FAM131A Gene
protein-coding GIFtS: 43
GCID: GC03P184053
|
|
family with sequence similarity 131, member A(Previous name: chromosome 3 open reading frame 40 )
(Previous symbol: C3orf40)
| |
Aliases
for FAM131A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 131, Member A1 2 | | FLAT7152 | | C3orf401 2 3 | | PRO13782 | | MGC216881 | | Protein FAM131A2 | | Chromosome 3 Open Reading Frame 401 | | |
Export aliases for FAM131A gene to outside databasesPrevious GC identifers: GC03P185538 GC03P181460 |
Summaries
for FAM131A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM131A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM131A gene promoter:
MAZR Pax-5 Tal-1beta C/EBPalpha AREB6 MZF-1 PPAR-gamma1 HSF2 PPAR-gamma2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM131A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM131A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27.1FAM131A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P184053: view genomic region
(about GC identifiers)
Start:
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184,053,714 bp from pter |
End:
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184,064,063 bp from pter |
Size:
|
10,350 bases |
Orientation:
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plus strand |
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Proteins
for FAM131A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F131A_HUMAN, Q6UXB0 (See
protein sequence)Recommended Name: Protein FAM131A precursor Size: 335 amino acids; 36108 Da
Subcellular location: Secreted (Potential)
Secondary accessions: D3DNT6 Q8TA84Alternative splicing: 2 isoforms: Q6UXB0-1 Q6UXB0-2 Explore the universe of human proteins at neXtProt for FAM131A: NX_Q6UXB0
FAM131A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001164564.1 NP_653236.3
ENSEMBL proteins: ENSP00000388551 ENSP00000414050 ENSP00000340974 ENSP00000399875 ENSP00000414913 ENSP00000373360 ENSP00000390588 ENSP00000310135
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
FAM131A for ontologies About GeneDecksing
FAM131A Antibody Products:
Assay Products for FAM131A: |
Protein
Domains /
Families
for FAM131A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM131A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6UXB0ProtoNet protein and cluster: Q6UXB0 UniProtKB/Swiss-Prot: F131A_HUMAN, Q6UXB0Similarity: Belongs to the FAM131 family |
Function
for FAM131A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM131A (NM_144635) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM131A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM131A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM131A |
1 GenomeRNAi human phenotype for FAM131A:
Animal Models:
Mouse knock-out Fam131atm1Lex for FAM131A
1 MGI phenotypic allele  for Fam131a (no phenotypes)
FAM131A for phenotypes About GeneDecksing
|
Pathways & Interactions
for FAM131A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM131A
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for FAM131A (Q6UXB03 ENSP000003101354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM131A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM131A
Search CenterWatch for drugs/clinical trials and news about FAM131A / F131A
|
Transcripts
for FAM131A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM131A gene (2 alternative transcripts): NM_001171093.1 NM_144635.4 Unigene Cluster for FAM131A: Family with sequence similarity 131, member A Hs.591307 [show with all ESTs]Unigene Representative Sequence: AK02437810 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000450976 ENST00000418281 ENST00000340957(uc003foc.3) ENST00000433578
ENST00000418768 ENST00000383847 ENST00000497070(uc003fod.2) ENST00000453072
ENST00000310585(uc003foe.3 uc003fog.3) ENST00000487702
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM131A (NM_144635) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM131A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM131A |
Additional cDNA sequence: AK024378.1 AK126656.1 BC026221.1 BC037299.1 8 DOTS entries: DT.100711929 DT.316476 DT.426893 DT.95194836 DT.97796567 DT.435199 DT.100777939 DT.75133329 24/139 AceView cDNA sequences (see all 139): CR601623 AI934602 Z45020 BM676410 CA416923 AL524237 CN478492 BQ269612 Z40751 BX099028 BQ286253 BM668716 BM807401 AW149550 BM699849 BQ011875 AI141670 AI953328 BC026221 BI754826 BM717677 BM264602 BM271972 BM547295
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FAM131A (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|
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| SP1: | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM131A
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Expression
for FAM131A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM131A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGAGTGTC
About this image
See FAM131A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM131A
SOURCE GeneReport for Unigene cluster: Hs.591307
SABiosciences Custom PCR Arrays for FAM131A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM131A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM131A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM131A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM131A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM131A |
Orthologs
for FAM131A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM131A gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for FAM131A (if available)
TreeFam Gene Tree for FAM131A (if available) |
Paralogs
for FAM131A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM131A gene
- FAM131C2 FAM131B2
2 SIMAP similar genes for FAM131A using alignment to 5 protein entries: F131A_HUMAN (see all proteins):KIAA0773 FAM131B
FAM131A for paralogs About GeneDecksing
|
Genomic Variants
for FAM131A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM131A (184053714 - 184064063 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM131A
1 CNV: 5215 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM131A |
|
Disorders
/ Diseases
for FAM131A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM131A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM131A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM131A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM131A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM131A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM131A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM131A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM131A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM131A gene:
Search GeneIP for patents involving FAM131A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM131A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM131A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM131A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM131A | | | OriGene Protein Over-expression Lysate for FAM131A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM131A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM131A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM131A | | OriGene Custom Protein Services for FAM131A | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM131A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM131A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM131A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM131A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM131A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM131A |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM131A |
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 | | | FAM131A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM131A |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM131A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM131A |
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