FAM126B Gene
protein-coding GIFtS: 38
GCID: GC02M201838
|
|
family with sequence similarity 126, member B
| |
Aliases
for FAM126B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 126, Member B1 2 | | HYCC21 2 | | MGC395181 | | Protein FAM126B2 |
Export aliases for FAM126B gene to outside databasesPrevious GC identifers: GC02M201551 GC02M193689 |
Summaries
for FAM126B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM126B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM126B gene promoter:
AML1a NF-YA NF-YB HEN1 CBF-B CBF-A CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM126B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM126B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.1 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33.1FAM126B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M201838: view genomic region
(about GC identifiers)
Start:
|
201,838,441 bp from pter |
End:
|
201,936,394 bp from pter |
Size:
|
97,954 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM126B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F126B_HUMAN, Q8IXS8 (See
protein sequence)Recommended Name: Protein FAM126B Size: 530 amino acids; 58647 Da
Secondary accessions: B2RCG7 Q4ZG87 Q53TX6Explore the universe of human proteins at neXtProt for FAM126B: NX_Q8IXS8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IXS8
FAM126B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_776183.1
ENSEMBL proteins: ENSP00000286181 ENSP00000393667 ENSP00000401905 ENSP00000408374 ENSP00000412139
Human Recombinant Protein Products for FAM126B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IDA | -- |
FAM126B for ontologies About GeneDecksing
FAM126B Antibody Products:
Assay Products for FAM126B: |
Protein
Domains /
Families
for FAM126B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM126B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IXS8ProtoNet protein and cluster: Q8IXS8 UniProtKB/Swiss-Prot: F126B_HUMAN, Q8IXS8Similarity: Belongs to the FAM126 family |
Function
for FAM126B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM126B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM126B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM126B (NM_173822) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM126B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM126B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM126B |
|
Pathways & Interactions
for FAM126B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM126B
|
Drugs & Compounds
for FAM126B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM126B
Search CenterWatch for drugs/clinical trials and news about FAM126B / F126B
|
Transcripts
for FAM126B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM126B gene: NM_173822.3 Unigene Cluster for FAM126B: Family with sequence similarity 126, member B Hs.24701 [show with all ESTs]Unigene Representative Sequence: NM_17382211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000286181(uc002uws.4 uc002uwu.3 uc002uwv.3) ENST00000418596
ENST00000490725 ENST00000498780(uc002uww.1) ENST00000452799 ENST00000453765
ENST00000446678 ENST00000485144 ENST00000474118 ENST00000485636 ENST00000494881
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM126B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM126B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM126B (NM_173822) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM126B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM126B |
Additional cDNA sequence: AK001843.1 AK027168.1 AK095236.1 AK097111.1 AK315104.1 AL832234.1 AL832346.1 AL833403.1 BC039295.1 BC045174.1 13 DOTS entries: DT.100022836 DT.424630 DT.211018 DT.120963371 DT.120963513 DT.101960781 DT.75175601 DT.100734335 DT.100668210 DT.40235183 DT.101971173 DT.120963504 DT.91841399 24/72 AceView cDNA sequences (see all 72): BQ011934 AA908691 CF994205 BM476462 AA513678 BU625415 CD652505 BM722708 AK097111 AA506467 BQ707542 BX484023 CK822031 Z46120 AL833403 AI241712 AA906711 AW001876 BX282063 AL832234 BU102051 AA721488 AA507260 BC039295
GeneLoc Exon Structure
|
Expression
for FAM126B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM126B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGCCATTA
About this image
See FAM126B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM126B
SOURCE GeneReport for Unigene cluster: Hs.24701
SABiosciences Custom PCR Arrays for FAM126B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM126B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM126B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM126B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM126B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM126B |
Orthologs
for FAM126B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM126B gene from 7/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fam126b1 , 5 |
family with sequence similarity 126, member B1, 5 |
91.82(n)1
95.28(a)1 |
|
1 (29.12 cM)5
2130561 NM_172513.31 NP_766101.31
585228065 |
chicken
(Gallus gallus) |
Aves |
FAM126B1 |
family with sequence similarity 126, member B |
82.2(n)
89.62(a) |
|
429010 XM_426567.3 XP_426567.2 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM126B6 |
-- |
87(a) |
1 ↔ 1 |
GL343478.1(483459-506066) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ068472.12 |
-- |
81.07(n) |
|
BJ068472.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.163172 |
Transcribed sequence with weak similarity to protein more |
74.05(n) |
|
CD754331.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG64066 |
-- |
23(a) |
1 → many |
2R(13621924-13624769) |
worm
(Caenorhabditis elegans) |
Secernentea |
D1069.36 |
Protein D1069.3, isoform b |
18(a) |
1 → many |
II(342137-347865) |
ENSEMBL Gene Tree for FAM126B (if available)
TreeFam Gene Tree for FAM126B (if available) |
Paralogs
for FAM126B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM126B gene
- FAM126A2
2 SIMAP similar genes for FAM126B using alignment to 5 protein entries: F126B_HUMAN (see all proteins):MGC39518 FAM126A
FAM126B for paralogs About GeneDecksing
|
Genomic Variants
for FAM126B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM126B (201838441 - 201936394 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM126B: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FAM126B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM126B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM126B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM126B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
|
External Searches for FAM126B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM126B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM126B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM126B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM126B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM126B gene:
Search GeneIP for patents involving FAM126B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM126B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM126B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM126B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM126B | | | OriGene Protein Over-expression Lysate for FAM126B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM126B | | OriGene 3'-UTR Clone for FAM126B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM126B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM126B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM126B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM126B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM126B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM126B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM126B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM126B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM126B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM126B |
| |  |  |  |  | | | | |
 |
 |
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 | | | FAM126B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM126B |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FAM126B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM126B |
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