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Aliases for FAM131B Gene

Aliases for FAM131B Gene

  • Family With Sequence Similarity 131 Member B 2 3 5
  • Family With Sequence Similarity 131, Member B 2
  • KIAA0773 4

External Ids for FAM131B Gene

Previous GeneCards Identifiers for FAM131B Gene

  • GC07M142761
  • GC07M143050
  • GC07M137387

Summaries for FAM131B Gene

GeneCards Summary for FAM131B Gene

FAM131B (Family With Sequence Similarity 131 Member B) is a Protein Coding gene. Among its related pathways are HIV Life Cycle. An important paralog of this gene is FAM131A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM131B Gene

Genomics for FAM131B Gene

Regulatory Elements for FAM131B Gene

Enhancers for FAM131B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143378 1.8 FANTOM5 Ensembl ENCODE 9.5 -3.9 -3891 15.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 ZNF2 YY1 ZYX EPHA1-AS1 EPHA1 CLCN1 HINT1P1 OR2A1 FAM131B LOC100507507 TAS2R60 ARHGEF35
GH07F143258 1.5 FANTOM5 Ensembl ENCODE 11.2 +123.0 123036 2.2 YY1 ZNF766 GATA2 CBX5 FOS SP3 JUNB NCOA1 SMARCA4 PBX2 TMEM139 LOC105375545 CASP2 RN7SL535P EPHA1 EPHA1-AS1 FAM131B HINT1P1 CLCN1 ZYX
GH07F143244 1.1 FANTOM5 Ensembl ENCODE 12.3 +137.2 137153 3.7 MCM7 PKNOX1 MCM3 ZNF266 KDM1A MYC FAM131B TMEM139 LOC105375545 CASP2 RN7SL535P LOC100507507 ZYX OR9A2 TAS2R39 TRPV6
GH07F143248 1.1 Ensembl ENCODE 10.9 +132.0 132004 4.2 ELF3 CBX3 MLX ARID4B RAD21 RARA YY1 MIXL1 THAP11 NR2F2 CASP2 TMEM139 LOC105375545 RN7SL535P FAM131B EPHB6 GSTK1
GH07F143310 1 Ensembl ENCODE 11.4 +71.6 71617 0.6 CTCF ATF1 CBX3 RAD21 ZNF335 ZNF143 SMC3 ZMIZ1 ZSCAN29 CREM CASP2 LOC105375545 RN7SL535P TMEM139 GSTK1 FAM131B ZYX LOC100507507 EPHA1 EPHA1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM131B on UCSC Golden Path with GeneCards custom track

Promoters for FAM131B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000635666 904 4401 CREB3L1 WRNIP1 SIN3A ZNF2 YY1 ZNF143 FOS KLF13 SP3 SP5
ENSR00001897232 -1996 601 ZFHX2 POLR2A EGR2

Genomic Location for FAM131B Gene

143,353,400 bp from pter
143,382,304 bp from pter
28,905 bases
Minus strand

Genomic View for FAM131B Gene

Genes around FAM131B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM131B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM131B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM131B Gene

Proteins for FAM131B Gene

  • Protein details for FAM131B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM131B
    Protein Accession:
    Secondary Accessions:
    • A4D2H6
    • A6NDW3
    • A8K605
    • B8ZZN2
    • D3DXE3
    • J3KQX2
    • Q7L0D6
    • Q86T97

    Protein attributes for FAM131B Gene

    332 amino acids
    Molecular mass:
    35769 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAS07501.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM131B Gene


neXtProt entry for FAM131B Gene

Post-translational modifications for FAM131B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM131B Gene

Domains & Families for FAM131B Gene

Protein Domains for FAM131B Gene


Suggested Antigen Peptide Sequences for FAM131B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM131 family.
  • Belongs to the FAM131 family.
genes like me logo Genes that share domains with FAM131B: view

No data available for Gene Families for FAM131B Gene

Function for FAM131B Gene

Gene Ontology (GO) - Molecular Function for FAM131B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with FAM131B: view
genes like me logo Genes that share phenotypes with FAM131B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM131B Gene

Localization for FAM131B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM131B gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for FAM131B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FAM131B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM131B Gene

Pathways & Interactions for FAM131B Gene

SuperPathways for FAM131B Gene

SuperPathway Contained pathways
1 HIV Life Cycle
genes like me logo Genes that share pathways with FAM131B: view

Pathways by source for FAM131B Gene

2 Reactome pathways for FAM131B Gene

Gene Ontology (GO) - Biological Process for FAM131B Gene


No data available for SIGNOR curated interactions for FAM131B Gene

Transcripts for FAM131B Gene

Unigene Clusters for FAM131B Gene

Family with sequence similarity 131, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM131B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for FAM131B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM131B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM131B Gene

mRNA differential expression in normal tissues according to GTEx for FAM131B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4), Brain - Cerebellum (x5.9), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.2), and Brain - Spinal cord (cervical c-1) (x4.8).

Protein differential expression in normal tissues from HIPED for FAM131B Gene

This gene is overexpressed in Fetal Brain (31.2), Frontal cortex (27.6), and Spinal cord (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM131B Gene

Protein tissue co-expression partners for FAM131B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM131B Gene:


SOURCE GeneReport for Unigene cluster for FAM131B Gene:

genes like me logo Genes that share expression patterns with FAM131B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM131B Gene

Orthologs for FAM131B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM131B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM131B 34 35
  • 99.63 (n)
(Canis familiaris)
Mammalia FAM131B 34 35
  • 92.07 (n)
(Monodelphis domestica)
Mammalia FAM131B 35
  • 91 (a)
(Bos Taurus)
Mammalia FAM131B 34 35
  • 90.96 (n)
(Rattus norvegicus)
Mammalia Fam131b 34
  • 90.46 (n)
(Mus musculus)
Mammalia Fam131b 34 16 35
  • 90.28 (n)
(Ornithorhynchus anatinus)
Mammalia FAM131B 35
  • 72 (a)
(Gallus gallus)
Aves FAM131B 34 35
  • 71.51 (n)
(Anolis carolinensis)
Reptilia FAM131B 35
  • 74 (a)
(Danio rerio)
Actinopterygii fam131ba 35
  • 35 (a)
fam131bb 35
  • 34 (a)
Species where no ortholog for FAM131B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM131B Gene

Gene Tree for FAM131B (if available)
Gene Tree for FAM131B (if available)

Paralogs for FAM131B Gene

Paralogs for FAM131B Gene

(2) SIMAP similar genes for FAM131B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM131B: view

Variants for FAM131B Gene

Sequence variations from dbSNP and Humsavar for FAM131B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10226669 -- 143,374,387(+) AAGCT(C/T)TCTAC intron-variant
rs10233736 -- 143,368,927(+) ACATA(A/G)TGGGT intron-variant
rs10234864 -- 143,363,835(+) GGCCA(G/T)GGGTC intron-variant, upstream-variant-2KB
rs10246321 -- 143,371,910(+) gatga(A/G)gccag intron-variant
rs10269527 -- 143,356,167(+) GTTAC(A/G)GCTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM131B Gene

Variant ID Type Subtype PubMed ID
nsv949966 CNV deletion 24416366
nsv517520 CNV loss 19592680

Variation tolerance for FAM131B Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.74; 83.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM131B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM131B Gene

Disorders for FAM131B Gene

Relevant External Links for FAM131B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM131B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM131B Gene

Publications for FAM131B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3 64
  5. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3 64

Products for FAM131B Gene

Sources for FAM131B Gene

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