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Aliases for FAM122C Gene

Aliases for FAM122C Gene

  • Family With Sequence Similarity 122C 2 3 5

External Ids for FAM122C Gene

Previous GeneCards Identifiers for FAM122C Gene

  • GC0XP133768
  • GC0XP133941
  • GC0XP123328

Summaries for FAM122C Gene

GeneCards Summary for FAM122C Gene

FAM122C (Family With Sequence Similarity 122C) is a Protein Coding gene. An important paralog of this gene is FAM122A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM122C Gene

Genomics for FAM122C Gene

Regulatory Elements for FAM122C Gene

Enhancers for FAM122C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG134795 1 ENCODE 5.2 +0.4 385 2.2 ATF1 CREB3L1 ARID4B SIN3A DMAP1 GLI4 GLIS2 KDM4B ZNF263 SP3 RPL36AP54 FAM122C FAM122B
GH0XG134806 1 ENCODE 5.1 +11.0 11037 1.8 HDGF PKNOX1 ATF1 ARID4B SIN3A BRCA1 YY1 TCF12 GATA2 ZHX2 FAM122C ENSG00000280249 GC0XP134858
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM122C on UCSC Golden Path with GeneCards custom track

Promoters for FAM122C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248975 587 1601 CREB3L1 ARID4B SIN3A DMAP1 GLI4 GLIS2 KDM4B ZNF263 SP3 NFYC

Genomic Location for FAM122C Gene

134,796,413 bp from pter
134,855,135 bp from pter
58,723 bases
Plus strand

Genomic View for FAM122C Gene

Genes around FAM122C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM122C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM122C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM122C Gene

Proteins for FAM122C Gene

  • Protein details for FAM122C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM122C
    Protein Accession:
    Secondary Accessions:
    • F5H036
    • Q8WVK9

    Protein attributes for FAM122C Gene

    195 amino acids
    Molecular mass:
    22522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM122C Gene


neXtProt entry for FAM122C Gene

Post-translational modifications for FAM122C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM122C Gene

Domains & Families for FAM122C Gene

Protein Domains for FAM122C Gene


Suggested Antigen Peptide Sequences for FAM122C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM122 family.
  • Belongs to the FAM122 family.
genes like me logo Genes that share domains with FAM122C: view

No data available for Gene Families for FAM122C Gene

Function for FAM122C Gene

genes like me logo Genes that share phenotypes with FAM122C: view

Animal Model Products

CRISPR Products

miRNA for FAM122C Gene

miRTarBase miRNAs that target FAM122C

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM122C Gene

Localization for FAM122C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM122C gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM122C Gene

Pathways & Interactions for FAM122C Gene

SuperPathways for FAM122C Gene

No Data Available

Interacting Proteins for FAM122C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6P4D5-F222C_HUMAN ENSP00000359820 for FAM122C Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM122C Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM122C Gene

Drugs & Compounds for FAM122C Gene

No Compound Related Data Available

Transcripts for FAM122C Gene

Unigene Clusters for FAM122C Gene

Family with sequence similarity 122C:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM122C Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - - - -
SP2: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - -

Relevant External Links for FAM122C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM122C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM122C Gene

mRNA differential expression in normal tissues according to GTEx for FAM122C Gene

This gene is overexpressed in Ovary (x5.0).

Protein differential expression in normal tissues from HIPED for FAM122C Gene

This gene is overexpressed in Amniocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM122C Gene

Protein tissue co-expression partners for FAM122C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM122C Gene:


SOURCE GeneReport for Unigene cluster for FAM122C Gene:


Evidence on tissue expression from TISSUES for FAM122C Gene

  • Pancreas(3.4)
genes like me logo Genes that share expression patterns with FAM122C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM122C Gene

Orthologs for FAM122C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM122C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM122C 35
  • 88 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 29 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
(Mus musculus)
Mammalia Fam122c 35
  • 27 (a)
(Canis familiaris)
Mammalia FAM122C 35
  • 23 (a)
(Gallus gallus)
Aves FAM122A 35
  • 30 (a)
(Danio rerio)
Actinopterygii fam122b 35
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4497 35
  • 8 (a)
Species where no ortholog for FAM122C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM122C Gene

Gene Tree for FAM122C (if available)
Gene Tree for FAM122C (if available)

Paralogs for FAM122C Gene

Paralogs for FAM122C Gene

(4) SIMAP similar genes for FAM122C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM122C: view

Variants for FAM122C Gene

Sequence variations from dbSNP and Humsavar for FAM122C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000029834 -- 134,802,095(+) TTCTT(C/T)TCTTT intron-variant
rs1000180848 -- 134,812,673(+) AGCGG(A/G)ACTGG intron-variant
rs1000255991 -- 134,819,817(+) GAAGT(A/G)AAGTT intron-variant
rs1000290999 -- 134,852,251(+) GGGTG(C/G)ATCAC intron-variant
rs1000339196 -- 134,822,609(+) CTTCC(C/T)ATCCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM122C Gene

Variant ID Type Subtype PubMed ID
nsv1139419 CNV deletion 24896259

Variation tolerance for FAM122C Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM122C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM122C Gene

Disorders for FAM122C Gene

Relevant External Links for FAM122C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM122C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM122C Gene

Publications for FAM122C Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64

Products for FAM122C Gene

Sources for FAM122C Gene

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