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Aliases for FAM114A1 Gene

Aliases for FAM114A1 Gene

  • Family With Sequence Similarity 114, Member A1 2 3
  • Nervous System Overexpressed Protein 20 3 4
  • Noxp20 3 4
  • Nervous System Over-Expressed Protein 20 3
  • Protein FAM114A1 4
  • Protein NOXP20 3

External Ids for FAM114A1 Gene

Summaries for FAM114A1 Gene

GeneCards Summary for FAM114A1 Gene

FAM114A1 (Family With Sequence Similarity 114, Member A1) is a Protein Coding gene. An important paralog of this gene is FAM114A2.

UniProtKB/Swiss-Prot for FAM114A1 Gene

  • May play a role in neuronal cell development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM114A1 Gene

Genomics for FAM114A1 Gene

Genomic Location for FAM114A1 Gene

Start:
38,867,677 bp from pter
End:
38,945,744 bp from pter
Size:
78,068 bases
Orientation:
Plus strand

Genomic View for FAM114A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM114A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM114A1 Gene

Proteins for FAM114A1 Gene

  • Protein details for FAM114A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWE2-NXP20_HUMAN
    Recommended name:
    Protein NOXP20
    Protein Accession:
    Q8IWE2
    Secondary Accessions:
    • A8K9W6
    • Q6MZV4
    • Q9BVL6

    Protein attributes for FAM114A1 Gene

    Size:
    563 amino acids
    Molecular mass:
    60742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM114A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM114A1 Gene

Proteomics data for FAM114A1 Gene at MOPED

Post-translational modifications for FAM114A1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys327

Other Protein References for FAM114A1 Gene

No data available for DME Specific Peptides for FAM114A1 Gene

Domains for FAM114A1 Gene

Protein Domains for FAM114A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM114A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWE2

UniProtKB/Swiss-Prot:

NXP20_HUMAN
Family:
  • Belongs to the FAM114 family.:
    • Q8IWE2
genes like me logo Genes that share domains with FAM114A1: view

No data available for Gene Families for FAM114A1 Gene

Function for FAM114A1 Gene

Molecular function for FAM114A1 Gene

UniProtKB/Swiss-Prot Function: May play a role in neuronal cell development.

Gene Ontology (GO) - Molecular Function for FAM114A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM114A1: view

Phenotypes for FAM114A1 Gene

GenomeRNAi human phenotypes for FAM114A1:
genes like me logo Genes that share phenotypes with FAM114A1: view

miRNA for FAM114A1 Gene

miRTarBase miRNAs that target FAM114A1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM114A1 Gene

Localization for FAM114A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM114A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM114A1 Gene COMPARTMENTS Subcellular localization image for FAM114A1 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM114A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FAM114A1: view

Pathways for FAM114A1 Gene

SuperPathways for FAM114A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM114A1 Gene

None

No data available for Pathways by source for FAM114A1 Gene

Transcripts for FAM114A1 Gene

Unigene Clusters for FAM114A1 Gene

Family with sequence similarity 114, member A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM114A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: - -
SP7:

Relevant External Links for FAM114A1 Gene

GeneLoc Exon Structure for
FAM114A1
ECgene alternative splicing isoforms for
FAM114A1

Expression for FAM114A1 Gene

mRNA expression in normal human tissues for FAM114A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM114A1 Gene

SOURCE GeneReport for Unigene cluster for FAM114A1 Gene Hs.476517

genes like me logo Genes that share expressions with FAM114A1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM114A1 Gene

Orthologs for FAM114A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM114A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM114A1 35
  • 99.29 (n)
  • 99.29 (a)
FAM114A1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM114A1 35
  • 87.09 (n)
  • 84.37 (a)
FAM114A1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM114A1 35
  • 86.13 (n)
  • 83.21 (a)
FAM114A1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam114a1 35
  • 80.78 (n)
  • 79.1 (a)
Fam114a1 16
Fam114a1 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM114A1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM114A1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam114a1 35
  • 79.37 (n)
  • 78.53 (a)
chicken
(Gallus gallus)
Aves FAM114A1 35
  • 67.81 (n)
  • 61.69 (a)
FAM114A1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM114A1 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33764 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733203 35
  • 72.96 (n)
  • 73.58 (a)
Str.18118 35
zebrafish
(Danio rerio)
Actinopterygii fam114a1 35
  • 59.64 (n)
  • 58.48 (a)
fam114a1 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9590 36
  • 24 (a)
OneToMany
Species with no ortholog for FAM114A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM114A1 Gene

ENSEMBL:
Gene Tree for FAM114A1 (if available)
TreeFam:
Gene Tree for FAM114A1 (if available)

Paralogs for FAM114A1 Gene

Paralogs for FAM114A1 Gene

Selected SIMAP similar genes for FAM114A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM114A1: view

Variants for FAM114A1 Gene

Sequence variations from dbSNP and Humsavar for FAM114A1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs11941 -- 38,944,647(-) GGAGG(C/T)AGAGC utr-variant-3-prime, nc-transcript-variant
rs13809 -- 38,945,393(-) TGTAT(C/T)GAACA utr-variant-3-prime, nc-transcript-variant
rs167250 -- 38,871,208(+) cctca(A/G)cctcc intron-variant
rs167252 -- 38,935,863(+) ATGCA(C/G)CGCCT intron-variant
rs186157 -- 38,881,584(+) GCCTG(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM114A1 Gene

Variant ID Type Subtype PubMed ID
esv2727452 CNV Deletion 23290073

Relevant External Links for FAM114A1 Gene

HapMap Linkage Disequilibrium report
FAM114A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM114A1 Gene

Disorders for FAM114A1 Gene

Relevant External Links for FAM114A1

Genetic Association Database (GAD)
FAM114A1
Human Genome Epidemiology (HuGE) Navigator
FAM114A1
genes like me logo Genes that share disorders with FAM114A1: view

No data available for UniProtKB/Swiss-Prot for FAM114A1 Gene

Publications for FAM114A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for FAM114A1 Gene

Sources for FAM114A1 Gene

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