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FAM129B Gene

protein-coding   GIFtS: 52
GCID: GC09M130267

Family With Sequence Similarity 129, Member B

(Previous name: chromosome 9 open reading frame 88)
(Previous symbol: C9orf88)
  Search for FAM129B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 129, Member B1 2     OC582
C9orf881 2 3     bA356B19.62
MINERVA2 3 5     Niban-Like Protein 12
Melanoma Invasion By ERK2 3     Meg-33
Chromosome 9 Open Reading Frame 881     Protein FAM129B3
MEG-32     

External Ids:    HGNC: 252821   Entrez Gene: 648552   Ensembl: ENSG000001368307   OMIM: 6140455   UniProtKB: Q96TA13   
ORGUL members:         

Export aliases for FAM129B gene to outside databases

Previous GC identifers: GC09M129309 GC09M099885


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM129B Gene:
FAM129B (family with sequence similarity 129, member B) is a protein-coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is FAM129A.

UniProtKB/Swiss-Prot: NIBL1_HUMAN, Q96TA1
Function: May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM129B gene promoter:
         c-Fos   PPAR-gamma1   AP-1   NCX/Ncx   c-Jun   PPAR-gamma2   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM129B promoter sequence
   Search Chromatin IP Primers for FAM129B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM129B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

FAM129B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM129B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130267:  view genomic region     (about GC identifiers)

Start:
130,267,618 bp from pter      End:
130,341,268 bp from pter
Size:
73,651 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NIBL1_HUMAN, Q96TA1 (See protein sequence)
Recommended Name: Niban-like protein 1  
Size: 746 amino acids; 84138 Da
Secondary accessions: Q4LE55 Q5VVW6 Q5VVW7 Q9BUS2 Q9NT35
Alternative splicing: 2 isoforms:  Q96TA1-1   Q96TA1-2   

Explore the universe of human proteins at neXtProt for FAM129B: NX_Q96TA1

Explore proteomics data for FAM129B at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells,
    the C-terminal phosphorylation may prevent targeting to the plasma membrane1
  • As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases (PubMed:21148485)1
  • Ubiquitination2 at Lys316, Lys401, Lys430
  • Modification sites at PhosphoSitePlus

  • See FAM129B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001030611.1  NP_073744.2  

    ENSEMBL proteins: 
     ENSP00000362411   ENSP00000362409  

    FAM129B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FAM129B

     
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    LSBio Antibodies in human, mouse, rat for FAM129B

    FAM129B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR026088 Niban_like

    Graphical View of Domain Structure for InterPro Entry Q96TA1

    ProtoNet protein and cluster: Q96TA1

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: NIBL1_HUMAN, Q96TA1
    Similarity: Belongs to the Niban family
    Similarity: Contains 1 PH domain


    Find genes that share domains with FAM129B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NIBL1_HUMAN, Q96TA1
    Function: May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro

    Phenotypes:
         2 GenomeRNAi human phenotypes for FAM129B:

     Decreased cell number, increas  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM129B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM129B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM129B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM129B

    miRNA
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    miRTarBase miRNAs that target FAM129B:
    hsa-mir-16-5p (MIRT032042), hsa-mir-92a-3p (MIRT049328), hsa-mir-484 (MIRT041768), hsa-mir-124-3p (MIRT004925)

    Block miRNA regulation of human, mouse, rat FAM129B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM129B (see all 18):
    hsa-miR-142-5p hsa-miR-125a-5p hsa-miR-411 hsa-miR-106a hsa-miR-124 hsa-miR-125b hsa-miR-93 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidFAM129B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAM129B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM129B

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    OriGene ORF clones in mouse, rat for FAM129B
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    GenScript: all cDNA clones in your preferred vector (see all 2): FAM129B (NM_001035534)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM129B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM129B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM129B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NIBL1_HUMAN, Q96TA1: Cytoplasm, cytosol. Cell junction, adherens junction. Note=In exponentially growing cells,
    exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase.
    In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634NOT nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with FAM129B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FAM129B About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31


    Find genes that share SuperPaths with FAM129B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FAM129B
        MAP Kinase Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM129B
    Interactions:

        Search GeneGlobe Interaction Network for FAM129B

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for FAM129B (Q96TA12, 3 ENSP000003624094) via UniProtKB, MINT, STRING, and/or I2D (see all 778)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF512BQ96KM62, 3MINT-60822 I2D: score=2 
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    KEAP1Q141453, ENSP000001711114I2D: score=2 STRING: ENSP00000171111
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043066negative regulation of apoptotic process IMP--

    Find genes that share ontologies with FAM129B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM129B (NIBL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM129B gene (2 alternative transcripts): 
    NM_001035534.2  NM_022833.3  

    Unigene Cluster for FAM129B:

    Family with sequence similarity 129, member B
    Hs.522401  [show with all ESTs]
    Unigene Representative Sequence: NM_022833
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373314(uc004bri.3) ENST00000478917 ENST00000373312(uc004brh.3 uc004brj.4)
    ENST00000468379 ENST00000484348 ENST00000465154 ENST00000476091
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM129B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM129B (see all 18):
    hsa-miR-142-5p hsa-miR-125a-5p hsa-miR-411 hsa-miR-106a hsa-miR-124 hsa-miR-125b hsa-miR-93 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidFAM129B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM129B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM129B
    Clone
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    OriGene clones in human, mouse for FAM129B (see all 12)
    OriGene ORF clones in mouse, rat for FAM129B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM129B (NM_001035534)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM129B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM129B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM129B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM129B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM129B
      QuantiFast Probe-based Assays in human, mouse, rat FAM129B

    Additional mRNA sequence: 

    AB210016.1 AF151783.1 AF192911.1 AK023580.1 AK025804.1 AK025951.1 AL137555.1 BC001979.1 
    BC018849.2 BC023210.1 BC110345.1 

    18 DOTS entries:

    DT.100803359  DT.40121502  DT.445956  DT.100802521  DT.100038716  DT.102834539  DT.75199470  DT.121147553 
    DT.91742274  DT.100813600  DT.121147609  DT.70102968  DT.85105661  DT.92032142  DT.95269138  DT.95346269 
    DT.99958544  DT.91945768 

    Selected AceView cDNA sequences (see all 498):

    BM552910 BQ647726 BQ934899 AI858410 CO246658 BQ900276 BM015917 BM671979 
    BQ961543 BM708559 BQ435984 BI087684 NM_022833 AK025804 BI861017 BQ919097 
    BP366066 BC067366 BQ272438 AW516158 AJ403121 BE772391 BG750134 BM551984 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM129B (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
    SP1:                    -     -     -     -     -                                         -                                                                     
    SP2:                    -     -     -     -     -                                         -                                                                     
    SP3:                    -     -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -     -                     
    SP4:        -     -     -     -     -     -     -                                                                                                               
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for FAM129B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM129B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTACTAA
    FAM129B Expression
    About this image


    FAM129B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Lung (Respiratory System)
     
     Esophagus (Gastrointestinal Tract)
     
     Placenta (Extraembryonic Tissues)
    FAM129B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM129B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522401
        Custom PCR Arrays for FAM129B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM129B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM129B
    QuantiTect SYBR Green Assays in human, mouse, rat FAM129B
    QuantiFast Probe-based Assays in human, mouse, rat FAM129B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM129B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM129B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam129b1 , 5 family with sequence similarity 129, member B1, 5 86.85(n)1
    90.2(a)1
      2 (22.09 cM)5
    2277371  NM_146119.21  NP_666231.11 
     328761145 
    chicken
    (Gallus gallus)
    Aves FAM129B1 family with sequence similarity 129, member B 78.99(n)
    77.09(a)
      771307  XM_003642273.2  XP_003642321.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAM129B6
    family with sequence similarity 129, member B
    65(a)
    1 ↔ 1
    GL343556.1(6712-90865)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.81242 Transcribed sequence with moderate similarity to protein more 76.84(n)    BX710375.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam129bb1 family with sequence similarity 129, member Bb 66.77(n)
    63.34(a)
      556540  XM_003198625.2  XP_003198673.1 


    ENSEMBL Gene Tree for FAM129B (if available)
    TreeFam Gene Tree for FAM129B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM129B gene
    FAM129A2  FAM129C2  
    1 SIMAP similar gene for FAM129B using alignment to 2 protein entries:     NIBL1_HUMAN (see all proteins):
    FAM129A

    Find genes that share paralogs with FAM129B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM129B (see all 1756)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48371581,2
    C,F,A,H--130267156(+) TCTCTC/TGAGGC 2 -- ds5001 int111Minor allele frequency- T:0.14NS EA NA WA 776
    rs122357401,2
    C,F--130267331(+) CTGCTG/ACCATC 2 -- ds5001 int16Minor allele frequency- A:0.19NA EA 248
    rs1828030891,2
    --130267374(+) GAGGGC/GCACCC 2 -- ds5001 int10--------
    rs562477391,2
    C--130267406(+) GCTGCC/GTGTGC 2 -- ds5001 int10--------
    rs1382237671,2
    --130267541(+) AAGCCA/GAGCCG 2 -- ds5001 int10--------
    rs1436038031,2
    --130267547(+) AGCCGC/TATGGG 2 -- ds5001 int10--------
    rs22452841,2
    C,F,A--130267563(+) AGACAT/CAGTCC 2 -- ds5001 int19Minor allele frequency- C:0.38NA WA CSA EA 370
    rs1460473021,2
    C--130267759(+) AGATGC/TGCCAG 2 -- ut310--------
    rs12771,2
    C,F,A,H--130267777(+) GGCTGG/CGGCAG 2 -- ut31 ese313Minor allele frequency- C:0.46MN EA NA CSA WA 2241
    rs12761,2
    C,F,A,H--130267856(+) GTCTAG/CGGCAC 2 -- ut31 ese314Minor allele frequency- C:0.24EA MN NS NA CSA WA 2431

    HapMap Linkage Disequilibrium report for FAM129B (130267618 - 130341268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FAM129B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739053CNV Deletion23290073
    dgv8286n71CNV Loss21882294
    nsv466569CNV Loss19166990
    nsv893865CNV Loss21882294
    nsv466570CNV Loss19166990
    nsv893859CNV Loss21882294
    nsv893860CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614045    OMIM disorders: --


    Find genes that share disorders with FAM129B           About GenesLikeMe


    Export disorders for FAM129B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM129B gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with FAM129B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. (PubMed id 19362540)1, 2, 3 Old W.M.... Ahn N.G. (Mol. Cell 2009)
    2. FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells. (PubMed id 21148485)1, 2 Chen S.... Evans D.R. (J. Biol. Chem. 2011)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64855 HGNC: 25282 AceView: C9orf88 Ensembl:ENSG00000136830 euGenes: HUgn64855
    ECgene: FAM129B H-InvDB: FAM129B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM129B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM129B gene:
    Search GeneIP for patents involving FAM129B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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