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Aliases for FAM131B Gene

Aliases for FAM131B Gene

  • Family With Sequence Similarity 131, Member B 2 3
  • KIAA0773 4

External Ids for FAM131B Gene

Previous GeneCards Identifiers for FAM131B Gene

  • GC07M142761
  • GC07M143050
  • GC07M137387

Summaries for FAM131B Gene

GeneCards Summary for FAM131B Gene

FAM131B (Family With Sequence Similarity 131, Member B) is a Protein Coding gene. An important paralog of this gene is FAM131A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM131B Gene

Genomics for FAM131B Gene

Regulatory Elements for FAM131B Gene

Transcription factor binding sites by QIAGEN in the FAM131B gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM131B Gene

143,353,400 bp from pter
143,382,283 bp from pter
28,884 bases
Minus strand

Genomic View for FAM131B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM131B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM131B Gene

Proteins for FAM131B Gene

  • Protein details for FAM131B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM131B
    Protein Accession:
    Secondary Accessions:
    • A4D2H6
    • A6NDW3
    • A8K605
    • B8ZZN2
    • D3DXE3
    • J3KQX2
    • Q7L0D6
    • Q86T97

    Protein attributes for FAM131B Gene

    332 amino acids
    Molecular mass:
    35769 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAS07501.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM131B Gene


neXtProt entry for FAM131B Gene

Proteomics data for FAM131B Gene at MOPED

Post-translational modifications for FAM131B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM131B Gene

Domains for FAM131B Gene

Protein Domains for FAM131B Gene


Suggested Antigen Peptide Sequences for FAM131B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM131 family.
  • Belongs to the FAM131 family.
genes like me logo Genes that share domains with FAM131B: view

No data available for Gene Families for FAM131B Gene

Function for FAM131B Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM131B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM131B Gene

Localization for FAM131B Gene

Subcellular locations from

Jensen Localization Image for FAM131B Gene COMPARTMENTS Subcellular localization image for FAM131B gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FAM131B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FAM131B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM131B Gene

Pathways for FAM131B Gene

SuperPathways for FAM131B Gene

No Data Available

Interacting Proteins for FAM131B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000410603 for FAM131B Gene via STRING

Gene Ontology (GO) - Biological Process for FAM131B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with FAM131B: view

No data available for Pathways by source for FAM131B Gene

Transcripts for FAM131B Gene

Unigene Clusters for FAM131B Gene

Family with sequence similarity 131, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM131B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM131B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for FAM131B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM131B Gene

mRNA expression in normal human tissues for FAM131B Gene

mRNA differential expression in normal tissues according to GTEx for FAM131B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.4), Brain - Cerebellum (5.9), Brain - Cortex (5.6), Brain - Frontal Cortex (BA9) (5.2), and Brain - Spinal cord (cervical c-1) (4.8).

Protein differential expression in normal tissues for FAM131B Gene

This gene is overexpressed in Fetal Brain (31.2), Frontal cortex (27.6), and Spinal cord (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM131B Gene

SOURCE GeneReport for Unigene cluster for FAM131B Gene Hs.648908

genes like me logo Genes that share expressions with FAM131B: view

Expression partners for FAM131B Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM131B Gene

Orthologs for FAM131B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM131B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM131B 35
  • 90.96 (n)
  • 96.73 (a)
FAM131B 36
  • 80 (a)
(Canis familiaris)
Mammalia FAM131B 35
  • 92.07 (n)
  • 96.32 (a)
FAM131B 36
  • 72 (a)
(Mus musculus)
Mammalia Fam131b 35
  • 90.28 (n)
  • 95.83 (a)
Fam131b 16
Fam131b 36
  • 96 (a)
(Pan troglodytes)
Mammalia FAM131B 35
  • 99.63 (n)
  • 99.44 (a)
FAM131B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam131b 35
  • 90.46 (n)
  • 96.11 (a)
(Monodelphis domestica)
Mammalia FAM131B 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia FAM131B 36
  • 72 (a)
(Gallus gallus)
Aves FAM131B 35
  • 71.51 (n)
  • 79.36 (a)
FAM131B 36
  • 69 (a)
(Anolis carolinensis)
Reptilia FAM131B 36
  • 74 (a)
(Danio rerio)
Actinopterygii fam131ba 36
  • 35 (a)
fam131bb 36
  • 34 (a)
Species with no ortholog for FAM131B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM131B Gene

Gene Tree for FAM131B (if available)
Gene Tree for FAM131B (if available)

Paralogs for FAM131B Gene

Paralogs for FAM131B Gene

(2) SIMAP similar genes for FAM131B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM131B: view

Variants for FAM131B Gene

Sequence variations from dbSNP and Humsavar for FAM131B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1801576 -- 143,354,016(-) AGGAA(A/G)AGGCT utr-variant-3-prime
rs3841180 -- 143,354,978(-) TGGAA(-/TTCC)GGGAG utr-variant-3-prime
rs4076124 -- 143,357,789(+) ataac(C/T)acatg intron-variant
rs4236482 -- 143,357,216(+) GTGGA(A/G)GCAGC intron-variant
rs4236483 -- 143,368,848(+) TTTCA(C/G)CTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM131B Gene

Variant ID Type Subtype PubMed ID
nsv517520 CNV Loss 19592680

Relevant External Links for FAM131B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM131B Gene

Disorders for FAM131B Gene

(1) University of Copenhagen DISEASES for FAM131B Gene

Relevant External Links for FAM131B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FAM131B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FAM131B Gene

Publications for FAM131B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3

Products for FAM131B Gene

Sources for FAM131B Gene

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