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Aliases for FAM127C Gene

Aliases for FAM127C Gene

  • Family With Sequence Similarity 127 Member C 2 3 5
  • Family With Sequence Similarity 127, Member C 2 3
  • Mammalian Retrotransposon Derived Protein 8B 3 4
  • CXX1c 3 4
  • MAR8B 3 4

External Ids for FAM127C Gene

Previous GeneCards Identifiers for FAM127C Gene

  • GC0XM133984
  • GC0XM134154
  • GC0XM123549

Summaries for FAM127C Gene

GeneCards Summary for FAM127C Gene

FAM127C (Family With Sequence Similarity 127 Member C) is a Protein Coding gene. An important paralog of this gene is FAM127B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM127C Gene

Genomics for FAM127C Gene

Regulatory Elements for FAM127C Gene

Enhancers for FAM127C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM127C on UCSC Golden Path with GeneCards custom track

Promoters for FAM127C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM127C on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FAM127C gene promoter:

Genomic Location for FAM127C Gene

Chromosome:
X
Start:
135,020,504 bp from pter
End:
135,022,536 bp from pter
Size:
2,033 bases
Orientation:
Minus strand

Genomic View for FAM127C Gene

Genes around FAM127C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM127C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM127C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM127C Gene

Proteins for FAM127C Gene

  • Protein details for FAM127C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RB0-F127C_HUMAN
    Recommended name:
    Protein FAM127C
    Protein Accession:
    Q17RB0

    Protein attributes for FAM127C Gene

    Size:
    113 amino acids
    Molecular mass:
    13246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM127C Gene

Proteomics data for FAM127C Gene at MOPED

Post-translational modifications for FAM127C Gene

  • Ubiquitination at Lys 9
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM127C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM127C Gene

Domains & Families for FAM127C Gene

Protein Domains for FAM127C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM127C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17RB0

UniProtKB/Swiss-Prot:

F127C_HUMAN :
  • Belongs to the FAM127 family.
Family:
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with FAM127C: view

No data available for Gene Families for FAM127C Gene

Function for FAM127C Gene

Phenotypes for FAM127C Gene

GenomeRNAi human phenotypes for FAM127C:
genes like me logo Genes that share phenotypes with FAM127C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM127C Gene

Localization for FAM127C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM127C Gene COMPARTMENTS Subcellular localization image for FAM127C gene
Compartment Confidence
mitochondrion 3
peroxisome 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM127C Gene

Pathways & Interactions for FAM127C Gene

SuperPathways for FAM127C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM127C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM127C Gene

Drugs & Compounds for FAM127C Gene

No Compound Related Data Available

Transcripts for FAM127C Gene

mRNA/cDNA for FAM127C Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM127C Gene

Family with sequence similarity 127, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM127C Gene

No ASD Table

Relevant External Links for FAM127C Gene

GeneLoc Exon Structure for
FAM127C
ECgene alternative splicing isoforms for
FAM127C

Expression for FAM127C Gene

mRNA expression in normal human tissues for FAM127C Gene

Protein differential expression in normal tissues from HIPED for FAM127C Gene

This gene is overexpressed in Bone (37.3), Pancreas (24.9), and Neutrophil (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM127C Gene



SOURCE GeneReport for Unigene cluster for FAM127C Gene Hs.378813

genes like me logo Genes that share expression patterns with FAM127C: view

Protein tissue co-expression partners for FAM127C Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM127C Gene

Orthologs for FAM127C Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM127C Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cxx1a 35
  • 78.79 (n)
  • 72.73 (a)
Cxx1b 16
Cxx1a 36
  • 70 (a)
ManyToMany
Cxx1b 36
  • 70 (a)
ManyToMany
Cxx1c 36
  • 61 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia FAM127C 35
  • 98.53 (n)
  • 98.23 (a)
rat
(Rattus norvegicus)
Mammalia LOC679038 35
  • 78.79 (n)
  • 73.64 (a)
cow
(Bos Taurus)
Mammalia FAM127A 36
  • 86 (a)
ManyToMany
FAM127A 36
  • 86 (a)
ManyToMany
FAM127A 36
  • 86 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
Species with no ortholog for FAM127C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM127C Gene

ENSEMBL:
Gene Tree for FAM127C (if available)
TreeFam:
Gene Tree for FAM127C (if available)

Paralogs for FAM127C Gene

Paralogs for FAM127C Gene

(6) SIMAP similar genes for FAM127C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM127C: view

Variants for FAM127C Gene

Sequence variations from dbSNP and Humsavar for FAM127C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs748897110 -- 135,022,452(+) CTCGA(C/G)CTTCC reference, missense
rs748986771 -- 135,022,646(+) AGGGG(A/G)TCCCG upstream-variant-2KB
rs749874896 -- 135,022,510(+) TCGCC(-/G)GGGGC utr-variant-5-prime
rs750249232 -- 135,022,429(+) CAGGA(A/G)GGCCT reference, missense
rs750557413 -- 135,022,232(+) TGCAG(C/G)GCGGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FAM127C Gene

Variant ID Type Subtype PubMed ID
nsv483147 CNV Loss 15286789

Variation tolerance for FAM127C Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM127C Gene

Disorders for FAM127C Gene

Relevant External Links for FAM127C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM127C

No disorders were found for FAM127C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM127C Gene

Publications for FAM127C Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3 67
  2. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A. … Vezzoni P. (Genomics 1997) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for FAM127C Gene

Sources for FAM127C Gene

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