FAM122A Gene
protein-coding GIFtS: 41
GCID: GC09P071394
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family with sequence similarity 122A(Previous name: chromosome 9 open reading frame 42 )
(Previous symbol: C9orf42)
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Aliases
for FAM122A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Family With Sequence Similarity 122A1 2 | | C9orf421 2 3 | | MGC173471 | | Chromosome 9 Open Reading Frame 421 | | Protein FAM122A2 |
Export aliases for FAM122A gene to outside databasesPrevious GC identifers: GC09P070584 GC09P041240 |
Summaries
for FAM122A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM122A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM122A gene promoter:
TBP RFX1 Sox5 MIF-1 Nkx2-5 Ik-3 POU2F1 POU2F1a TFIID ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM122A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM122A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q21.11 Ensembl cytogenetic band: 9q21.11 HGNC cytogenetic band: 9q21.13FAM122A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P071394: view genomic region
(about GC identifiers)
Start:
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71,394,964 bp from pter |
End:
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71,398,609 bp from pter |
Size:
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3,646 bases |
Orientation:
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plus strand |
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Proteins
for FAM122A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F122A_HUMAN, Q96E09 (See
protein sequence)Recommended Name: Protein FAM122A Size: 287 amino acids; 30529 DaExplore the universe of human proteins at neXtProt for FAM122A: NX_Q96E09
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96E09
FAM122A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612206.3
ENSEMBL proteins: ENSP00000377807
Human Recombinant Protein Products:
FAM122A Antibody Products:
Assay Products for FAM122A: |
Protein
Domains /
Families
for FAM122A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM122A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96E09ProtoNet protein and cluster: Q96E09 UniProtKB/Swiss-Prot: F122A_HUMAN, Q96E09Similarity: Belongs to the FAM122 family |
Function
for FAM122A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM122A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM122A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM122A (NM_138333) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM122A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM122A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122A |
1 GenomeRNAi human phenotype for FAM122A:
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Pathways & Interactions
for FAM122A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM122A
1 Interacting protein for FAM122A (Q96E093) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM122A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM122A
Search CenterWatch for drugs/clinical trials and news about FAM122A / F122A
|
Transcripts
for FAM122A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM122A gene: NM_138333.3 Unigene Cluster for FAM122A: Family with sequence similarity 122A Hs.655572 [show with all ESTs]Unigene Representative Sequence: NM_1383331 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000394264(uc004agw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM122A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM122A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM122A (NM_138333) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM122A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM122A |
Additional cDNA sequence: AK126379.1 AK304099.1 BC013062.1 1 DOTS entry: DT.451625 24/130 AceView cDNA sequences (see all 130): AA812460 AA757388 AA725067 Z40664 AW673011 AI471186 BC013062 BE349155 BQ881049 AA621802 NM_138333 BF109044 AW675180 AW798921 BF593656 AI039202 BQ215298 F03267 AI697413 BM720476 CR612982 CR597654 H54310 AA884091
GeneLoc Exon Structure
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Expression
for FAM122A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM122A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCTTCTG
About this image
See FAM122A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM122A
SOURCE GeneReport for Unigene cluster: Hs.655572
SABiosciences Custom PCR Arrays for FAM122A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM122A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM122A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM122A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM122A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122A |
Orthologs
for FAM122A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for FAM122A gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for FAM122A (if available)
TreeFam Gene Tree for FAM122A (if available) |
Paralogs
for FAM122A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM122A gene
- FAM122C2 FAM122B2
4 SIMAP similar genes for FAM122A using alignment to 1 protein entry: F122A_HUMAN:FAM122C SPACIA2 RP3-473B4.1 FAM122B
FAM122A for paralogs About GeneDecksing
|
Genomic Variants
for FAM122A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for FAM122A (71394964 - 71398609 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM122A
1 CNV: 5262 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM122A |
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Disorders
/ Diseases
for FAM122A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM122A for disorders About GeneDecksing
2  diseases for FAM122A: About MalaCardskidney disease choroiditis
Export disorders for FAM122A gene to outside databases
|
Publications
for FAM122A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM122A gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with FAM122A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
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External Searches for FAM122A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FAM122A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing FAM122A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM122A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM122A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FAM122A gene:
Search GeneIP for patents involving FAM122A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM122A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM122A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM122A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM122A | | | OriGene Protein Over-expression Lysate for FAM122A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM122A | | OriGene 3'-UTR Clone for FAM122A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM122A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM122A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM122A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM122A | | OriGene Custom Protein Services for FAM122A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM122A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM122A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM122A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM122A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM122A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM122A |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM122A |
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 | | | FAM122A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM122A |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM122A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM122A |
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