168:  view genomic region     (about GC identifiers)

Start:
1,177,826 bp from pter      End:
1,182,102 bp from pter
Size:
4,277 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F132A_HUMAN, Q5T7M4 (See protein sequence)
Recommended Name: Protein FAM132A precursor  
Size: 302 amino acids; 32416 Da
Subunit: May interact with FAM132B (By similarity)
Subcellular location: Secreted (Potential)
Secondary accessions: Q5EBL5

Explore the universe of human proteins at neXtProt for FAM132A: NX_Q5T7M4

Explore proteomics data for FAM132A at MOPED 

FAM132A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FAM132A Protein Expression

REFSEQ proteins: NP_001014980.1  
ENSEMBL proteins: 
 ENSP00000329137  

Human Recombinant Protein Products for FAM132A: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--

FAM132A for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR008983 Tumour_necrosis_fac-like_dom

Graphical View of Domain Structure for InterPro Entry Q5T7M4

ProtoNet protein and cluster: Q5T7M4

UniProtKB/Swiss-Prot: F132A_HUMAN, Q5T7M4
Similarity: Belongs to the FAM132 family
Similarity: Contains 1 C1q domain


FAM132A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
FAM132A for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for FAM132A:
 Increased TP53 protein express 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM132A

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/19 Interacting proteins for FAM132A (ENSP000003291374) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
InteractantInteraction Details
GeneCardExternal ID(s)
ARHGEF10LENSP000003550604STRING: ENSP00000355060
ATPAF1ENSP000003610054STRING: ENSP00000361005
C1orf146ENSP000003594014STRING: ENSP00000359401
CRYZENSP000003393994STRING: ENSP00000339399
ENSG00000184494ENSP000002297254STRING: ENSP00000229725
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0010906regulation of glucose metabolic process ----
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA--
GO:0045721negative regulation of gluconeogenesis IEA--
GO:0046326positive regulation of glucose import IEA--
GO:0046628positive regulation of insulin receptor signaling pathway IEA--

FAM132A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM132A (F132A)

Search CenterWatch for drugs/clinical trials and news about FAM132A / F132A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM132A gene: 
NM_001014980.2  

Unigene Cluster for FAM132A:

Family with sequence similarity 132, member A
Hs.197613  [show with all ESTs]
Unigene Representative Sequence: BC089443
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000462849 ENST00000478606 ENST00000330388(uc001adl.2) ENST00000468365
ENST00000486627
miRNA
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Inhib. RNA
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OriGene ORF clones in mouse, rat for FAM132A
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM132A
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Primer
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Additional mRNA sequence: BC089443.1 

3 DOTS entries:

DT.101961684  DT.70105502  DT.100012665 

12 AceView cDNA sequences:

AW873053 BX119870 CF131018 CA394474 AI634846 BU621109 AI660577 BE906672 
AW008561 AI241049 BQ711062 BF589994 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM132A    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:                                      -                           
SP2:                                                                  
SP3:                                                                  


ECgene alternative splicing isoforms for FAM132A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM132A expression in normal human tissues (normalized intensities)      FAM132A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTTTCCAGGC
FAM132A Expression
About this image


FAM132A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Gut Tube (Gastrointestinal Tract)
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

See FAM132A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM132A

SOURCE GeneReport for Unigene cluster: Hs.197613
    SABiosciences Custom PCR Arrays for FAM132A
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM132A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM132A gene from 5/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam132a1 , 5 family with sequence similarity 132, member A1, 5 74.55(n)1
72.64(a)1
  4 (87.66 cM)5
673891  NM_026125.31  NP_080401.11 
 1559623185 
chicken
(Gallus gallus)
Aves FAM132A1 family with sequence similarity 132, member A 62.82(n)
60.65(a)
  419422  XM_417583.3  XP_417583.1 
lizard
(Anolis carolinensis)
Reptilia FAM132A6
Uncharacterized protein
56(a)
1 ↔ 1
AAWZ02038050(1463-12718)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.125172 Transcribed sequence with weak similarity to protein more 72.39(n)    BX714430.1 
zebrafish
(Danio rerio)
Actinopterygii fam132a1 family with sequence similarity 132, member A 59.23(n)
52.7(a)
  790933  NM_001080078.1  NP_001073547.1 


ENSEMBL Gene Tree for FAM132A (if available)
TreeFam Gene Tree for FAM132A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM132A gene
FAM132B2  
1 SIMAP similar gene for FAM132A using alignment to 1 protein entry:     F132A_HUMAN:
FAM132B

FAM132A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/255 SNPs in FAM132A are shown (see all 255)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1174120881,2
C,F--1168093(+) CACTCT/CACCCT 1 -- us2k11Minor allele frequency- C:0.28EA 120
rs1472523421,2
--1177339(+) CTGGGC/TGCACC 1 -- int10--------
rs22978631,2
C,F,A--1177474(+) TCCCGA/GGGGCC 1 -- int14Minor allele frequency- G:0.17EA WA NA 1842
rs22978641,2
C,F,A,H--1177630(+) GGGCTA/GCCAGG 1 -- int119Minor allele frequency- G:0.20NS EA NA CSA WA 2341
rs798619941,2
C,F--1177773(+) GCCGAC/GCTCGG 1 -- int11Minor allele frequency- G:0.09WA 118
rs1130228121,2
C,F--1177795(+) CCACCC/TCCAGT 1 -- int11Minor allele frequency- T:0.50CSA 2
rs580803751,2
C--1177821(+) CACTCA/GAAGGC 1 -- int10--------
rs120956911,2
C--1177886(+) GTCCCC/TGGGAT 1 -- ut31 ese32Minor allele frequency- T:0.04CSA WA 119
rs124106801,2
C,F,H--1177893(+) GGATCC/TGGCGG 1 -- ut31 ese31Minor allele frequency- T:0.33NA 6
rs1145446311,2
C,F--1177896(+) TCCGGC/TGGCAG 1 -- ut311Minor allele frequency- T:0.02WA 118

HapMap Linkage Disequilibrium report for FAM132A (1177826 - 1182102 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/29 variations for FAM132A (see all 29):    About this table     
Variant IDTypeSubtypePubMed ID
esv2745363CNV Deletion23290073
dgv17n71CNV Loss21882294
nsv470680CNV Loss18288195
nsv455661CNV Loss19166990
nsv870639CNV Loss21882294
nsv871327CNV Loss21882294
nsv482937CNV Loss15286789
dgv12n71CNV Loss21882294
dgv25n71CNV Loss21882294
dgv21n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM132A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM132A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Adipolin/C1qdc2/CTRP12 protein functions as an adipok ine that improves glucose metabolism. (PubMed id 21849507)1, 3 Enomoto T....Ouchi N. (2011)
  2. Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line. (PubMed id 22736092)1 Conde J....Gualillo O. (2013)
  3. Endopeptidase cleavage generates a functionally distin ct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an alte red oligomeric state and signaling specificity. (PubMed id 22942287)1 Wei Z....Wong G.W. (2012)
  4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 388581 HGNC: 32308 AceView: LOC388581 Ensembl:ENSG00000184163 euGenes: HUgn388581
ECgene: FAM132A H-InvDB: FAM132A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM132A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM132A gene:
Search GeneIP for patents involving FAM132A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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