FAM129C Gene
protein-coding GIFtS: 44
GCID: GC19P017634
|
|
family with sequence similarity 129, member C
| |
Aliases
for FAM129C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 129, Member C1 2 | | BCNP11 2 3 5 | | B-Cell Novel Protein 12 3 | | FLJ398021 | | Niban-Like Protein 22 | | Protein FAM129C3 |
Export aliases for FAM129C gene to outside databasesPrevious GC identifers: GC19P017496 GC19P017202 |
Summaries
for FAM129C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM129C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM129C gene promoter:
AML1a MyoD Lmo2 RelA AP-2gamma E47 Arnt PPAR-gamma1 PPAR-gamma2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM129C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM129C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11FAM129C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P017634: view genomic region
(about GC identifiers)
Start:
|
17,634,110 bp from pter |
End:
|
17,664,648 bp from pter |
Size:
|
30,539 bases |
Orientation:
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plus strand |
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Proteins
for FAM129C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NIBL2_HUMAN, Q86XR2 (See
protein sequence)Recommended Name: Niban-like protein 2 Size: 697 amino acids; 77413 Da
Secondary accessions: Q7Z6H6 Q86XR3 Q86XR4 Q8TEQ3Alternative splicing: 5 isoforms: Q86XR2-1 Q86XR2-2 Q86XR2-3 Q86XR2-4 Q86XR2-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM129C: NX_Q86XR2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XR2
FAM129C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001091994.1 NP_775815.2
ENSEMBL proteins: ENSP00000335040 ENSP00000333447 ENSP00000341067 ENSP00000300971 ENSP00000394929
Human Recombinant Protein Products:
FAM129C Antibody Products:
Assay Products for FAM129C: |
Protein
Domains /
Families
for FAM129C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM129C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86XR2ProtoNet protein and cluster: Q86XR2 1 Blocks protein family: IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: NIBL2_HUMAN, Q86XR2Similarity: Belongs to the Niban family |
Function
for FAM129C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM129C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM129C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM129C (NM_173544) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM129C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM129C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM129C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005543 | phospholipid binding |
IEA | -- |
FAM129C for ontologies About GeneDecksing
|
Pathways & Interactions
for FAM129C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM129C
|
Drugs & Compounds
for FAM129C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM129C
Search CenterWatch for drugs/clinical trials and news about FAM129C / NIBL2
|
Transcripts
for FAM129C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM129C gene (2 alternative transcripts): NM_001098524.1 NM_173544.4 Unigene Cluster for FAM129C: Family with sequence similarity 129, member C Hs.434133 [show with all ESTs]Unigene Representative Sequence: NM_1735445 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335393(uc021uqj.1) ENST00000332386(uc021uqi.1 uc010xpu.2 uc002ngz.4)
ENST00000352727(uc010eaw.3) ENST00000300971(uc010xps.2 uc010xpt.2 uc002nhb.3)
ENST00000449408(uc002ngy.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM129C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM129C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM129C (NM_173544) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM129C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM129C |
Additional cDNA sequence: AK097121.1 AK298062.1 AK300046.1 AK301159.1 AY254197.1 AY254198.1 AY254199.1 BC033225.1 BC053606.1 8 DOTS entries: DT.421960 DT.100744788 DT.100017632 DT.95324786 DT.100744787 DT.95357255 DT.99962920 DT.440985 24/31 AceView cDNA sequences (see all 31): AA731836 AA214525 AA649002 BF941096 AY254197 AI281478 AY254198 AI524105 AI436406 AY254199 BC033225 BC053606 BQ707062 AK097121 AK074069 AW732765 BG614622 BQ708587 BU152936 BI261711 NM_173544 AI688885 BI262248 W84738
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FAM129C (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | - | | | | | | |
| SP5: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM129C
|
Expression
for FAM129C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM129C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAACAGGAG
About this image
See FAM129C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM129C
SOURCE GeneReport for Unigene cluster: Hs.434133
UniProtKB/Swiss-Prot: NIBL2_HUMAN, Q86XR2Tissue specificity: Specifically expressed in B-lymphocytes
SABiosciences Custom PCR Arrays for FAM129C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM129C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM129C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM129C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM129C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM129C |
Orthologs
for FAM129C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for FAM129C gene from 1/8 species (see all 8) About this table
ENSEMBL Gene Tree for FAM129C (if available)
TreeFam Gene Tree for FAM129C (if available) |
Paralogs
for FAM129C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM129C gene
- FAM129B2 FAM129A2
8 SIMAP similar genes for FAM129C using alignment to 8 protein entries: NIBL2_HUMAN (see all proteins):NRAMP1 AURA2 FAM175A NF2 DNAPTP3 EIF3L
LINC00596 GLT8D2
FAM129C for paralogs About GeneDecksing
|
Genomic Variants
for FAM129C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM129C (17634110 - 17664648 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM129C
1 CNV: 5338 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM129C |
|
Disorders
/ Diseases
for FAM129C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM129C for disorders About GeneDecksing
OMIM gene information: 609967
OMIM disorders: --
3  diseases for FAM129C: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia leukemia
Export disorders for FAM129C gene to outside databases
|
Publications
for FAM129C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM129C gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM129C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B. (PubMed id 12886250)1, 2, 3 Boyd R.S.... Dyer M.J.S. (2003)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)2 Jikuya H....Ohara O. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM129C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM129C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM129C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM129C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM129C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM129C gene:
Search GeneIP for patents involving FAM129C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM129C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM129C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM129C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM129C | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM129C | | OriGene 3'-UTR Clone for FAM129C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM129C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM129C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM129C | | OriGene Custom Protein Services for FAM129C | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM129C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM129C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM129C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM129C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM129C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM129C |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM129C |
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 | | | FAM129C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM129C |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM129C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM129C |
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