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Aliases for FAM129B Gene

Aliases for FAM129B Gene

  • Family With Sequence Similarity 129 Member B 2 3 5
  • Melanoma Invasion By ERK 3 4
  • C9orf88 3 4
  • MINERVA 3 4
  • MEG-3 3 4
  • Family With Sequence Similarity 129, Member B 2
  • Chromosome 9 Open Reading Frame 88 2
  • Niban-Like Protein 1 3
  • Protein FAM129B 4
  • BA356B19.6 3
  • OC58 3

External Ids for FAM129B Gene

Previous HGNC Symbols for FAM129B Gene

  • C9orf88

Previous GeneCards Identifiers for FAM129B Gene

  • GC09M129309
  • GC09M130267
  • GC09M099885

Summaries for FAM129B Gene

GeneCards Summary for FAM129B Gene

FAM129B (Family With Sequence Similarity 129 Member B) is a Protein Coding gene. Diseases associated with FAM129B include Melanoma. Among its related pathways are MAP Kinase Signaling. An important paralog of this gene is FAM129A.

UniProtKB/Swiss-Prot for FAM129B Gene

  • May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM129B Gene

Genomics for FAM129B Gene

Regulatory Elements for FAM129B Gene

Enhancers for FAM129B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM129B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM129B Gene

Chromosome:
9
Start:
127,505,338 bp from pter
End:
127,579,007 bp from pter
Size:
73,670 bases
Orientation:
Minus strand

Genomic View for FAM129B Gene

Genes around FAM129B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM129B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM129B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM129B Gene

Proteins for FAM129B Gene

  • Protein details for FAM129B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96TA1-NIBL1_HUMAN
    Recommended name:
    Niban-like protein 1
    Protein Accession:
    Q96TA1
    Secondary Accessions:
    • Q4LE55
    • Q5VVW6
    • Q5VVW7
    • Q9BUS2
    • Q9NT35

    Protein attributes for FAM129B Gene

    Size:
    746 amino acids
    Molecular mass:
    84138 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM129B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM129B Gene

Post-translational modifications for FAM129B Gene

  • As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.
  • Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.
  • Ubiquitination at Lys 316, Lys 401, and Lys 430
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM129B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM129B Gene

Domains & Families for FAM129B Gene

Protein Domains for FAM129B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM129B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96TA1

UniProtKB/Swiss-Prot:

NIBL1_HUMAN :
  • Contains 1 PH domain.
  • Belongs to the Niban family.
Domain:
  • Contains 1 PH domain.
Family:
  • Belongs to the Niban family.
genes like me logo Genes that share domains with FAM129B: view

No data available for Gene Families for FAM129B Gene

Function for FAM129B Gene

Molecular function for FAM129B Gene

UniProtKB/Swiss-Prot Function:
May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.

Gene Ontology (GO) - Molecular Function for FAM129B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with FAM129B: view
genes like me logo Genes that share phenotypes with FAM129B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM129B Gene

Localization for FAM129B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM129B Gene

Cytoplasm, cytosol. Cell junction, adherens junction. Membrane; Lipid-anchor. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM129B Gene COMPARTMENTS Subcellular localization image for FAM129B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FAM129B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 21148485
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA,IDA 21148485
genes like me logo Genes that share ontologies with FAM129B: view

Pathways & Interactions for FAM129B Gene

SuperPathways for FAM129B Gene

Superpath Contained pathways
1 MAP Kinase Signaling
genes like me logo Genes that share pathways with FAM129B: view

Pathways by source for FAM129B Gene

1 Cell Signaling Technology pathway for FAM129B Gene

Gene Ontology (GO) - Biological Process for FAM129B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IMP 21148485
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with FAM129B: view

No data available for SIGNOR curated interactions for FAM129B Gene

Drugs & Compounds for FAM129B Gene

No Compound Related Data Available

Transcripts for FAM129B Gene

Unigene Clusters for FAM129B Gene

Family with sequence similarity 129, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM129B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - -
SP4: - - - - - - -
SP5:
SP6: - - - -
SP7:

Relevant External Links for FAM129B Gene

GeneLoc Exon Structure for
FAM129B
ECgene alternative splicing isoforms for
FAM129B

Expression for FAM129B Gene

mRNA expression in normal human tissues for FAM129B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM129B Gene

This gene is overexpressed in Esophagus - Mucosa (x9.1).

Protein differential expression in normal tissues from HIPED for FAM129B Gene

This gene is overexpressed in Salivary gland (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM129B Gene



Protein tissue co-expression partners for FAM129B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM129B Gene:

FAM129B

SOURCE GeneReport for Unigene cluster for FAM129B Gene:

Hs.522401
genes like me logo Genes that share expression patterns with FAM129B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAM129B Gene

Orthologs for FAM129B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM129B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM129B 34
  • 90.02 (n)
  • 90.34 (a)
FAM129B 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM129B 34
  • 88.86 (n)
  • 90.2 (a)
FAM129B 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam129b 34
  • 86.85 (n)
  • 90.2 (a)
Fam129b 16
Fam129b 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM129B 34
  • 98.95 (n)
  • 98.95 (a)
FAM129B 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam129b 34
  • 86.26 (n)
  • 89.53 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM129B 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM129B 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM129B 34
  • 78.99 (n)
  • 77.09 (a)
FAM129B 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM129B 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam129b 34
  • 69.2 (n)
  • 66.99 (a)
Str.8124 34
zebrafish
(Danio rerio)
Actinopterygii fam129bb 34
  • 66.77 (n)
  • 63.34 (a)
FAM129B (3 of 3) 35
  • 53 (a)
OneToMany
fam129ba 35
  • 48 (a)
OneToMany
fam129bb 35
  • 54 (a)
OneToMany
Species where no ortholog for FAM129B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM129B Gene

ENSEMBL:
Gene Tree for FAM129B (if available)
TreeFam:
Gene Tree for FAM129B (if available)

Paralogs for FAM129B Gene

Paralogs for FAM129B Gene

(1) SIMAP similar genes for FAM129B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM129B: view

Variants for FAM129B Gene

Sequence variations from dbSNP and Humsavar for FAM129B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1276 -- 127,505,577(+) GTCTA(C/G)GGCAC utr-variant-3-prime
rs1277 -- 127,505,498(+) GGCTG(C/G)GGCAG utr-variant-3-prime
rs10386 -- 127,505,641(+) TTTCT(G/T)CCCTG utr-variant-3-prime
rs7852611 -- 127,530,304(+) GTCCT(A/G)ACCTC intron-variant
rs7853611 -- 127,518,154(+) AAGGC(A/G)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM129B Gene

Variant ID Type Subtype PubMed ID
esv2739053 CNV deletion 23290073
nsv1133741 CNV deletion 24896259
nsv1145265 CNV deletion 24896259
nsv466569 CNV loss 19166990
nsv466570 CNV loss 19166990
nsv615368 CNV loss 21841781

Variation tolerance for FAM129B Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM129B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM129B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM129B Gene

Disorders for FAM129B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM129B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM129B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM129B
genes like me logo Genes that share disorders with FAM129B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM129B Gene

Publications for FAM129B Gene

  1. Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. (PMID: 19362540) Old W.M. … Ahn N.G. (Mol. Cell 2009) 2 3 4 65
  2. FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells. (PMID: 21148485) Chen S. … Evans D.R. (J. Biol. Chem. 2011) 3 4 65
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for FAM129B Gene

Sources for FAM129B Gene

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