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FAM115C Gene

protein-coding   GIFtS: 39
GCID: GC07P143322

Family With Sequence Similarity 115, Member C

(Previous names: family with sequence similarity 139, member A)
(Previous symbol: FAM139A)
  Search for FAM115C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 115, Member C1 2
FAM139A1 2 3
Family With Sequence Similarity 139, Member A1 2
Protein FAM115C2
Protein FAM139A3

External Ids:    HGNC: 268781   Entrez Gene: 2859662   Ensembl: ENSG000001703797   UniProtKB: A6NFQ23   

Export aliases for FAM115C gene to outside databases

Previous GC identifers: GC07P143031 GC07P143320 GC07P137646


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM115C Gene:
FAM115C (family with sequence similarity 115, member C) is a protein-coding gene. An important paralog of this gene is FAM115A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAM115C gene promoter:
         AML1a   Tal-1beta   E47   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM115C promoter sequence
   Search Chromatin IP Primers for FAM115C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM115C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

FAM115C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM115C gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P143322:  view genomic region     (about GC identifiers)

Start:
143,318,043 bp from pter      End:
143,427,502 bp from pter
Size:
109,460 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,735,400-142,765,339     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F115C_HUMAN, A6NFQ2 (See protein sequence)
Recommended Name: Protein FAM115C  
Size: 919 amino acids; 100906 Da
Sequence caution: Sequence=BAC03376.1; Type=Erroneous initiation;
Secondary accessions: B4DK02 Q14D25 Q17RQ4 Q8IWQ0 Q8NF84
Alternative splicing: 3 isoforms:  A6NFQ2-1   A6NFQ2-2   A6NFQ2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM115C: NX_A6NFQ2

Explore proteomics data for FAM115C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM115C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123497.1  NP_001123498.2  NP_775949.2  

    ENSEMBL proteins: 
     ENSP00000412724   ENSP00000431079   ENSP00000349902   ENSP00000404265   ENSP00000389100  
     ENSP00000386405   ENSP00000390603   ENSP00000441099  

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    Cloud-Clone Corp. CLIAs for FAM115C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: A6NFQ2

    UniProtKB/Swiss-Prot: F115C_HUMAN, A6NFQ2
    Similarity: Belongs to the FAM115 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for FAM115C:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM115C
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    miRTarBase miRNAs that target FAM115C:
    hsa-mir-15b-5p (MIRT046513)

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    3 qRT-PCR Assays for microRNAs that regulate FAM115C:
    hsa-miR-516b hsa-miR-519e hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmidFAM115C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM115C

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM115C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM115C
    Interactions:

        Search GeneGlobe Interaction Network for FAM115C

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM115C (F115C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM115C gene (3 alternative transcripts): 
    NM_001130025.1  NM_001130026.2  NM_173678.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444908(uc011kti.1 uc011ktj.1 uc003wdf.3 uc011ktk.2 uc003wdg.3)
    ENST00000518791 ENST00000357344(uc011ktl.1 uc003wdh.3 uc011ktm.2)
    ENST00000441159(uc003wdi.2) ENST00000411935 ENST00000409703(uc011ktt.2)
    ENST00000411497 ENST00000425618
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate FAM115C:
    hsa-miR-516b hsa-miR-519e hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmidFAM115C 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAM115C
    Predesigned siRNA for gene silencing in human, mouse, rat FAM115C
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM115C
      QuantiTect SYBR Green Assays in human, mouse, rat FAM115C
      QuantiFast Probe-based Assays in human, mouse, rat FAM115C

    Selected AceView cDNA sequences (see all 29):

    AL040412 BU070900 BX282317 AL040411 BX446481 NM_173678 BF355616 BX282363 
    AK090395 BX103503 AY167570 BM876519 AL832734 BG740332 AW389919 CN479606 
    BG677363 AK098041 AI660732 AA927613 AA332247 BI964937 CK903502 BG231542 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM115C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c
    SP1:              -                     
    SP2:              -                     
    SP3:                                    


    ECgene alternative splicing isoforms for FAM115C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM115C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCGACCTG
    FAM115C Expression
    About this image


    FAM115C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Kidney (Urinary System)
             Metanephros
    FAM115C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM115C Protein Expression
        Custom PCR Arrays for FAM115C
    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM115C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM115C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM115C gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam115c1 , 5 family with sequence similarity 115, member C1, 5 79.27(n)1
    76.12(a)1
      6 (20.82 cM)5
    2327481  NM_146174.11  NP_666286.11 
     426230195 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    41(a)
    many ↔ many
    5(946588-968772)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16162 Xenopus laevis transcribed sequence with weak similarity more 78.17(n)    BJ069388.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1621931 zgc:162193 49.82(n)
    41.39(a)
      323315  NM_001089327.1  NP_001082796.1 


    ENSEMBL Gene Tree for FAM115C (if available)
    TreeFam Gene Tree for FAM115C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM115C gene
    FAM115A2  
    1 SIMAP similar gene for FAM115C using alignment to 3 protein entries:     F115C_HUMAN (see all proteins):
    FAM115A

    FAM115C for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for FAM115C
    PGOHUM00000250915 PGOHUM00000233056 PGOHUM00000250916 PGOHUM00000233618 PGOHUM00000250974


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM115C (see all 179)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000029641,2
    C--137660188(+) GGAGA-/AGTTTT 1 -- us2k10--------
    rs3697519701,2
    C--137660331(+) CTAGTC/TTTTTT 1 -- us2k10--------
    rs3751688021,2
    C--137664799(-) TATTC-/CTTTTCTT 1 -- int10--------
    rs3764223461,2
    C--137664903(-) TCTGAC/TTAGGA 1 -- int10--------
    rs1858439711,2
    --137664928(-) AAATCC/TGGACT 1 -- int10--------
    rs1807509351,2
    --137665000(-) TGCCCA/TGAGAA 1 -- int10--------
    rs3737566631,2
    C--137665071(-) TATTTA/TGCTTC 1 -- int10--------
    rs3772701021,2
    C--137665510(-) AGTTTC/TCTCTG 1 -- int10--------
    rs1892720591,2
    --137665570(-) CTTTCC/TTTTCT 1 -- int10--------
    rs1855155541,2
    --137665615(-) TATCAC/TTTAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM115C (143318043 - 143427502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM115C (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422489CNV Duplication17116639
    dgv7514n71CNV Loss21882294
    nsv520055CNV Loss19592680
    nsv824356CNV Loss20364138
    dgv7508n71CNV Loss21882294
    nsv889303CNV Loss21882294
    dgv7507n71CNV Loss21882294
    nsv889306CNV Loss21882294
    nsv818565CNV Gain17921354
    nsv522225CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FAM115C
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM115C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM115C gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM115C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)2 Jikuya H....Ohara O. (DNA Res. 2003)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285966 HGNC: 26878 AceView: FLJ40722 Ensembl:ENSG00000170379 euGenes: HUgn285966
    ECgene: FAM115C H-InvDB: FAM115C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM115C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM115C gene:
    Search GeneIP for patents involving FAM115C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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