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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM115C Gene

protein-coding   GIFtS: 40
GCID: GC07P143322

family with sequence similarity 115, member C

(Previous names: family with sequence similarity 139, member A )
(Previous symbol: FAM139A)
  Search for FAM115C
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAM115C    

Aliases
for FAM115C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Family With Sequence Similarity 115, Member C1 2
FAM139A1 2 3
Family With Sequence Similarity 139, Member A1 2
FLJ407221
Protein FAM115C2
Protein FAM139A3

External Ids:    HGNC: 268781   Entrez Gene: 2859662   Ensembl: ENSG000001703797   UniProtKB: A6NFQ23   

Export aliases for FAM115C gene to outside databases

Previous GC identifers: GC07P143031 GC07P143320 GC07P137646


Summaries
for FAM115C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for FAM115C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM115C gene promoter:
         AML1a   Tal-1beta   E47   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM115C promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM115C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM115C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

FAM115C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM115C gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P143322:  view genomic region     (about GC identifiers)

Start:
 143,318,043 bp from pter      End:
 143,427,502 bp from pter
Size:
 109,460 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,735,400-142,765,339     

Proteins
for FAM115C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F115C_HUMAN, A6NFQ2 (See protein sequence)
Recommended Name: Protein FAM115C  
Size: 919 amino acids; 100906 Da
Sequence caution: Sequence=BAC03376.1; Type=Erroneous initiation;
Secondary accessions: B4DK02 Q14D25 Q17RQ4 Q8IWQ0 Q8NF84
Alternative splicing: 3 isoforms:  A6NFQ2-1   A6NFQ2-2   A6NFQ2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM115C: NX_A6NFQ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NFQ2

    • FAM115C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123497.1  NP_001123498.2  NP_775949.2  

    ENSEMBL proteins: 
     ENSP00000412724   ENSP00000431079   ENSP00000349902   ENSP00000404265   ENSP00000389100  
     ENSP00000386405   ENSP00000390603   ENSP00000441099  

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    Uscn Proteins for FAM115C


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    Protein Domains /
    Families
    for FAM115C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A6NFQ2

    UniProtKB/Swiss-Prot: F115C_HUMAN, A6NFQ2
    Similarity: Belongs to the FAM115 family


    Function
    for FAM115C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Inhib. RNA
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    2 GenomeRNAi human phenotypes for FAM115C:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 


    Pathways & Interactions
    for FAM115C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM115C

    Drugs & Compounds
    for FAM115C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM115C
    Search CenterWatch for drugs/clinical trials and news about FAM115C / F115C 

    Transcripts
    for FAM115C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FAM115C gene (3 alternative transcripts): 
    NM_001130025.1  NM_001130026.2  NM_173678.2  

    Unigene Cluster for FAM115C:

    Family with sequence similarity 115, member C
    Hs.743565  [show with all ESTs]
    Unigene Representative Sequence: NM_001130026
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444908(uc011kti.1 uc011ktj.1 uc003wdf.3 uc011ktk.2 uc003wdg.3)
    ENST00000518791 ENST00000357344(uc011ktl.1 uc003wdh.3 uc011ktm.2)
    ENST00000441159(uc003wdi.2) ENST00000411935 ENST00000409703(uc011ktt.2)
    ENST00000411497 ENST00000425618

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    hsa-miR-516b hsa-miR-519e hsa-miR-515-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FAM115C 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM115C
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK090395.1 AK098041.1 AK296318.1 AK315909.1 AL832734.1 AY167570.1 BC113530.1 BC117233.1 

    8 DOTS entries:

    DT.100024212  DT.99940301  DT.100024214  DT.102833584  DT.75177397  DT.97772379  DT.99943199  DT.101981738 

    24/29 AceView cDNA sequences (see all 29):

    BX282317 BU070900 AL040412 BF355616 AW389919 BX446481 AY167570 AA332247 
    BG231542 BG677363 BI964937 AA927613 BX282363 BU682696 CN479606 AI660732 
    AL040411 AK098041 BX103503 NM_173678 AL832734 BG740332 AK090395 BM876519 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM115C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c
    SP1:              -                     
    SP2:              -                     
    SP3:                                    


    ECgene alternative splicing isoforms for FAM115C

    Expression
    for FAM115C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM115C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGCGACCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FAM115C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FAM115C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM115C

    SOURCE GeneReport for Unigene cluster: Hs.743565
        SABiosciences Custom PCR Arrays for FAM115C
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM115C

    Orthologs
    for FAM115C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FAM115C gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 43(a)
    42(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343236.1(1123926-1138603)
    5(946184-962546)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.16162 Xenopus laevis transcribed sequence with weak similarity more 78.17(n)    BJ069388.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005359981 protein FAM115-like 50.45(n)
    41.38(a)    		   100535998  XM_003199982.1  XP_003200030.1 


    ENSEMBL Gene Tree for FAM115C (if available)
    TreeFam Gene Tree for FAM115C (if available) 

    Paralogs
    for FAM115C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM115C gene
    FAM115A2  
    1 SIMAP similar gene for FAM115C using alignment to 3 protein entries:     F115C_HUMAN (see all proteins):
    FAM115A

    FAM115C for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for FAM115C
    PGOHUM00000250915 PGOHUM00000233056 PGOHUM00000250916 PGOHUM00000233618 PGOHUM00000250974


    Genomic Variants
    for FAM115C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 NCBI SNPs in FAM115C are shown (see all 130)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1842549361,2
    		--143318051(+) CCGACA/CCGTCC 2 -- ut51 us2k10--------
    rs1895003091,2
    		--143318061(+) CCCCGC/GGCGCC 2 -- ut51 us2k10--------
    rs1412236221,2
    		--143321155(+) AGTGCA/GTCCAT 2 -- int10--------
    rs2000029641,2
    		--143331939(+) GAGAC-/AGTTTT 2 -- int10--------
    rs1820495051,2
    		--143343652(+) TCTTCC/TTGAGG 2 -- int10--------
    rs2009272451,2
    		--143344105(+) GAATT-/GAGAGAG 2 -- int10--------
    rs1855155541,2
    		--143344961(+) TATCAC/TTTAAT 2 -- int10--------
    rs1892720591,2
    		--143345003(+) CTTTCC/TTTTCT 2 -- int10--------
    rs1807509351,2
    		--143345553(+) TGCCCA/TGAGAA 2 -- int10--------
    rs1858439711,2
    		--143345625(+) AAATCC/TGGACT 2 -- int10--------

    HapMap Linkage Disequilibrium report for FAM115C (143318043 - 143427502 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 18 variations for FAM115C
         15/17 CNVs (see all 17): 38957 32962 82211 70052 5247 82213 59390 82210 70051 94914 3708 31396 2108 2107 94913
         1 Inversion: 0624

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    Disorders / Diseases
    for FAM115C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for FAM115C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM115C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM115C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
    4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)2 Jikuya H....Ohara O. (2003)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for FAM115C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM115C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285966 HGNC: 26878 AceView: FLJ40722 Ensembl:ENSG00000170379 euGenes: HUgn285966
    ECgene: FAM115C H-InvDB: FAM115C

    Other Databases showing FAM115C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FAM115C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM115C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAM115C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAM115C gene:
    Search GeneIP for patents involving FAM115C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FAM115C gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    von Willebrand factor
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