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FAM111A Gene

protein-coding   GIFtS: 50
GCID: GC11P058910

Family With Sequence Similarity 111, Member A

  See FAM111A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 111, Member A1 2
GCLEB2 5
KCS22 5
KIAA18953 5
Protein FAM111A2

External Ids:    HGNC: 247251   Entrez Gene: 639012   Ensembl: ENSG000001668017   OMIM: 6152925   UniProtKB: Q96PZ23   

Export aliases for FAM111A gene to outside databases

Previous GC identifers: GC11P058669 GC11P055256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM111A Gene:
FAM111A (family with sequence similarity 111, member A) is a protein-coding gene. Diseases associated with FAM111A include kenny-caffey syndrome type 2, and gracile bone dysplasia. An important paralog of this gene is FAM111B.

UniProtKB/Swiss-Prot: F111A_HUMAN, Q96PZ2
Function: Acts as a Simian virus 40 (SV40) host range restriction factor and can restrict SV40 and adenovirus
replication




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM111A gene promoter:
         Max   c-Rel   SRY   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM111A promoter sequence
   Search Chromatin IP Primers for FAM111A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM111A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

FAM111A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM111A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P058910:  view genomic region     (about GC identifiers)

Start:
58,910,221 bp from pter      End:
58,922,512 bp from pter
Size:
12,292 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F111A_HUMAN, Q96PZ2 (See protein sequence)
Recommended Name: Protein FAM111A  
Size: 611 amino acids; 70196 Da
Subunit: Interacts with SV40 virus large T antigen and this interaction is required for efficient viral
replication and sustained viral gene expression in restrictive cell types
Sequence caution: Sequence=BAB15486.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB67788.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K5Y8 Q5RKS9 Q5XKM2 Q68DK9 Q6IPR7 Q9H5Y1

Explore the universe of human proteins at neXtProt for FAM111A: NX_Q96PZ2

Explore proteomics data for FAM111A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys30, Lys65, Lys163, Lys165, Lys286, Lys304, Lys321, Lys586
  • Modification sites at PhosphoSitePlus

  • See FAM111A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001135991.1  NP_001135992.1  NP_001135993.1  NP_071357.2  NP_942144.1  

    ENSEMBL proteins: 
     ENSP00000434435   ENSP00000436128   ENSP00000355264   ENSP00000432821   ENSP00000433154  
     ENSP00000431631   ENSP00000406683  

    FAM111A Human Recombinant Protein Products:

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    Novus Biologicals FAM111A Protein
    Novus Biologicals FAM111A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for FAM111A

     
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    FAM111A Assay Products:

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    Search eBioscience for ELISAs for FAM111A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q96PZ2

    ProtoNet protein and cluster: Q96PZ2

    UniProtKB/Swiss-Prot: F111A_HUMAN, Q96PZ2
    Similarity: Belongs to the FAM111 family


    Find genes that share domains with FAM111A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F111A_HUMAN, Q96PZ2
    Function: Acts as a Simian virus 40 (SV40) host range restriction factor and can restrict SV40 and adenovirus
    replication
    Induction: Regulated in a cell cycle dependent manner with the lowest expression during G0 or the quiescent phase
    and with peak expression during G2/M phase (at protein level)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0004252serine-type endopeptidase activity ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with FAM111A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FAM111A:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM111A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM111A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM111A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM111A

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM111A:
    hsa-mir-193b-3p (MIRT016290)

    Block miRNA regulation of human, mouse, rat FAM111A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FAM111A:
    hsa-miR-143
    SwitchGear 3'UTR luciferase reporter plasmidFAM111A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAM111A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM111A

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM111A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM111A

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FAM111A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM111A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F111A_HUMAN, Q96PZ2: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with FAM111A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM111A
    Interactions:

        Search GeneGlobe Interaction Network for FAM111A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM111A (Q96PZ23 ENSP000003552644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087mitotic M phase IEP--
    GO:0006508proteolysis ----
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0045071negative regulation of viral genome replication IMP--

    Find genes that share ontologies with FAM111A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM111A (F111A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM111A gene (5 alternative transcripts): 
    NM_001142519.1  NM_001142520.1  NM_001142521.1  NM_022074.3  NM_198847.2  

    Unigene Cluster for FAM111A:

    Family with sequence similarity 111, member A
    Hs.150651  [show with all ESTs]
    Unigene Representative Sequence: NM_001142520
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528737(uc010rkr.2 uc001nno.3 uc001nnp.3) ENST00000532790
    ENST00000529985 ENST00000531676 ENST00000527629 ENST00000361723(uc001nnq.3)
    ENST00000531408 ENST00000529358 ENST00000533703 ENST00000531147 ENST00000420244(uc010rkp.2 uc010rkq.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM111A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FAM111A:
    hsa-miR-143
    SwitchGear 3'UTR luciferase reporter plasmidFAM111A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM111A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM111A
    Clone
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    OriGene clones in human, mouse for FAM111A (see all 31)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): FAM111A (NM_001142519)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM111A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM111A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM111A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM111A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM111A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM111A
      QuantiFast Probe-based Assays in human, mouse, rat FAM111A

    Additional mRNA sequence: 

    AK025319.1 AK026447.1 AK092061.1 AK092953.1 AK130799.1 AK291453.1 BC013137.1 BC041693.1 
    BC054515.1 BC071759.1 

    10 DOTS entries:

    DT.92414823  DT.87024788  DT.91917153  DT.91696581  DT.97785830  DT.100786216  DT.97860920  DT.100786213 
    DT.100033157  DT.120736268 

    Selected AceView cDNA sequences (see all 205):

    AA465584 BE348759 BV180165 AA430754 CR749358 BX091275 AI290188 NM_022074 
    AA688159 AI521118 AW135098 AI439614 CA395994 AI301638 AX747824 AW241889 
    BQ420366 BC013137 AA281196 AA827837 AW058020 AI192409 AA465228 NM_198847 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM111A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e
    SP1:              -           -     -     -                                       
    SP2:                    -     -     -     -                                       
    SP3:                          -     -                                             
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for FAM111A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM111A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGACTGCTG
    FAM111A Expression
    About this image


    FAM111A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    FAM111A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM111A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150651
        Custom PCR Arrays for FAM111A
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    OriGene qPCR primer pairs and template standards for FAM111A
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    QuantiFast Probe-based Assays in human, mouse, rat FAM111A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM111A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM111A gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam111a1 , 5 family with sequence similarity 111, member A1, 5 72.7(n)1
    57.81(a)1
      19 (8.72 cM)5
    1073731  NM_026640.21  NP_080916.11 
     125457405 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    1 → many
    1(91216226-91227509)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018868341 protein FAM111A-like 49.37(n)
    33.73(a)
      101886834  XM_005165680.1  XP_005165737.1 


    ENSEMBL Gene Tree for FAM111A (if available)
    TreeFam Gene Tree for FAM111A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM111A gene
    FAM111B2  
    1 SIMAP similar gene for FAM111A using alignment to 3 protein entries:     F111A_HUMAN (see all proteins):
    FAM111B

    Find genes that share paralogs with FAM111A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM111A (see all 380)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0695164
    Gracile bone dysplasia (GCLEB)4--see VAR_0695162 P T mis40--------
    VAR_0695154
    Kenny-Caffey syndrome 2 (KCS2)4--see VAR_0695152 Y H mis40--------
    VAR_0695184
    Kenny-Caffey syndrome 2 (KCS2)4--see VAR_0695182 R H mis40--------
    VAR_0695134
    Gracile bone dysplasia (GCLEB)4--see VAR_0695132 T A mis40--------
    VAR_0695174
    Gracile bone dysplasia (GCLEB)4--see VAR_0695172 D G mis40--------
    rs107922201,2
    C,F,A,H--58908381(+) AATATA/GTCAAA 3 -- us2k115Minor allele frequency- G:0.29NS EA WA NA CSA 766
    rs1421202101,2
    C--58908384(+) ATGTCA/GAAGTC 3 -- us2k10--------
    rs122718311,2
    C,F,H--58908423(+) ACTTCG/ATAGAT 3 -- us2k118Minor allele frequency- A:0.20NS EA NA WA 1324
    rs1913893431,2
    --58908496(+) TAAACG/TCATGT 3 -- us2k10--------
    rs1448045211,2
    --58908538(+) ACCAAG/TGTATT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM111A (58910221 - 58922512 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAM111A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674064CNV Deletion23128226
    dgv386e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FAM111A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM111A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM111A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615292   
    OMIM disorders: 127000  602361  
    UniProtKB/Swiss-Prot: F111A_HUMAN, Q96PZ2
  • Kenny-Caffey syndrome 2 (KCS2) [MIM:127000]: A disorder characterized by impaired skeletal development
    with small and dense bones, short stature, and primary hypoparathyroidism with hypocalcemia. Clinical features
    include cortical thickening and medullary stenosis of the tubular bones, delayed closure of fontanels, defective
    dentition, small eyes with hypermetropia, and frontal bossing with a triangular face. Note=The disease is caused
    by mutations affecting the gene represented in this entry
  • Gracile bone dysplasia (GCLEB) [MIM:602361]: A perinatally lethal condition characterized by narrowing of
    the medullary cavity of the long bones and of the skull, gracile bones with thin diaphyses, premature closure of
    basal cranial sutures, and microphthalmia. Most affected individuals who survive beyond the perinatal period
    develop hypocalcemia with low parathyroid hormone levels. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 2 diseases for FAM111A:    
    About MalaCards
    kenny-caffey syndrome type 2    gracile bone dysplasia


    Find genes that share disorders with FAM111A           About GenesLikeMe


    Export disorders for FAM111A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM111A gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with FAM111A)
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    1. FAM111A mutations result in hypoparathyroidism and impaired skeletal development. (PubMed id 23684011)1, 2, 3 Unger S.... Superti-Furga A. (Am. J. Hum. Genet. 2013)
    2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    3. A recurrent de novo FAM111A mutation causes Kenny-Caffey syndrome type 2. (PubMed id 23996431)1, 3 Isojima T....Kitanaka S. (J. Bone Miner. Res. 2013)
    4. Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor. (PubMed id 23093934)1, 2 Fine D.A.... DeCaprio J.A. (PLoS Pathog. 2012)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63901 HGNC: 24725 AceView: FLJ22794 Ensembl:ENSG00000166801 euGenes: HUgn63901
    ECgene: FAM111A H-InvDB: FAM111A

    (According to HUGE)
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    HUGE: KIAA1895

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM111A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM111A gene:
    Search GeneIP for patents involving FAM111A

    GeneCards and IP:
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