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Aliases for FAM127B Gene

Aliases for FAM127B Gene

  • Family With Sequence Similarity 127 Member B 2 3 5
  • Mammalian Retrotransposon Derived Protein 8A 3 4
  • CXX1b 3 4
  • MAR8A 3 4
  • Family With Sequence Similarity 127, Member B 2
  • Protein FAM127B 3

External Ids for FAM127B Gene

Previous GeneCards Identifiers for FAM127B Gene

  • GC0XM134014
  • GC0XM134184

Summaries for FAM127B Gene

GeneCards Summary for FAM127B Gene

FAM127B (Family With Sequence Similarity 127 Member B) is a Protein Coding gene. An important paralog of this gene is FAM127C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM127B Gene

Genomics for FAM127B Gene

Regulatory Elements for FAM127B Gene

Enhancers for FAM127B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF134870 0.6 ENCODE 12.5 +181.6 181560 0.8 ZNF362 ZNF585B ZNF140 ZBTB8A ATF2 TCF7L2 FAM127B RPL36AP54 GC0XP134864 MOSPD1
GH0XF135098 0.5 ENCODE 10.3 -46.7 -46720 0.2 KLF1 PKNOX1 SAP130 CCNT2 ZFHX2 ZNF366 ZBTB48 POLR2A PATZ1 KLF8 FAM127B SMIM10L2B LINC00633
GH0XF134965 1 Ensembl ENCODE 7.9 +86.7 86744 0.7 CTCF ZNF362 ZNF654 USF2 ZNF384 REST RAD21 ZNF121 ZNF664 GATA3 SMIM10 FAM127B HMGB3P31
GH0XF135050 0.6 ENCODE 0.8 +0.3 275 2.0 ATF1 CREB3L1 SIN3A ZNF2 GLIS2 ELK1 KLF7 ZNF263 SP3 REST FAM127C FAM127B GC0XM135052 GC0XM135054
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM127B on UCSC Golden Path with GeneCards custom track

Promoters for FAM127B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000161333 395 2399 ATF1 CREB3L1 SIN3A ZNF2 GLIS2 ELK1 KLF7 ZNF263 SP3 REST

Genomic Location for FAM127B Gene

Chromosome:
X
Start:
135,050,932 bp from pter
End:
135,052,196 bp from pter
Size:
1,265 bases
Orientation:
Minus strand

Genomic View for FAM127B Gene

Genes around FAM127B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM127B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM127B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM127B Gene

Proteins for FAM127B Gene

  • Protein details for FAM127B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWD3-F127B_HUMAN
    Recommended name:
    Protein FAM127B
    Protein Accession:
    Q9BWD3
    Secondary Accessions:
    • A2A2V9
    • Q8TBU2

    Protein attributes for FAM127B Gene

    Size:
    113 amino acids
    Molecular mass:
    13188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM127B Gene

Post-translational modifications for FAM127B Gene

  • Ubiquitination at Lys 9
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM127B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM127B Gene

Domains & Families for FAM127B Gene

Protein Domains for FAM127B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM127B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWD3

UniProtKB/Swiss-Prot:

F127B_HUMAN :
  • Belongs to the FAM127 family.
Family:
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with FAM127B: view

No data available for Gene Families for FAM127B Gene

Function for FAM127B Gene

Gene Ontology (GO) - Molecular Function for FAM127B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FAM127B: view
genes like me logo Genes that share phenotypes with FAM127B: view

Animal Model Products

miRNA for FAM127B Gene

miRTarBase miRNAs that target FAM127B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM127B Gene

Localization for FAM127B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM127B Gene COMPARTMENTS Subcellular localization image for FAM127B gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM127B Gene

Pathways & Interactions for FAM127B Gene

SuperPathways for FAM127B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM127B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM127B Gene

Transcripts for FAM127B Gene

Unigene Clusters for FAM127B Gene

Family with sequence similarity 127, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM127B Gene

No ASD Table

Relevant External Links for FAM127B Gene

GeneLoc Exon Structure for
FAM127B
ECgene alternative splicing isoforms for
FAM127B

Expression for FAM127B Gene

mRNA expression in normal human tissues for FAM127B Gene

Protein differential expression in normal tissues from HIPED for FAM127B Gene

This gene is overexpressed in Bone (62.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM127B Gene



Protein tissue co-expression partners for FAM127B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM127B Gene:

FAM127B

SOURCE GeneReport for Unigene cluster for FAM127B Gene:

Hs.460924
genes like me logo Genes that share expression patterns with FAM127B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM127B Gene

Orthologs for FAM127B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM127B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM127B 34 35
  • 98.53 (n)
cow
(Bos Taurus)
Mammalia FAM127A 35 35 35
  • 88 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 84 (a)
ManyToMany
-- 35
  • 84 (a)
ManyToMany
-- 35
  • 84 (a)
ManyToMany
-- 35
  • 84 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cxx1a 35
  • 69 (a)
ManyToMany
Cxx1b 35
  • 69 (a)
ManyToMany
Cxx1c 35
  • 63 (a)
ManyToMany
Species where no ortholog for FAM127B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM127B Gene

ENSEMBL:
Gene Tree for FAM127B (if available)
TreeFam:
Gene Tree for FAM127B (if available)

Paralogs for FAM127B Gene

Paralogs for FAM127B Gene

(5) SIMAP similar genes for FAM127B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM127B: view

Variants for FAM127B Gene

Sequence variations from dbSNP and Humsavar for FAM127B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112681744 -- 135,052,611(+) TCTTC(A/C/G)TATAT upstream-variant-2KB
rs146928069 -- 135,053,931(+) TGTCA(G/T)CACTG upstream-variant-2KB
rs148564684 -- 135,052,405(+) GCCAG(C/T)GGGGC upstream-variant-2KB
rs182524853 -- 135,052,449(+) AGCCT(C/G)TTGCC upstream-variant-2KB
rs182669004 -- 135,051,523(+) GGCTG(A/G)CAAAA intron-variant, utr-variant-3-prime

Variation tolerance for FAM127B Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM127B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM127B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM127B Gene

Disorders for FAM127B Gene

Relevant External Links for FAM127B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM127B

No disorders were found for FAM127B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM127B Gene

Publications for FAM127B Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3 64
  2. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A. … Vezzoni P. (Genomics 1997) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for FAM127B Gene

Sources for FAM127B Gene

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