FAM122C Gene
protein-coding GIFtS : 38
GCID: GC0X P133941
family with sequence similarity 122C
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Aliasesfor FAM122C gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 122C 1 2 RP3-473B4.11 Protein FAM122C2
Export aliases for FAM122C gene to outside databases Previous GC identifers: GC0XP133768 GC0XP123328
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Summariesfor FAM122C gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor FAM122C gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011786.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM122C gene promoter: AML1a Pbx1a NRSF form 1 NRSF form 2 AP-2gamma Evi-1 E47 E2F-1 E2F Hand1 Other transcription factors Search SABiosciences Chromatin IP Primers for FAM122C Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM122C
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3 FAM122C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP133941: view genomic region
(about GC identifiers )
Start:
133,930,443 bp from pter
End:
133,988,641 bp from pter
Size:
58,199 bases
Orientation:
plus strand
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Proteinsfor FAM122C gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F222C_HUMAN, Q6P4D5 (See
protein sequence )Recommended Name: Protein FAM122C Size : 195 amino acids; 22522 Da
Secondary accessions : F5H036 Q8WVK9Alternative splicing : 3 isoforms : Q6P4D5-1 Q6P4D5-2 Q6P4D5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM122C: NX_Q6P4D5 FAM122C Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (7 alternative transcripts):
NP_001164250.1 NP_001164251.1 NP_001164252.1 NP_001164253.1 NP_001164254.1 NP_001164255.1 NP_620174.1 ENSEMBL proteins: ENSP00000359821 ENSP00000402477 ENSP00000359820 ENSP00000389955 Human Recombinant Protein Products for FAM122C: FAM122C Antibody Products: Assay Products for FAM122C:
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Protein
Domains / Familiesfor FAM122C gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM122C for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6P4D5 ProtoNet protein and cluster: Q6P4D5
UniProtKB/Swiss-Prot: F222C_HUMAN, Q6P4D5 Similarity : Belongs to the FAM122 family
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Functionfor FAM122C gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122C (see all 7 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122C (see all 9 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 7 ): FAM122C (NM_001170783 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM122C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM122C
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122C
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Pathways & Interactionsfor FAM122C gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM122C STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for FAM122C (ENSP00000359821 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor FAM122C gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM122C Search CenterWatch for drugs/clinical trials and news about FAM122C / F222C
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Transcriptsfor FAM122C gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM122C gene (7 alternative transcripts): NM_001170779.1 NM_001170780.1 NM_001170781.1 NM_001170782.1 NM_001170783.1 NM_001170784.1 NM_138819.3 Unigene Cluster for FAM122C:
Family with sequence similarity 122C Hs.269127 [show with all ESTs ] Unigene Representative Sequence: NM_001170781 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000495147 (uc004exx.3 uc004exw.3 uc022ceo.1 ) ENST00000370785 (uc004exy.2 )ENST00000482240 ENST00000475361 (uc022cen.1 ) ENST00000494709 ENST00000470657 ENST00000460216 ENST00000463842 ENST00000414371 (uc010nru.2 ) ENST00000370784 (uc004exz.2 )ENST00000445123 (uc011mvq.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122C (see all 7 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122C (see all 9 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 7 ): FAM122C (NM_001170783 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM122C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM122C
Additional cDNA sequence: AF088001.1 AK090611.1 AK130840.1 AK307219.1 AK310079.1 BC016784.1 BC017868.1 BC063491.1 BC065225.1
11 DOTS entries : DT.92418258 DT.204166
DT.100751693 DT.100751695 DT.95239552 DT.70101892 DT.97792014 DT.121286258 DT.121286269 DT.75132642 DT.91699759 24/47 AceView cDNA sequences (see all 47 ):
BM782360 BX118023 BC065225 BM679295 BM702000 AU185275 NM_138819 BC063491 BC017868 AI459248 BU188977 AK090611 BI834902 AI701427 BG503249 AI597723 AF088001 CD521696 AI653705 CA416235 BX105391 BC016784 BG506509 BP368401 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM122C (see all 8 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c SP1 :                     -   -   -           -   -   -         SP2 :                     -   -   -         -   -   -           SP3 :                                               SP4 :             -   -   -                               SP5 :             -   -   -     -                          
ECgene alternative splicing isoforms for FAM122C
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Expression for FAM122C gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM122C expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image FAM122C expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM122C Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM122C SOURCE GeneReport for Unigene cluster: Hs.269127 SABiosciences Custom PCR Arrays for FAM122C Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM122CBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat FAM122C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM122C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM122C In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122C
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Orthologsfor FAM122C gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for FAM122C gene from 3/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
FAM122A6
hypothetical protein LOC422237
26(a)
1 → many
4(4086089-4100308)
zebrafish (Danio rerio)
Actinopterygii
fam122b6
family with sequence similarity 122B
25(a)
possible ortholog
14(32399837-32415255)
fruit fly (Drosophila melanogaster)
Insecta
CG44976
--
8(a)
1 → many
2L(7190431-7194588)
ENSEMBL Gene Tree for FAM122C (if available)TreeFam Gene Tree for FAM122C (if available)
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Paralogsfor FAM122C gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM122C gene FAM122A 2 FAM122B 2 4 SIMAP similar genes for FAM122C using alignment to 3 protein entries: F222C_HUMAN (see all proteins ):RP3-473B4.1 FAM122A SPACIA2 FAM122B
FAM122C for paralogs About GeneDecksing
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Genomic Variantsfor FAM122C gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM122C (133930443 - 133988641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FAM122C: -- Locus Specific Mutation Databases (LSDB): FAM122C
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM122C
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Disorders
/ Diseasesfor FAM122C gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor FAM122C gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM122C gene integrated from 9 sources : (articles sorted by number of sources associating them with FAM122C) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674) 1 Altun M....Kessler B.M. (2011) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007)
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External Searches for FAM122C gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM122C gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM122C gene
(According to HUGE )
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Specialized Databases showing FAM122C gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM122C Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM122C gene: Search GeneIP for patents involving FAM122C GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM122C gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM122C OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM122C OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM122C OriGene Protein Over-expression Lysate for FAM122C Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM122C Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122C OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122C Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM122C OriGene Custom Protein Services for FAM122C OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM122C QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM122C QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM122C QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM122C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM122C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM122C
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FAM122C Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122C
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM122C
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Aliases for FAM122C
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Disorders / Diseases for FAM122C
Domains / Families for FAM122C
Drugs / Compounds for FAM122C
Expression for FAM122C
Function for FAM122C
Genomic Views for FAM122C
Intellectual Property for FAM122C
Orthologs for FAM122C
Paralogs for FAM122C
Pathways / Interactions for FAM122C
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Proteins for FAM122C
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Summaries for FAM122C
Transcripts for FAM122C
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