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Aliases for FAM131A Gene

Aliases for FAM131A Gene

  • Family With Sequence Similarity 131 Member A 2 3 5
  • C3orf40 3 4
  • Family With Sequence Similarity 131, Member A 2
  • Chromosome 3 Open Reading Frame 40 2
  • Protein FAM131A 3
  • FLAT715 3
  • PRO1378 3

External Ids for FAM131A Gene

Previous HGNC Symbols for FAM131A Gene

  • C3orf40

Previous GeneCards Identifiers for FAM131A Gene

  • GC03P185538
  • GC03P184053
  • GC03P181460

Summaries for FAM131A Gene

GeneCards Summary for FAM131A Gene

FAM131A (Family With Sequence Similarity 131 Member A) is a Protein Coding gene. An important paralog of this gene is FAM131B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM131A Gene

Genomics for FAM131A Gene

Regulatory Elements for FAM131A Gene

Enhancers for FAM131A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F184523 1.3 Ensembl ENCODE 10.7 +189.3 189276 2.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 FOS PAF1 SP3 SP5 MAGEF1 LINC02054 CHRD THPO LINC01840 CLCN2 POLR2H EPHB3 FAM131A EIF4G1
GH03F184371 1.2 Ensembl ENCODE 11 +36.0 35975 1.0 ELF3 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 RAD21 RARA ZNF143 LINC02054 FAM131A EIF4G1 SNORD66 LINC01840 EPHB3 PSMD2 THPO POLR2H
GH03F184543 1.2 Ensembl ENCODE 10.3 +208.3 208290 0.7 SREBF2 ZNF76 SIN3A INSM2 ARID4B NFXL1 FEZF1 ZBTB40 ZNF2 RAD21 CHRD THPO MAGEF1 FAM131A EIF4G1 LINC01840 LINC01839
GH03F184655 1.2 Ensembl ENCODE 10.2 +322.6 322583 5.8 HDGF PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS SP3 MAGEF1 EHHADH-AS1 HTR3D EPHB3 LINC01840 LINC02069 FAM131A YEATS2-AS1
GH03F184513 1.1 Ensembl ENCODE 10.3 +178.2 178214 1.7 ZNF76 ARID4B ZSCAN9 ZNF2 RAD21 GLIS2 ZNF143 ZNF280D ZNF654 REST LINC02054 LINC01840 EPHB3 FAM131A EIF4G1 EIF2B5-IT1 VPS8 LINC01839
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM131A on UCSC Golden Path with GeneCards custom track

Promoters for FAM131A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001381301 474 1601 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ETS1 GLIS2 ZNF143

Genomic Location for FAM131A Gene

184,335,926 bp from pter
184,346,275 bp from pter
10,350 bases
Plus strand

Genomic View for FAM131A Gene

Genes around FAM131A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM131A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM131A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM131A Gene

Proteins for FAM131A Gene

  • Protein details for FAM131A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM131A
    Protein Accession:
    Secondary Accessions:
    • D3DNT6
    • G5E9B1
    • Q8TA84

    Protein attributes for FAM131A Gene

    335 amino acids
    Molecular mass:
    36108 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM131A Gene


neXtProt entry for FAM131A Gene

Post-translational modifications for FAM131A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM131A Gene

Domains & Families for FAM131A Gene

Protein Domains for FAM131A Gene


Suggested Antigen Peptide Sequences for FAM131A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM131 family.
  • Belongs to the FAM131 family.
genes like me logo Genes that share domains with FAM131A: view

No data available for Gene Families for FAM131A Gene

Function for FAM131A Gene

Phenotypes for FAM131A Gene

genes like me logo Genes that share phenotypes with FAM131A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM131A

miRNA for FAM131A Gene

miRTarBase miRNAs that target FAM131A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM131A Gene

Localization for FAM131A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM131A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM131A gene
Compartment Confidence
extracellular 4
nucleus 3
lysosome 1

Gene Ontology (GO) - Cellular Components for FAM131A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FAM131A: view

Pathways & Interactions for FAM131A Gene

SuperPathways for FAM131A Gene

No Data Available

Interacting Proteins for FAM131A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6UXB0-F131A_HUMAN ENSP00000373360 for FAM131A Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM131A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM131A Gene

Transcripts for FAM131A Gene

Unigene Clusters for FAM131A Gene

Family with sequence similarity 131, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM131A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP6: - - - - - -

Relevant External Links for FAM131A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM131A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM131A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM131A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM131A Gene:


SOURCE GeneReport for Unigene cluster for FAM131A Gene:

genes like me logo Genes that share expression patterns with FAM131A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM131A Gene

Orthologs for FAM131A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM131A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM131A 34 35
  • 99 (n)
(Canis familiaris)
Mammalia FAM131A 34 35
  • 93.17 (n)
(Bos Taurus)
Mammalia FAM131A 34 35
  • 92.99 (n)
(Mus musculus)
Mammalia Fam131a 34 16 35
  • 89.72 (n)
(Rattus norvegicus)
Mammalia Fam131a 34
  • 88.98 (n)
(Ornithorhynchus anatinus)
Mammalia FAM131A 35
  • 76 (a)
(Monodelphis domestica)
Mammalia FAM131A 35
  • 73 (a)
(Gallus gallus)
Aves FAM131A 34 35
  • 68.87 (n)
(Anolis carolinensis)
Reptilia FAM131A 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam131a 34
  • 59.24 (n)
(Danio rerio)
Actinopterygii zgc:165508 34
  • 59.95 (n)
FAM131A 35
  • 51 (a)
Species where no ortholog for FAM131A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM131A Gene

Gene Tree for FAM131A (if available)
Gene Tree for FAM131A (if available)

Paralogs for FAM131A Gene

Paralogs for FAM131A Gene

(2) SIMAP similar genes for FAM131A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM131A: view

Variants for FAM131A Gene

Sequence variations from dbSNP and Humsavar for FAM131A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_036118 A breast cancer sample
rs1061353 -- 184,335,219(+) ATTTT(C/T)TGAAA upstream-variant-2KB, utr-variant-3-prime
rs1105000 -- 184,338,098(+) GGAAA(C/T)GGGAA intron-variant, upstream-variant-2KB
rs111277397 -- 184,341,153(+) AGATA(C/T)GGGCA intron-variant
rs111461548 -- 184,336,165(+) GGCTG(C/T)GGCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM131A Gene

Variant ID Type Subtype PubMed ID
esv2422400 CNV duplication 17116639
esv2726297 CNV deletion 23290073
nsv829813 CNV loss 17160897

Variation tolerance for FAM131A Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM131A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM131A Gene

Disorders for FAM131A Gene

Relevant External Links for FAM131A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM131A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM131A Gene

Publications for FAM131A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64

Products for FAM131A Gene

Sources for FAM131A Gene

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