FAM127B Gene
protein-coding GIFtS: 38
GCID: GC0XM134184
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|
family with sequence similarity 127, member B
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Aliases
for FAM127B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 127, Member B1 2 | | DKFZP564B1471 | | MAR8A1 2 3 | | Protein FAM127B2 | | CXX1b1 2 | | CXX1B3 | | Mammalian Retrotransposon Derived Protein 8A2 3 | | |
Export aliases for FAM127B gene to outside databasesPrevious GC identifer: GC0XM134014 |
Summaries
for FAM127B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM127B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAM127B
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM127B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM127B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3FAM127B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM134184: view genomic region
(about GC identifiers)
Start:
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134,184,962 bp from pter |
End:
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134,186,226 bp from pter |
Size:
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1,265 bases |
Orientation:
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minus strand |
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Proteins
for FAM127B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F127B_HUMAN, Q9BWD3 (See
protein sequence)Recommended Name: Protein FAM127B Size: 113 amino acids; 13188 Da
Secondary accessions: A2A2V9 Q8TBU2Explore the universe of human proteins at neXtProt for FAM127B: NX_Q9BWD3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWD3
FAM127B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001071640.1 NP_001127793.1
ENSEMBL proteins: ENSP00000375267
Human Recombinant Protein Products:
FAM127B Antibody Products:
Assay Products for FAM127B: |
Protein
Domains /
Families
for FAM127B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BWD3 UniProtKB/Swiss-Prot: F127B_HUMAN, Q9BWD3Similarity: Belongs to the FAM127 family |
Function
for FAM127B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM127B (NM_001134321) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM127B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM127B |
4 GenomeRNAi human phenotypes for FAM127B:
|
Pathways & Interactions
for FAM127B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM127B
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for FAM127B (Q9BWD33 ENSP000003752674) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM127B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM127B
Search CenterWatch for drugs/clinical trials and news about FAM127B / F127B
|
Transcripts
for FAM127B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM127B gene (3 alternative transcripts): NM_015582.2 NM_001078172.1 NM_001134321.1 Unigene Cluster for FAM127B: Family with sequence similarity 127, member B Hs.460924 [show with all ESTs]Unigene Representative Sequence: NM_0010781724 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000518153 ENST00000370775(uc004eyf.3) ENST00000520964(uc004eyg.4)
ENST00000522309
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM127B (NM_001134321) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM127B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM127B |
Additional cDNA sequence: AL117556.1 BC000393.2 BC008096.1 BC019300.1 BC071991.1 CR457123.1 CR542228.1 12 DOTS entries: DT.87078990 DT.121279037 DT.100790200 DT.121279048 DT.100038977 DT.100790203 DT.121279036 DT.87007687 DT.102844329 DT.95078660 DT.95078699 DT.95078661 24/37 AceView cDNA sequences (see all 37): AI536970 AI679644 BM691822 AI369299 BM845251 AW361511 BU728681 BU196125 BU729202 BM841478 BI765262 BV201889 BC071991 BM707626 BM841831 BM760076 BI093923 BG030673 N30279 CD248631 W87391 BM695958 CA396243 BM843996
GeneLoc Exon Structure
|
Expression
for FAM127B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM127B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCGTGGACG
About this image
See FAM127B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM127B
SOURCE GeneReport for Unigene cluster: Hs.460924
SABiosciences Custom PCR Arrays for FAM127B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM127B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM127B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM127B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM127B |
Orthologs
for FAM127B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
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ENSEMBL Gene Tree for FAM127B (if available)
TreeFam Gene Tree for FAM127B (if available) |
Paralogs
for FAM127B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM127B gene
- RGAG42 FAM127C2 LDOC1L2 LDOC12 FAM127A2
5 SIMAP similar genes for FAM127B using alignment to 2 protein entries: F127B_HUMAN (see all proteins):FAM127A FAM127C LDOC1 RTL1 PEG10
FAM127B for paralogs About GeneDecksing
|
Genomic Variants
for FAM127B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM127B (134184962 - 134186226 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM127B
1 CNV: 0254 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM127B |
|
Disorders
/ Diseases
for FAM127B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM127B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM127B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with FAM127B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PubMed id 15716091)1, 3 Brandt J.... Volff J.-N. (2005)
- A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PubMed id 9403077)1, 3 Frattini A.... Vezzoni P. (1997)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PubMed id 16093683)1 Brandt J....Volff J.N. (2005)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
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External Searches for FAM127B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FAM127B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM127B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM127B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM127B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FAM127B gene:
Search GeneIP for patents involving FAM127B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM127B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM127B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM127B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM127B | | | OriGene Protein Over-expression Lysate for FAM127B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM127B | | OriGene 3'-UTR Clone for FAM127B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM127B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM127B | | OriGene Custom Protein Services for FAM127B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM127B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM127B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM127B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM127B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM127B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM127B |
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| | | | Search Tocris compounds for FAM127B |
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 | | | FAM127B Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for FAM127B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM127B |
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