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Aliases for FAM129A Gene

Aliases for FAM129A Gene

  • Family With Sequence Similarity 129 Member A 2 3 5
  • Cell Growth-Inhibiting Gene 39 Protein 3 4
  • C1orf24 3 4
  • NIBAN 3 4
  • Family With Sequence Similarity 129, Member A 2
  • Chromosome 1 Open Reading Frame 24 2
  • Cell Growth Inhibiting Protein 39 2
  • Protein FAM129A 4
  • Protein Niban 3
  • GIG39 3

External Ids for FAM129A Gene

Previous HGNC Symbols for FAM129A Gene

  • C1orf24

Previous GeneCards Identifiers for FAM129A Gene

  • GC01M183027
  • GC01M155995

Summaries for FAM129A Gene

Entrez Gene Summary for FAM129A Gene

  • This gene encodes a member of the family with sequence similarity 129 protein family. This gene is highly expressed in several cancer cells and may serve as a prognostic marker for certain cancers. The encoded protein may play a role in regulating p53-mediated apoptosis. [provided by RefSeq, Sep 2016]

GeneCards Summary for FAM129A Gene

FAM129A (Family With Sequence Similarity 129 Member A) is a Protein Coding gene. An important paralog of this gene is FAM129B.

UniProtKB/Swiss-Prot for FAM129A Gene

  • Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity).

Gene Wiki entry for FAM129A Gene

Additional gene information for FAM129A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM129A Gene

Genomics for FAM129A Gene

Regulatory Elements for FAM129A Gene

Enhancers for FAM129A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H184866 1.7 FANTOM5 Ensembl ENCODE dbSUPER 32.7 +107.7 107711 2.5 HDGF PKNOX1 TBL1XR1 BMI1 BATF ZNF143 FOS ATF7 ETV6 RUNX3 FAM129A IVNS1ABP SWT1 EDEM3 TRMT1L GC01P184860 GC01P184916
GH01H185420 1.3 FANTOM5 Ensembl ENCODE 29.1 -445.7 -445665 1.5 CTCF POLR2A IKZF1 CEBPB FOXP2 REST IKZF2 FAM129A IVNS1ABP SWT1 TRMT1L RNF2 RNU7-183P LOC102724897
GH01H184836 1.3 Ensembl ENCODE dbSUPER 19 +137.3 137260 3.3 GTF2F1 TBP NFIB JUN ZSCAN4 MAX BMI1 RAD21 RFX5 CTBP1 FAM129A EDEM3 RNF2 RNU7-13P GC01P184860
GH01H184953 1.3 FANTOM5 Ensembl ENCODE 18.1 +21.1 21080 2 BHLHE40 REST RAD21 NR2F2 FOSL1 HIC1 PRDM6 GATA3 IKZF1 SMC3 FAM129A RNU7-13P SWT1 IVNS1ABP RNF2 EDEM3 GC01P184916
GH01H184882 1.2 Ensembl ENCODE dbSUPER 19.3 +92.5 92543 1.2 BATF POLR2A EED FOS ATF7 ETV6 NFE2 RUNX3 IKZF2 CREM FAM129A GC01P184860 GC01P184916
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM129A on UCSC Golden Path with GeneCards custom track

Promoters for FAM129A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000017079 1438 1801 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF207 ZNF548 SP3 JUNB REST

Genomic Locations for FAM129A Gene

Genomic Locations for FAM129A Gene
184,415 bases
Minus strand

Genomic View for FAM129A Gene

Genes around FAM129A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM129A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM129A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM129A Gene

Proteins for FAM129A Gene

  • Protein details for FAM129A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Niban
    Protein Accession:
    Secondary Accessions:
    • Q2TTR2
    • Q5TEM8
    • Q8TEI5
    • Q9H593
    • Q9H9Y8
    • Q9HCB9

    Protein attributes for FAM129A Gene

    928 amino acids
    Molecular mass:
    103135 Da
    Quaternary structure:
    No Data Available
    • Niban means second in Japanese.
    • Sequence=BAB17230.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM129A Gene

Post-translational modifications for FAM129A Gene

  • Ubiquitination at isoforms=482
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM129A Gene

No data available for DME Specific Peptides for FAM129A Gene

Domains & Families for FAM129A Gene

Gene Families for FAM129A Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for FAM129A Gene


Suggested Antigen Peptide Sequences for FAM129A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Niban family.
  • Belongs to the Niban family.
genes like me logo Genes that share domains with FAM129A: view

Function for FAM129A Gene

Molecular function for FAM129A Gene

UniProtKB/Swiss-Prot Function:
Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity).

Phenotypes From GWAS Catalog for FAM129A Gene

Gene Ontology (GO) - Molecular Function for FAM129A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 22510990
genes like me logo Genes that share ontologies with FAM129A: view

Phenotypes for FAM129A Gene

genes like me logo Genes that share phenotypes with FAM129A: view

Animal Models for FAM129A Gene

MGI Knock Outs for FAM129A:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM129A Gene

Localization for FAM129A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM129A Gene

Cytoplasm. Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM129A gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM129A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 16949643
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IDA,IEA 19946888
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with FAM129A: view

Pathways & Interactions for FAM129A Gene

SuperPathways for FAM129A Gene

No Data Available

SIGNOR curated interactions for FAM129A Gene

Other effect:

Gene Ontology (GO) - Biological Process for FAM129A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0006417 regulation of translation IEA --
GO:0034976 response to endoplasmic reticulum stress ISS --
GO:0045727 positive regulation of translation ISS --
genes like me logo Genes that share ontologies with FAM129A: view

No data available for Pathways by source for FAM129A Gene

Drugs & Compounds for FAM129A Gene

No Compound Related Data Available

Transcripts for FAM129A Gene

Unigene Clusters for FAM129A Gene

Family with sequence similarity 129, member A:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM129A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - -
SP2: -

Relevant External Links for FAM129A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM129A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM129A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM129A Gene

This gene is overexpressed in Whole Blood (x6.2) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for FAM129A Gene

This gene is overexpressed in Salivary gland (18.9) and Prostate (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM129A Gene

Protein tissue co-expression partners for FAM129A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM129A Gene:


SOURCE GeneReport for Unigene cluster for FAM129A Gene:


mRNA Expression by UniProt/SwissProt for FAM129A Gene:

Tissue specificity: Expressed in various types of thyroid tumor such as papillary thyroid carcinomas and oxyphilic thyroid tumors but not in normal thyroid tissue (at protein level). Strongly expressed in heart, skeletal muscle, pancreas, white blood cells and prostate with moderate expression in colon and spleen. Expressed in renal carcinoma cells but not in normal kidney.

Evidence on tissue expression from TISSUES for FAM129A Gene

  • Blood(4.4)
  • Spleen(4.3)
  • Liver(4.1)
  • Heart(2.5)
  • Nervous system(2.5)
  • Thyroid gland(2.4)
genes like me logo Genes that share expression patterns with FAM129A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM129A Gene

Orthologs for FAM129A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM129A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM129A 33 34
  • 99.35 (n)
(Canis familiaris)
Mammalia FAM129A 33 34
  • 84.04 (n)
(Bos Taurus)
Mammalia FAM129A 33 34
  • 83.94 (n)
(Rattus norvegicus)
Mammalia Fam129a 33
  • 80.21 (n)
(Mus musculus)
Mammalia Fam129a 33 16 34
  • 79.46 (n)
(Monodelphis domestica)
Mammalia FAM129A 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia FAM129A 34
  • 67 (a)
(Gallus gallus)
Aves FAM129A 34 33
  • 73.51 (n)
(Anolis carolinensis)
Reptilia FAM129A 34
  • 54 (a)
(Danio rerio)
Actinopterygii LOC561414 33
  • 58.94 (n)
fam129ab 34
  • 39 (a)
fam129aa 34
  • 33 (a)
Species where no ortholog for FAM129A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM129A Gene

Gene Tree for FAM129A (if available)
Gene Tree for FAM129A (if available)

Paralogs for FAM129A Gene

Paralogs for FAM129A Gene

(2) SIMAP similar genes for FAM129A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM129A: view

Variants for FAM129A Gene

Sequence variations from dbSNP and Humsavar for FAM129A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs201876014 Uncertain significance 184,795,563(+) CATTC(A/G)TATCT reference, missense
rs1000011072 -- 184,943,978(+) ACATA(C/T)GGAAA intron-variant
rs1000014237 -- 184,948,293(+) ATTCA(G/T)TTATT intron-variant
rs1000042745 -- 184,915,313(+) TTATA(C/T)TCAAT intron-variant
rs1000046788 -- 184,947,909(+) TGAAG(C/T)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM129A Gene

Variant ID Type Subtype PubMed ID
nsv958155 CNV deletion 24416366
nsv946539 CNV duplication 23825009
nsv832048 CNV loss 17160897
nsv525731 CNV gain 19592680
nsv511721 CNV loss 21212237
nsv508677 CNV deletion 20534489
nsv498696 CNV loss 21111241
nsv436157 CNV deletion 17901297
nsv3843 CNV deletion 18451855
nsv3832 CNV deletion 18451855
nsv1133924 CNV deletion 24896259
nsv1068748 CNV deletion 25765185
nsv1068746 CNV deletion 25765185
nsv1012048 CNV loss 25217958
esv4945 CNV loss 18987735
esv3890815 CNV gain 25118596
esv3588130 CNV loss 21293372
esv3588129 CNV gain 21293372
esv3543600 CNV deletion 23714750
esv3543589 CNV deletion 23714750
esv3384812 CNV insertion 20981092
esv2848791 CNV deletion 24192839
esv2720217 CNV deletion 23290073
esv2720206 CNV deletion 23290073
esv2720195 CNV deletion 23290073
esv2617140 CNV deletion 19546169
esv2521611 CNV deletion 19546169
esv2335294 CNV deletion 18987734
esv2244253 CNV deletion 18987734
esv1416043 CNV deletion 17803354
esv1001682 CNV deletion 20482838
dgv6n6 CNV deletion 16902084
dgv232n106 CNV deletion 24896259

Variation tolerance for FAM129A Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM129A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM129A Gene

Disorders for FAM129A Gene

Relevant External Links for FAM129A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM129A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM129A Gene

Publications for FAM129A Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis. (PMID: 16949643) Matsumoto F … Hino O (Human pathology 2006) 3 4 60
  4. [Pathogenesis of differentiated thyroid cancer (papillary and follicular)]. (PMID: 16444351) Maciel RM … Cerutti JM (Arquivos brasileiros de endocrinologia e metabologia 2005) 2 3 60
  5. A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression. (PMID: 15085203) Cerutti JM … Riggins GJ (The Journal of clinical investigation 2004) 2 3 60

Products for FAM129A Gene

Sources for FAM129A Gene

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