FAM111A Gene
protein-coding GIFtS: 46
GCID: GC11P058910
|
|
family with sequence similarity 111, member A
| |
Aliases
for FAM111A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 111, Member A1 2 | | KIAA18951 3 | | FLJ227941 | | Protein FAM111A2 |
Export aliases for FAM111A gene to outside databasesPrevious GC identifers: GC11P058669 GC11P055256 |
Summaries
for FAM111A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM111A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM111A gene promoter:
Max c-Rel SRY FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM111A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM111A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.1 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1FAM111A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P058910: view genomic region
(about GC identifiers)
Start:
|
58,910,221 bp from pter |
End:
|
58,922,512 bp from pter |
Size:
|
12,292 bases |
Orientation:
|
plus strand |
|
Proteins
for FAM111A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F111A_HUMAN, Q96PZ2 (See
protein sequence)Recommended Name: Protein FAM111A Size: 611 amino acids; 70196 Da
Sequence caution: Sequence=BAB15486.1; Type=Erroneous initiation; Sequence=BAB67788.1; Type=Erroneous initiation;
Secondary accessions: A8K5Y8 Q5RKS9 Q5XKM2 Q68DK9 Q6IPR7 Q9H5Y1Explore the universe of human proteins at neXtProt for FAM111A: NX_Q96PZ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PZ2
FAM111A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001135991.1 NP_001135992.1 NP_001135993.1 NP_071357.2 NP_942144.1
ENSEMBL proteins: ENSP00000434435 ENSP00000436128 ENSP00000355264 ENSP00000432821 ENSP00000433154 ENSP00000431631 ENSP00000406683
Human Recombinant Protein Products:
FAM111A Antibody Products:
Assay Products for FAM111A: |
Protein
Domains /
Families
for FAM111A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM111A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96PZ2ProtoNet protein and cluster: Q96PZ2 UniProtKB/Swiss-Prot: F111A_HUMAN, Q96PZ2Similarity: Belongs to the FAM111 family |
Function
for FAM111A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111A (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111A (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): FAM111A (NM_001142519) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM111A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM111A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM111A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
IEA | -- |
FAM111A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FAM111A:
|
Pathways & Interactions
for FAM111A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM111A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FAM111A (Q96PZ23 ENSP000003552644) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM111A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM111A
Search CenterWatch for drugs/clinical trials and news about FAM111A / F111A
|
Transcripts
for FAM111A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM111A gene (5 alternative transcripts): NM_001142519.1 NM_001142520.1 NM_001142521.1 NM_022074.3 NM_198847.2 Unigene Cluster for FAM111A: Family with sequence similarity 111, member A Hs.150651 [show with all ESTs]Unigene Representative Sequence: NM_00114252011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528737(uc010rkr.2 uc001nno.3 uc001nnp.3) ENST00000532790
ENST00000529985 ENST00000531676 ENST00000527629 ENST00000361723(uc001nnq.3)
ENST00000531408 ENST00000529358 ENST00000533703 ENST00000531147 ENST00000420244(uc010rkp.2 uc010rkq.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111A (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111A (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): FAM111A (NM_001142519) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM111A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM111A |
Additional cDNA sequence: AK025319.1 AK026447.1 AK092061.1 AK092953.1 AK130799.1 AK291453.1 BC013137.1 BC041693.1 BC054515.1 BC071759.1 10 DOTS entries: DT.92414823 DT.87024788 DT.91917153 DT.91696581 DT.97785830 DT.100786216 DT.97860920 DT.100786213 DT.100033157 DT.120736268 24/205 AceView cDNA sequences (see all 205): AA830008 BX091275 AW752815 BC013137 AA281071 BE221218 AA430754 AA236604 AA465228 CA407668 AX747824 AW058020 AJ713805 AA433947 AI301638 AI521118 AI290188 AW301207 AA088809 BV180165 AW752800 AX747338 BM979479 AA465584
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM111A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|
|
| SP1: | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM111A
|
Expression
for FAM111A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM111A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGACTGCTG
About this image
See FAM111A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM111A
SOURCE GeneReport for Unigene cluster: Hs.150651
SABiosciences Custom PCR Arrays for FAM111A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM111A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM111A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM111A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM111A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM111A |
Orthologs
for FAM111A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM111A gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for FAM111A (if available)
TreeFam Gene Tree for FAM111A (if available) |
Paralogs
for FAM111A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM111A gene
- FAM111B2
1 SIMAP similar gene for FAM111A using alignment to 3 protein entries: F111A_HUMAN (see all proteins):FAM111B
FAM111A for paralogs About GeneDecksing
|
Genomic Variants
for FAM111A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM111A (58910221 - 58922512 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM111A
1 CNV: 3853 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM111A |
|
Disorders
/ Diseases
for FAM111A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM111A for disorders About GeneDecksing
2  diseases for FAM111A: About MalaCardsfanconi's anemia anemia
Export disorders for FAM111A gene to outside databases
|
Publications
for FAM111A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM111A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM111A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T....Ohara O. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM111A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM111A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM111A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM111A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM111A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM111A gene:
Search GeneIP for patents involving FAM111A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM111A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM111A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM111A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM111A | | | OriGene Protein Over-expression Lysate for FAM111A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM111A | | OriGene 3'-UTR Clone for FAM111A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM111A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM111A | | OriGene Custom Protein Services for FAM111A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM111A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM111A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM111A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM111A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM111A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM111A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM111A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM111A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM111A |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM111A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM111A |
|
|
|
|
