Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM124A Gene

Aliases for FAM124A Gene

  • Family With Sequence Similarity 124 Member A 2 3 5
  • Family With Sequence Similarity 124A 2

External Ids for FAM124A Gene

Previous GeneCards Identifiers for FAM124A Gene

  • GC13P050695
  • GC13P051796
  • GC13P032585

Summaries for FAM124A Gene

GeneCards Summary for FAM124A Gene

FAM124A (Family With Sequence Similarity 124 Member A) is a Protein Coding gene. An important paralog of this gene is FAM124B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM124A Gene

Genomics for FAM124A Gene

Regulatory Elements for FAM124A Gene

Enhancers for FAM124A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G051243 1.1 ENCODE dbSUPER 18.3 +22.0 22032 2.7 CTCF HDGF ATF1 PKNOX1 PTBP1 TEAD4 CHD7 ZNF664 CTBP1 POLR2A FAM124A GC13P051237 GC13P051260
GH13G051225 0.6 FANTOM5 dbSUPER 23.8 +3.7 3664 0.0 PRDM1 FAM124A DLEU7 GC13P051237
GH13G051255 0.8 ENCODE dbSUPER 17 +33.4 33406 0.2 SMARCA4 POLR2A ZNF341 GLIS1 ZIC2 FAM124A GC13P051260 GC13P051237
GH13G051286 1.1 Ensembl ENCODE dbSUPER 11.6 +64.2 64196 0.4 CTCF ZNF654 SUZ12 TRIM22 REST RAD21 SMC3 ZNF143 FAM124A CCDC70 GC13P051260 SERPINE3
GH13G051330 1.1 Ensembl ENCODE 10.3 +108.8 108773 1.0 PKNOX1 BMI1 SCRT2 ZNF207 RELB IKZF2 CREM EGR2 CBFB JUNB FAM124A ENSG00000231856 DHRS12 SERPINE3 GC13P051260
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM124A on UCSC Golden Path with GeneCards custom track

Promoters for FAM124A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000272086 -433 200 INSM2 KLF17 FEZF1 GLI4 ZNF2 GLIS2 ZNF354C KLF7 ZNF391 EGR2
ENSR00000062973 466 1201 ARNT ZSCAN4 INSM2 KLF17 FEZF1 GLI4 ZNF2 RAD21 GLIS2 ZNF354C

Genomic Location for FAM124A Gene

51,222,334 bp from pter
51,284,241 bp from pter
61,908 bases
Plus strand

Genomic View for FAM124A Gene

Genes around FAM124A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM124A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM124A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM124A Gene

Proteins for FAM124A Gene

  • Protein details for FAM124A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM124A
    Protein Accession:
    Secondary Accessions:
    • A2A324
    • Q8N8P9
    • Q8NE66
    • Q96NJ9

    Protein attributes for FAM124A Gene

    546 amino acids
    Molecular mass:
    60104 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34497.1; Type=Frameshift; Positions=286; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM124A Gene


neXtProt entry for FAM124A Gene

Post-translational modifications for FAM124A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM124A Gene

No data available for DME Specific Peptides for FAM124A Gene

Domains & Families for FAM124A Gene

Protein Domains for FAM124A Gene


Suggested Antigen Peptide Sequences for FAM124A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM124 family.
  • Belongs to the FAM124 family.
genes like me logo Genes that share domains with FAM124A: view

No data available for Gene Families for FAM124A Gene

Function for FAM124A Gene

Gene Ontology (GO) - Molecular Function for FAM124A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM124A: view

Phenotypes for FAM124A Gene

GenomeRNAi human phenotypes for FAM124A:
genes like me logo Genes that share phenotypes with FAM124A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM124A Gene

Localization for FAM124A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM124A gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM124A Gene

Pathways & Interactions for FAM124A Gene

SuperPathways for FAM124A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM124A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM124A Gene

Drugs & Compounds for FAM124A Gene

No Compound Related Data Available

Transcripts for FAM124A Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM124A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for FAM124A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM124A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM124A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM124A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2).

Protein differential expression in normal tissues from HIPED for FAM124A Gene

This gene is overexpressed in Monocytes (18.0), Spleen (11.1), Uterus (7.7), and Lymph node (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM124A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM124A Gene:


SOURCE GeneReport for Unigene cluster for FAM124A Gene:


Evidence on tissue expression from TISSUES for FAM124A Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with FAM124A: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM124A Gene

Orthologs for FAM124A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM124A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM124A 34 35
  • 99.54 (n)
(Canis familiaris)
Mammalia FAM124A 34 35
  • 86.88 (n)
(Bos Taurus)
Mammalia FAM124A 34 35
  • 82.29 (n)
(Mus musculus)
Mammalia Fam124a 34 16 35
  • 79.23 (n)
(Rattus norvegicus)
Mammalia Fam124a 34
  • 78.79 (n)
(Ornithorhynchus anatinus)
Mammalia FAM124A 35
  • 72 (a)
(Monodelphis domestica)
Mammalia FAM124A 35
  • 65 (a)
(Gallus gallus)
Aves FAM124A 34 35
  • 63.69 (n)
(Anolis carolinensis)
Reptilia FAM124A 35
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam124a 34
  • 60.03 (n)
(Danio rerio)
Actinopterygii LOC556683 34
  • 56.03 (n)
FAM124A 35
  • 39 (a)
Species where no ortholog for FAM124A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM124A Gene

Gene Tree for FAM124A (if available)
Gene Tree for FAM124A (if available)

Paralogs for FAM124A Gene

Paralogs for FAM124A Gene

(1) SIMAP similar genes for FAM124A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM124A: view

Variants for FAM124A Gene

Sequence variations from dbSNP and Humsavar for FAM124A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000043224 -- 51,227,988(+) TATAG(A/G)AGACC intron-variant
rs1000083001 -- 51,246,408(+) GTGGG(C/G/T)GGGGG intron-variant
rs1000143233 -- 51,272,928(+) ACAGA(A/G)TTCTA intron-variant
rs1000160926 -- 51,241,302(+) TCTGC(A/G)TCATT intron-variant
rs1000225685 -- 51,259,164(+) GAACC(A/C)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM124A Gene

Variant ID Type Subtype PubMed ID
esv2747418 CNV deletion 23290073
esv3550464 CNV deletion 23714750
nsv1069753 CNV deletion 25765185
nsv1118264 CNV deletion 24896259
nsv1145663 CNV deletion 24896259
nsv561618 CNV loss 21841781
nsv832610 CNV gain 17160897
nsv832611 CNV loss 17160897

Variation tolerance for FAM124A Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM124A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM124A Gene

Disorders for FAM124A Gene

Relevant External Links for FAM124A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM124A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM124A Gene

Publications for FAM124A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 64
  4. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. (PMID: 24532677) Bossini-Castillo L. … Koeleman B.P. (Ann. Rheum. Dis. 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FAM124A Gene

Sources for FAM124A Gene

Loading form....