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Aliases for FAM126B Gene

Aliases for FAM126B Gene

  • Family With Sequence Similarity 126, Member B 2 3
  • Protein FAM126B 3
  • HYCC2 3

External Ids for FAM126B Gene

Previous GeneCards Identifiers for FAM126B Gene

  • GC02M201551
  • GC02M201838
  • GC02M193689

Summaries for FAM126B Gene

GeneCards Summary for FAM126B Gene

FAM126B (Family With Sequence Similarity 126, Member B) is a Protein Coding gene. An important paralog of this gene is FAM126A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM126B Gene

Genomics for FAM126B Gene

Regulatory Elements for FAM126B Gene

Genomic Location for FAM126B Gene

200,973,718 bp from pter
201,071,671 bp from pter
97,954 bases
Minus strand

Genomic View for FAM126B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM126B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM126B Gene

Proteins for FAM126B Gene

  • Protein details for FAM126B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM126B
    Protein Accession:
    Secondary Accessions:
    • B2RCG7
    • Q4ZG87
    • Q53TX6

    Protein attributes for FAM126B Gene

    530 amino acids
    Molecular mass:
    58647 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM126B Gene

Proteomics data for FAM126B Gene at MOPED

Post-translational modifications for FAM126B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM126B Gene

No data available for DME Specific Peptides for FAM126B Gene

Domains for FAM126B Gene

Protein Domains for FAM126B Gene


Suggested Antigen Peptide Sequences for FAM126B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IXS8
  • Belongs to the FAM126 family.
genes like me logo Genes that share domains with FAM126B: view

No data available for Gene Families for FAM126B Gene

Function for FAM126B Gene

Gene Ontology (GO) - Molecular Function for FAM126B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM126B: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM126B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM126B Gene

Localization for FAM126B Gene

Subcellular locations from

Jensen Localization Image for FAM126B Gene COMPARTMENTS Subcellular localization image for FAM126B gene
Compartment Confidence
nucleus 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM126B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with FAM126B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM126B Gene

Pathways for FAM126B Gene

SuperPathways for FAM126B Gene

No Data Available

Interacting Proteins for FAM126B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000393667 Q8IXS8-F126B_HUMAN for FAM126B Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for FAM126B Gene


No data available for Pathways by source for FAM126B Gene

Transcripts for FAM126B Gene

Unigene Clusters for FAM126B Gene

Family with sequence similarity 126, member B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM126B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM126B Gene

No ASD Table

Relevant External Links for FAM126B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM126B Gene

mRNA expression in normal human tissues for FAM126B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM126B Gene

This gene is overexpressed in Whole Blood (5.5).

Protein differential expression in normal tissues for FAM126B Gene

This gene is overexpressed in Retina (19.7), Peripheral blood mononuclear cells (15.5), Frontal cortex (12.3), Placenta (11.2), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FAM126B Gene

SOURCE GeneReport for Unigene cluster for FAM126B Gene Hs.24701

genes like me logo Genes that share expressions with FAM126B: view

Expression partners for FAM126B Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM126B Gene

Orthologs for FAM126B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM126B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM126B 35
  • 94.21 (n)
  • 96.04 (a)
FAM126B 36
  • 97 (a)
(Canis familiaris)
Mammalia FAM126B 35
  • 94.91 (n)
  • 96.6 (a)
FAM126B 36
  • 88 (a)
(Mus musculus)
Mammalia Fam126b 35
  • 91.82 (n)
  • 95.28 (a)
Fam126b 16
Fam126b 36
  • 95 (a)
(Pan troglodytes)
Mammalia FAM126B 35
  • 99.87 (n)
  • 100 (a)
FAM126B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam126b 35
  • 90.99 (n)
  • 95.6 (a)
(Monodelphis domestica)
Mammalia FAM126B 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia FAM126B 36
  • 81 (a)
(Gallus gallus)
Aves FAM126B 35
  • 82.2 (n)
  • 89.62 (a)
FAM126B 36
  • 89 (a)
(Anolis carolinensis)
Reptilia FAM126B 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam126b 35
  • 75.17 (n)
  • 80.38 (a)
(Danio rerio)
Actinopterygii Dr.16317 35
LOC100536464 35
  • 65.05 (n)
  • 69.35 (a)
FAM126B (1 of 3) 36
  • 55 (a)
FAM126B (2 of 3) 36
  • 71 (a)
FAM126B (3 of 3) 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6406 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea D1069.3 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for FAM126B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM126B Gene

Gene Tree for FAM126B (if available)
Gene Tree for FAM126B (if available)

Paralogs for FAM126B Gene

Paralogs for FAM126B Gene

Selected SIMAP similar genes for FAM126B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM126B: view

Variants for FAM126B Gene

Sequence variations from dbSNP and Humsavar for FAM126B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1344480 -- 201,047,559(-) gtcat(C/G)agttt intron-variant
rs3731716 -- 200,980,680(-) TCCAC(A/C)CCCCC utr-variant-3-prime
rs3731717 -- 200,980,570(-) GATAA(G/T)GCACT utr-variant-3-prime
rs3890557 -- 201,009,646(+) gtaga(C/G)acgcg intron-variant
rs3900738 -- 200,999,080(-) TCTAG(G/T)CAGGT intron-variant

Relevant External Links for FAM126B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM126B Gene

Disorders for FAM126B Gene

No disorders were found for FAM126B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM126B Gene

Publications for FAM126B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  5. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3

Products for FAM126B Gene

Sources for FAM126B Gene

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