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Aliases for FAM114A2 Gene

Aliases for FAM114A2 Gene

  • Family With Sequence Similarity 114, Member A2 2 3
  • C5orf3 3 4
  • Chromosome 5 Open Reading Frame 3 2
  • Protein FAM114A2 3
  • 133K02 3

External Ids for FAM114A2 Gene

Previous HGNC Symbols for FAM114A2 Gene

  • C5orf3

Previous GeneCards Identifiers for FAM114A2 Gene

  • GC05M153352
  • GC05M148512

Summaries for FAM114A2 Gene

GeneCards Summary for FAM114A2 Gene

FAM114A2 (Family With Sequence Similarity 114, Member A2) is a Protein Coding gene. GO annotations related to this gene include purine nucleotide binding. An important paralog of this gene is FAM114A1.

Gene Wiki entry for FAM114A2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM114A2 Gene

Genomics for FAM114A2 Gene

Regulatory Elements for FAM114A2 Gene

Genomic Location for FAM114A2 Gene

Start:
153,990,128 bp from pter
End:
154,038,937 bp from pter
Size:
48,810 bases
Orientation:
Minus strand

Genomic View for FAM114A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM114A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM114A2 Gene

Proteins for FAM114A2 Gene

  • Protein details for FAM114A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY5-F1142_HUMAN
    Recommended name:
    Protein FAM114A2
    Protein Accession:
    Q9NRY5
    Secondary Accessions:
    • B2R8D8
    • Q9H7E0

    Protein attributes for FAM114A2 Gene

    Size:
    505 amino acids
    Molecular mass:
    55468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM114A2 Gene

Proteomics data for FAM114A2 Gene at MOPED

Post-translational modifications for FAM114A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM114A2 Gene

Domains for FAM114A2 Gene

Protein Domains for FAM114A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM114A2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRY5

UniProtKB/Swiss-Prot:

F1142_HUMAN :
  • Q9NRY5
Family:
  • Belongs to the FAM114 family.
genes like me logo Genes that share domains with FAM114A2: view

No data available for Gene Families for FAM114A2 Gene

Function for FAM114A2 Gene

Gene Ontology (GO) - Molecular Function for FAM114A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017076 purine nucleotide binding NAS 10843801
genes like me logo Genes that share ontologies with FAM114A2: view

miRNA for FAM114A2 Gene

miRTarBase miRNAs that target FAM114A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM114A2 Gene

Localization for FAM114A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM114A2 Gene COMPARTMENTS Subcellular localization image for FAM114A2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM114A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with FAM114A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM114A2 Gene

Pathways for FAM114A2 Gene

SuperPathways for FAM114A2 Gene

No Data Available

Interacting Proteins for FAM114A2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341597%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000341597 for FAM114A2 Gene via STRING

Gene Ontology (GO) - Biological Process for FAM114A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM114A2: view

No data available for Pathways by source for FAM114A2 Gene

Transcripts for FAM114A2 Gene

Unigene Clusters for FAM114A2 Gene

Family with sequence similarity 114, member A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM114A2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - -
SP11: - - - - -
SP12:
SP13:
SP14: - - -
SP15:

ExUns: 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -

Relevant External Links for FAM114A2 Gene

GeneLoc Exon Structure for
FAM114A2
ECgene alternative splicing isoforms for
FAM114A2

Expression for FAM114A2 Gene

mRNA expression in normal human tissues for FAM114A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM114A2 Gene

SOURCE GeneReport for Unigene cluster for FAM114A2 Gene Hs.166551

genes like me logo Genes that share expressions with FAM114A2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM114A2 Gene

Orthologs for FAM114A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM114A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM114A2 35
  • 99.54 (n)
  • 99.21 (a)
FAM114A2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM114A2 35
  • 89.43 (n)
  • 87.73 (a)
FAM114A2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM114A2 35
  • 89.25 (n)
  • 86.73 (a)
FAM114A2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam114a2 35
  • 83.47 (n)
  • 81.76 (a)
Fam114a2 16
Fam114a2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM114A2 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM114A2 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM114A2 35
  • 71 (n)
  • 71 (a)
FAM114A2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM114A2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam114a2 35
  • 63.14 (n)
  • 62.37 (a)
Str.15039 35
zebrafish
(Danio rerio)
Actinopterygii FAM114A2 36
  • 40 (a)
OneToOne
si:dkey-13f9.5 35
  • 60.65 (n)
  • 58.26 (a)
wufi43h01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004464 35
  • 44.7 (n)
  • 37.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9590 35
  • 45.13 (n)
  • 32.58 (a)
CG9590 36
  • 21 (a)
OneToMany
Species with no ortholog for FAM114A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM114A2 Gene

ENSEMBL:
Gene Tree for FAM114A2 (if available)
TreeFam:
Gene Tree for FAM114A2 (if available)

Paralogs for FAM114A2 Gene

Paralogs for FAM114A2 Gene

genes like me logo Genes that share paralogs with FAM114A2: view

Variants for FAM114A2 Gene

Sequence variations from dbSNP and Humsavar for FAM114A2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs496618 -- 154,012,069(+) TGGAT(C/T)AGAAG intron-variant
rs497503 -- 154,012,149(+) GAAAA(A/G)AGGAT intron-variant
rs552556 -- 154,020,162(+) cactg(C/T)attta intron-variant
rs555490 -- 154,003,178(+) GGTAG(C/T)ATTTT intron-variant
rs555493 -- 154,003,179(+) GTAGT(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM114A2 Gene

Variant ID Type Subtype PubMed ID
nsv883056 CNV Gain 21882294
nsv508385 CNV Loss 20534489

Relevant External Links for FAM114A2 Gene

HapMap Linkage Disequilibrium report
FAM114A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM114A2 Gene

Disorders for FAM114A2 Gene

No disorders were found for FAM114A2 Gene.

No data available for UniProtKB/Swiss-Prot for FAM114A2 Gene

Publications for FAM114A2 Gene

  1. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PMID: 10843801) Boultwood J. … Wainscoat J.S. (Genomics 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for FAM114A2 Gene

Sources for FAM114A2 Gene

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