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Aliases for FAM131B Gene

Aliases for FAM131B Gene

  • Family With Sequence Similarity 131 Member B 2 3 5
  • Family With Sequence Similarity 131, Member B 2
  • KIAA0773 4

External Ids for FAM131B Gene

Previous GeneCards Identifiers for FAM131B Gene

  • GC07M142761
  • GC07M143050
  • GC07M137387

Summaries for FAM131B Gene

GeneCards Summary for FAM131B Gene

FAM131B (Family With Sequence Similarity 131 Member B) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Oncogenic MAPK signaling. An important paralog of this gene is FAM131A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM131B Gene

Genomics for FAM131B Gene

Regulatory Elements for FAM131B Gene

Enhancers for FAM131B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G143378 2 FANTOM5 Ensembl ENCODE dbSUPER 9.5 -3.9 -3891 15.9 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 ZBTB7B ZYX EPHA1-AS1 EPHA1 HINT1P1 CLCN1 OR2A1 FAM131B LOC100507507 TAS2R60 ARHGEF35
GH07G143258 1.5 FANTOM5 Ensembl ENCODE 11.2 +123.0 123036 2.2 FOXA2 YY1 TCF12 ZNF766 GATA2 CBX5 FOS SP3 CAVIN1 JUNB TMEM139 LOC105375545 CASP2 RN7SL535P EPHA1-AS1 EPHA1 FAM131B HINT1P1 CLCN1 ZYX
GH07G143248 1.2 Ensembl ENCODE 10.9 +132.3 132301 2.6 ELF3 CBX3 MLX ARID4B RAD21 RARA YY1 MIXL1 THAP11 NR2F2 TMEM139 LOC105375545 CASP2 RN7SL535P FAM131B EPHB6 GSTK1
GH07G143300 1.2 Ensembl ENCODE dbSUPER 10.5 +81.1 81077 1.8 TAL1 MAX TCF12 CTBP1 GATA3 POLR2A FOSL2 FOS EZH2 BHLHE40 GSTK1 ZYX LOC100507507 FAM131B CASP2 RN7SL481P HINT1P1
GH07G143244 1 FANTOM5 Ensembl ENCODE 12.3 +137.0 137009 1.3 MCM7 PRDM6 ZNF266 FOS FAM131B TMEM139 CASP2 LOC105375545 RN7SL535P ZYX LOC100507507 OR9A2 TAS2R39 TRPV6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM131B on UCSC Golden Path with GeneCards custom track

Promoters for FAM131B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219365 904 2801 HDGF CREB3L1 WRNIP1 SIN3A ZNF2 ZBTB7B YY1 ZNF143 FOS KLF13

Genomic Location for FAM131B Gene

Chromosome:
7
Start:
143,353,400 bp from pter
End:
143,382,304 bp from pter
Size:
28,905 bases
Orientation:
Minus strand

Genomic View for FAM131B Gene

Genes around FAM131B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM131B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM131B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM131B Gene

Proteins for FAM131B Gene

  • Protein details for FAM131B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XD5-F131B_HUMAN
    Recommended name:
    Protein FAM131B
    Protein Accession:
    Q86XD5
    Secondary Accessions:
    • A4D2H6
    • A6NDW3
    • A8K605
    • B8ZZN2
    • D3DXE3
    • J3KQX2
    • Q7L0D6
    • Q86T97

    Protein attributes for FAM131B Gene

    Size:
    332 amino acids
    Molecular mass:
    35769 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAS07501.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM131B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM131B Gene

Post-translational modifications for FAM131B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM131B Gene

Domains & Families for FAM131B Gene

Protein Domains for FAM131B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM131B Gene

Graphical View of Domain Structure for InterPro Entry

Q86XD5

UniProtKB/Swiss-Prot:

F131B_HUMAN :
  • Belongs to the FAM131 family.
Family:
  • Belongs to the FAM131 family.
genes like me logo Genes that share domains with FAM131B: view

No data available for Gene Families for FAM131B Gene

Function for FAM131B Gene

Gene Ontology (GO) - Molecular Function for FAM131B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with FAM131B: view
genes like me logo Genes that share phenotypes with FAM131B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM131B Gene

Localization for FAM131B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM131B gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for FAM131B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FAM131B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM131B Gene

Pathways & Interactions for FAM131B Gene

genes like me logo Genes that share pathways with FAM131B: view

Pathways by source for FAM131B Gene

Interacting Proteins for FAM131B Gene

Gene Ontology (GO) - Biological Process for FAM131B Gene

None

No data available for SIGNOR curated interactions for FAM131B Gene

Drugs & Compounds for FAM131B Gene

No Compound Related Data Available

Transcripts for FAM131B Gene

Unigene Clusters for FAM131B Gene

Family with sequence similarity 131, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM131B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - -
SP8:

Relevant External Links for FAM131B Gene

GeneLoc Exon Structure for
FAM131B
ECgene alternative splicing isoforms for
FAM131B

Expression for FAM131B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM131B Gene

mRNA differential expression in normal tissues according to GTEx for FAM131B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4), Brain - Cerebellum (x5.9), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.2), and Brain - Spinal cord (cervical c-1) (x4.8).

Protein differential expression in normal tissues from HIPED for FAM131B Gene

This gene is overexpressed in Fetal Brain (31.2), Frontal cortex (27.6), and Spinal cord (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM131B Gene



Protein tissue co-expression partners for FAM131B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM131B Gene:

FAM131B

SOURCE GeneReport for Unigene cluster for FAM131B Gene:

Hs.648908

Evidence on tissue expression from TISSUES for FAM131B Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with FAM131B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM131B Gene

Orthologs for FAM131B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM131B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM131B 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia FAM131B 34 35
  • 92.07 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM131B 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM131B 34 35
  • 90.96 (n)
rat
(Rattus norvegicus)
Mammalia Fam131b 34
  • 90.46 (n)
mouse
(Mus musculus)
Mammalia Fam131b 34 16 35
  • 90.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM131B 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM131B 34 35
  • 71.51 (n)
lizard
(Anolis carolinensis)
Reptilia FAM131B 35
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam131ba 35
  • 35 (a)
OneToMany
fam131bb 35
  • 34 (a)
OneToMany
Species where no ortholog for FAM131B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM131B Gene

ENSEMBL:
Gene Tree for FAM131B (if available)
TreeFam:
Gene Tree for FAM131B (if available)

Paralogs for FAM131B Gene

Paralogs for FAM131B Gene

(2) SIMAP similar genes for FAM131B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM131B: view

Variants for FAM131B Gene

Sequence variations from dbSNP and Humsavar for FAM131B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000019148 -- 143,381,249(+) TATGG(C/T)CTGGG intron-variant, upstream-variant-2KB, reference, missense
rs1000104340 -- 143,356,268(+) TTGTC(A/G/T)GCACA utr-variant-3-prime
rs1000163934 -- 143,367,826(+) TCAAC(A/G)TCCCC intron-variant
rs1000185995 -- 143,366,181(+) ACGTT(A/C)TTTCA intron-variant
rs1000211478 -- 143,358,625(+) ATTAC(A/G)CGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM131B Gene

Variant ID Type Subtype PubMed ID
nsv517520 CNV loss 19592680
nsv949966 CNV deletion 24416366

Variation tolerance for FAM131B Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.74; 83.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM131B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM131B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM131B Gene

Disorders for FAM131B Gene

Relevant External Links for FAM131B

Genetic Association Database (GAD)
FAM131B
Human Genome Epidemiology (HuGE) Navigator
FAM131B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM131B

No disorders were found for FAM131B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM131B Gene

Publications for FAM131B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3 64
  5. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3 64

Products for FAM131B Gene

Sources for FAM131B Gene

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