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Aliases for FAM120AOS Gene

Aliases for FAM120AOS Gene

  • Family With Sequence Similarity 120A Opposite Strand 2 3 5
  • FAM120A Opposite Strand Protein 3 4
  • C9orf10OS 3 4
  • Chromosome 9 Open Reading Frame 10 Opposite Strand 2
  • Uncharacterized Protein FAM120AOS 3

External Ids for FAM120AOS Gene

Previous HGNC Symbols for FAM120AOS Gene

  • C9orf10OS

Previous GeneCards Identifiers for FAM120AOS Gene

  • GC09M095242
  • GC09M096208
  • GC09M065886

Summaries for FAM120AOS Gene

Entrez Gene Summary for FAM120AOS Gene

  • Differences in the expression level of this gene are associated with the survival rate of those with glioma. [provided by RefSeq, May 2017]

GeneCards Summary for FAM120AOS Gene

FAM120AOS (Family With Sequence Similarity 120A Opposite Strand) is a Protein Coding gene.

Additional gene information for FAM120AOS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM120AOS Gene

Genomics for FAM120AOS Gene

GeneHancer (GH) Regulatory Elements for FAM120AOS Gene

Promoters and enhancers for FAM120AOS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I093449 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 908 5.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ZNF766 FAM120A FAM120AOS PIR40533 PIR42067 PIR60796 ENSG00000227603 PHF2 LOC100132077 RNU6-829P PIR45755
GH09I093500 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.6 -47.8 -47800 1.2 IRF2 ZNF792 ZKSCAN8 IKZF1 PYGO2 IKZF2 ENSG00000227603 FAM120A FAM120AOS RNU6-829P LOC100419516 GC09M093574
GH09I093155 Enhancer 0.7 dbSUPER 11.3 +297.2 297212 2.1 PKNOX1 MAX ZMYM3 EBF1 BATF IRF4 RARA ZNF143 ETV6 IKZF2 NINJ1 ENSG00000227603 FAM120A FAM120AOS RNU6-829P ENSG00000203364 WNK2
GH09I093473 Enhancer 0.6 ENCODE 12.2 -20.0 -20016 0 SMARCE1 CEBPB DPF2 CEBPG ZNF217 GATA3 JUND FOS FOSL2 ENSG00000227603 FAM120A FAM120AOS LOC100419516
GH09I093525 Enhancer 0.6 dbSUPER 11.4 -72.4 -72365 1.8 MEIS2 SOX6 NRF1 MAFG MNT DPF2 ZNF592 FOSL1 ZNF316 NFE2 ENSG00000227603 FAM120A FAM120AOS RNU6-829P LOC100419516 GC09M093574
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM120AOS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM120AOS gene promoter:

Genomic Locations for FAM120AOS Gene

Genomic Locations for FAM120AOS Gene
chr9:93,443,332-93,453,592
(GRCh38/hg38)
Size:
10,261 bases
Orientation:
Minus strand
chr9:96,208,776-96,215,874
(GRCh37/hg19)

Genomic View for FAM120AOS Gene

Genes around FAM120AOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM120AOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM120AOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM120AOS Gene

Proteins for FAM120AOS Gene

  • Protein details for FAM120AOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T036-F120S_HUMAN
    Recommended name:
    Uncharacterized protein FAM120AOS
    Protein Accession:
    Q5T036
    Secondary Accessions:
    • A6NN20

    Protein attributes for FAM120AOS Gene

    Size:
    256 amino acids
    Molecular mass:
    27929 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM120AOS Gene

Post-translational modifications for FAM120AOS Gene

No Post-translational modifications

Other Protein References for FAM120AOS Gene

No data available for DME Specific Peptides for FAM120AOS Gene

Domains & Families for FAM120AOS Gene

Gene Families for FAM120AOS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM120AOS Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FAM120AOS: view

No data available for UniProtKB/Swiss-Prot for FAM120AOS Gene

Function for FAM120AOS Gene

Phenotypes From GWAS Catalog for FAM120AOS Gene

Phenotypes for FAM120AOS Gene

genes like me logo Genes that share phenotypes with FAM120AOS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM120AOS Gene

Localization for FAM120AOS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM120AOS gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM120AOS Gene

Pathways & Interactions for FAM120AOS Gene

SuperPathways for FAM120AOS Gene

No Data Available

Interacting Proteins for FAM120AOS Gene

Selected Interacting proteins: Q5T036-F120S_HUMAN for FAM120AOS Gene via IID

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for FAM120AOS Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM120AOS Gene

Drugs & Compounds for FAM120AOS Gene

No Compound Related Data Available

Transcripts for FAM120AOS Gene

Unigene Clusters for FAM120AOS Gene

Family with sequence similarity 120A opposite strand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM120AOS Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - -
SP2: -
SP3: - -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP7: - - -
SP8:

Relevant External Links for FAM120AOS Gene

GeneLoc Exon Structure for
FAM120AOS
ECgene alternative splicing isoforms for
FAM120AOS

Expression for FAM120AOS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM120AOS Gene

Protein differential expression in normal tissues from HIPED for FAM120AOS Gene

This gene is overexpressed in Adipocyte (62.1) and Bone marrow mesenchymal stem cell (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM120AOS Gene



Protein tissue co-expression partners for FAM120AOS Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM120AOS Gene:

FAM120AOS

SOURCE GeneReport for Unigene cluster for FAM120AOS Gene:

Hs.350364

Evidence on tissue expression from TISSUES for FAM120AOS Gene

  • Nervous system(2.8)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with FAM120AOS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM120AOS Gene

Orthologs for FAM120AOS Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM120AOS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM120AOS 33 34
  • 99.74 (n)
Species where no ortholog for FAM120AOS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM120AOS Gene

ENSEMBL:
Gene Tree for FAM120AOS (if available)
TreeFam:
Gene Tree for FAM120AOS (if available)

Paralogs for FAM120AOS Gene

No data available for Paralogs for FAM120AOS Gene

Variants for FAM120AOS Gene

Sequence variations from dbSNP and Humsavar for FAM120AOS Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs140119177 likely-pathogenic, Bilateral undescended testicles, Chronic lung disease, Coarse facial features, Cutis laxa, Gastroesophageal reflux, Hyperactive airways, Muscular hypotonia, Pectus excavatum, Scoliosis 93,447,639(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000363955 -- 93,451,649(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000533616 -- 93,452,790(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000625591 -- 93,446,110(-) A/C downstream_transcript_variant
rs1000967783 -- 93,453,190(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM120AOS Gene

Variant ID Type Subtype PubMed ID
esv2672054 CNV deletion 23128226
esv2738783 CNV deletion 23290073
esv2738785 CNV deletion 23290073
esv3621099 CNV loss 21293372
nsv1075663 CNV deletion 25765185
nsv1124450 CNV deletion 24896259
nsv950899 CNV duplication 24416366

Variation tolerance for FAM120AOS Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.96; 74.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM120AOS Gene

Human Gene Mutation Database (HGMD)
FAM120AOS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM120AOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM120AOS Gene

Disorders for FAM120AOS Gene

Additional Disease Information for FAM120AOS

No disorders were found for FAM120AOS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM120AOS Gene

Publications for FAM120AOS Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34. (PMID: 14585507) Holden S … Raymond FL (Gene 2003) 2 3 58
  3. Independent validation of a mathematical genomic model for survival of glioma patients. (PMID: 27429853) Nikas JB (American journal of cancer research 2016) 3 58
  4. Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families. (PMID: 25558065) Alazami AM … Alkuraya FS (Cell reports 2015) 3 58
  5. A genome-wide association study of body mass index across early life and childhood. (PMID: 25953783) Warrington NM … Palmer LJ (International journal of epidemiology 2015) 3 58

Products for FAM120AOS Gene

Sources for FAM120AOS Gene

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