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Aliases for FAM118A Gene

Aliases for FAM118A Gene

  • Family With Sequence Similarity 118 Member A 2 3 5
  • Family With Sequence Similarity 118, Member A 2 3
  • C22orf8 3 4
  • Chromosome 22 Open Reading Frame 8 2
  • BK268H5.C22.4 3

External Ids for FAM118A Gene

Previous HGNC Symbols for FAM118A Gene

  • C22orf8

Previous GeneCards Identifiers for FAM118A Gene

  • GC22P044083
  • GC22P045704
  • GC22P028649

Summaries for FAM118A Gene

GeneCards Summary for FAM118A Gene

FAM118A (Family With Sequence Similarity 118 Member A) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is FAM118B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM118A Gene

Genomics for FAM118A Gene

Regulatory Elements for FAM118A Gene

Enhancers for FAM118A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM118A on UCSC Golden Path with GeneCards custom track

Promoters for FAM118A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM118A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM118A Gene

Chromosome:
22
Start:
45,308,968 bp from pter
End:
45,341,955 bp from pter
Size:
32,988 bases
Orientation:
Plus strand

Genomic View for FAM118A Gene

Genes around FAM118A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM118A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM118A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM118A Gene

Proteins for FAM118A Gene

  • Protein details for FAM118A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWS6-F118A_HUMAN
    Recommended name:
    Protein FAM118A
    Protein Accession:
    Q9NWS6
    Secondary Accessions:
    • B3KWG4
    • B4DY02
    • Q5TII5
    • Q96CY3

    Protein attributes for FAM118A Gene

    Size:
    357 amino acids
    Molecular mass:
    40269 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM118A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM118A Gene

Proteomics data for FAM118A Gene at MOPED

Post-translational modifications for FAM118A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM118A Gene

No data available for DME Specific Peptides for FAM118A Gene

Domains & Families for FAM118A Gene

Protein Domains for FAM118A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM118A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWS6

UniProtKB/Swiss-Prot:

F118A_HUMAN :
  • Belongs to the FAM118 family.
Family:
  • Belongs to the FAM118 family.
genes like me logo Genes that share domains with FAM118A: view

No data available for Gene Families for FAM118A Gene

Function for FAM118A Gene

genes like me logo Genes that share phenotypes with FAM118A: view

Animal Model Products

CRISPR Products

miRNA for FAM118A Gene

miRTarBase miRNAs that target FAM118A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM118A Gene

Localization for FAM118A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM118A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM118A Gene COMPARTMENTS Subcellular localization image for FAM118A gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
plasma membrane 2
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for FAM118A Gene

Pathways & Interactions for FAM118A Gene

SuperPathways for FAM118A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM118A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM118A Gene

Drugs & Compounds for FAM118A Gene

No Compound Related Data Available

Transcripts for FAM118A Gene

Unigene Clusters for FAM118A Gene

Family with sequence similarity 118, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM118A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: -
SP8: -
SP9: -
SP10:
SP11: - - -

ExUns: 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for FAM118A Gene

GeneLoc Exon Structure for
FAM118A
ECgene alternative splicing isoforms for
FAM118A

Expression for FAM118A Gene

mRNA expression in normal human tissues for FAM118A Gene

Protein differential expression in normal tissues from HIPED for FAM118A Gene

This gene is overexpressed in Bone (48.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM118A Gene



SOURCE GeneReport for Unigene cluster for FAM118A Gene Hs.265018

genes like me logo Genes that share expression patterns with FAM118A: view

Protein tissue co-expression partners for FAM118A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM118A Gene

Orthologs for FAM118A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM118A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM118A 35
  • 87.86 (n)
  • 93 (a)
FAM118A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM118A 35
  • 87.3 (n)
  • 92.72 (a)
FAM118A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam118a 35
  • 86.93 (n)
  • 92.44 (a)
Fam118a 16
Fam118a 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM118A 35
  • 98.97 (n)
  • 98.32 (a)
FAM118A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam118a 35
  • 87.49 (n)
  • 92.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FAM118A 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM118A 36
  • 76 (a)
OneToOne
Species with no ortholog for FAM118A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM118A Gene

ENSEMBL:
Gene Tree for FAM118A (if available)
TreeFam:
Gene Tree for FAM118A (if available)

Paralogs for FAM118A Gene

Paralogs for FAM118A Gene

(1) SIMAP similar genes for FAM118A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM118A: view

Variants for FAM118A Gene

Sequence variations from dbSNP and Humsavar for FAM118A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs11556482 - 45,327,926(+) GTCCT(C/G)TGGTG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs6007594 - 45,332,489(+) CCTTC(A/G/T)TGATC nc-transcript-variant, reference, synonymous-codon, missense
rs10343 -- 45,341,606(+) GAAAC(A/G)GCTGT nc-transcript-variant, utr-variant-3-prime
rs79055 -- 45,312,742(+) gatat(C/T)gcaaa intron-variant
rs104664 -- 45,315,973(+) CAGCT(A/G)GATCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM118A Gene

Variant ID Type Subtype PubMed ID
dgv1411e1 CNV Complex 17122850
nsv9921 CNV Gain+Loss 18304495
esv34218 CNV Gain 17911159
nsv508741 CNV Insertion 20534489
nsv471210 CNV Gain 18288195
esv1005664 CNV Insertion 20482838
esv2724400 CNV Deletion 23290073
esv2052102 CNV Deletion 18987734
esv2645741 CNV Deletion 19546169
esv2724401 CNV Deletion 23290073
nsv514972 CNV Complex 21397061
esv1530597 CNV Insertion 17803354
esv1390438 CNV Insertion 17803354
esv1087404 CNV Insertion 17803354

Variation tolerance for FAM118A Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM118A Gene

HapMap Linkage Disequilibrium report
FAM118A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM118A Gene

Disorders for FAM118A Gene

Relevant External Links for FAM118A

Genetic Association Database (GAD)
FAM118A
Human Genome Epidemiology (HuGE) Navigator
FAM118A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM118A

No disorders were found for FAM118A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM118A Gene

Publications for FAM118A Gene

  1. Tissue effect on genetic control of transcript isoform variation. (PMID: 19680542) Kwan T. … Majewski J. (PLoS Genet. 2009) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for FAM118A Gene

Sources for FAM118A Gene

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