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Aliases for FAM127B Gene

Aliases for FAM127B Gene

  • Family With Sequence Similarity 127 Member B 2 3 5
  • Family With Sequence Similarity 127, Member B 2 3
  • Mammalian Retrotransposon Derived Protein 8A 3 4
  • CXX1b 3 4
  • MAR8A 3 4

External Ids for FAM127B Gene

Previous GeneCards Identifiers for FAM127B Gene

  • GC0XM134014
  • GC0XM134184

Summaries for FAM127B Gene

GeneCards Summary for FAM127B Gene

FAM127B (Family With Sequence Similarity 127 Member B) is a Protein Coding gene. An important paralog of this gene is LDOC1L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM127B Gene

Genomics for FAM127B Gene

Regulatory Elements for FAM127B Gene

Enhancers for FAM127B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM127B on UCSC Golden Path with GeneCards custom track

Promoters for FAM127B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM127B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM127B Gene

Chromosome:
X
Start:
135,050,932 bp from pter
End:
135,052,196 bp from pter
Size:
1,265 bases
Orientation:
Minus strand

Genomic View for FAM127B Gene

Genes around FAM127B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM127B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM127B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM127B Gene

Proteins for FAM127B Gene

  • Protein details for FAM127B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWD3-F127B_HUMAN
    Recommended name:
    Protein FAM127B
    Protein Accession:
    Q9BWD3
    Secondary Accessions:
    • A2A2V9
    • Q8TBU2

    Protein attributes for FAM127B Gene

    Size:
    113 amino acids
    Molecular mass:
    13188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM127B Gene

Proteomics data for FAM127B Gene at MOPED

Post-translational modifications for FAM127B Gene

  • Ubiquitination at Lys 9
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM127B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM127B Gene

Domains & Families for FAM127B Gene

Protein Domains for FAM127B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM127B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWD3

UniProtKB/Swiss-Prot:

F127B_HUMAN :
  • Belongs to the FAM127 family.
Family:
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with FAM127B: view

No data available for Gene Families for FAM127B Gene

Function for FAM127B Gene

genes like me logo Genes that share phenotypes with FAM127B: view

Animal Model Products

CRISPR Products

miRNA for FAM127B Gene

miRTarBase miRNAs that target FAM127B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM127B Gene

Localization for FAM127B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM127B Gene COMPARTMENTS Subcellular localization image for FAM127B gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM127B Gene

Pathways & Interactions for FAM127B Gene

SuperPathways for FAM127B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM127B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM127B Gene

Drugs & Compounds for FAM127B Gene

No Compound Related Data Available

Transcripts for FAM127B Gene

Unigene Clusters for FAM127B Gene

Family with sequence similarity 127, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM127B Gene

No ASD Table

Relevant External Links for FAM127B Gene

GeneLoc Exon Structure for
FAM127B
ECgene alternative splicing isoforms for
FAM127B

Expression for FAM127B Gene

mRNA expression in normal human tissues for FAM127B Gene

Protein differential expression in normal tissues from HIPED for FAM127B Gene

This gene is overexpressed in Bone (62.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM127B Gene



SOURCE GeneReport for Unigene cluster for FAM127B Gene Hs.460924

genes like me logo Genes that share expression patterns with FAM127B: view

Protein tissue co-expression partners for FAM127B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM127B Gene

Orthologs for FAM127B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM127B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM127B 35
  • 98.53 (n)
  • 98.23 (a)
FAM127B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM127A 36
  • 88 (a)
ManyToMany
FAM127A 36
  • 88 (a)
ManyToMany
FAM127A 36
  • 88 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cxx1a 36
  • 69 (a)
ManyToMany
Cxx1b 36
  • 69 (a)
ManyToMany
Cxx1c 36
  • 63 (a)
ManyToMany
Species with no ortholog for FAM127B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM127B Gene

ENSEMBL:
Gene Tree for FAM127B (if available)
TreeFam:
Gene Tree for FAM127B (if available)

Paralogs for FAM127B Gene

Paralogs for FAM127B Gene

(5) SIMAP similar genes for FAM127B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM127B: view

Variants for FAM127B Gene

Sequence variations from dbSNP and Humsavar for FAM127B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2498776 - 135,051,967(+) GGAGC(A/C/T)CGTCT reference, missense
rs747922476 -- 135,051,986(+) AACTC(C/T)GGGAG reference, synonymous-codon
rs747943747 -- 135,052,071(+) GCCCG(A/G)CCAGG reference, missense
rs748246875 -- 135,051,271(+) GGGCT(C/G)TGTCC utr-variant-3-prime
rs748905632 -- 135,051,159(+) TGGCA(C/G)CTATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM127B Gene

Variant ID Type Subtype PubMed ID
nsv483147 CNV Loss 15286789

Variation tolerance for FAM127B Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM127B Gene

HapMap Linkage Disequilibrium report
FAM127B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM127B Gene

Disorders for FAM127B Gene

Relevant External Links for FAM127B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM127B

No disorders were found for FAM127B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM127B Gene

Publications for FAM127B Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3 67
  2. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A. … Vezzoni P. (Genomics 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for FAM127B Gene

Sources for FAM127B Gene

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