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Aliases for FAM127A Gene

Aliases for FAM127A Gene

  • Family With Sequence Similarity 127 Member A 2 3 5
  • Mammalian Retrotransposon Derived Protein 8C 3 4
  • CAAX Box 1 2 3
  • Mart8 3 4
  • MAR8C 3 4
  • Mar8 3 4
  • CXX1 3 4
  • Family With Sequence Similarity 127, Member A 2
  • Cerebral Protein 5 4
  • Protein FAM127A 3
  • MART8C 3

External Ids for FAM127A Gene

Previous HGNC Symbols for FAM127A Gene

  • CXX1

Previous GeneCards Identifiers for FAM127A Gene

  • GC0XP133995
  • GC0XP134166
  • GC0XP123560

Summaries for FAM127A Gene

GeneCards Summary for FAM127A Gene

FAM127A (Family With Sequence Similarity 127 Member A) is a Protein Coding gene. An important paralog of this gene is FAM127B.

Gene Wiki entry for FAM127A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM127A Gene

Genomics for FAM127A Gene

Regulatory Elements for FAM127A Gene

Enhancers for FAM127A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF135031 0.6 ENCODE 0.8 +0.4 401 2.1 ATF1 CREB3L1 SIN3A GLI4 DMAP1 ZNF2 YY1 GLIS2 SP3 REST FAM127C GC0XM135032 FAM127A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM127A on UCSC Golden Path with GeneCards custom track

Promoters for FAM127A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001491758 498 2399 ATF1 CREB3L1 SIN3A GLI4 DMAP1 ZNF2 YY1 GLIS2 SP3 REST

Genomic Location for FAM127A Gene

Chromosome:
X
Start:
135,032,303 bp from pter
End:
135,033,546 bp from pter
Size:
1,244 bases
Orientation:
Plus strand

Genomic View for FAM127A Gene

Genes around FAM127A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM127A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM127A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM127A Gene

Proteins for FAM127A Gene

  • Protein details for FAM127A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ZKI3-F127A_HUMAN
    Recommended name:
    Protein FAM127A
    Protein Accession:
    A6ZKI3

    Protein attributes for FAM127A Gene

    Size:
    113 amino acids
    Molecular mass:
    13171 Da
    Quaternary structure:
    No Data Available
  • Protein details for FAM127A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15255-CXX1_HUMAN
    Recommended name:
    CAAX box protein 1
    Protein Accession:
    O15255
    Secondary Accessions:
    • Q6IBF1

    Protein attributes for FAM127A Gene

    Size:
    209 amino acids
    Molecular mass:
    22278 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM127A Gene

Post-translational modifications for FAM127A Gene

  • Ubiquitination at Lys 9
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM127A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM127A Gene

Domains & Families for FAM127A Gene

Protein Domains for FAM127A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM127A Gene

Graphical View of Domain Structure for InterPro Entry

A6ZKI3

UniProtKB/Swiss-Prot:

CXX1_HUMAN :
  • Belongs to the FAM127 family.
Family:
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with FAM127A: view

No data available for Gene Families for FAM127A Gene

Function for FAM127A Gene

Phenotypes for FAM127A Gene

genes like me logo Genes that share phenotypes with FAM127A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM127A Gene

Localization for FAM127A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM127A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM127A Gene COMPARTMENTS Subcellular localization image for FAM127A gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for FAM127A Gene

Pathways & Interactions for FAM127A Gene

SuperPathways for FAM127A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM127A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM127A Gene

Transcripts for FAM127A Gene

mRNA/cDNA for FAM127A Gene

Unigene Clusters for FAM127A Gene

Family with sequence similarity 127, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM127A Gene

No ASD Table

Relevant External Links for FAM127A Gene

GeneLoc Exon Structure for
FAM127A
ECgene alternative splicing isoforms for
FAM127A

Expression for FAM127A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM127A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM127A Gene

This gene is overexpressed in Ovary (17.4), Fetal Brain (8.0), Prostate (7.8), Placenta (6.7), Fetal gut (6.0), and Fetal ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM127A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM127A Gene:

FAM127A

SOURCE GeneReport for Unigene cluster for FAM127A Gene:

Hs.522789

mRNA Expression by UniProt/SwissProt for FAM127A Gene:

A6ZKI3-F127A_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with FAM127A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM127A Gene

Orthologs for FAM127A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM127A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM127A 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia LOC100683691 34
  • 91.45 (n)
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia FAM127A 35 35 35
  • 90 (a)
ManyToMany
FAM127C 34
  • 89.68 (n)
mouse
(Mus musculus)
Mammalia Cxx1c 34 16
  • 73.57 (n)
Cxx1b 35
  • 71 (a)
ManyToMany
Species where no ortholog for FAM127A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM127A Gene

ENSEMBL:
Gene Tree for FAM127A (if available)
TreeFam:
Gene Tree for FAM127A (if available)

Paralogs for FAM127A Gene

Paralogs for FAM127A Gene

(5) SIMAP similar genes for FAM127A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM127A: view

Variants for FAM127A Gene

Sequence variations from dbSNP and Humsavar for FAM127A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1056723 -- 135,033,371(+) ATTTT(C/T)TCTTG utr-variant-3-prime
rs1056731 -- 135,033,410(+) GTATT(C/T)TGAGT utr-variant-3-prime
rs1056781 -- 135,033,480(+) CTGCT(C/T)TAATA utr-variant-3-prime
rs1056977 -- 135,032,562(+) CTCCA(A/G)CGACG reference, missense
rs1056983 -- 135,032,692(+) AAGCG(A/G)GTCTT reference, synonymous-codon

Variation tolerance for FAM127A Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM127A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM127A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM127A Gene

Disorders for FAM127A Gene

Relevant External Links for FAM127A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM127A

No disorders were found for FAM127A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM127A Gene

Publications for FAM127A Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3 4 64
  2. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J. … Volff J.-N. (Cytogenet. Genome Res. 2005) 2 3 4 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A. … Vezzoni P. (Genomics 1997) 2 3 64

Products for FAM127A Gene

Sources for FAM127A Gene

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