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Aliases for FAM122B Gene

Aliases for FAM122B Gene

  • Family With Sequence Similarity 122B 2 3 5
  • Synoviocyte Proliferation Associated In Collagen-Induced Arthritis 2 3
  • Protein FAM122B 3
  • SPACIA2 3

External Ids for FAM122B Gene

Previous GeneCards Identifiers for FAM122B Gene

  • GC0XM133731
  • GC0XM133903
  • GC0XM123302

Summaries for FAM122B Gene

GeneCards Summary for FAM122B Gene

FAM122B (Family With Sequence Similarity 122B) is a Protein Coding gene. An important paralog of this gene is FAM122A.

Gene Wiki entry for FAM122B Gene

Additional gene information for FAM122B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM122B Gene

Genomics for FAM122B Gene

Regulatory Elements for FAM122B Gene

Enhancers for FAM122B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH134795 1 ENCODE 14 +0.4 435 2 ATF1 ARID4B SIN3A DMAP1 GLI4 GLIS2 SP3 NFYC REST KAT8 FAM122B RPL36AP54 INTS6L FAM122C
GH0XH134913 1.3 FANTOM5 ENCODE 10.5 -117.6 -117639 2 PKNOX1 ARID4B SIN3A GLI4 ZNF2 ZNF121 ZNF766 ZNF143 ATF7 SP3 ZNF75D INTS6L FAM122B PHF6 RTL8B MOSPD1 GC0XP134864
GH0XH134684 0.7 ENCODE dbSUPER 10.5 +111.8 111843 2 JUND POLR2A ZNF140 ZNF75D FAM122B INTS6L PHF6 GC0XP134651 GC0XM134761 RNU4-44P
GH0XH134003 0.7 ENCODE 10.4 +793.2 793206 1 ZNF777 ZNF362 ZNF140 ZBTB8A ATF2 PRDM6 ZNF366 ZNF512 SCRT2 ZNF629 FAM122B PHF6 ENSG00000232068 ENSG00000200572 GC0XM134143
GH0XH134870 0.4 ENCODE 15.7 -73.4 -73405 0 ZNF585B TCF7L2 FAM122B RTL8A PHF6 RPL36AP54 GC0XP134864 MOSPD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM122B on UCSC Golden Path with GeneCards custom track

Promoters for FAM122B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248975 232 1601 ARID4B SIN3A DMAP1 GLI4 GLIS2 SP3 NFYC REST KAT8 MBD2

Genomic Location for FAM122B Gene

Chromosome:
X
Start:
134,769,566 bp from pter
End:
134,797,232 bp from pter
Size:
27,667 bases
Orientation:
Minus strand

Genomic View for FAM122B Gene

Genes around FAM122B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM122B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM122B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM122B Gene

Proteins for FAM122B Gene

  • Protein details for FAM122B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z309-F122B_HUMAN
    Recommended name:
    Protein FAM122B
    Protein Accession:
    Q7Z309
    Secondary Accessions:
    • A8K902
    • Q6PIM2
    • Q6ZU47
    • Q6ZV64
    • Q6ZVE4
    • Q8TB75

    Protein attributes for FAM122B Gene

    Size:
    247 amino acids
    Molecular mass:
    26928 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32419.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM122B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM122B Gene

Post-translational modifications for FAM122B Gene

  • Isoform 3 and isoform 4 are phosphorylated on Ser-62 and Ser-64.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM122B Gene

Domains & Families for FAM122B Gene

Gene Families for FAM122B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM122B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM122B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z309

UniProtKB/Swiss-Prot:

F122B_HUMAN :
  • Belongs to the FAM122 family.
Family:
  • Belongs to the FAM122 family.
genes like me logo Genes that share domains with FAM122B: view

Function for FAM122B Gene

genes like me logo Genes that share phenotypes with FAM122B: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for FAM122B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM122B Gene

Localization for FAM122B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM122B gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM122B Gene

Pathways & Interactions for FAM122B Gene

SuperPathways for FAM122B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM122B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM122B Gene

Drugs & Compounds for FAM122B Gene

No Compound Related Data Available

Transcripts for FAM122B Gene

Unigene Clusters for FAM122B Gene

Family with sequence similarity 122B:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for FAM122B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM122B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6:
SP7: - - - - -
SP8: - -
SP9: - -

Relevant External Links for FAM122B Gene

GeneLoc Exon Structure for
FAM122B
ECgene alternative splicing isoforms for
FAM122B

Expression for FAM122B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM122B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM122B Gene

This gene is overexpressed in Fetal testis (35.1), Testis (20.4), and Fetal ovary (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM122B Gene



Protein tissue co-expression partners for FAM122B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM122B Gene:

FAM122B

SOURCE GeneReport for Unigene cluster for FAM122B Gene:

Hs.404706

Evidence on tissue expression from TISSUES for FAM122B Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with FAM122B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM122B Gene

Orthologs for FAM122B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM122B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM122B 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM122B 33 34
  • 91.35 (n)
mouse
(Mus musculus)
Mammalia Fam122b 33 16 34
  • 87.31 (n)
rat
(Rattus norvegicus)
Mammalia Fam122b 33
  • 87.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM122B 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM122B 34
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM122B 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM122B 33 34
  • 78.2 (n)
lizard
(Anolis carolinensis)
Reptilia FAM122B 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC550042 33
  • 67.8 (n)
zebrafish
(Danio rerio)
Actinopterygii fam122b 34
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4497 34
  • 13 (a)
OneToMany
Species where no ortholog for FAM122B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM122B Gene

ENSEMBL:
Gene Tree for FAM122B (if available)
TreeFam:
Gene Tree for FAM122B (if available)

Paralogs for FAM122B Gene

Paralogs for FAM122B Gene

(4) SIMAP similar genes for FAM122B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM122B: view

Variants for FAM122B Gene

Sequence variations from dbSNP and Humsavar for FAM122B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000413629 -- 134,791,526(+) TGAGT(A/C)TGGAG intron-variant
rs1000636478 -- 134,774,386(+) CTCTT(C/T)GCTAC intron-variant
rs1000841775 -- 134,795,986(+) AAGTC(A/G)CCACC intron-variant, upstream-variant-2KB
rs1000928044 -- 134,796,848(+) GCACC(C/G)AGGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001022098 -- 134,794,195(+) CGCCC(C/T)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM122B Gene

Variant ID Type Subtype PubMed ID
dgv1323e201 CNV deletion 23290073
dgv1324e201 CNV deletion 23290073
esv2740487 CNV deletion 23290073
esv2740488 CNV deletion 23290073
esv2740489 CNV deletion 23290073

Variation tolerance for FAM122B Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM122B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM122B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM122B Gene

Disorders for FAM122B Gene

Relevant External Links for FAM122B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM122B

No disorders were found for FAM122B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM122B Gene

Publications for FAM122B Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for FAM122B Gene

Sources for FAM122B Gene

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