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Aliases for FAM132A Gene

Aliases for FAM132A Gene

  • Family With Sequence Similarity 132, Member A 2 3
  • Adipose-Derived Insulin-Sensitizing Factor 2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 12 3 4
  • C1q Domain Containing 2 2 3
  • Adipolin 2 3
  • C1QDC2 3 4
  • CTRP12 3 4
  • C1q/TNF-Related Protein 12 3
  • Protein FAM132A 3
  • C1QTNF12 3

External Ids for FAM132A Gene

Previous Symbols for FAM132A Gene

  • C1QDC2

Summaries for FAM132A Gene

GeneCards Summary for FAM132A Gene

FAM132A (Family With Sequence Similarity 132, Member A) is a Protein Coding gene. An important paralog of this gene is FAM132B.

UniProtKB/Swiss-Prot for FAM132A Gene

  • Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM132A Gene

Genomics for FAM132A Gene

Genomic Location for FAM132A Gene

Start:
1,242,446 bp from pter
End:
1,246,722 bp from pter
Size:
4,277 bases
Orientation:
Minus strand

Genomic View for FAM132A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM132A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM132A Gene

Regulatory Elements for FAM132A Gene

Proteins for FAM132A Gene

  • Protein details for FAM132A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7M4-ADIPL_HUMAN
    Recommended name:
    Adipolin
    Protein Accession:
    Q5T7M4
    Secondary Accessions:
    • Q5EBL5

    Protein attributes for FAM132A Gene

    Size:
    302 amino acids
    Molecular mass:
    32416 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked. May interact with FAM132B (By similarity).

neXtProt entry for FAM132A Gene

Proteomics data for FAM132A Gene at MOPED

Post-translational modifications for FAM132A Gene

Other Protein References for FAM132A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM132A Gene

Domains for FAM132A Gene

Protein Domains for FAM132A Gene

UniProtKB/Swiss-Prot:

ADIPL_HUMAN
Domain:
  • Contains 1 C1q domain.:
    • Q5T7M4
Family:
  • Belongs to the adipolin/erythroferrone family.:
    • Q5T7M4
genes like me logo Genes that share domains with FAM132A: view

No data available for Gene Families for FAM132A Gene

Function for FAM132A Gene

Molecular function for FAM132A Gene

UniProtKB/Swiss-Prot Function: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (By similarity).
UniProtKB/Swiss-Prot Induction: By insulin in subcutaneous adipose tissue.

Gene Ontology (GO) - Molecular Function for FAM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity ISS --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FAM132A: view

Phenotypes for FAM132A Gene

genes like me logo Genes that share phenotypes with FAM132A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM132A Gene

Localization for FAM132A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM132A Gene

Adipolin fCTRP12: Secreted.
Adipolin gCTRP12: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM132A Gene COMPARTMENTS Subcellular localization image for FAM132A gene
Compartment Confidence
extracellular 3
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with FAM132A: view

Pathways for FAM132A Gene

SuperPathways for FAM132A Gene

No Data Available

Interacting Proteins for FAM132A Gene

Gene Ontology (GO) - Biological Process for FAM132A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010906 regulation of glucose metabolic process --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0045721 negative regulation of gluconeogenesis IEA --
GO:0046324 regulation of glucose import ISS --
GO:0046326 positive regulation of glucose import IEA --
genes like me logo Genes that share ontologies with FAM132A: view

No data available for Pathways by source for FAM132A Gene

Transcripts for FAM132A Gene

mRNA/cDNA for FAM132A Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM132A Gene

Family with sequence similarity 132, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM132A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3:

Relevant External Links for FAM132A Gene

GeneLoc Exon Structure for
FAM132A
ECgene alternative splicing isoforms for
FAM132A

Expression for FAM132A Gene

mRNA expression in normal human tissues for FAM132A Gene

mRNA differential expression in normal tissues according to GTEx for FAM132A Gene

This gene is overexpressed in Colon - Transverse (6.5), Small Intestine - Terminal Ileum (5.2), and Skin - Not Sun Exposed (Suprapubic) (4.8).

SOURCE GeneReport for Unigene cluster for FAM132A Gene Hs.197613

mRNA Expression by UniProt/SwissProt for FAM132A Gene

Q5T7M4-ADIPL_HUMAN
Tissue specificity: Predominantly expressed by adipose tissues.
genes like me logo Genes that share expressions with FAM132A: view

Orthologs for FAM132A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM132A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM132A 36
  • 76.11 (n)
  • 68.53 (a)
FAM132A 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM132A 36
  • 79.07 (n)
  • 74.74 (a)
FAM132A 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam132a 36
  • 74.55 (n)
  • 72.64 (a)
Fam132a 16
Fam132a 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM132A 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam132a 36
  • 75 (n)
  • 73.31 (a)
chicken
(Gallus gallus)
Aves FAM132A 36
  • 62.21 (n)
  • 58.53 (a)
FAM132A 37
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM132A 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam132a 36
  • 58.19 (n)
  • 56.52 (a)
Str.12517 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12580 36
zebrafish
(Danio rerio)
Actinopterygii fam132a 36
  • 58.7 (n)
  • 53.58 (a)
fam132a 37
  • 46 (a)
OneToOne
Species with no ortholog for FAM132A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM132A Gene

ENSEMBL:
Gene Tree for FAM132A (if available)
TreeFam:
Gene Tree for FAM132A (if available)

Paralogs for FAM132A Gene

Paralogs for FAM132A Gene

Selected SIMAP similar genes for FAM132A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM132A: view

Variants for FAM132A Gene

Sequence variations from dbSNP and Humsavar for FAM132A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2297863 -- 1,242,094(+) TCCCG(A/G)GGGCC downstream-variant-500B
rs2297864 -- 1,242,250(+) GGGCT(A/G)CCAGG downstream-variant-500B
rs3835300 -- 1,242,539(+) CCCCC(-/T)GGGCG utr-variant-3-prime
rs6603783 -- 1,246,371(+) GATTC(C/T)CAAGG intron-variant
rs7539412 - 1,246,651(+) CGGCC(C/T)GAGGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FAM132A Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
nsv871107 CNV Loss 21882294
dgv23n71 CNV Loss 21882294
nsv871329 CNV Gain 21882294
dgv25n71 CNV Loss 21882294
dgv26n71 CNV Loss 21882294
nsv455661 CNV Loss 19166990
nsv871327 CNV Loss 21882294
nsv870639 CNV Loss 21882294
nsv871666 CNV Gain+Loss 21882294
nsv871965 CNV Loss 21882294
esv2745363 CNV Deletion 23290073

Relevant External Links for FAM132A Gene

HapMap Linkage Disequilibrium report
FAM132A

Disorders for FAM132A Gene

No disorders were found for FAM132A Gene.

No data available for UniProtKB/Swiss-Prot for FAM132A Gene

Publications for FAM132A Gene

  1. Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex vivo effects. (PMID: 24492466) Tan B.K. … Randeva H.S. (J. Endocrinol. 2014) 3 4
  2. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. (PMID: 21849507) Enomoto T. … Ouchi N. (J. Biol. Chem. 2011) 2 3
  3. Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line. (PMID: 22736092) Conde J. … Gualillo O. (Ann. Rheum. Dis. 2013) 3
  4. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. (PMID: 22942287) Wei Z. … Wong G.W. (J. Biol. Chem. 2012) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM132A Gene

Sources for FAM132A Gene

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