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Aliases for FAM124A Gene

Aliases for FAM124A Gene

  • Family With Sequence Similarity 124A 2 3

External Ids for FAM124A Gene

Summaries for FAM124A Gene

GeneCards Summary for FAM124A Gene

FAM124A (Family With Sequence Similarity 124A) is a Protein Coding gene. An important paralog of this gene is FAM124B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM124A Gene

Genomics for FAM124A Gene

Genomic Location for FAM124A Gene

Start:
51,222,334 bp from pter
End:
51,284,241 bp from pter
Size:
61,908 bases
Orientation:
Plus strand

Genomic View for FAM124A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM124A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM124A Gene

Regulatory Elements for FAM124A Gene

Proteins for FAM124A Gene

  • Protein details for FAM124A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V42-F124A_HUMAN
    Recommended name:
    Protein FAM124A
    Protein Accession:
    Q86V42
    Secondary Accessions:
    • A2A324
    • Q8N8P9
    • Q8NE66
    • Q96NJ9

    Protein attributes for FAM124A Gene

    Size:
    546 amino acids
    Molecular mass:
    60104 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34497.1; Type=Frameshift; Positions=286; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM124A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM124A Gene

Proteomics data for FAM124A Gene at MOPED

Post-translational modifications for FAM124A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM124A Gene

No data available for DME Specific Peptides for FAM124A Gene

Domains for FAM124A Gene

Protein Domains for FAM124A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

F124A_HUMAN
Family:
  • Belongs to the FAM124 family.:
    • Q86V42
genes like me logo Genes that share domains with FAM124A: view

No data available for Gene Families for FAM124A Gene

Function for FAM124A Gene

Gene Ontology (GO) - Molecular Function for FAM124A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM124A: view

Phenotypes for FAM124A Gene

GenomeRNAi human phenotypes for FAM124A:
genes like me logo Genes that share phenotypes with FAM124A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM124A Gene

Localization for FAM124A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM124A Gene COMPARTMENTS Subcellular localization image for FAM124A gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FAM124A Gene

Pathways for FAM124A Gene

SuperPathways for FAM124A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM124A Gene

None

No data available for Pathways by source for FAM124A Gene

Transcripts for FAM124A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FAM124A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for FAM124A Gene

GeneLoc Exon Structure for
FAM124A
ECgene alternative splicing isoforms for
FAM124A

Expression for FAM124A Gene

mRNA expression in normal human tissues for FAM124A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM124A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM124A Gene

SOURCE GeneReport for Unigene cluster for FAM124A Gene Hs.71913

genes like me logo Genes that share expressions with FAM124A: view

Orthologs for FAM124A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM124A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM124A 36
  • 99.54 (n)
  • 99.66 (a)
FAM124A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM124A 36
  • 82.29 (n)
  • 76.47 (a)
FAM124A 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM124A 36
  • 86.88 (n)
  • 85.92 (a)
FAM124A 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam124a 36
  • 79.23 (n)
  • 74.63 (a)
Fam124a 16
Fam124a 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM124A 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM124A 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam124a 36
  • 78.79 (n)
  • 74.63 (a)
chicken
(Gallus gallus)
Aves FAM124A 36
  • 63.69 (n)
  • 62.13 (a)
FAM124A 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM124A 37
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam124a 36
  • 60.03 (n)
  • 57.77 (a)
zebrafish
(Danio rerio)
Actinopterygii FAM124A 37
  • 39 (a)
OneToOne
LOC556683 36
  • 56.03 (n)
  • 52.26 (a)
Species with no ortholog for FAM124A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM124A Gene

ENSEMBL:
Gene Tree for FAM124A (if available)
TreeFam:
Gene Tree for FAM124A (if available)

Paralogs for FAM124A Gene

Paralogs for FAM124A Gene

Selected SIMAP similar genes for FAM124A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM124A: view

Variants for FAM124A Gene

Sequence variations from dbSNP and Humsavar for FAM124A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs12540 -- 51,284,011(+) GGGAG(A/C)GGATG utr-variant-3-prime
rs15652 -- 51,253,470(+) CATTT(A/G)CTCTA intron-variant
rs729483 -- 51,234,106(-) AGGAA(C/T)CAGGA intron-variant
rs729484 -- 51,233,912(-) CCCTG(C/T)AACTA intron-variant
rs751702 -- 51,274,241(+) GAGTC(A/G)CTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM124A Gene

Variant ID Type Subtype PubMed ID
nsv832610 CNV Gain 17160897
nsv832611 CNV Loss 17160897
esv2747418 CNV Deletion 23290073

Relevant External Links for FAM124A Gene

HapMap Linkage Disequilibrium report
FAM124A

Disorders for FAM124A Gene

Relevant External Links for FAM124A

Genetic Association Database (GAD)
FAM124A
Human Genome Epidemiology (HuGE) Navigator
FAM124A
genes like me logo Genes that share disorders with FAM124A: view

No data available for UniProtKB/Swiss-Prot for FAM124A Gene

Publications for FAM124A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. (PMID: 24532677) Bossini-Castillo L. … Koeleman B.P. (Ann. Rheum. Dis. 2015) 3

Products for FAM124A Gene

Sources for FAM124A Gene

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