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Aliases for FAM131C Gene

Aliases for FAM131C Gene

  • Family With Sequence Similarity 131 Member C 2 3 5
  • C1orf117 3 4
  • Family With Sequence Similarity 131, Member C 2
  • Chromosome 1 Open Reading Frame 117 2
  • Protein FAM131C 3

External Ids for FAM131C Gene

Previous HGNC Symbols for FAM131C Gene

  • C1orf117

Previous GeneCards Identifiers for FAM131C Gene

  • GC01M016258
  • GC01M016384
  • GC01M014902

Summaries for FAM131C Gene

GeneCards Summary for FAM131C Gene

FAM131C (Family With Sequence Similarity 131 Member C) is a Protein Coding gene. An important paralog of this gene is FAM131A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM131C Gene

Genomics for FAM131C Gene

Regulatory Elements for FAM131C Gene

Enhancers for FAM131C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G016137 1.5 Ensembl ENCODE dbSUPER 16.6 -66.6 -66560 4.9 HDGF PKNOX1 ZNF133 GLI4 ZNF121 GATA2 FOS ZNF592 MEF2D SMARCA4 FAM131C SPEN RPL22P3 ENSG00000237938 RPS16P1 MFAP2 LINC01772 FBXO42 EPHA2 LOC101927479
GH01G016171 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -104.8 -104786 13.9 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D SSRP1 ZNF610 SPEN RPL22P3 EIF1AXP1 LINC01772 ARHGEF19 EPHA2 FAM131C ENSG00000237938 RPS16P1 MFAP2
GH01G015791 2 FANTOM5 Ensembl ENCODE dbSUPER 11 +276.1 276130 11.3 MLX CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 CLCNKA HSPB7 FBLIM1 ENSG00000233078 FAM131C ARHGEF19-AS1 RPS16P1 FLJ37453 C1orf64 CROCCP2
GH01G016161 1.6 Ensembl ENCODE dbSUPER 11.7 -90.2 -90240 4.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 FOS ARHGEF19-AS1 FAM131C ARHGEF19 EPHA2 ENSG00000224621 GC01P016173
GH01G016167 1.4 Ensembl ENCODE dbSUPER 12.4 -94.8 -94798 2.6 HDAC1 PKNOX1 RB1 ARNT SIN3A NFXL1 BMI1 ZBTB40 ZNF48 ETS1 ARHGEF19-AS1 FAM131C ARHGEF19 LOC440568 DDI2 GC01P016173 ENSG00000224621
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM131C on UCSC Golden Path with GeneCards custom track

Promoters for FAM131C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002000 132 601 TBP HDAC1 RB1 ARNT KLF17 ZNF2 RAD21 ZBTB40 ZEB1 GLIS2

Genomic Location for FAM131C Gene

Chromosome:
1
Start:
16,057,769 bp from pter
End:
16,073,632 bp from pter
Size:
15,864 bases
Orientation:
Minus strand

Genomic View for FAM131C Gene

Genes around FAM131C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM131C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM131C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM131C Gene

Proteins for FAM131C Gene

  • Protein details for FAM131C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AQ9-F131C_HUMAN
    Recommended name:
    Protein FAM131C
    Protein Accession:
    Q96AQ9
    Secondary Accessions:
    • Q5T5Q5
    • Q8N3X3
    • Q8N9P9

    Protein attributes for FAM131C Gene

    Size:
    280 amino acids
    Molecular mass:
    30351 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM131C Gene

Post-translational modifications for FAM131C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM131C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM131C Gene

Domains & Families for FAM131C Gene

Protein Domains for FAM131C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM131C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AQ9

UniProtKB/Swiss-Prot:

F131C_HUMAN :
  • Belongs to the FAM131 family.
Family:
  • Belongs to the FAM131 family.
genes like me logo Genes that share domains with FAM131C: view

No data available for Gene Families for FAM131C Gene

Function for FAM131C Gene

Gene Ontology (GO) - Molecular Function for FAM131C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FAM131C: view

Phenotypes for FAM131C Gene

genes like me logo Genes that share phenotypes with FAM131C: view

Animal Model Products

CRISPR Products

miRNA for FAM131C Gene

miRTarBase miRNAs that target FAM131C

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM131C Gene

Localization for FAM131C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM131C gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM131C Gene

Pathways & Interactions for FAM131C Gene

SuperPathways for FAM131C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM131C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM131C Gene

Drugs & Compounds for FAM131C Gene

No Compound Related Data Available

Transcripts for FAM131C Gene

mRNA/cDNA for FAM131C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM131C Gene

Family with sequence similarity 131, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM131C Gene

No ASD Table

Relevant External Links for FAM131C Gene

GeneLoc Exon Structure for
FAM131C
ECgene alternative splicing isoforms for
FAM131C

Expression for FAM131C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM131C Gene

mRNA differential expression in normal tissues according to GTEx for FAM131C Gene

This gene is overexpressed in Brain - Cerebellum (x10.5), Brain - Cerebellar Hemisphere (x9.7), and Brain - Spinal cord (cervical c-1) (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of FAM131C Gene:

FAM131C

SOURCE GeneReport for Unigene cluster for FAM131C Gene:

Hs.126825
genes like me logo Genes that share expression patterns with FAM131C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM131C Gene

Orthologs for FAM131C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM131C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM131C 34 35
  • 98.45 (n)
dog
(Canis familiaris)
Mammalia FAM131C 34 35
  • 86.03 (n)
cow
(Bos Taurus)
Mammalia FAM131C 34 35
  • 83.72 (n)
rat
(Rattus norvegicus)
Mammalia Fam131c 34
  • 82.26 (n)
mouse
(Mus musculus)
Mammalia Fam131c 34 16 35
  • 81.99 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM131C 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM131C 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM131C 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam131c 34 35
  • 57.76 (n)
Species where no ortholog for FAM131C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM131C Gene

ENSEMBL:
Gene Tree for FAM131C (if available)
TreeFam:
Gene Tree for FAM131C (if available)

Paralogs for FAM131C Gene

Paralogs for FAM131C Gene

Pseudogenes.org Pseudogenes for FAM131C Gene

genes like me logo Genes that share paralogs with FAM131C: view

Variants for FAM131C Gene

Sequence variations from dbSNP and Humsavar for FAM131C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000048319 -- 16,061,710(+) CCGCT(G/T)CCTGC intron-variant
rs1000091630 -- 16,070,558(+) AGGCC(A/G)AGGTG intron-variant
rs1000318520 -- 16,065,422(+) CTGCC(C/T)GCCAG intron-variant
rs1000382845 -- 16,072,264(+) CGATA(C/T)CTCCC intron-variant
rs1000415527 -- 16,072,092(+) GCCTC(A/C)CGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM131C Gene

Variant ID Type Subtype PubMed ID
dgv155n54 CNV gain 21841781
dgv157n54 CNV gain 21841781
dgv1e19 CNV loss 19470904
dgv20e199 CNV deletion 23128226
dgv9e201 CNV deletion 23290073
esv2434454 CNV deletion 19546169
esv25815 CNV gain 19812545
esv2672024 CNV deletion 23128226
esv2744386 CNV deletion 23290073
esv2760188 CNV gain+loss 21179565
esv32650 CNV gain 17666407
esv3448687 CNV duplication 20981092
esv6377 CNV loss 19470904
esv995840 CNV deletion 20482838
nsv1075223 CNV deletion 25765185
nsv1114931 CNV deletion 24896259
nsv1116588 CNV tandem duplication 24896259
nsv1118430 CNV duplication 24896259
nsv1161228 CNV duplication 26073780
nsv436443 CNV deletion 17901297
nsv470698 CNV loss 18288195
nsv508936 CNV insertion 20534489
nsv520148 CNV loss 19592680
nsv524045 CNV loss 19592680
nsv545634 CNV gain 21841781
nsv545640 CNV gain 21841781
nsv829570 CNV gain 20364138
nsv833758 CNV gain+loss 17160897
nsv954844 CNV deletion 24416366
nsv997887 CNV gain 25217958

Variation tolerance for FAM131C Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.23; 98.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM131C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM131C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM131C Gene

Disorders for FAM131C Gene

Relevant External Links for FAM131C

Genetic Association Database (GAD)
FAM131C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM131C

No disorders were found for FAM131C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM131C Gene

Publications for FAM131C Gene

  1. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for FAM131C Gene

Sources for FAM131C Gene

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