FAM115A Gene
protein-coding GIFtS : 44
GCID: GC07 M143548
family with sequence similarity 115, member A
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Aliasesfor FAM115A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 115, Member A 1 2 KIAA07381 3 Protein FAM115A2
Export aliases for FAM115A gene to outside databases Previous GC identifers: GC07M143185 GC07M137749
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Summariesfor FAM115A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor FAM115A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM115A gene promoter: HOXA3 Evi-1 NF-AT NF-AT4 NF-AT2 FOXO4 Chx10 NF-AT3 NF-AT1 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for FAM115A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM115A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q35 Ensembl cytogenetic band: 7q35 HGNC cytogenetic band: 7q35 FAM115A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M143548: view genomic region
(about GC identifiers )
Start:
143,548,468 bp from pter
End:
143,599,291 bp from pter
Size:
50,824 bases
Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 142,888,215-142,937,336
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Proteinsfor FAM115A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F115A_HUMAN, Q9Y4C2 (See
protein sequence )Recommended Name: Protein FAM115A Size : 921 amino acids; 102126 Da
Sequence caution : Sequence=BAA34458.2; Type=Erroneous initiation;
Secondary accessions : A8K6E0 Q75KM8 Q75KM9 Q7L665 Q9BW63Alternative splicing : 2 isoforms : Q9Y4C2-1 Q9Y4C2-2 Explore the universe of human proteins at neXtProt for FAM115A: NX_Q9Y4C2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9Y4C2 FAM115A Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts):
NP_001193867.1 NP_001193870.1 NP_055534.1 ENSEMBL proteins: ENSP00000419235 ENSP00000348220 ENSP00000420607 ENSP00000417600 ENSP00000419622 ENSP00000418432 Human Recombinant Protein Products for FAM115A: FAM115A Antibody Products: Assay Products for FAM115A:
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Protein
Domains / Familiesfor FAM115A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q9Y4C2
UniProtKB/Swiss-Prot: F115A_HUMAN, Q9Y4C2 Similarity : Belongs to the FAM115 family
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Functionfor FAM115A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM115A (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM115AOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM115A (NM_014719 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM115A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM115A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM115A
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Pathways & Interactionsfor FAM115A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM115A STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/10 Interacting proteins for FAM115A (Q9Y4C2 3 ENSP00000419235 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 10 )About this table
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Drugs & Compoundsfor FAM115A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM115A Search CenterWatch for drugs/clinical trials and news about FAM115A / F115A
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Transcriptsfor FAM115A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM115A gene (3 alternative transcripts): NM_001206938.1 NM_001206941.1 NM_014719.2 Unigene Cluster for FAM115A:
Family with sequence similarity 115, member A Hs.744048 [show with all ESTs ] Unigene Representative Sequence: NM_001206938 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000479870 (uc011ktu.2 uc003wdo.2 uc003wdp.2 ) ENST00000355951 ENST00000392900 ENST00000460532 ENST00000491908 ENST00000478172 ENST00000485416 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM115A (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM115AOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM115A (NM_014719 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM115A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM115A
Additional cDNA sequence: AB018281.1 AF086218.1 AF119896.2 AK001640.1 AK291605.1 AK294312.1 AK299911.1 BC000609.2 BC039457.1 DQ786274.1 DQ786304.1
13 DOTS entries : DT.95132560 DT.91737630
DT.97770974 DT.99938388 DT.95234937 DT.100738436 DT.449983 DT.100789777 DT.121058700 DT.121058666 DT.101955090 DT.121058684 DT.97759712 24/384 AceView cDNA sequences (see all 384 ):
AA504900 AI074680 BX112580 AA424796 BQ718637 CF139306 BU736275 BE790130 BU855685 BU677827 Z42047 BE219463 AK125491 BM711688 AW020001 BP348619 AI696613 AW162318 AL553100 AI375658 BF110496 AI679242 AI435061 CB242329 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM115A (see all 8 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b SP1 :           -   -   -   -                             -       SP2 :         -   -   -   -   -                                   SP3 :             -   -                                     SP4 :                                                   SP5 :                                                  
ECgene alternative splicing isoforms for FAM115A
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Expression for FAM115A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM115A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATTACTTTGAbout this image FAM115A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Retina Eye Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM115A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM115A SOURCE GeneReport for Unigene cluster: Hs.744048 SABiosciences Custom PCR Arrays for FAM115A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM115ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM115A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM115A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM115A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM115A
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Orthologsfor FAM115A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for FAM115A gene from 3/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for FAM115A (if available)TreeFam Gene Tree for FAM115A (if available)
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Paralogsfor FAM115A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM115A gene FAM115C 2 1 SIMAP similar gene for FAM115A using alignment to 5 protein entries: F115A_HUMAN (see all proteins ):FAM115C
FAM115A for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for FAM115A PGOHUM00000233617
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Genomic Variantsfor FAM115A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM115A (143548468 - 143599291 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 16 variations for FAM115A 15 CNVs : 82233 31397 38957 82234 82231 32962 3708 70052 70053 8581 5247 53583 94931 0725 2109 1 Inversion : 0624
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor FAM115A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM115A for disorders About GeneDecksing 1 disease for FAM115A : About MalaCards ataxia Export disorders for FAM115A gene to outside databases
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Publicationsfor FAM115A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM115A gene, integrated from 9 sources (see all 18 ): (articles sorted by number of sources associating them with FAM115A) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452) 1 , 2 , 3 Nagase T.... Ohara O. (1998) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422) 1 Li S....Dorf M.E. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572) 1 Lee K.A....Doedens J.R. (2011) Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732) 1 Sowa M.E....Harper J.W. (2009) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006)
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External Searches for FAM115A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM115A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM115A gene
(According to HUGE )
About This Section
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Specialized Databases showing FAM115A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM115A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM115A gene: Search GeneIP for patents involving FAM115A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM115A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM115A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM115A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM115A OriGene Protein Over-expression Lysate for FAM115A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM115A OriGene 3'-UTR Clone for FAM115A OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM115A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM115A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for FAM115A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM115A OriGene Custom Protein Services for FAM115A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM115A Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM115A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM115A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM115A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM115A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM115A
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FAM115A Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM115A
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM115A
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Aliases for FAM115A
Databases for FAM115A
Disorders / Diseases for FAM115A
Domains / Families for FAM115A
Drugs / Compounds for FAM115A
Expression for FAM115A
Function for FAM115A
Genomic Views for FAM115A
Intellectual Property for FAM115A
Orthologs for FAM115A
Paralogs for FAM115A
Pathways / Interactions for FAM115A
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Proteins for FAM115A
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Summaries for FAM115A
Transcripts for FAM115A
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