FAM131B Gene
protein-coding GIFtS: 44
GCID: GC07M143050
|
|
family with sequence similarity 131, member B
| |
Aliases
for FAM131B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 131, Member B1 2 | | KIAA07731 3 | | Protein FAM131B2 |
Export aliases for FAM131B gene to outside databasesPrevious GC identifers: GC07M142761 GC07M137387 |
Summaries
for FAM131B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM131B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM131B gene promoter:
SRF SRF (504 AA) c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM131B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM131B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34FAM131B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M143050: view genomic region
(about GC identifiers)
Start:
|
143,050,493 bp from pter |
End:
|
143,059,863 bp from pter |
Size:
|
9,371 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 142,452,619-142,461,973 |
|
Proteins
for FAM131B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F131B_HUMAN, Q86XD5 (See
protein sequence)Recommended Name: Protein FAM131B Size: 332 amino acids; 35769 Da
Sequence caution: Sequence=AAS07501.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D2H6 A8K605 B8ZZN2 D3DXE3 Q7L0D6 Q86T97Alternative splicing: 2 isoforms: Q86XD5-1 Q86XD5-2 (Myristoylated at Gly-2)Explore the universe of human proteins at neXtProt for FAM131B: NX_Q86XD5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XD5
FAM131B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001026860.2 NP_055505.3
ENSEMBL proteins: ENSP00000410603 ENSP00000386396 ENSP00000386568 ENSP00000386984 ENSP00000387017 ENSP00000387147 ENSP00000430601 ENSP00000430805
Human Recombinant Protein Products:
FAM131B Antibody Products:
Assay Products for FAM131B: |
Protein
Domains /
Families
for FAM131B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM131B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86XD5ProtoNet protein and cluster: Q86XD5 UniProtKB/Swiss-Prot: F131B_HUMAN, Q86XD5Similarity: Belongs to the FAM131 family |
Function
for FAM131B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM131B (NM_014690) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM131B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM131B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM131B |
|
Pathways & Interactions
for FAM131B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM131B
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for FAM131B (ENSP000004106034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM131B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM131B
Search CenterWatch for drugs/clinical trials and news about FAM131B / F131B
|
Transcripts
for FAM131B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM131B gene (2 alternative transcripts): NM_001031690.2 NM_014690.4 Unigene Cluster for FAM131B: Family with sequence similarity 131, member B Hs.648908 [show with all ESTs]Unigene Representative Sequence: AL8325799 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000443739(uc003wcu.4 uc010lpa.3) ENST00000410085(uc010loz.3)
ENST00000409578 ENST00000409346 ENST00000409408(uc003wct.3) ENST00000409222
ENST00000519279 ENST00000521347 ENST00000519161
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM131B (NM_014690) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM131B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM131B |
Additional cDNA sequence: AB018316.1 AK124557.1 AK291470.1 AL832579.2 BC045611.1 BC050543.1 9 DOTS entries: DT.40223700 DT.97813859 DT.411568 DT.100762692 DT.100678917 DT.100707222 DT.121071423 DT.91653609 DT.97864739 24/85 AceView cDNA sequences (see all 85): AL533847 AL534947 BM680677 BC050543 AB018316 BI523526 BE858741 H46919 BM927316 BF477525 T07074 BG179233 BX410068 CD625926 AW197576 BG819654 BX431154 BG910557 AL832579 AI871761 BF057655 D55764 BX460751 H30704
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM131B (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|
|
| SP1: | | | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM131B
|
Expression
for FAM131B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM131B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTCAAATG
About this image
See FAM131B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM131B
SOURCE GeneReport for Unigene cluster: Hs.648908
SABiosciences Custom PCR Arrays for FAM131B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM131B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM131B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM131B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM131B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM131B |
Orthologs
for FAM131B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM131B gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for FAM131B (if available)
TreeFam Gene Tree for FAM131B (if available) |
Paralogs
for FAM131B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM131B gene
- FAM131C2 FAM131A2
2 SIMAP similar genes for FAM131B using alignment to 5 protein entries: F131B_HUMAN (see all proteins):KIAA0773 FAM131A
FAM131B for paralogs About GeneDecksing
|
Genomic Variants
for FAM131B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM131B (143050493 - 143059863 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM131B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM131B |
|
Disorders
/ Diseases
for FAM131B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM131B for disorders About GeneDecksing
2  diseases for FAM131B: About MalaCardspilocytic astrocytoma astrocytoma
1 disease from the University of Copenhagen DISEASES database for FAM131B:Pilocytic astrocytoma Human Genome Epidemiology (HuGE) Navigator: FAM131B (1 document)
Export disorders for FAM131B gene to outside databases
|
Publications
for FAM131B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM131B gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FAM131B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system. (PubMed id 20213681)2 Suzuki T.... Utsumi T. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
|
External Searches for FAM131B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM131B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM131B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM131B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM131B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM131B gene:
Search GeneIP for patents involving FAM131B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM131B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM131B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM131B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM131B | | | OriGene Protein Over-expression Lysate for FAM131B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM131B | | OriGene 3'-UTR Clone for FAM131B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM131B | | OriGene Custom Protein Services for FAM131B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM131B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM131B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM131B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM131B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM131B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM131B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM131B |
| |  |  |  |  | | | | |
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 | | | FAM131B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM131B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM131B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM131B |
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