FAM111B Gene
protein-coding GIFtS: 40
GCID: GC11P058874
|
|
family with sequence similarity 111, member B
| |
Aliases
for FAM111B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 111, Member B1 2 | | CANP1 2 3 | | Cancer-Associated Nucleoprotein2 3 | | Protein FAM111B2 |
Export aliases for FAM111B gene to outside databasesPrevious GC identifers: GC11P058632 GC11P055220 |
Summaries
for FAM111B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM111B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM111B gene promoter:
RORalpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM111B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM111B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.1 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1FAM111B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P058874: view genomic region
(about GC identifiers)
Start:
|
58,874,658 bp from pter |
End:
|
58,894,888 bp from pter |
Size:
|
20,231 bases |
Orientation:
|
plus strand |
|
Proteins
for FAM111B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F111B_HUMAN, Q6SJ93 (See
protein sequence)Recommended Name: Protein FAM111B Size: 734 amino acids; 84674 Da
Sequence caution: Sequence=AAH62456.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: B4E2G2 Q6P661Alternative splicing: 2 isoforms: Q6SJ93-1 Q6SJ93-2 Explore the universe of human proteins at neXtProt for FAM111B: NX_Q6SJ93
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6SJ93
FAM111B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001136175.1 NP_001136176.1 NP_945185.1
ENSEMBL proteins: ENSP00000432875 ENSP00000432143 ENSP00000341565 ENSP00000393855
Human Recombinant Protein Products:
FAM111B Antibody Products:
Assay Products for FAM111B: |
Protein
Domains /
Families
for FAM111B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM111B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6SJ93ProtoNet protein and cluster: Q6SJ93 UniProtKB/Swiss-Prot: F111B_HUMAN, Q6SJ93Similarity: Belongs to the FAM111 family |
Function
for FAM111B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FAM111B (NM_001142704) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM111B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM111B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM111B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
IEA | -- |
FAM111B for ontologies About GeneDecksing
|
Pathways & Interactions
for FAM111B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM111B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FAM111B (ENSP000003415654) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM111B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM111B
Search CenterWatch for drugs/clinical trials and news about FAM111B / F111B
|
Transcripts
for FAM111B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM111B gene (3 alternative transcripts): NM_001142703.1 NM_001142704.1 NM_198947.3 Unigene Cluster for FAM111B: Family with sequence similarity 111, member B Hs.186579 [show with all ESTs]Unigene Representative Sequence: NM_1989475 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528234 ENST00000529618 ENST00000534403 ENST00000343597(uc001nnl.3)
ENST00000411426(uc001nnm.3 uc010rko.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FAM111B (NM_001142704) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM111B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM111B |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM111B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM111B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM111B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM111B |
Additional cDNA sequence: AK303520.1 AK304258.1 AY457926.1 BC005998.1 BC062456.1 BC130513.1 BC130539.1 BC144078.1 3 DOTS entries: DT.40214968 DT.91751392 DT.409512 24/29 AceView cDNA sequences (see all 29): BQ014206 AY457926 AA278964 AW500244 AI806359 NM_198947 BM716746 BX279565 AA768088 AA278305 BM674379 BG393116 AA960844 BF207688 AW014033 BC062456 BU431348 BG613098 BF980482 BC005998 BG390686 BF028721 BG954248 N87918
GeneLoc Exon Structure
|
Expression
for FAM111B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM111B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTCTTAAA
About this image
See FAM111B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM111B
SOURCE GeneReport for Unigene cluster: Hs.186579
SABiosciences Custom PCR Arrays for FAM111B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM111B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM111B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM111B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM111B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM111B |
Orthologs
for FAM111B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM111B gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
35(a) |
1 → many |
1(91216226-91227509) |
zebrafish
(Danio rerio) |
Actinopterygii |
CR450726.16FP102192.16 |
-- |
21(a)21(a) |
many ↔ manymany ↔ many |
5(7947916-7950134) 5(8033742-8035457) |
ENSEMBL Gene Tree for FAM111B (if available)
TreeFam Gene Tree for FAM111B (if available) |
Paralogs
for FAM111B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM111B gene
- FAM111A2
1 SIMAP similar gene for FAM111B using alignment to 2 protein entries: F111B_HUMAN (see all proteins):FAM111A
FAM111B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FAM111B
PGOHUM00000244292
|
Genomic Variants
for FAM111B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM111B (58874658 - 58894888 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FAM111B
3 CNVs: 2928 75673 3853 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM111B |
|
Disorders
/ Diseases
for FAM111B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM111B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM111B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM111B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for FAM111B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM111B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM111B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM111B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM111B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM111B gene:
Search GeneIP for patents involving FAM111B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM111B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM111B | | | OriGene Protein Over-expression Lysate for FAM111B | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for FAM111B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM111B | | OriGene Custom Protein Services for FAM111B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM111B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM111B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM111B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM111B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM111B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM111B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM111B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM111B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM111B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM111B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM111B |
|
|
|
|
