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Aliases for FAM118A Gene

Aliases for FAM118A Gene

  • Family With Sequence Similarity 118, Member A 2 3
  • C22orf8 3 4
  • Chromosome 22 Open Reading Frame 8 2
  • Protein FAM118A 3
  • BK268H5.C22.4 3

External Ids for FAM118A Gene

Previous HGNC Symbols for FAM118A Gene

  • C22orf8

Previous GeneCards Identifiers for FAM118A Gene

  • GC22P044083
  • GC22P045704
  • GC22P028649

Summaries for FAM118A Gene

GeneCards Summary for FAM118A Gene

FAM118A (Family With Sequence Similarity 118, Member A) is a Protein Coding gene. An important paralog of this gene is FAM118B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM118A Gene

Genomics for FAM118A Gene

Regulatory Elements for FAM118A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM118A Gene

45,308,968 bp from pter
45,341,955 bp from pter
32,988 bases
Plus strand

Genomic View for FAM118A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM118A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM118A Gene

Proteins for FAM118A Gene

  • Protein details for FAM118A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM118A
    Protein Accession:
    Secondary Accessions:
    • B3KWG4
    • B4DY02
    • Q5TII5
    • Q96CY3

    Protein attributes for FAM118A Gene

    357 amino acids
    Molecular mass:
    40269 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM118A Gene


neXtProt entry for FAM118A Gene

Proteomics data for FAM118A Gene at MOPED

Post-translational modifications for FAM118A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM118A Gene

Antibody Products

No data available for DME Specific Peptides for FAM118A Gene

Domains for FAM118A Gene

Protein Domains for FAM118A Gene


Suggested Antigen Peptide Sequences for FAM118A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NWS6
  • Belongs to the FAM118 family.
genes like me logo Genes that share domains with FAM118A: view

No data available for Gene Families for FAM118A Gene

Function for FAM118A Gene

Gene Ontology (GO) - Molecular Function for FAM118A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM118A: view

Phenotypes for FAM118A Gene

GenomeRNAi human phenotypes for FAM118A:
genes like me logo Genes that share phenotypes with FAM118A: view

Animal Model Products

CRISPR Products

miRNA for FAM118A Gene

miRTarBase miRNAs that target FAM118A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM118A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM118A Gene

Localization for FAM118A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM118A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAM118A Gene COMPARTMENTS Subcellular localization image for FAM118A gene
Compartment Confidence
plasma membrane 2
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM118A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM118A: view

Pathways for FAM118A Gene

SuperPathways for FAM118A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM118A Gene


No data available for Pathways by source for FAM118A Gene

Transcripts for FAM118A Gene

Unigene Clusters for FAM118A Gene

Family with sequence similarity 118, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM118A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM118A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: -
SP8: -
SP9: -
SP11: - - -

ExUns: 15

Relevant External Links for FAM118A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM118A Gene

mRNA expression in normal human tissues for FAM118A Gene

Protein differential expression in normal tissues for FAM118A Gene

This gene is overexpressed in Bone (48.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM118A Gene

SOURCE GeneReport for Unigene cluster for FAM118A Gene Hs.265018

genes like me logo Genes that share expressions with FAM118A: view

Expression partners for FAM118A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM118A Gene

Orthologs for FAM118A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM118A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM118A 35
  • 87.86 (n)
  • 93 (a)
FAM118A 36
  • 93 (a)
(Canis familiaris)
Mammalia FAM118A 35
  • 87.3 (n)
  • 92.72 (a)
FAM118A 36
  • 91 (a)
(Mus musculus)
Mammalia Fam118a 35
  • 86.93 (n)
  • 92.44 (a)
Fam118a 16
Fam118a 36
  • 91 (a)
(Pan troglodytes)
Mammalia FAM118A 35
  • 98.97 (n)
  • 98.32 (a)
FAM118A 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fam118a 35
  • 87.49 (n)
  • 92.72 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
-- 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia FAM118A 36
  • 85 (a)
(Anolis carolinensis)
Reptilia FAM118A 36
  • 76 (a)
Species with no ortholog for FAM118A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM118A Gene

Gene Tree for FAM118A (if available)
Gene Tree for FAM118A (if available)

Paralogs for FAM118A Gene

Paralogs for FAM118A Gene

Selected SIMAP similar genes for FAM118A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM118A: view

Variants for FAM118A Gene

Sequence variations from dbSNP and Humsavar for FAM118A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs10343 -- 45,341,606(+) GAAAC(A/G)GCTGT utr-variant-3-prime
rs79055 -- 45,312,742(+) gatat(C/T)gcaaa intron-variant
rs104664 -- 45,315,973(+) CAGCT(A/G)GATCG intron-variant
rs170505 -- 45,317,139(+) tggga(A/G)gctga intron-variant
rs226490 -- 45,317,883(-) GATAA(C/T)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM118A Gene

Variant ID Type Subtype PubMed ID
dgv1411e1 CNV Complex 17122850
nsv9921 CNV Gain+Loss 18304495
esv34218 CNV Gain 17911159
nsv508741 CNV Insertion 20534489
nsv471210 CNV Gain 18288195
esv1005664 CNV Insertion 20482838
esv2724400 CNV Deletion 23290073
esv2052102 CNV Deletion 18987734
esv2645741 CNV Deletion 19546169
esv2724401 CNV Deletion 23290073
nsv514972 CNV Complex 21397061
esv1530597 CNV Insertion 17803354
esv1390438 CNV Insertion 17803354
esv1087404 CNV Insertion 17803354

Relevant External Links for FAM118A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM118A Gene

Disorders for FAM118A Gene

Relevant External Links for FAM118A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FAM118A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FAM118A Gene

Publications for FAM118A Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FAM118A Gene

Sources for FAM118A Gene

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