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Aliases for FAM124B Gene

Aliases for FAM124B Gene

  • Family With Sequence Similarity 124B 2 3

External Ids for FAM124B Gene

Previous GeneCards Identifiers for FAM124B Gene

  • GC02M224951
  • GC02M224806
  • GC02M225243
  • GC02M217095

Summaries for FAM124B Gene

GeneCards Summary for FAM124B Gene

FAM124B (Family With Sequence Similarity 124B) is a Protein Coding gene. Diseases associated with FAM124B include charge syndrome. An important paralog of this gene is FAM124A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM124B Gene

Genomics for FAM124B Gene

Regulatory Elements for FAM124B Gene

Genomic Location for FAM124B Gene

224,378,698 bp from pter
224,402,085 bp from pter
23,388 bases
Minus strand

Genomic View for FAM124B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM124B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM124B Gene

Proteins for FAM124B Gene

  • Protein details for FAM124B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM124B
    Protein Accession:
    Secondary Accessions:
    • A6NNC7
    • Q8NBZ4
    • Q8TAV7

    Protein attributes for FAM124B Gene

    455 amino acids
    Molecular mass:
    50961 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15471.1; Type=Frameshift; Positions=264; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM124B Gene


neXtProt entry for FAM124B Gene

Proteomics data for FAM124B Gene at MOPED

Post-translational modifications for FAM124B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM124B Gene

No data available for DME Specific Peptides for FAM124B Gene

Domains & Families for FAM124B Gene

Protein Domains for FAM124B Gene


Suggested Antigen Peptide Sequences for FAM124B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM124 family.
  • Belongs to the FAM124 family.
genes like me logo Genes that share domains with FAM124B: view

No data available for Gene Families for FAM124B Gene

Function for FAM124B Gene

Gene Ontology (GO) - Molecular Function for FAM124B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FAM124B: view

Phenotypes for FAM124B Gene

GenomeRNAi human phenotypes for FAM124B:
genes like me logo Genes that share phenotypes with FAM124B: view

Animal Model Products

CRISPR Products

miRNA for FAM124B Gene

miRTarBase miRNAs that target FAM124B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM124B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM124B Gene

Localization for FAM124B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM124B Gene

Pathways & Interactions for FAM124B Gene

SuperPathways for FAM124B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM124B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM124B Gene

Drugs & Compounds for FAM124B Gene

No Compound Related Data Available

Transcripts for FAM124B Gene

mRNA/cDNA for FAM124B Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM124B Gene

Family with sequence similarity 124B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM124B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM124B Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP2: -

Relevant External Links for FAM124B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM124B Gene

mRNA expression in normal human tissues for FAM124B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM124B Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM124B Gene

SOURCE GeneReport for Unigene cluster for FAM124B Gene Hs.147585

genes like me logo Genes that share expression patterns with FAM124B: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM124B Gene

Orthologs for FAM124B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM124B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM124B 35
  • 81.04 (n)
  • 74.94 (a)
FAM124B 36
  • 73 (a)
(Canis familiaris)
Mammalia FAM124B 35
  • 79.62 (n)
  • 72.19 (a)
FAM124B 36
  • 71 (a)
(Mus musculus)
Mammalia Fam124b 35
  • 75.38 (n)
  • 65.45 (a)
Fam124b 16
Fam124b 36
  • 64 (a)
(Pan troglodytes)
Mammalia FAM124B 35
  • 99.05 (n)
  • 98.46 (a)
FAM124B 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fam124b 35
  • 75.98 (n)
  • 66.59 (a)
(Monodelphis domestica)
Mammalia FAM124B 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia FAM124B 36
  • 51 (a)
(Gallus gallus)
Aves FAM124B 35
  • 64.41 (n)
  • 57.82 (a)
FAM124B 36
  • 1 (a)
(Anolis carolinensis)
Reptilia FAM124B 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam124b 35
  • 54.91 (n)
  • 46.11 (a)
Str.19998 35
(Danio rerio)
Actinopterygii LOC572460 35
  • 54.9 (n)
  • 48.18 (a)
FAM124B 36
  • 38 (a)
Species with no ortholog for FAM124B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM124B Gene

Gene Tree for FAM124B (if available)
Gene Tree for FAM124B (if available)

Paralogs for FAM124B Gene

Paralogs for FAM124B Gene

(1) SIMAP similar genes for FAM124B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM124B: view

Variants for FAM124B Gene

Sequence variations from dbSNP and Humsavar for FAM124B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs741533 -- 224,395,901(+) AGGAG(C/T)TTCTA intron-variant
rs741534 -- 224,395,879(+) GCACC(A/G/T)CAGTT intron-variant
rs2216460 -- 224,382,770(-) GCTGC(G/T)CTAAT intron-variant
rs2543658 -- 224,394,827(-) TGTGT(A/T)GGGAA intron-variant
rs2543659 -- 224,390,297(-) GGGCC(A/G)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM124B Gene

Variant ID Type Subtype PubMed ID
nsv875903 CNV Loss 21882294

Variation tolerance for FAM124B Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM124B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM124B Gene

Disorders for FAM124B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM124B Gene - From: DISEASES

Disorder Aliases PubMed IDs
charge syndrome
  • charge association
- elite association

Relevant External Links for FAM124B

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM124B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM124B Gene

Publications for FAM124B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex. (PMID: 23285124) Batsukh T. … Pauli S. (PLoS ONE 2012) 67
  4. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 67
  5. Shifted Transversal Design smart-pooling for high coverage interactome mapping. (PMID: 19447967) Xin X. … Thierry-Mieg N. (Genome Res. 2009) 67

Products for FAM124B Gene

Sources for FAM124B Gene

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