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FAM126B Gene

protein-coding   GIFtS: 41
GCID: GC02M201838

Family With Sequence Similarity 126, Member B

  Search for FAM126B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 126, Member B1 2
HYCC22
Protein FAM126B2

External Ids:    HGNC: 285931   Entrez Gene: 2851722   Ensembl: ENSG000001557447   UniProtKB: Q8IXS83   
ORGUL members:         

Export aliases for FAM126B gene to outside databases

Previous GC identifers: GC02M201551 GC02M193689


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM126B Gene:
FAM126B (family with sequence similarity 126, member B) is a protein-coding gene. An important paralog of this gene is FAM126A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM126B gene promoter:
         AML1a   NF-YA   NF-YB   HEN1   CBF-B   CBF-A   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM126B promoter sequence
   Search Chromatin IP Primers for FAM126B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM126B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

FAM126B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM126B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M201838:  view genomic region     (about GC identifiers)

Start:
201,838,441 bp from pter      End:
201,936,394 bp from pter
Size:
97,954 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F126B_HUMAN, Q8IXS8 (See protein sequence)
Recommended Name: Protein FAM126B  
Size: 530 amino acids; 58647 Da
Secondary accessions: B2RCG7 Q4ZG87 Q53TX6

Explore the universe of human proteins at neXtProt for FAM126B: NX_Q8IXS8

Explore proteomics data for FAM126B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM126B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_776183.1  
    ENSEMBL proteins: 
     ENSP00000393667   ENSP00000286181   ENSP00000401905   ENSP00000408374   ENSP00000412139  

    FAM126B Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for FAM126B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018619 Hyccin

    Graphical View of Domain Structure for InterPro Entry Q8IXS8

    ProtoNet protein and cluster: Q8IXS8

    UniProtKB/Swiss-Prot: F126B_HUMAN, Q8IXS8
    Similarity: Belongs to the FAM126 family


    Find genes that share domains with FAM126B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM126B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM126B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM126B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM126B

    miRNA
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    miRTarBase miRNAs that target FAM126B:
    hsa-mir-32-5p (MIRT028346), hsa-mir-215-5p (MIRT024578), hsa-mir-7-5p (MIRT025962), hsa-mir-29c-3p (MIRT044245), hsa-mir-222-3p (MIRT046786), hsa-mir-375 (MIRT020021), hsa-mir-192-5p (MIRT026962), hsa-mir-769-5p (MIRT016092), hsa-mir-21-5p (MIRT031036)

    Block miRNA regulation of human, mouse, rat FAM126B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM126B (see all 195):
    hsa-miR-193a-3p hsa-miR-640 hsa-miR-376b hsa-miR-106a hsa-miR-605 hsa-miR-128 hsa-miR-519a hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidFAM126B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAM126B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM126B

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    GenScript: all cDNA clones in your preferred vector: FAM126B (NM_173822)
    Sino Biological Human cDNA Clone for FAM126B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM126B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM126B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM126B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    Find genes that share ontologies with FAM126B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM126B
    Interactions:

        Search GeneGlobe Interaction Network for FAM126B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM126B (F126B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM126B gene: 
    NM_173822.3  

    Unigene Cluster for FAM126B:

    Family with sequence similarity 126, member B
    Hs.24701  [show with all ESTs]
    Unigene Representative Sequence: NM_173822
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418596 ENST00000286181(uc002uws.4 uc002uwu.3 uc002uwv.3)
    ENST00000490725 ENST00000498780(uc002uww.1) ENST00000452799 ENST00000453765
    ENST00000446678 ENST00000485144 ENST00000474118 ENST00000485636 ENST00000494881

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM126B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM126B (see all 195):
    hsa-miR-193a-3p hsa-miR-640 hsa-miR-376b hsa-miR-106a hsa-miR-605 hsa-miR-128 hsa-miR-519a hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidFAM126B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM126B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM126B
    Clone
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    OriGene clones in human, mouse for FAM126B (see all 6)
    OriGene ORF clones in mouse, rat for FAM126B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM126B (NM_173822)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM126B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM126B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM126B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM126B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM126B
      QuantiFast Probe-based Assays in human, mouse, rat FAM126B

    Additional mRNA sequence: 

    AK001843.1 AK027168.1 AK095236.1 AK097111.1 AK315104.1 AL832234.1 AL832346.1 AL833403.1 
    BC039295.1 BC045174.1 

    13 DOTS entries:

    DT.100022836  DT.424630  DT.211018  DT.120963371  DT.120963513  DT.101960781  DT.75175601  DT.100734335 
    DT.100668210  DT.40235183  DT.101971173  DT.120963504  DT.91841399 

    Selected AceView cDNA sequences (see all 72):

    AL833403 AA721488 CF994205 AA908691 BU625415 AI241712 BQ707542 CK822031 
    BM722708 BU102051 CD652505 AA906711 AK097111 BQ011934 AW001876 BM476462 
    BX484023 AA506467 Z46120 BX282063 AA513678 AL832234 BQ023330 BC039295 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM126B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGCCATTA
    FAM126B Expression
    About this image


    FAM126B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    FAM126B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM126B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24701
        Custom PCR Arrays for FAM126B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM126B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM126B
    QuantiTect SYBR Green Assays in human, mouse, rat FAM126B
    QuantiFast Probe-based Assays in human, mouse, rat FAM126B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM126B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM126B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam126b1 , 5 family with sequence similarity 126, member B1, 5 91.82(n)1
    95.28(a)1
      1 (29.12 cM)5
    2130561  NM_172513.31  NP_766101.31 
     585228065 
    chicken
    (Gallus gallus)
    Aves FAM126B1 family with sequence similarity 126, member B 82.2(n)
    89.62(a)
      429010  XM_426567.4  XP_426567.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAM126B6
    family with sequence similarity 126, member B
    87(a)
    1 ↔ 1
    GL343478.1(481125-506066)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ068472.12   -- 81.07(n)    BJ068472.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.163172 Transcribed sequence with weak similarity to protein refNP_115970.1 (H.sapiens) down-regulated by Ctnnb1, a [Homo sapiens] less 74.05(n)    CD754331.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64066
    --
    24(a)
    1 → many
    2R(13621924-13624769)
    worm
    (Caenorhabditis elegans)
    Secernentea D1069.36
    Protein D1069.3, isoform b
    19(a)
    1 → many
    II(342137-347865) WBGene00017037


    ENSEMBL Gene Tree for FAM126B (if available)
    TreeFam Gene Tree for FAM126B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM126B gene
    FAM126A2  
    2 SIMAP similar genes for FAM126B using alignment to 5 protein entries:     F126B_HUMAN (see all proteins):
    MGC39518    FAM126A

    Find genes that share paralogs with FAM126B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM126B (see all 1556)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913621691,2
    --201838013(+) CCTTCA/GTAAGT 1 -- int10--------
    rs1820528421,2
    --201838457(+) GCCAAA/GTAGAG 1 -- ut310--------
    rs1508490841,2
    --201838498(+) CACTCC/TTAATG 1 -- ut310--------
    rs1877919311,2
    --201838565(+) CTAAGA/GTATGT 1 -- ut310--------
    rs1924844801,2
    --201838683(+) CACATA/TTCAAC 1 -- ut310--------
    rs1852817931,2
    --201838858(+) CCTATA/CCTATT 1 -- ut310--------
    rs1901854831,2
    --201838991(+) CATATA/GAAAGT 1 -- ut310--------
    rs1392785751,2
    C--201839252(+) CATGGA/GGCATA 1 -- ut310--------
    rs1928372931,2
    --201839335(+) GTGATG/TGTTAG 1 -- ut310--------
    rs1499779181,2
    C--201839440(+) GAACAC/TCAATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM126B (201838441 - 201936394 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM126B: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FAM126B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM126B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM126B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM126B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    8. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285172 HGNC: 28593 AceView: MGC39518 Ensembl:ENSG00000155744 euGenes: HUgn285172
    ECgene: FAM126B H-InvDB: FAM126B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM126B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM126B gene:
    Search GeneIP for patents involving FAM126B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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