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Aliases for FAM120B Gene

Aliases for FAM120B Gene

  • Family With Sequence Similarity 120B 2 3
  • KIAA1838 2 3 4 6
  • Constitutive Coactivator Of PPAR-Gamma 2 3 4
  • PGCC1 3 4 6
  • CCPG 3 4 6
  • PPARgamma Constitutive Coactivator 1 2 3
  • PPARG Constitutive Coactivator 1 3 4
  • Constitutive Coactivator Of Peroxisome Proliferator-Activated Receptor Gamma 3
  • Constitutive Coactivator Of PPARG 4
  • Protein FAM120B 4
  • DJ894D12.1 3

External Ids for FAM120B Gene

Previous Symbols for FAM120B Gene

  • KIAA1838

Summaries for FAM120B Gene

GeneCards Summary for FAM120B Gene

FAM120B (Family With Sequence Similarity 120B) is a Protein Coding gene. Among its related pathways are RXR and RAR heterodimerization with other nuclear receptor. An important paralog of this gene is FAM120A.

UniProtKB/Swiss-Prot for FAM120B Gene

  • Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM120B Gene

Genomics for FAM120B Gene

Genomic Location for FAM120B Gene

Start:
170,290,703 bp from pter
End:
170,407,071 bp from pter
Size:
116,369 bases
Orientation:
Plus strand

Genomic View for FAM120B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM120B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM120B Gene

Regulatory Elements for FAM120B Gene

Proteins for FAM120B Gene

  • Protein details for FAM120B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EK7-F120B_HUMAN
    Recommended name:
    Constitutive coactivator of peroxisome proliferator-activated receptor gamma
    Protein Accession:
    Q96EK7
    Secondary Accessions:
    • B4DL34
    • Q86V68
    • Q96JI9

    Protein attributes for FAM120B Gene

    Size:
    910 amino acids
    Molecular mass:
    103783 Da
    Quaternary structure:
    • Interacts with ESR1 and RXRA. Interacts with PPARG; in a ligand-independent manner (By similarity).
    SequenceCaution:
    • Sequence=BAB47467.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM120B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM120B Gene

Proteomics data for FAM120B Gene at MOPED

Post-translational modifications for FAM120B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys299 and Lys813

Other Protein References for FAM120B Gene

No data available for DME Specific Peptides for FAM120B Gene

Domains for FAM120B Gene

Protein Domains for FAM120B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

F120B_HUMAN
Family:
  • Belongs to the constitutive coactivator of PPAR-gamma family.:
    • Q96EK7
genes like me logo Genes that share domains with FAM120B: view

No data available for Gene Families for FAM120B Gene

Function for FAM120B Gene

Molecular function for FAM120B Gene

UniProtKB/Swiss-Prot Function: Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).
genes like me logo Genes that share phenotypes with FAM120B: view

miRNA for FAM120B Gene

miRTarBase miRNAs that target FAM120B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM120B Gene

Localization for FAM120B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM120B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM120B Gene COMPARTMENTS Subcellular localization image for FAM120B gene
Compartment Confidence
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM120B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FAM120B: view

Pathways for FAM120B Gene

genes like me logo Genes that share pathways with FAM120B: view

Pathways by source for FAM120B Gene

1 BioSystems pathway for FAM120B Gene

Gene Ontology (GO) - Biological Process for FAM120B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with FAM120B: view

Transcripts for FAM120B Gene

Unigene Clusters for FAM120B Gene

Family with sequence similarity 120B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM120B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for FAM120B Gene

GeneLoc Exon Structure for
FAM120B
ECgene alternative splicing isoforms for
FAM120B

Expression for FAM120B Gene

mRNA expression in normal human tissues for FAM120B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM120B Gene

SOURCE GeneReport for Unigene cluster for FAM120B Gene Hs.369522

mRNA Expression by UniProt/SwissProt for FAM120B Gene

Q96EK7-F120B_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with FAM120B: view

Orthologs for FAM120B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM120B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM120B 36
  • 99.17 (n)
  • 98.86 (a)
FAM120B 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM120B 37
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM120B 36
  • 82.77 (n)
  • 80 (a)
FAM120B 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam120b 36
  • 75.31 (n)
  • 73.88 (a)
Fam120b 16
Fam120b 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM120B 37
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM120B 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam120b 36
  • 79.19 (n)
  • 80.64 (a)
chicken
(Gallus gallus)
Aves FAM120B 36
  • 61.97 (n)
  • 54.13 (a)
FAM120B 37
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM120B 37
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam120b 36
  • 58.97 (n)
  • 51.68 (a)
zebrafish
(Danio rerio)
Actinopterygii fam120b 36
  • 53.88 (n)
  • 47.75 (a)
fam120b 37
  • 45 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
ManyToMany
-- 37
  • 16 (a)
ManyToMany
Species with no ortholog for FAM120B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM120B Gene

ENSEMBL:
Gene Tree for FAM120B (if available)
TreeFam:
Gene Tree for FAM120B (if available)

Paralogs for FAM120B Gene

Paralogs for FAM120B Gene

genes like me logo Genes that share paralogs with FAM120B: view

Variants for FAM120B Gene

Sequence variations from dbSNP and Humsavar for FAM120B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1274 -- 170,404,919(-) TGCAC(A/G)ATGGG utr-variant-3-prime
rs25636 -- 170,333,783(-) GGGGC(-/CCATA)CCATA intron-variant
rs714869 -- 170,310,752(-) CTCAA(C/T)TGTCT intron-variant
rs725313 -- 170,310,915(-) CTGTG(C/T)TCCAA intron-variant
rs910424 -- 170,348,868(-) ATCGC(C/T)CCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM120B Gene

Variant ID Type Subtype PubMed ID
dgv7054n71 CNV Loss 21882294
nsv464226 CNV Loss 19166990
dgv2040e1 CNV Complex 17122850
esv344 CNV CNV 17122850
nsv428158 CNV Gain 18775914
nsv8016 CNV Gain 18304495
nsv8017 CNV Gain+Loss 18304495
esv2673814 CNV Deletion 23128226
dgv7055n71 CNV Gain 21882294
nsv509178 CNV Insertion 20534489
nsv510954 CNV Complex 20534489
esv2656495 CNV Deletion 23128226
esv28253 CNV Loss 19812545
nsv8018 CNV Loss 18304495
nsv499527 CNV Gain 21111241
esv995563 CNV Loss 20482838
nsv511934 CNV Loss 21212237
nsv522949 CNV Loss 19592680
esv33609 CNV Gain 17666407
nsv5604 CNV Insertion 18451855
nsv5605 CNV Insertion 18451855
esv1391753 CNV Insertion 17803354
nsv509179 CNV Insertion 20534489
esv1000363 CNV Insertion 20482838
nsv8019 CNV Gain 18304495
nsv821571 CNV Deletion 20802225
esv25729 CNV Gain 19812545
esv993022 CNV Gain 20482838
esv2676691 CNV Deletion 23128226
esv1002776 CNV Insertion 20482838
dgv7056n71 CNV Gain 21882294

Relevant External Links for FAM120B Gene

HapMap Linkage Disequilibrium report
FAM120B
Human Gene Mutation Database (HGMD)
FAM120B

Disorders for FAM120B Gene

(1) University of Copenhagen DISEASES for FAM120B Gene

Relevant External Links for FAM120B

Genetic Association Database (GAD)
FAM120B
Human Genome Epidemiology (HuGE) Navigator
FAM120B
genes like me logo Genes that share disorders with FAM120B: view

No data available for UniProtKB/Swiss-Prot for FAM120B Gene

Publications for FAM120B Gene

  1. The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34. (PMID: 14585507) Holden S. … Raymond F.L. (Gene 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis. (PMID: 17595322) Li D. … Wang D.-M. (Mol. Endocrinol. 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for FAM120B Gene

Sources for FAM120B Gene

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