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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM114A1 Gene

protein-coding   GIFtS: 46
GCID: GC04P038871

family with sequence similarity 114, member A1

 Explore 2 diseases affiliated with
FAM114A1 via our new
 Human Malady Compendium 
Biological research products
for FAM114A1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 114, Member A11 2     Protein NOXP202
Noxp201 2     NOXP203
Nervous System Overexpressed Protein 202 3     Protein FAM114A13
Nervous System Over-Expressed Protein 202     

External Ids:    HGNC: 250871   Entrez Gene: 926892   Ensembl: ENSG000001977127   UniProtKB: Q8IWE23   
ORGUL members:         
NONCODE:n409153    

Export aliases for FAM114A1 gene to outside databases

Previous GC identifers: GC04P038548 GC04P038550 GC04P038552 GC04P038870 GC04P038193


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NXP20_HUMAN, Q8IWE2
Function: May play a role in neuronal cell development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016297.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM114A1 gene promoter:
         Nkx3-1   Nkx3-1 v4   AP-2alpha isoform 3   GATA-3   AP-2alpha isoform 2   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   AP-2alpha isoform 4   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM114A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM114A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM114A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

FAM114A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM114A1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P038871:  view genomic region     (about GC identifiers)

Start:
38,869,298 bp from pter      End:
38,947,365 bp from pter
Size:
78,068 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NXP20_HUMAN, Q8IWE2 (See protein sequence)
Recommended Name: Protein NOXP20  
Size: 563 amino acids; 60742 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: A8K9W6 Q9BVL6

Explore the universe of human proteins at neXtProt for FAM114A1: NX_Q8IWE2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IWE2

  • FAM114A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_612398.2  
    ENSEMBL proteins: 
     ENSP00000422965   ENSP00000424115   ENSP00000351740  

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    Uscn Proteins for FAM114A1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    FAM114A1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FAM114A1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007998 DUF719

    Graphical View of Domain Structure for InterPro Entry Q8IWE2

    ProtoNet protein and cluster: Q8IWE2

    UniProtKB/Swiss-Prot: NXP20_HUMAN, Q8IWE2
    Similarity: Belongs to the FAM114 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NXP20_HUMAN, Q8IWE2
    Function: May play a role in neuronal cell development (By similarity)

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM114A1

    2 GenomeRNAi human phenotypes for FAM114A1:
     Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM114A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for FAM114A1 (Q8IWE23 ENSP000003517404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCHIP1Q9P0W53I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM114A1
    Search CenterWatch for drugs/clinical trials and news about FAM114A1 / NXP20 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM114A1 gene: 
    NM_138389.2  

    Unigene Cluster for FAM114A1:

    Family with sequence similarity 114, member A1
    Hs.476517  [show with all ESTs]
    Unigene Representative Sequence: NM_138389
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510213(uc011byg.2) ENST00000515037 ENST00000358869(uc003gtn.3 uc011byh.2 uc010ifi.3)
    ENST00000512889 ENST00000508737 ENST00000513966

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM114A1
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM114A1 (see all 33):
    hsa-miR-579 hsa-miR-548j hsa-miR-562 hsa-miR-570 hsa-miR-3122 hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidFAM114A1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM114A1
    OriGene shRNA RFP: FAM114A1
    OriGene siRNA: FAM114A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM114A1
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM114A1 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM114A1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM114A1
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    Additional cDNA sequence: 

    AK057713.1 AK094179.1 AK292831.1 AK296859.1 AK304050.1 AK308959.1 BC001096.2 BC040452.1 
    BC041559.1 BX640862.1 NR_033290.1 

    13 DOTS entries:

    DT.118810  DT.310971  DT.101972427  DT.100653119  DT.75126153  DT.310972  DT.121245238  DT.95159315 
    DT.121245263  DT.427151  DT.40114155  DT.75149194  DT.95159314 

    24/188 AceView cDNA sequences (see all 188):

    AI754304 W91877 CF593230 AA974716 CD722113 AA070706 AA126862 CA430977 
    BQ019963 NM_138389 AI140029 BC001096 BM988553 AW117891 AI620502 CB306584 
    BG054720 BU786080 AA416997 BC040452 AA826974 BM928637 BU517200 AW027003 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FAM114A1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
    SP1:              -                                                                                                                                 
    SP2:                                                                                                                                                
    SP3:                                                                    -                                                                           
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for FAM114A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM114A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAAGCCTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FAM114A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM114A1

    SOURCE GeneReport for Unigene cluster: Hs.476517
        SABiosciences Custom PCR Arrays for FAM114A1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM114A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FAM114A1 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FAM114A11 family with sequence similarity 114, member A1 68.35(n)
    64.39(a)
      426196  XM_423859.3  XP_423859.3 
    lizard
    (Anolis carolinensis)
    Reptilia FAM114A16
    --
    63(a)
    1 ↔ 1
    GL343361.1(71157-112150)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.337642 Xenopus laevis transcribed sequence with weak similarity more 74.92(n)    BJ619206.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam114a11 family with sequence similarity 114, member A1 60.59(n)
    59.11(a)
      560911  NM_001089478.1  NP_001082947.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95906
    --
    22(a)
    1 → many
    3R(11612423-11614063)


    ENSEMBL Gene Tree for FAM114A1 (if available)
    TreeFam Gene Tree for FAM114A1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM114A1 gene
    FAM114A22  
    2 SIMAP similar genes for FAM114A1 using alignment to 2 protein entries:     NXP20_HUMAN (see all proteins):
    DKFZp686F20250    FAM114A2

    FAM114A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM114A1
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM114A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM114A1 for disorders           About GeneDecksing

    2 diseases for FAM114A1:    About MalaCards
    teratocarcinoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: FAM114A1 (4 documents)

    Export disorders for FAM114A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM114A1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with FAM114A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92689 HGNC: 25087 AceView: LOC92689 Ensembl:ENSG00000197712 euGenes: HUgn92689
    ECgene: FAM114A1 H-InvDB: FAM114A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM114A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM114A1 gene:
    Search GeneIP for patents involving FAM114A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
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