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FAM122C Gene

protein-coding   GIFtS: 38
GCID: GC0XP133941

Family With Sequence Similarity 122C

  Search for FAM122C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 122C1 2
Protein FAM122C2

External Ids:    HGNC: 252021   Entrez Gene: 1590912   Ensembl: ENSG000001565007   UniProtKB: Q6P4D53   

Export aliases for FAM122C gene to outside databases

Previous GC identifers: GC0XP133768 GC0XP123328


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM122C Gene:
FAM122C (family with sequence similarity 122C) is a protein-coding gene. An important paralog of this gene is FAM122A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM122C gene promoter:
         AML1a   Pbx1a   NRSF form 1   NRSF form 2   AP-2gamma   Evi-1   E47   E2F-1   E2F   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM122C promoter sequence
   Search Chromatin IP Primers for FAM122C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM122C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

FAM122C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM122C gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP133941:  view genomic region     (about GC identifiers)

Start:
133,930,443 bp from pter      End:
133,988,641 bp from pter
Size:
58,199 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F222C_HUMAN, Q6P4D5 (See protein sequence)
Recommended Name: Protein FAM122C  
Size: 195 amino acids; 22522 Da
Secondary accessions: F5H036 Q8WVK9
Alternative splicing: 3 isoforms:  Q6P4D5-1   Q6P4D5-2   Q6P4D5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM122C: NX_Q6P4D5

Explore proteomics data for FAM122C at MOPED


See FAM122C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (7 alternative transcripts): 
NP_001164250.1  NP_001164251.1  NP_001164252.1  NP_001164253.1  NP_001164254.1  NP_001164255.1  NP_620174.1  

ENSEMBL proteins: 
 ENSP00000359821   ENSP00000402477   ENSP00000359820   ENSP00000389955  

FAM122C Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for FAM122C

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Cloud-Clone Corp. ELISAs for FAM122C
Cloud-Clone Corp. CLIAs for FAM122C


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR026716 FAM122

Graphical View of Domain Structure for InterPro Entry Q6P4D5

ProtoNet protein and cluster: Q6P4D5

UniProtKB/Swiss-Prot: F222C_HUMAN, Q6P4D5
Similarity: Belongs to the FAM122 family


FAM122C for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM122C
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM122C

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM122C
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM122C

miRNA
Products:
    
miRTarBase miRNAs that target FAM122C:
hsa-mir-16-5p (MIRT004373), hsa-mir-15a-5p (MIRT003879)

Block miRNA regulation of human, mouse, rat FAM122C using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate FAM122C (see all 9):
hsa-miR-200c hsa-miR-429 hsa-miR-3658 hsa-miR-138 hsa-miR-513a-3p hsa-miR-599 hsa-miR-200b hsa-miR-2113
SwitchGear 3'UTR luciferase reporter plasmidFAM122C 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for FAM122C
Predesigned siRNA for gene silencing in human, mouse, rat FAM122C

Gene Editing
Products:
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Clone
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OriGene clones in human, mouse for FAM122C (see all 34)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 7): FAM122C (NM_001170783)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM122C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM122C

Cell Line
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GenScript Custom overexpressing Cell Line Services for FAM122C
Browse ESI BIO Cell Lines and PureStem Progenitors for FAM122C 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122C


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM122C
Interactions:

    Search GeneGlobe Interaction Network for FAM122C

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for FAM122C (ENSP000003598214) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBCENSP000003448184STRING: ENSP00000344818
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FAM122C (F222C)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FAM122C gene (7 alternative transcripts): 
NM_001170779.1  NM_001170780.1  NM_001170781.1  NM_001170782.1  NM_001170783.1  NM_001170784.1  NM_138819.3  

Unigene Cluster for FAM122C:

Family with sequence similarity 122C
Hs.269127  [show with all ESTs]
Unigene Representative Sequence: NM_001170781
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000495147(uc004exx.3 uc004exw.3 uc022ceo.1) ENST00000370785(uc004exy.2)
ENST00000482240 ENST00000475361(uc022cen.1) ENST00000494709 ENST00000470657
ENST00000460216 ENST00000463842 ENST00000414371(uc010nru.2) ENST00000370784(uc004exz.2)
ENST00000445123(uc011mvq.2)
miRNA
Products:
     
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Selected qRT-PCR Assays for microRNAs that regulate FAM122C (see all 9):
hsa-miR-200c hsa-miR-429 hsa-miR-3658 hsa-miR-138 hsa-miR-513a-3p hsa-miR-599 hsa-miR-200b hsa-miR-2113
SwitchGear 3'UTR luciferase reporter plasmidFAM122C 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FAM122C
Predesigned siRNA for gene silencing in human, mouse, rat FAM122C
Clone
Products:
     
OriGene clones in human, mouse for FAM122C (see all 34)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 7): FAM122C (NM_001170783)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM122C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM122C
Primer
Products:
    
OriGene qPCR primer pairs and template standards for FAM122C
OriGene qSTAR qPCR primer pairs in human, mouse for FAM122C
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM122C
  QuantiTect SYBR Green Assays in human, mouse, rat FAM122C
  QuantiFast Probe-based Assays in human, mouse, rat FAM122C

Additional mRNA sequence: 

AF088001.1 AK090611.1 AK130840.1 AK307219.1 AK310079.1 BC016784.1 BC017868.1 BC063491.1 
BC065225.1 

11 DOTS entries:

DT.92418258  DT.204166  DT.100751693  DT.100751695  DT.95239552  DT.70101892  DT.97792014  DT.121286258 
DT.121286269  DT.75132642  DT.91699759 

Selected AceView cDNA sequences (see all 47):

AI459248 BM702000 AU185275 BM782360 BM679295 BX118023 BC017868 BC065225 
BU188977 NM_138819 BC063491 AK090611 AW028188 BF447210 AA737100 BG506509 
BM547454 BX105391 AI653705 BP368401 CD300383 N21327 BC016784 CD521696 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM122C (see all 8)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1:                                                              -     -     -                             -     -     -                     
SP2:                                                              -     -     -                       -     -     -                           
SP3:                                                                                                                                          
SP4:                                      -     -     -                                                                                       
SP5:                                      -     -     -           -                                                                           


ECgene alternative splicing isoforms for FAM122C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM122C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FAM122C Expression
About this image

FAM122C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM122C Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.269127
    Custom PCR Arrays for FAM122C
Primer
Products:
OriGene qPCR primer pairs and template standards for FAM122C
OriGene qSTAR qPCR primer pairs in human, mouse for FAM122C
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM122C
QuantiTect SYBR Green Assays in human, mouse, rat FAM122C
QuantiFast Probe-based Assays in human, mouse, rat FAM122C
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122C

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for FAM122C gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves FAM122A6
Gallus gallus family with sequence similarity 122A...
30(a)
1 → many
4(4059981-4073526)
zebrafish
(Danio rerio)
Actinopterygii fam122b6
family with sequence similarity 122B
25(a)
1 → many
14(32399837-32415255) ENSDARG00000036500
fruit fly
(Drosophila melanogaster)
Insecta CG44976
--
8(a)
1 → many
2L(7190431-7194588)
        Species with no ortholog for FAM122C

ENSEMBL Gene Tree for FAM122C (if available)
TreeFam Gene Tree for FAM122C (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM122C gene
FAM122A2  FAM122B2  
4 SIMAP similar genes for FAM122C using alignment to 3 protein entries:     F222C_HUMAN (see all proteins):
RP3-473B4.1    FAM122A    SPACIA2    FAM122B

FAM122C for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM122C (see all 630)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1813702661,2
--133886207(+) ATGCAA/TTCACT 1 -- us2k10--------
rs341078881,2
C--133886557(+) CCTGGT/GCTCCT 1 -- us2k13Minor allele frequency- G:0.10NA 10
rs1862612991,2
--133886940(+) GTTTTC/TGGCTA 1 -- us2k10--------
rs1905757961,2
--133886958(+) TCTCAA/TCTCCT 1 -- us2k10--------
rs1835038491,2
--133887056(+) AGGCTA/CAGGAG 1 -- us2k10--------
rs1503019381,2
C--133887082(+) CTTCAC/GTATTA 1 -- us2k10--------
rs1877889581,2
C--133887166(+) AGAGTA/CGATTC 1 -- us2k10--------
rs1448792491,2
--133887195(+) ACCTGA/CCTTTT 1 -- us2k10--------
rs1490679681,2
--133887299(+) ATCACA/GTACTA 1 -- us2k10--------
rs1899129491,2
C--133887722(+) CATGGA/GGGCAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FAM122C (133930443 - 133988641 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FAM122C: --
Locus Specific Mutation Databases (LSDB): FAM122C

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FAM122C
DNA2.0 Custom Variant and Variant Library Synthesis for FAM122C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM122C gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM122C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
  6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 159091 HGNC: 25202 AceView: LOC159091 Ensembl:ENSG00000156500 euGenes: HUgn159091
ECgene: FAM122C H-InvDB: FAM122C

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM122C Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM122C gene:
Search GeneIP for patents involving FAM122C

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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