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Aliases for FAM129B Gene

Aliases for FAM129B Gene

  • Family With Sequence Similarity 129 Member B 2 3 5
  • Melanoma Invasion By ERK 2 3 4
  • C9orf88 3 4
  • MINERVA 3 4
  • MEG-3 3 4
  • Family With Sequence Similarity 129, Member B 2
  • Chromosome 9 Open Reading Frame 88 2
  • Niban-Like Protein 1 3
  • Protein FAM129B 4
  • BA356B19.6 3
  • OC58 3

External Ids for FAM129B Gene

Previous HGNC Symbols for FAM129B Gene

  • C9orf88

Previous GeneCards Identifiers for FAM129B Gene

  • GC09M129309
  • GC09M130267
  • GC09M099885

Summaries for FAM129B Gene

GeneCards Summary for FAM129B Gene

FAM129B (Family With Sequence Similarity 129 Member B) is a Protein Coding gene. Diseases associated with FAM129B include Melanoma. Among its related pathways are MAP Kinase Signaling. An important paralog of this gene is FAM129A.

UniProtKB/Swiss-Prot for FAM129B Gene

  • May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.

Additional gene information for FAM129B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM129B Gene

Genomics for FAM129B Gene

GeneHancer (GH) Regulatory Elements for FAM129B Gene

Promoters and enhancers for FAM129B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I127553 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.1 +14.1 14060 23.7 HDGF PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B YY1 FAM129B ENG SNORA65 FPGS RPL12 TOR2A LOC102723566 SLC2A8 CDK9 ST6GALNAC6
GH09I127577 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 554.9 -0.5 -468 3.5 PKNOX1 FOXA2 MLX ARID4B SIN3A SLC30A9 ELK1 ZNF143 FOS DEK FAM129B STXBP1 CFAP157 TTC16 ENG LOC102723566 RPL12 GC09M127606
GH09I127761 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -187.8 -187827 11.3 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZBTB7B YY1 TCF12 ZNF121 SH2D3C FPGS ENG LOC102723566 AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 FAM129B SWI5
GH09I127826 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -249.2 -249200 3.7 HDGF ATF1 ARID4B SIN3A ZNF48 YY1 SLC30A9 TCF12 ZNF121 POLR2B FPGS ENG FAM129B AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 CDK9 ENSG00000227218 TOR2A
GH09I127446 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 +129.5 129477 7.5 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC RPL12 SNORA65 LRSAM1 GC09M127449 ZNF79 ENSG00000272593 NAIF1 LOC102723566 FPGS URM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM129B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM129B gene promoter:

Genomic Locations for FAM129B Gene

Genomic Locations for FAM129B Gene
73,670 bases
Minus strand

Genomic View for FAM129B Gene

Genes around FAM129B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM129B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM129B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM129B Gene

Proteins for FAM129B Gene

  • Protein details for FAM129B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Niban-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q4LE55
    • Q5VVW6
    • Q5VVW7
    • Q9BUS2
    • Q9NT35

    Protein attributes for FAM129B Gene

    746 amino acids
    Molecular mass:
    84138 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM129B Gene


neXtProt entry for FAM129B Gene

Post-translational modifications for FAM129B Gene

  • As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.
  • Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.
  • Ubiquitination at Lys316, posLast=401401, and posLast=430430

Other Protein References for FAM129B Gene

No data available for DME Specific Peptides for FAM129B Gene

Domains & Families for FAM129B Gene

Gene Families for FAM129B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FAM129B Gene

Suggested Antigen Peptide Sequences for FAM129B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Niban family.
  • Belongs to the Niban family.
genes like me logo Genes that share domains with FAM129B: view

Function for FAM129B Gene

Molecular function for FAM129B Gene

UniProtKB/Swiss-Prot Function:
May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.

Phenotypes From GWAS Catalog for FAM129B Gene

Gene Ontology (GO) - Molecular Function for FAM129B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 17569660
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with FAM129B: view
genes like me logo Genes that share phenotypes with FAM129B: view

Animal Model Products

miRNA for FAM129B Gene

miRTarBase miRNAs that target FAM129B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM129B Gene

Localization for FAM129B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM129B Gene

Cytoplasm, cytosol. Cell junction, adherens junction. Membrane; Lipid-anchor. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM129B gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM129B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 21148485
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 14602737
GO:0005829 cytosol IDA,IEA 21148485
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with FAM129B: view

Pathways & Interactions for FAM129B Gene

SuperPathways for FAM129B Gene

SuperPathway Contained pathways
1 MAP Kinase Signaling
genes like me logo Genes that share pathways with FAM129B: view

Pathways by source for FAM129B Gene

1 Cell Signaling Technology pathway for FAM129B Gene

Gene Ontology (GO) - Biological Process for FAM129B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance ISS --
GO:0008285 negative regulation of cell proliferation IDA 14602737
GO:0016525 negative regulation of angiogenesis ISS --
GO:0030154 cell differentiation ISS --
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with FAM129B: view

No data available for SIGNOR curated interactions for FAM129B Gene

Drugs & Compounds for FAM129B Gene

No Compound Related Data Available

Transcripts for FAM129B Gene

Unigene Clusters for FAM129B Gene

Family with sequence similarity 129, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM129B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - -
SP4: - - - - - - -
SP6: - - - -

Relevant External Links for FAM129B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM129B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM129B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM129B Gene

This gene is overexpressed in Esophagus - Mucosa (x9.1).

Protein differential expression in normal tissues from HIPED for FAM129B Gene

This gene is overexpressed in Salivary gland (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM129B Gene

Protein tissue co-expression partners for FAM129B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM129B Gene:


SOURCE GeneReport for Unigene cluster for FAM129B Gene:


Evidence on tissue expression from TISSUES for FAM129B Gene

  • Liver(4.2)
  • Lung(3.7)
  • Skin(3)
  • Nervous system(2.5)
  • Intestine(2)
genes like me logo Genes that share expression patterns with FAM129B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM129B Gene

Orthologs for FAM129B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM129B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM129B 33 34
  • 98.95 (n)
(Bos Taurus)
Mammalia FAM129B 33 34
  • 90.02 (n)
(Canis familiaris)
Mammalia FAM129B 33 34
  • 88.86 (n)
(Mus musculus)
Mammalia Fam129b 33 16 34
  • 86.85 (n)
(Rattus norvegicus)
Mammalia Fam129b 33
  • 86.26 (n)
(Monodelphis domestica)
Mammalia FAM129B 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FAM129B 34
  • 68 (a)
(Gallus gallus)
Aves FAM129B 33 34
  • 78.99 (n)
(Anolis carolinensis)
Reptilia FAM129B 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam129b 33
  • 69.2 (n)
Str.8124 33
(Danio rerio)
Actinopterygii fam129bb 33 34
  • 66.77 (n)
FAM129B (3 of 3) 34
  • 53 (a)
fam129ba 34
  • 48 (a)
Species where no ortholog for FAM129B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM129B Gene

Gene Tree for FAM129B (if available)
Gene Tree for FAM129B (if available)

Paralogs for FAM129B Gene

Paralogs for FAM129B Gene

(1) SIMAP similar genes for FAM129B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM129B: view

Variants for FAM129B Gene

Sequence variations from dbSNP and Humsavar for FAM129B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000042576 -- 127,504,878(-) G/A/C downstream_transcript_variant
rs1000045118 -- 127,540,887(-) C/T intron_variant
rs1000096891 -- 127,541,086(-) G/A intron_variant
rs1000163333 -- 127,570,211(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000178709 -- 127,544,011(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM129B Gene

Variant ID Type Subtype PubMed ID
esv2739053 CNV deletion 23290073
nsv1133741 CNV deletion 24896259
nsv1145265 CNV deletion 24896259
nsv466569 CNV loss 19166990
nsv466570 CNV loss 19166990
nsv615368 CNV loss 21841781

Variation tolerance for FAM129B Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM129B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM129B Gene

Disorders for FAM129B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM129B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM129B

genes like me logo Genes that share disorders with FAM129B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM129B Gene

Publications for FAM129B Gene

  1. Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. (PMID: 19362540) Old WM … Ahn NG (Molecular cell 2009) 2 3 4 58
  2. EGFR phosphorylates FAM129B to promote Ras activation. (PMID: 26721396) Ji H … Lu Z (Proceedings of the National Academy of Sciences of the United States of America 2016) 2 3 58
  3. FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells. (PMID: 21148485) Chen S … Evans DR (The Journal of biological chemistry 2011) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FAM129B Gene

Sources for FAM129B Gene

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