FAM122B Gene
protein-coding GIFtS : 46
GCID: GC0X M133903
family with sequence similarity 122B
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Aliasesfor FAM122B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 122B 1 2 DKFZp686L201161 RP11-308B5.51 SPACIA22 Protein FAM122B2 Synoviocyte Proliferation Associated In Collagen-Induced Arthritis 22
Export aliases for FAM122B gene to outside databases Previous GC identifers: GC0XM133731 GC0XM123302
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Summariesfor FAM122B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for FAM122B
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Genomic Viewsfor FAM122B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011786.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM122B gene promoter: AML1a Pbx1a NRSF form 1 NRSF form 2 AP-2gamma Evi-1 E47 E2F-1 E2F Hand1 Other transcription factors Search SABiosciences Chromatin IP Primers for FAM122B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM122B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3 FAM122B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM133903: view genomic region
(about GC identifiers )
Start:
133,903,596 bp from pter
End:
133,931,262 bp from pter
Size:
27,667 bases
Orientation:
minus strand
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Proteinsfor FAM122B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F122B_HUMAN, Q7Z309 (See
protein sequence )Recommended Name: Protein FAM122B Size : 247 amino acids; 26928 Da
Sequence caution : Sequence=AAH32419.1; Type=Erroneous initiation;
Secondary accessions : A8K902 Q6PIM2 Q6ZU47 Q6ZV64 Q6ZVE4 Q8TB75Alternative splicing : 5 isoforms : Q7Z309-1 Q7Z309-2 Q7Z309-3 Q7Z309-4 Q7Z309-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM122B: NX_Q7Z309 Post-translational modifications:
Isoform 3 and isoform 4 are phosphorylated on Ser-62 and Ser-641
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q7Z309 FAM122B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (5 alternative transcripts):
NP_001160071.1 NP_001160072.1 NP_001164227.1 NP_001164228.1 NP_660327.2 ENSEMBL proteins: ENSP00000359826 ENSP00000419592 ENSP00000298090 ENSP00000339207 Human Recombinant Protein Products: FAM122B Antibody Products: Assay Products for FAM122B:
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Protein
Domains / Familiesfor FAM122B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM122B for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q7Z309 ProtoNet protein and cluster: Q7Z309
UniProtKB/Swiss-Prot: F122B_HUMAN, Q7Z309 Similarity : Belongs to the FAM122 family
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Functionfor FAM122B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122B (see all 8 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122B (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 5 ): FAM122B (NM_145284 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM122B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM122B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122B
1 GenomeRNAi human phenotype for FAM122B :Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Fam122b) :
FAM122B for phenotypes About GeneDecksing
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Pathways & Interactionsfor FAM122B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM122B STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)5/6 Interacting proteins for FAM122B (Q7Z309 3 ENSP00000298090 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table
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Drugs & Compoundsfor FAM122B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM122B Search CenterWatch for drugs/clinical trials and news about FAM122B / F122B
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Transcriptsfor FAM122B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM122B gene (5 alternative transcripts): NM_001166599.2 NM_001166600.2 NM_001170756.1 NM_001170757.1 NM_145284.5 Unigene Cluster for FAM122B:
Family with sequence similarity 122B Hs.404706 [show with all ESTs ] Unigene Representative Sequence: NM_001166599 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000370790 (uc004ext.3 uc022cek.1 uc022cel.1 uc004exr.3 )ENST00000478384 ENST00000486347 ENST00000465128 ENST00000493333 ENST00000467413 ENST00000298090 (uc011mvp.2 uc004exv.3 ) ENST00000343004 (uc004exq.3 uc022cem.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122B (see all 8 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122B (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 5 ): FAM122B (NM_145284 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM122B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM122B
Additional cDNA sequence: AB541014.1 AB541015.1 AK026809.1 AK124650.1 AK124940.1 AK125991.1 AK292517.1 AK297720.1 AL832218.1 BC019221.2 BC032419.2 BX538218.1
9 DOTS entries : DT.101982482 DT.97838951
DT.101982481 DT.101971911 DT.95371762 DT.100648077 DT.442675 DT.95371763 DT.100747002 24/150 AceView cDNA sequences (see all 150 ):
BP340807 AI082743 BM469325 AW467739 AA708622 AL832218 BX538218 BC019221 AK026809 CK000427 AW073884 BE220345 AK124940 AI350656 BF149426 AK125991 AI241674 AA243478 BE349112 AL709054 BU596476 NM_145284 AK124650 BQ222245 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for FAM122B (see all 9 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d SP1 :       -       -                 -   -   -           SP2 :       -       -                               SP3 :       -       -   -                             SP4 :       -       -   -                             SP5 :             -   -               -   -   -          
ECgene alternative splicing isoforms for FAM122B
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Expression for FAM122B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM122B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CATAAAAAAA
About this image FAM122B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See FAM122B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM122B SOURCE GeneReport for Unigene cluster: Hs.404706 SABiosciences Custom PCR Arrays for FAM122B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM122BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM122B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM122B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM122B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122B
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Orthologsfor FAM122B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for FAM122B gene from 4/13 species (see all 13 ) About this table
ENSEMBL Gene Tree for FAM122B (if available)TreeFam Gene Tree for FAM122B (if available)
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Paralogsfor FAM122B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM122B gene FAM122C 2 FAM122A 2 4 SIMAP similar genes for FAM122B using alignment to 1 protein entry: F122B_HUMAN :SPACIA2 FAM122A FAM122C RP3-473B4.1
FAM122B for paralogs About GeneDecksing
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Genomic Variantsfor FAM122B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM122B (133903596 - 133931262 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FAM122B: -- Locus Specific Mutation Databases (LSDB): FAM122B
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM122B
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Disorders
/ Diseasesfor FAM122B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM122B for disorders About GeneDecksing 1 disease for FAM122B : About MalaCards arthritis Export disorders for FAM122B gene to outside databases
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Publicationsfor FAM122B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM122B gene, integrated from 9 sources (see all 20 ): (articles sorted by number of sources associating them with FAM122B) Utopia : connect your pdf to the dynamic world of online information
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 1 , 2 Beausoleil S.A.... Gygi S.P. (2006) The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022) 1 Golebiowski F....Hay R.T. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732) 1 Sowa M.E....Harper J.W. (2009)
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External Searches for FAM122B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM122B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM122B gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM122B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM122B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM122B gene: Search GeneIP for patents involving FAM122B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM122B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for FAM122B OriGene shRNA RFP for FAM122B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM122B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM122B OriGene Protein Over-expression Lysate for FAM122B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM122B OriGene 3'-UTR Clone for FAM122B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM122B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for FAM122B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM122B OriGene Custom Protein Services for FAM122B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM122B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM122B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM122B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM122B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM122B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM122B
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FAM122B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122B
Search ThermoFisher Antibodies for FAM122B
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM122B
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Aliases for FAM122B
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Disorders / Diseases for FAM122B
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Expression for FAM122B
Function for FAM122B
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Transcripts for FAM122B
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