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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM124A Gene

protein-coding GIFtS: 45
GCID: GC13P051796

family with sequence similarity 124A

Search for FAM124A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 124A¹ ²
FLJ30707¹
Protein FAM124A²

External Ids:	HGNC: 26413¹	Entrez Gene: 220108²	Ensembl: ENSG00000150510⁷	UniProtKB: Q86V42³

Export aliases for FAM124A gene to outside databases

Previous GC identifers: GC13P050695 GC13P032585

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM124A gene promoter:
AML1a Pbx1a NF-AT NF-AT4 NF-AT2 FOXJ2 (long isoform) NF-AT3 FOXJ2 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM124A promoter sequence

Search SABiosciences Chromatin IP Primers for FAM124A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM124A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.3

FAM124A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM124A gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P051796: view genomic region (about GC identifiers)

Start:	51,796,503 bp from pter	End:	51,857,930 bp from pter
Size:	61,428 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F124A_HUMAN, Q86V42 (See protein sequence)

Recommended Name: Protein FAM124A

Size: 546 amino acids; 60104 Da

Sequence caution: Sequence=AAH34497.1; Type=Frameshift; Positions=286;

Secondary accessions: A2A324 Q8N8P9 Q8NE66 Q96NJ9

Alternative splicing: 3 isoforms: Q86V42-1 Q86V42-2 Q86V42-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM124A: NX_Q86V42

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86V42

FAM124A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001229241.1 NP_659456.3

ENSEMBL proteins:

ENSP00000324625 ENSP00000280057

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q86V42

UniProtKB/Swiss-Prot: F124A_HUMAN, Q86V42

Similarity: Belongs to the FAM124 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
Products:

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1 GenomeRNAi human phenotype for FAM124A:

Increased cell number in G2M,

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM124A

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/9 Interacting proteins for FAM124A (Q86V42^{2, 3} ENSP00000280057⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RBM10	P98175³, ENSP00000366829⁴	I2D: score=2 STRING: ENSP00000366829
NKAP	Q8N5F7³, ENSP00000360464⁴	I2D: score=2 STRING: ENSP00000360464
ZNF165	P49910³	I2D: score=2
BEND7	Q8N7W2³	I2D: score=1
CCDC33	Q8N5R6³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM124A
Search CenterWatch for drugs/clinical trials and news about FAM124A / F124A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for FAM124A gene (2 alternative transcripts):

NM_001242312.1 NM_145019.3

Unigene Clusters for FAM124A:

Family with sequence similarity 124A

Hs.71913 [show with all ESTs], Hs.737490 [show with all ESTs]

Unigene Representative Sequences: NM_001242312, NM_145019

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000322475(uc001vfe.3 uc001vff.2 uc001vfg.2) ENST00000280057

ENST00000497449

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM124A
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM124A (see all 29):
		hsa-miR-485-5p hsa-miR-30c hsa-miR-579 hsa-miR-3607-3p hsa-miR-607 hsa-miR-448 hsa-miR-29a hsa-miR-29c

		SwitchGear 3'UTR luciferase reporter plasmid: FAM124A 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM124A OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM124A (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM124A

Additional cDNA sequence:

AK056643.1 AK096364.1 AY358177.1

5 DOTS entries:

DT.75192811 DT.210791 DT.110953 DT.100019354 DT.311440

24/92 AceView cDNA sequences (see all 92):

AI613106 CB156709 BM684001 BF001835 AI203198 BC051771 BX098663 D59503

AA999894 AK096364 BU186359 AW025774 BQ019601 BM931534 AK055269 AI142125

NM_145019 AW183327 BF339192 AI636688 AA366478 AI498066 BX477750 AI631980

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM124A About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b
SP1:									-
SP2:			-						-
SP3:

ECgene alternative splicing isoforms for FAM124A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM124A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCACCATT

About this image

FAM124A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM124A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM124A

SOURCE GeneReport for Unigene clusters: Hs.71913 Hs.737490

SABiosciences Custom PCR Arrays for FAM124A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM124A Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM124A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM124A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM124A gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fam124a^{1 , 5}	family with sequence similarity 124, member A^{1, 5}	79.04(n)¹ 74.63(a)¹		14 (33.23 cM)⁵ 629059¹ NM_001243857.1¹ NP_001230786.1¹ 62555737⁵
chicken (Gallus gallus)	Aves	FAM124A¹	family with sequence similarity 124A	61.45(n) 59.2(a)		770395 XM_001233731.2 XP_001233732.2
lizard (Anolis carolinensis)	Reptilia	FAM124A⁶	--	54(a)	1 ↔ 1	1(140106429-140115771)
zebrafish (Danio rerio)	Actinopterygii	LOC556683¹	protein FAM124A-like	54.27(n) 50.94(a)		556683 XM_001922340.3 XP_001922375.3

ENSEMBL Gene Tree for FAM124A (if available)
TreeFam Gene Tree for FAM124A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM124A gene

FAM124B²

1 SIMAP similar gene for FAM124A using alignment to 1 protein entry: F124A_HUMAN:

FAM124B

FAM124A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4942974^1,2	C,F,H,	--	51794555(+)	`CACTTC/GAAGGT`	2	--	us2k¹ tfbs³		24		NS EA WA NA CSA	2275
rs114353625^1,2	F,	--	51794558(+)	`TTGAAG/AGTTCT`	2	--	us2k¹		1		WA	118
rs191179572^1,2		--	51794594(+)	`TTATAC/TCCCGC`	2	--	us2k¹		0	--	--	--	--
rs116466771^1,2	F,	--	51794598(+)	`ACCCCG/ACCCTC`	2	--	us2k¹		1		WA	118
rs115695700^1,2	F,	--	51794628(+)	`CAATGC/GCTCAT`	2	--	us2k¹		1		WA	118
rs114096971^1,2	F,	--	51794633(+)	`CCTCAT/CGCCTA`	2	--	us2k¹		1		WA	118
rs149351846^1,2		--	51794661(+)	`GAGGCC/TGAGGC`	2	--	us2k¹		0	--	--	--	--
rs182977734^1,2		--	51794694(+)	`AGTTCA/GAGACC`	2	--	us2k¹		0	--	--	--	--
rs188382513^1,2		--	51794713(+)	`CAACAC/TATTTT`	2	--	us2k¹		0	--	--	--	--
rs192876629^1,2		--	51794842(+)	`GTGCCA/TCTGTA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM124A (51796503 - 51857930 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM124A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM124A

DNA2.0 Custom Variant and Variant Library Synthesis for FAM124A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM124A for disorders About MalaCards

FAM124A for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: FAM124A (1 document)

Export disorders for FAM124A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM124A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM124A)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 3} Clark H.F.... Gray A.M. (2003)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)² Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 220108	HGNC: 26413	AceView: FLJ30707	Ensembl:ENSG00000150510	euGenes: HUgn220108
ECgene: FAM124A	H-InvDB: FAM124A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM124A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM124A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM124A gene:
Search GeneIP for patents involving FAM124A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM124A

	SwitchGear 3'UTR luciferase reporter plasmids for FAM124A
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ThermoFisher Antibodies for FAM124A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM124A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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FAM124A Gene

family with sequence similarity 124A

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Export list of displayed genes

FAM124A Gene

family with sequence similarity 124A

Aliasesfor FAM124A gene

Summariesfor FAM124A gene

Genomic Viewsfor FAM124A gene

Proteinsfor FAM124A gene

Protein Domains /Familiesfor FAM124A gene

Functionfor FAM124A gene

Pathways & Interactionsfor FAM124A gene

Drugs & Compoundsfor FAM124A gene

Transcriptsfor FAM124A gene

Expression for FAM124A gene

Orthologsfor FAM124A gene

Paralogsfor FAM124A gene

Genomic Variantsfor FAM124A gene

Disorders / Diseasesfor FAM124A gene

Publicationsfor FAM124A gene

External Searches for FAM124A gene

Genome Databases showing FAM124A gene

Other Databases showing FAM124A gene

Specialized Databases showing FAM124A gene

Intellectual Propertyfor FAM124A gene

Productsfor FAM124A gene

View Random Gene

Aliases
for FAM124A gene

Summaries
for FAM124A gene

Genomic Views
for FAM124A gene

Proteins
for FAM124A gene

Protein Domains /
Families
for FAM124A gene

Function
for FAM124A gene

Pathways & Interactions
for FAM124A gene

Drugs & Compounds
for FAM124A gene

Transcripts
for FAM124A gene

Expression
for FAM124A gene

Orthologs
for FAM124A gene

Paralogs
for FAM124A gene

Genomic Variants
for FAM124A gene

Disorders / Diseases
for FAM124A gene

Publications
for FAM124A gene

Intellectual Property
for FAM124A gene

Products
for FAM124A gene