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FAM120AOS Gene

protein-coding   GIFtS: 39
GCID: GC09M096208

Family With Sequence Similarity 120A Opposite Strand

(Previous name: chromosome 9 open reading frame 10 opposite strand)
(Previous symbol: C9orf10OS)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 120A Opposite Strand1 2
C9orf10OS1 2 3
Chromosome 9 Open Reading Frame 10 Opposite Strand1
Putative FAM120A Opposite Strand Protein2

External Ids:    HGNC: 233891   Entrez Gene: 1582932   Ensembl: ENSG000001889387   UniProtKB: Q5T0363   
ORGUL members:         

Export aliases for FAM120AOS gene to outside databases

Previous GC identifers: GC09M095242 GC09M065886


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM120AOS Gene:
FAM120AOS (family with sequence similarity 120A opposite strand) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM120AOS gene promoter:
         Pax-5   NCX/Ncx   GCNF   HNF-4alpha2   NF-kappaB   HNF-4alpha1   GCNF-1   GCNF-2   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM120AOS promoter sequence
   Search Chromatin IP Primers for FAM120AOS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM120AOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.31   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22.32

FAM120AOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM120AOS gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M096208:  view genomic region     (about GC identifiers)

Start:
96,208,776 bp from pter      End:
96,215,874 bp from pter
Size:
7,099 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F120S_HUMAN, Q5T036 (See protein sequence)
Recommended Name: Putative FAM120A opposite strand protein  
Size: 256 amino acids; 27929 Da
Caution: Product of a dubious gene prediction
Secondary accessions: A6NN20

Explore the universe of human proteins at neXtProt for FAM120AOS: NX_Q5T036

Explore proteomics data for FAM120AOS at MOPED


See FAM120AOS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_942138.2  
ENSEMBL proteins: 
 ENSP00000414298   ENSP00000364561   ENSP00000429212   ENSP00000416978  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5T036


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM120AOS
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miRNA
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miRTarBase miRNAs that target FAM120AOS:
hsa-mir-192-5p (MIRT026475)

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SwitchGear 3'UTR luciferase reporter plasmidFAM120AOS 3' UTR sequence
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GenScript: all cDNA clones in your preferred vector: FAM120AOS (NM_198841)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM120AOS

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM120AOS


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM120AOS
Interactions:

    Search GeneGlobe Interaction Network for FAM120AOS

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for FAM120AOS (ENSP000003645614) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ELAVL1ENSP000003852694STRING: ENSP00000385269
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FAM120AOS (F120S)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FAM120AOS gene: 
NM_198841.2  

Unigene Cluster for FAM120AOS:

Family with sequence similarity 120A opposite strand
Hs.350364  [show with all ESTs]
Unigene Representative Sequence: NM_198841
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000479094(uc004atn.4) ENST00000423591(uc004atp.4 uc004atq.4)
ENST00000375412(uc004ats.4 uc004att.4 uc004atu.4) ENST00000523407
ENST00000520403 ENST00000483149 ENST00000520470 ENST00000483056 ENST00000476484
ENST00000428152 ENST00000428378
miRNA
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Primer
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OriGene qPCR primer pairs and template standards for FAM120AOS
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Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAM120AOS
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  QuantiFast Probe-based Assays in human, mouse, rat FAM120AOS

Additional mRNA sequence: 

AK056096.1 AK309269.1 BC037551.1 BC038803.1 BC046183.1 BC063650.1 BC080634.1 BC107135.1 
BC107136.1 BC113074.1 

15 DOTS entries:

DT.100782234  DT.445599  DT.97844655  DT.91939154  DT.100027381  DT.95136928  DT.100844983  DT.121189003 
DT.417217  DT.95279271  DT.100782235  DT.121189006  DT.449081  DT.95279304  DT.95279275 

Selected AceView cDNA sequences (see all 277):

BC080634 AI458697 BQ213444 BM718922 AA401521 BM893650 N20137 AA495932 
BM978516 BU159650 CA422837 AW024466 BM966801 AA983581 AI223244 H86064 
CA394323 BE467518 AW778742 AA973558 AW261850 AI311454 BU687126 BX113019 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM120AOS (see all 8)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1:                                -     -                                                         
SP2:                                      -                                                         
SP3:                                      -     -                                                   
SP4:        -     -     -     -     -     -                 -                                       
SP5:                                -     -                 -                                       


ECgene alternative splicing isoforms for FAM120AOS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM120AOS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGGGCCTTC
FAM120AOS Expression
About this image

FAM120AOS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM120AOS Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.350364
    Custom PCR Arrays for FAM120AOS
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM120AOS

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for FAM120AOS gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam120aos5 RIKEN cDNA C030044B11 gene   --   13 (25.04 cM) 48968112 


ENSEMBL Gene Tree for FAM120AOS (if available)
TreeFam Gene Tree for FAM120AOS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM120AOS (see all 86)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1430939721,2
C--96208305(+) CTTAT-/ACCACCAC 1 -- int10--------
rs96964761,2
C--96208379(+) GTTCCA/CCCCTA 1 -- int12Minor allele frequency- C:0.00NA 4
rs1385650581,2
--96208443(+) TTCCTA/GGAGCT 1 -- int10--------
rs1123933131,2
C--96208452(+) CTCTCG/ATCAAC 1 -- int13Minor allele frequency- A:0.04CSA WA EA 240
rs768283681,2
C,F--96208489(+) TCAAAC/GGCCTG 1 -- int11Minor allele frequency- G:0.03WA 118
rs1860625641,2
--96208493(+) ACGCCC/TGAGCC 1 -- int10--------
rs595099001,2
C,F--96208544(+) CACCTA/GTATCT 1 -- int14Minor allele frequency- G:0.05NA WA 126
rs1494104591,2
--96208600(+) TTACTC/TAAGCC 1 -- int10--------
rs625745321,2
C,F--96208665(+) CTTTAT/CGGTTT 1 -- int12Minor allele frequency- C:0.04NA 122
rs1909674221,2
--96208743(+) CTTACA/GGGAAT 1 -- int10--------

HapMap Linkage Disequilibrium report for FAM120AOS (96208776 - 96215874 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for FAM120AOS:    About this table    
Variant IDTypeSubtypePubMed ID
esv2738785CNV Deletion23290073
esv2738783CNV Deletion23290073
esv2672054CNV Deletion23128226

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM120AOS gene integrated from 10 sources:
(articles sorted by number of sources associating them with FAM120AOS)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34. (PubMed id 14585507)1, 3 Holden S. and Raymond F.L. (Gene 2003)
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 158293 HGNC: 23389 AceView: C9orf10OS Ensembl:ENSG00000188938 euGenes: HUgn158293
ECgene: FAM120AOS H-InvDB: FAM120AOS

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM120AOS Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM120AOS gene:
Search GeneIP for patents involving FAM120AOS

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM120AOS
 SwitchGear 3'UTR luciferase reporter plasmids for FAM120AOS
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 ThermoFisher Antibodies for FAM120AOS
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM120AOS
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM120AOS
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM120AOS
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Customized transgenic rodents for:
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 Search Addgene for plasmids for FAM120AOS
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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