FAM118B Gene
protein-coding GIFtS : 45
GCID: GC11 P126081
family with sequence similarity 118, member B
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Aliasesfor FAM118B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 118, Member B 1 2 FLJ211031 Protein FAM118B2
Export aliases for FAM118B gene to outside databases Previous GC identifers: GC11P125587 GC11P122023
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Summariesfor FAM118B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor FAM118B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM118B gene promoter: AML1a MyoD STAT5A Arnt Egr-2 COMP1 Chx10 IRF-7A Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for FAM118B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM118B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q24.2 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q24.2 FAM118B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P126081: view genomic region
(about GC identifiers )
Start:
126,081,309 bp from pter
End:
126,132,881 bp from pter
Size:
51,573 bases
Orientation:
plus strand
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Proteinsfor FAM118B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F118B_HUMAN, Q9BPY3 (See
protein sequence )Recommended Name: Protein FAM118B Size : 351 amino acids; 39499 Da
Secondary accessions : Q9H7B0Explore the universe of human proteins at neXtProt for FAM118B: NX_Q9BPY3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BPY3 FAM118B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_078832.1 ENSEMBL proteins: ENSP00000433343 ENSP00000434952 ENSP00000432712 ENSP00000353321 ENSP00000437285 ENSP00000435754 Human Recombinant Protein Products: FAM118B Antibody Products: Assay Products for FAM118B:
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Protein
Domains / Familiesfor FAM118B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q9BPY3
UniProtKB/Swiss-Prot: F118B_HUMAN, Q9BPY3 Similarity : Belongs to the FAM118 family
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Functionfor FAM118B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM118B (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM118B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM118B (NM_024556 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM118B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM118B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM118B
1 GenomeRNAi human phenotype for FAM118B :
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Pathways & Interactionsfor FAM118B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM118B STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)5/22 Interacting proteins for FAM118B (Q9BPY3 2 , 3 ENSP00000353321 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 22 )About this table
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Drugs & Compoundsfor FAM118B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM118B Search CenterWatch for drugs/clinical trials and news about FAM118B / F118B
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Transcriptsfor FAM118B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM118B gene: NM_024556.3 Unigene Cluster for FAM118B:
Family with sequence similarity 118, member B Hs.276315 [show with all ESTs ] Unigene Representative Sequence: NM_024556 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000533050 (uc001qdf.3 uc009zca.3 ) ENST00000525728 ENST00000528985 ENST00000529731 ENST00000360194 ENST00000530043 ENST00000527247 ENST00000525338 ENST00000531935 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM118B (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM118B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM118B (NM_024556 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM118B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM118B
Additional cDNA sequence: AK024756.1 AK225081.1 AK315615.1 BC001340.1 BC001647.2 CR457334.1
10 DOTS entries : DT.448082 DT.100885980
DT.100798722 DT.215963 DT.95303645 DT.100798723 DT.120713352 DT.92426827 DT.91968240 DT.92426825 24/258 AceView cDNA sequences (see all 258 ):
BE885891 AA973898 AA461153 CA426481 AW245099 CR625659 BM981176 CR623279 AA291660 NM_024556 BM468830 BU736762 CA950379 BQ934234 BX444269 CR595100 AI936072 AI696142 BQ880898 BM726905 BQ681746 CR599154 BQ673035 BX442959 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FAM118B (see all 10 ) About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c SP1 :         -       -           -                     SP2 :                                 -             SP3 :         -       -   -   -   -   -   -                     SP4 :         -   -     -           -                     SP5 :               -                              
ECgene alternative splicing isoforms for FAM118B
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Expression for FAM118B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM118B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACTTGAAGCT
About this image FAM118B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Antral Follicle Secondary Oocyte Female Gametocytes, Germ Cells Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM118B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM118B SOURCE GeneReport for Unigene cluster: Hs.276315 SABiosciences Custom PCR Arrays for FAM118B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM118BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM118B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM118B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM118B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM118B
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Orthologsfor FAM118B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for FAM118B gene from 4/11 species (see all 11 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
FAM118B1
family with sequence similarity 118, member B
80.29(n) 91.59(a)
 
419714 NM_001048266.2 NP_001041731.2
lizard (Anolis carolinensis)
Reptilia
FAM118B6
--
88(a)
1 ↔ 1
GL343322.1(1075415-1079994)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.194762
Transcribed sequence with moderate similarity to protein more
80.82(n)
 
BX779341.1
zebrafish (Danio rerio)
Actinopterygii
LOC7991021
protein FAM118B-like
70.98(n) 80.72(a)
 
799102 XM_001339459.4 XP_001339495.3
ENSEMBL Gene Tree for FAM118B (if available)TreeFam Gene Tree for FAM118B (if available)
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Paralogsfor FAM118B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM118B gene FAM118A 2 1 SIMAP similar gene for FAM118B using alignment to 6 protein entries: F118B_HUMAN (see all proteins ):FAM118A
FAM118B for paralogs About GeneDecksing
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Genomic Variantsfor FAM118B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM118B (126081309 - 126132881 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for FAM118B 2 CNVs : 34921 101368
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM118B
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Disorders
/ Diseasesfor FAM118B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM118B for disorders About GeneDecksing 2 diseases for FAM118B : About MalaCards intrahepatic cholangiocarcinoma cholangiocarcinoma Export disorders for FAM118B gene to outside databases
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Publicationsfor FAM118B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM118B gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with FAM118B) Utopia : connect your pdf to the dynamic world of online information
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206) 1 Vinayagam A....Wanker E.E. (2011) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791) 1 Wang A.G....Kim N.S. (2006) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005)
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External Searches for FAM118B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM118B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM118B gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM118B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM118B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM118B gene: Search GeneIP for patents involving FAM118B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM118B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM118B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM118B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM118B OriGene Protein Over-expression Lysate for FAM118B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM118B OriGene 3'-UTR Clone for FAM118B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM118B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM118B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for FAM118B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM118B OriGene Custom Protein Services for FAM118B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM118B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM118B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM118B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM118B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM118B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM118B
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FAM118B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM118B
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM118B
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Aliases for FAM118B
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Disorders / Diseases for FAM118B
Domains / Families for FAM118B
Drugs / Compounds for FAM118B
Expression for FAM118B
Function for FAM118B
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Pathways / Interactions for FAM118B
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Transcripts for FAM118B
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