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Aliases for FAM127A Gene

Aliases for FAM127A Gene

  • Family With Sequence Similarity 127, Member A 2 3
  • CXX1 3 4 6
  • Mammalian Retrotransposon Derived Protein 8C 3 4
  • CAAX Box 1 2 3
  • Mart8 3 4
  • MAR8C 3 4
  • Mar8 3 4
  • Cerebral Protein 5 4
  • Protein FAM127A 3
  • MART8C 3

External Ids for FAM127A Gene

Previous HGNC Symbols for FAM127A Gene

  • CXX1

Previous GeneCards Identifiers for FAM127A Gene

  • GC0XP133995
  • GC0XP134166
  • GC0XP123560

Summaries for FAM127A Gene

GeneCards Summary for FAM127A Gene

FAM127A (Family With Sequence Similarity 127, Member A) is a Protein Coding gene. An important paralog of this gene is FAM127B.

Gene Wiki entry for FAM127A Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM127A Gene

Genomics for FAM127A Gene

Regulatory Elements for FAM127A Gene

Transcription factor binding sites by QIAGEN in the FAM127A gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM127A Gene

135,032,303 bp from pter
135,033,546 bp from pter
1,244 bases
Plus strand

Genomic View for FAM127A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM127A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM127A Gene

Proteins for FAM127A Gene

  • Protein details for FAM127A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM127A
    Protein Accession:
    Secondary Accessions:

    Protein attributes for FAM127A Gene

    113 amino acids
    Molecular mass:
    13171 Da
    Quaternary structure:
    No Data Available
  • Protein details for FAM127A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CAAX box protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6IBF1

    Protein attributes for FAM127A Gene

    209 amino acids
    Molecular mass:
    22278 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM127A Gene

Proteomics data for FAM127A Gene at MOPED

Post-translational modifications for FAM127A Gene

  • Ubiquitination at Lys9 and Lys86
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM127A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM127A Gene

Domains for FAM127A Gene

Protein Domains for FAM127A Gene


Suggested Antigen Peptide Sequences for FAM127A Gene

Graphical View of Domain Structure for InterPro Entry



  • A6ZKI3
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with FAM127A: view

No data available for Gene Families for FAM127A Gene

Function for FAM127A Gene

Gene Ontology (GO) - Molecular Function for FAM127A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM127A: view

Animal Model Products

CRISPR Products

miRNA for FAM127A Gene

miRTarBase miRNAs that target FAM127A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM127A Gene

Localization for FAM127A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM127A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for FAM127A Gene COMPARTMENTS Subcellular localization image for FAM127A gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for FAM127A Gene

Pathways for FAM127A Gene

SuperPathways for FAM127A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM127A Gene


No data available for Pathways by source for FAM127A Gene

Transcripts for FAM127A Gene

mRNA/cDNA for FAM127A Gene

Unigene Clusters for FAM127A Gene

Family with sequence similarity 127, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM127A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM127A Gene

No ASD Table

Relevant External Links for FAM127A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM127A Gene

mRNA expression in normal human tissues for FAM127A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM127A Gene

SOURCE GeneReport for Unigene cluster for FAM127A Gene Hs.522789

mRNA Expression by UniProt/SwissProt for FAM127A Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with FAM127A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FAM127A Gene

Orthologs for FAM127A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM127A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM127A 35
  • 99.71 (n)
  • 100 (a)
FAM127A 36
  • 100 (a)
(Bos Taurus)
Mammalia FAM127A 36
  • 90 (a)
FAM127A 36
  • 90 (a)
FAM127A 36
  • 90 (a)
FAM127C 35
  • 89.68 (n)
  • 91.15 (a)
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
-- 36
  • 87 (a)
-- 36
  • 87 (a)
-- 36
  • 87 (a)
LOC100683691 35
  • 91.45 (n)
  • 92.04 (a)
(Mus musculus)
Mammalia Cxx1b 36
  • 71 (a)
Cxx1c 35
  • 73.57 (n)
  • 65.77 (a)
Species with no ortholog for FAM127A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM127A Gene

Gene Tree for FAM127A (if available)
Gene Tree for FAM127A (if available)

Paralogs for FAM127A Gene

Paralogs for FAM127A Gene

Selected SIMAP similar genes for FAM127A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM127A: view

Variants for FAM127A Gene

Sequence variations from dbSNP and Humsavar for FAM127A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1056723 -- 135,033,371(+) ATTTT(C/T)TCTTG utr-variant-3-prime
rs1056731 -- 135,033,410(+) GTATT(C/T)TGAGT utr-variant-3-prime
rs1056781 -- 135,033,480(+) CTGCT(C/T)TAATA utr-variant-3-prime
rs1056977 - 135,032,562(+) CTCCA(A/G)CGACG missense, reference
rs1056983 -- 135,032,692(+) AAGCG(A/G)GTCTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FAM127A Gene

Variant ID Type Subtype PubMed ID
nsv483147 CNV Loss 15286789

Relevant External Links for FAM127A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM127A Gene

Disorders for FAM127A Gene

No disorders were found for FAM127A Gene.

No data available for UniProtKB/Swiss-Prot for FAM127A Gene

Publications for FAM127A Gene

  1. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J. … Volff J.-N. (Cytogenet. Genome Res. 2005) 2 3 4
  2. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A. … Vezzoni P. (Genomics 1997) 2 3

Products for FAM127A Gene

Sources for FAM127A Gene

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