FAM127A Gene
protein-coding GIFtS: 41
GCID: GC0XP134166
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family with sequence similarity 127, member A(Previous name: CAAX box 1 )
(Previous symbol: CXX1)
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Aliases
for FAM127A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 127, Member A1 2 | | Mammalian Retrotransposon Derived Protein 8C2 3 | | CXX11 2 3 5 | | MART8C2 | | MAR8C1 2 3 | | Protein FAM127A2 | | Mar81 2 | | MAR83 | | Mart81 2 | | MART83 | | CAAX Box 11 2 | | Cerebral Protein 53 |
Export aliases for FAM127A gene to outside databasesPrevious GC identifers: GC0XP133995 GC0XP123560 |
Summaries
for FAM127A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for FAM127A
|
Genomic Views
for FAM127A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM127A gene promoter:
Elk-1 Nkx5-1 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM127A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM127A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26FAM127A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP134166: view genomic region
(about GC identifiers)
Start:
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134,166,333 bp from pter |
End:
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134,167,576 bp from pter |
Size:
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1,244 bases |
Orientation:
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plus strand |
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Proteins
for FAM127A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CXX1_HUMAN, O15255 (See
protein sequence)Recommended Name: CAAX box protein 1 precursor Size: 209 amino acids; 22278 Da
Subcellular location: Cell membrane; Lipid-anchor (Potential)
Caution: There seems to be two proteins encoded by the FAM127A gene, one with a C-terminal CAAX box (the sequence shownhere) and a smaller protein (AC A6ZKI3)
Secondary accessions: Q6IBF1UniProtKB/Swiss-Prot: F127A_HUMAN, A6ZKI3 (See
protein sequence) Recommended Name: Protein FAM127A Size: 113 amino acids; 13171 Da
Caution: There seems to be two proteins that can be transcribed from FAM127A, one with a C-terminal CAAX box (ACO15255) and a smaller protein (the sequence shown here) that seems to be encoded by a multicopy gene originating froma retrotransposonExplore the universe of human proteins at neXtProt for FAM127A: NX_A6ZKI3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6ZKI3
FAM127A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001071639.1
ENSEMBL proteins: ENSP00000257013
Human Recombinant Protein Products:
FAM127A Antibody Products:
Assay Products for FAM127A: |
Protein
Domains /
Families
for FAM127A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O15255 UniProtKB/Swiss-Prot: F127A_HUMAN, A6ZKI3Similarity: Belongs to the FAM127 family |
Function
for FAM127A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM127A (NM_001078171) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM127A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM127A |
|
Pathways & Interactions
for FAM127A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM127A
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for FAM127A (O152551, 2, 3 ENSP000002570134) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM127A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM127A
Search CenterWatch for drugs/clinical trials and news about FAM127A / F127A
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Transcripts
for FAM127A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM127A gene (2 alternative transcripts): NM_003928.1 NM_001078171.1 Unigene Cluster for FAM127A: Family with sequence similarity 127, member A Hs.522789 [show with all ESTs]Unigene Representative Sequence: BM8082563 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495563 ENST00000464369 ENST00000257013(uc004eyd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM127A (NM_001078171) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM127A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM127A |
Additional cDNA sequence: AF038168.1 AF052096.1 BC002385.2 BC002410.2 BC106076.1 CR456853.1 D88756.1 Y13374.1 8 DOTS entries: DT.117281 DT.100812503 DT.97860340 DT.100812499 DT.95363236 DT.121308288 DT.95078708 DT.100785137 24/343 AceView cDNA sequences (see all 343): BQ637647 Z39040 BQ009998 BM710608 F27176 BQ023698 AA864654 D88756 BF220132 AA555038 AF052096 BQ962292 C16717 AI092787 BU625652 CB215031 CF127452 BQ015924 AA716124 BM696732 AI252231 W76590 N57880 BC002385
GeneLoc Exon Structure
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Expression
for FAM127A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM127A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACATTTGGA
About this image
See FAM127A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM127A
SOURCE GeneReport for Unigene cluster: Hs.522789
UniProtKB/Swiss-Prot: CXX1_HUMAN, O15255Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for FAM127A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM127A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM127A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM127A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM127A |
Orthologs
for FAM127A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for FAM127A (if available)
TreeFam Gene Tree for FAM127A (if available) |
Paralogs
for FAM127A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM127A gene
- RGAG42 FAM127C2 LDOC1L2 FAM127B2 LDOC12
5 SIMAP similar genes for FAM127A using alignment to 2 protein entries: CXX1_HUMAN (see all proteins):FAM127C FAM127B DKFZP564B147 LDOC1 RTL1
FAM127A for paralogs About GeneDecksing
|
Genomic Variants
for FAM127A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for FAM127A (134166333 - 134167576 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM127A
1 CNV: 0254 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM127A |
|
Disorders
/ Diseases
for FAM127A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM127A for disorders About GeneDecksing
OMIM gene information: 300213
OMIM disorders: --
3  diseases for FAM127A: About MalaCardsvon hippel-lindau disease fundus dystrophy ataxia
Export disorders for FAM127A gene to outside databases
|
Publications
for FAM127A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM127A gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with FAM127A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PubMed id 15716091)1, 2, 3 Brandt J.... Volff J.-N. (2005)
- A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PubMed id 16093683)1, 2, 3 Brandt J....Volff J.N. (2005)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PubMed id 9403077)1, 3 Frattini A.... Vezzoni P. (1997)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
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External Searches for FAM127A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FAM127A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM127A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM127A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM127A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FAM127A gene:
Search GeneIP for patents involving FAM127A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM127A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM127A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM127A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM127A | | | OriGene Protein Over-expression Lysate for FAM127A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM127A | | OriGene 3'-UTR Clone for FAM127A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM127A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM127A | | OriGene Custom Protein Services for FAM127A | | | OriGene Custom Immunoassay Development | | |
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| | | | Search Tocris compounds for FAM127A |
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 | | | FAM127A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FAM127A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM127A |
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