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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM120AOS Gene

protein-coding   GIFtS: 38
GCID: GC09M096208

Family With Sequence Similarity 120A Opposite Strand

(Previous name: chromosome 9 open reading frame 10 opposite strand)
(Previous symbol: C9orf10OS)
  Search for FAM120AOS
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 120A Opposite Strand1 2
C9orf10OS1 2 3
Chromosome 9 Open Reading Frame 10 Opposite Strand1
Putative FAM120A Opposite Strand Protein2

External Ids:    HGNC: 233891   Entrez Gene: 1582932   Ensembl: ENSG000001889387   UniProtKB: Q5T0363   

Export aliases for FAM120AOS gene to outside databases

Previous GC identifers: GC09M095242 GC09M065886


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM120AOS Gene: 
FAM120AOS (family with sequence similarity 120A opposite strand) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM120AOS gene promoter:
         Pax-5   NCX/Ncx   GCNF   HNF-4alpha2   NF-kappaB   HNF-4alpha1   GCNF-1   GCNF-2   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM120AOS promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM120AOS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM120AOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.31   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22.32

FAM120AOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM120AOS gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M096208:  view genomic region     (about GC identifiers)

Start:
96,208,776 bp from pter      End:
96,215,874 bp from pter
Size:
7,099 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F120S_HUMAN, Q5T036 (See protein sequence)
Recommended Name: Putative FAM120A opposite strand protein  
Size: 256 amino acids; 27929 Da
Caution: Product of a dubious gene prediction
Secondary accessions: A6NN20

Explore the universe of human proteins at neXtProt for FAM120AOS: NX_Q5T036

Explore proteomics data for FAM120AOS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T036

  • FAM120AOS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM120AOS Protein Expression
    REFSEQ proteins: NP_942138.2  
    ENSEMBL proteins: 
     ENSP00000414298   ENSP00000364561   ENSP00000429212   ENSP00000416978  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5T036


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM120AOS

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM120AOS (ENSP000003645614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM120AOS (F120S)

    Search CenterWatch for drugs/clinical trials and news about FAM120AOS / F120S

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM120AOS gene: 
    NM_198841.2  

    Unigene Clusters for FAM120AOS:

    Family with sequence similarity 120A opposite strand
    Hs.350364  [show with all ESTs], Hs.709859  [show with all ESTs]
    Unigene Representative Sequences: NM_198841, AK093641
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479094(uc004atn.4) ENST00000423591(uc004atp.4 uc004atq.4)
    ENST00000375412(uc004ats.4 uc004att.4 uc004atu.4) ENST00000523407
    ENST00000520403 ENST00000483149 ENST00000520470 ENST00000483056 ENST00000476484
    ENST00000428152 ENST00000428378
    miRNA
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    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of FAM120AOS 
                         Customized lentivirus expression plasmids for stable overexpression of FAM120AOS 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM120AOS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM120AOS

    Additional mRNA sequence: 

    AK093641.1 BC015241.2 BC068089.1 

    16 DOTS entries:

    DT.100782234  DT.445599  DT.91939154  DT.97844655  DT.100027381  DT.95136928  DT.100844983  DT.121189003 
    DT.110215  DT.417217  DT.95279271  DT.100782235  DT.121189006  DT.449081  DT.95279304  DT.95279275 

    24/277 AceView cDNA sequences (see all 277):

    CA310955 N20137 AI819330 CK823300 AW028729 BM966801 BG621088 AA633092 
    BQ776242 BG333216 CR602701 BM893650 BU687126 BU608111 BI333799 W25679 
    AI382273 BQ065057 AA401521 H86064 BQ213444 BM978516 AI690123 AW778742 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM120AOS (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                                -     -                                                         
    SP2:                                      -                                                         
    SP3:                                      -     -                                                   
    SP4:        -     -     -     -     -     -                 -                                       
    SP5:                                -     -                 -                                       


    ECgene alternative splicing isoforms for FAM120AOS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM120AOS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGCCTTC
    FAM120AOS Expression
    About this image


    See FAM120AOS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM120AOS

    SOURCE GeneReport for Unigene clusters: Hs.350364 Hs.709859
        SABiosciences Custom PCR Arrays for FAM120AOS
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM120AOS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for FAM120AOS gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam120aos5 RIKEN cDNA C030044B11 gene   --   13 (25.04 cM) 48968112 


    ENSEMBL Gene Tree for FAM120AOS (if available)
    TreeFam Gene Tree for FAM120AOS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/86 SNPs in FAM120AOS are shown (see all 86)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0436774
    ----see VAR_0436772 L F mis40--------
    rs1430939721,2
    C--96208305(+) CTTAT-/ACCACCAC 1 -- int10--------
    rs96964761,2
    C--96208379(+) GTTCCA/CCCCTA 1 -- int12Minor allele frequency- C:0.00NA 4
    rs1385650581,2
    --96208443(+) TTCCTA/GGAGCT 1 -- int10--------
    rs1123933131,2
    C--96208452(+) CTCTCG/ATCAAC 1 -- int13Minor allele frequency- A:0.04CSA WA EA 240
    rs768283681,2
    C,F--96208489(+) TCAAAC/GGCCTG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1860625641,2
    --96208493(+) ACGCCC/TGAGCC 1 -- int10--------
    rs595099001,2
    C,F--96208544(+) CACCTA/GTATCT 1 -- int14Minor allele frequency- G:0.05NA WA 126
    rs1494104591,2
    --96208600(+) TTACTC/TAAGCC 1 -- int10--------
    rs625745321,2
    C,F--96208665(+) CTTTAT/CGGTTT 1 -- int12Minor allele frequency- C:0.04NA 122

    HapMap Linkage Disequilibrium report for FAM120AOS (96208776 - 96215874 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FAM120AOS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738785CNV Deletion23290073
    esv2738783CNV Deletion23290073
    esv2672054CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM120AOS gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM120AOS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34. (PubMed id 14585507)1, 3 Holden S. and Raymond F.L. (2003)
    3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 158293 HGNC: 23389 AceView: C9orf10OS Ensembl:ENSG00000188938 euGenes: HUgn158293
    ECgene: FAM120AOS H-InvDB: FAM120AOS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM120AOS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM120AOS gene:
    Search GeneIP for patents involving FAM120AOS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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