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Aliases for FAM127C Gene

Aliases for FAM127C Gene

  • Family With Sequence Similarity 127, Member C 2 3
  • Mammalian Retrotransposon Derived Protein 8B 3 4
  • CXX1c 3 4
  • MAR8B 3 4
  • Protein FAM127C 3

External Ids for FAM127C Gene

Previous GeneCards Identifiers for FAM127C Gene

  • GC0XM133984
  • GC0XM134154
  • GC0XM123549

Summaries for FAM127C Gene

GeneCards Summary for FAM127C Gene

FAM127C (Family With Sequence Similarity 127, Member C) is a Protein Coding gene. An important paralog of this gene is FAM127B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM127C Gene

Genomics for FAM127C Gene

Regulatory Elements for FAM127C Gene

Transcription factor binding sites by QIAGEN in the FAM127C gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM127C Gene

135,020,504 bp from pter
135,022,536 bp from pter
2,033 bases
Minus strand

Genomic View for FAM127C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM127C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM127C Gene

Proteins for FAM127C Gene

  • Protein details for FAM127C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM127C
    Protein Accession:
    Secondary Accessions:

    Protein attributes for FAM127C Gene

    113 amino acids
    Molecular mass:
    13246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM127C Gene

Proteomics data for FAM127C Gene at MOPED

Post-translational modifications for FAM127C Gene

  • Ubiquitination at Lys9
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM127C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM127C Gene

Domains for FAM127C Gene

Protein Domains for FAM127C Gene


Suggested Antigen Peptide Sequences for FAM127C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q17RB0
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with FAM127C: view

No data available for Gene Families for FAM127C Gene

Function for FAM127C Gene

Gene Ontology (GO) - Molecular Function for FAM127C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM127C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM127C

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM127C Gene

Localization for FAM127C Gene

Subcellular locations from

Jensen Localization Image for FAM127C Gene COMPARTMENTS Subcellular localization image for FAM127C gene
Compartment Confidence
mitochondrion 3
peroxisome 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM127C Gene

Pathways for FAM127C Gene

SuperPathways for FAM127C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM127C Gene


No data available for Pathways by source for FAM127C Gene

Transcripts for FAM127C Gene

mRNA/cDNA for FAM127C Gene

(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM127C Gene

Family with sequence similarity 127, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM127C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM127C Gene

No ASD Table

Relevant External Links for FAM127C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM127C Gene

mRNA expression in normal human tissues for FAM127C Gene

Protein differential expression in normal tissues for FAM127C Gene

This gene is overexpressed in Bone (37.3), Pancreas (24.9), and Neutrophil (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM127C Gene

SOURCE GeneReport for Unigene cluster for FAM127C Gene Hs.378813

genes like me logo Genes that share expressions with FAM127C: view

Expression partners for FAM127C Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM127C Gene

Orthologs for FAM127C Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM127C Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Cxx1a 35
  • 78.79 (n)
  • 72.73 (a)
Cxx1b 16
Cxx1a 36
  • 70 (a)
Cxx1b 36
  • 70 (a)
Cxx1c 36
  • 61 (a)
(Pan troglodytes)
Mammalia FAM127C 35
  • 98.53 (n)
  • 98.23 (a)
(Rattus norvegicus)
Mammalia LOC679038 35
  • 78.79 (n)
  • 73.64 (a)
(Bos Taurus)
Mammalia FAM127A 36
  • 86 (a)
FAM127A 36
  • 86 (a)
FAM127A 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
-- 36
  • 81 (a)
-- 36
  • 81 (a)
-- 36
  • 81 (a)
Species with no ortholog for FAM127C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM127C Gene

Gene Tree for FAM127C (if available)
Gene Tree for FAM127C (if available)

Paralogs for FAM127C Gene

Paralogs for FAM127C Gene

Selected SIMAP similar genes for FAM127C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM127C: view

Variants for FAM127C Gene

Sequence variations from dbSNP and Humsavar for FAM127C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2475853 -- 135,022,091(+) GCACC(C/G)GTCCC utr-variant-3-prime
rs6654682 -- 135,020,878(+) AATCA(C/T)GGGTT utr-variant-3-prime
rs7880514 -- 135,021,782(+) GCGGC(C/T)GTCAG utr-variant-3-prime
rs12836936 -- 135,020,224(+) gggag(G/T)gggga downstream-variant-500B
rs12856424 -- 135,023,521(+) attct(A/G)tgaaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM127C Gene

Variant ID Type Subtype PubMed ID
nsv483147 CNV Loss 15286789

Relevant External Links for FAM127C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM127C Gene

Disorders for FAM127C Gene

No disorders were found for FAM127C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM127C Gene

Publications for FAM127C Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3
  2. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A. … Vezzoni P. (Genomics 1997) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J. … Volff J.-N. (Cytogenet. Genome Res. 2005) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for FAM127C Gene

Sources for FAM127C Gene

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