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Aliases for FAM120A Gene

Aliases for FAM120A Gene

  • Family With Sequence Similarity 120A 2 3 5
  • Oxidative Stress-Associated Src Activator 3 4
  • Oxidative Stess-Associated Src Activator 2 3
  • DNA Polymerase-Transactivated Protein 1 2 3
  • C9orf10 3 4
  • OSSA 3 4
  • DNA Polymerase-Transactivated Protein 5 3
  • Chromosome 9 Open Reading Frame 10 2
  • Protein FAM120A 4
  • KIAA0183 4
  • DNAPTP1 3
  • DNAPTP5 3

External Ids for FAM120A Gene

Previous HGNC Symbols for FAM120A Gene

  • C9orf10

Previous GeneCards Identifiers for FAM120A Gene

  • GC09P095253
  • GC09P096214
  • GC09P065891
  • GC09P093471
  • GC09P093497

Summaries for FAM120A Gene

GeneCards Summary for FAM120A Gene

FAM120A (Family With Sequence Similarity 120A) is a Protein Coding gene. Diseases associated with FAM120A include myiasis and achondrogenesis. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FAM120B.

UniProtKB/Swiss-Prot for FAM120A Gene

  • May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.

Gene Wiki entry for FAM120A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM120A Gene

Genomics for FAM120A Gene

Regulatory Elements for FAM120A Gene

Enhancers for FAM120A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM120A on UCSC Golden Path with GeneCards custom track

Promoters for FAM120A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM120A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM120A Gene

Chromosome:
9
Start:
93,451,696 bp from pter
End:
93,566,115 bp from pter
Size:
114,420 bases
Orientation:
Plus strand

Genomic View for FAM120A Gene

Genes around FAM120A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM120A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM120A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM120A Gene

Proteins for FAM120A Gene

  • Protein details for FAM120A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZB2-F120A_HUMAN
    Recommended name:
    Constitutive coactivator of PPAR-gamma-like protein 1
    Protein Accession:
    Q9NZB2
    Secondary Accessions:
    • A6NGU0
    • C4AMC6
    • O60649
    • Q14688
    • Q4VXF4
    • Q4VXF5
    • Q4VXG2
    • Q86V69
    • Q96I21
    • Q9NZB1

    Protein attributes for FAM120A Gene

    Size:
    1118 amino acids
    Molecular mass:
    121888 Da
    Quaternary structure:
    • Interacts with PURA (By similarity). Interacts with YES1, SRC, FYN. Upon tyrosine phosphorylation, interacts with PIK3R1.
    SequenceCaution:
    • Sequence=AAF72866.1; Type=Frameshift; Positions=1055; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM120A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM120A Gene

Proteomics data for FAM120A Gene at MOPED

Post-translational modifications for FAM120A Gene

  • Arg-982 is dimethylated, probably to asymmetric dimethylarginine.
  • Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.
  • Ubiquitination at Lys 304, Lys 818, Lys 932, and Lys 946
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM120A Gene

Antibody Products

No data available for DME Specific Peptides for FAM120A Gene

Domains & Families for FAM120A Gene

Protein Domains for FAM120A Gene

Suggested Antigen Peptide Sequences for FAM120A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZB2

UniProtKB/Swiss-Prot:

F120A_HUMAN :
  • Belongs to the constitutive coactivator of PPAR-gamma family.
Family:
  • Belongs to the constitutive coactivator of PPAR-gamma family.
genes like me logo Genes that share domains with FAM120A: view

No data available for Gene Families for FAM120A Gene

Function for FAM120A Gene

Molecular function for FAM120A Gene

UniProtKB/Swiss-Prot Function:
May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.
genes like me logo Genes that share phenotypes with FAM120A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM120A Gene

Localization for FAM120A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM120A Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to plasma membrane upon ultraviolet exposure.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM120A Gene COMPARTMENTS Subcellular localization image for FAM120A gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM120A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FAM120A: view

Pathways & Interactions for FAM120A Gene

SuperPathways for FAM120A Gene

No Data Available

Interacting Proteins for FAM120A Gene

Gene Ontology (GO) - Biological Process for FAM120A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM120A Gene

Drugs & Compounds for FAM120A Gene

No Compound Related Data Available

Transcripts for FAM120A Gene

Unigene Clusters for FAM120A Gene

Family with sequence similarity 120A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM120A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8: -
SP9:
SP10:
SP11:

ExUns: 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for FAM120A Gene

GeneLoc Exon Structure for
FAM120A
ECgene alternative splicing isoforms for
FAM120A

Expression for FAM120A Gene

mRNA expression in normal human tissues for FAM120A Gene

Protein differential expression in normal tissues from HIPED for FAM120A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.5) and Islet of Langerhans (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM120A Gene



SOURCE GeneReport for Unigene cluster for FAM120A Gene Hs.372003

mRNA Expression by UniProt/SwissProt for FAM120A Gene

Q9NZB2-F120A_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level).
genes like me logo Genes that share expression patterns with FAM120A: view

Protein tissue co-expression partners for FAM120A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FAM120A Gene

Orthologs for FAM120A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM120A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM120A 35
  • 91.26 (n)
  • 96.41 (a)
FAM120A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM120A 35
  • 87.89 (n)
  • 93.77 (a)
FAM120A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam120a 35
  • 91.94 (n)
  • 96.94 (a)
Fam120a 16
Fam120a 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM120A 35
  • 99.7 (n)
  • 100 (a)
C9ORF10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam120a 35
  • 91.91 (n)
  • 96.33 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM120A 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM120A 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM120A 35
  • 85.67 (n)
  • 91.36 (a)
FAM120A 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fam120a 35
  • 77.96 (n)
  • 84.12 (a)
zebrafish
(Danio rerio)
Actinopterygii FAM120A 36
  • 70 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
Species with no ortholog for FAM120A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM120A Gene

ENSEMBL:
Gene Tree for FAM120A (if available)
TreeFam:
Gene Tree for FAM120A (if available)

Paralogs for FAM120A Gene

Paralogs for FAM120A Gene

(2) SIMAP similar genes for FAM120A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM120A Gene

genes like me logo Genes that share paralogs with FAM120A: view

Variants for FAM120A Gene

Sequence variations from dbSNP and Humsavar for FAM120A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs11541747 - 93,498,835(+) TTGGA(C/T)ATTAT reference, missense
rs882851 -- 93,512,223(-) TTACC(C/T)CAGTC intron-variant
rs883782 -- 93,520,003(-) TCAGG(C/T)GGAAC intron-variant
rs883783 -- 93,519,987(-) AAGGT(A/G)TGAGG intron-variant
rs883784 -- 93,519,954(-) AGGCT(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM120A Gene

Variant ID Type Subtype PubMed ID
esv2662964 CNV Deletion 23128226
nsv824984 CNV Gain 20364138

Variation tolerance for FAM120A Gene

Residual Variation Intolerance Score: 2.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM120A Gene

HapMap Linkage Disequilibrium report
FAM120A
Human Gene Mutation Database (HGMD)
FAM120A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM120A Gene

Disorders for FAM120A Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM120A Gene - From: DISEASES

Disorder Aliases PubMed IDs
myiasis
  • infestation by fly larvae
achondrogenesis
  • achondrogenesis syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM120A

Genetic Association Database (GAD)
FAM120A
Human Genome Epidemiology (HuGE) Navigator
FAM120A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM120A
genes like me logo Genes that share disorders with FAM120A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM120A Gene

Publications for FAM120A Gene

  1. The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34. (PMID: 14585507) Holden S. … Raymond F.L. (Gene 2003) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. IL-13 receptor I+2 signaling requires a scaffold protein, FAM120A, to activate the FAK and PI3K pathways in colon cancer metastasis. (PMID: 25896327) Bartolome R.A. … Casal J.I. (Cancer Res. 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for FAM120A Gene

Sources for FAM120A Gene

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