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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM110D Gene

protein-coding   GIFtS: 36
GCID: GC01P026486

Family With Sequence Similarity 110, Member D

(Previous name: glycine/arginine rich protein 1)
(Previous symbol: GRRP1)
  Search for FAM110D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 110, Member D1 2
GRRP11 2 3
Glycine/Arginine Rich Protein 11 2
RP11-96L14.52
Glycine/Arginine-Rich Protein 12
Protein FAM110D2

External Ids:    HGNC: 258601   Entrez Gene: 799272   Ensembl: ENSG000001972457   UniProtKB: Q8TAY73   

Export aliases for FAM110D gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM110D Gene: 
FAM110D (family with sequence similarity 110, member D) is a protein-coding gene. An important paralog of this gene is FAM110A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM110D
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM110D promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM110D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM110D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

FAM110D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM110D gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P026486:  view genomic region     (about GC identifiers)

Start:
26,485,511 bp from pter      End:
26,489,119 bp from pter
Size:
3,609 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F110D_HUMAN, Q8TAY7 (See protein sequence)
Recommended Name: Protein FAM110D  
Size: 271 amino acids; 28710 Da
Sequence caution: Sequence=BAB14829.1; Type=Frameshift; Positions=90;
Secondary accessions: A8K3V0 Q9H7Z4

Explore the universe of human proteins at neXtProt for FAM110D: NX_Q8TAY7

Explore proteomics data for FAM110D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TAY7

  • FAM110D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM110D Protein Expression
    REFSEQ proteins: NP_079145.2  
    ENSEMBL proteins: 
     ENSP00000363386  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR025741 FAM110_C
     IPR025740 FAM110
     IPR025739 FAM110_N

    Graphical View of Domain Structure for InterPro Entry Q8TAY7

    ProtoNet protein and cluster: Q8TAY7

    UniProtKB/Swiss-Prot: F110D_HUMAN, Q8TAY7
    Similarity: Belongs to the FAM110 family


    FAM110D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM110D 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM110D 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM110D

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM110D (F110D)

    Search CenterWatch for drugs/clinical trials and news about FAM110D / F110D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM110D gene: 
    NM_024869.2  

    Unigene Cluster for FAM110D:

    Family with sequence similarity 110, member D
    Hs.694119  [show with all ESTs]
    Unigene Representative Sequence: NM_024869
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374268(uc001blk.3)
    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of FAM110D 
    Primer
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    Additional mRNA sequence: 

    AK024112.1 AK290715.1 BC025658.1 

    2 DOTS entries:

    DT.65285791  DT.121407009 

    20 AceView cDNA sequences:

    AK024112 BX091810 BM994693 CR594191 CA866201 CR612361 AI700484 NM_024869 
    BC025658 AI373328 AU119858 BX379842 AL575401 BE857044 BP381891 BX379841 
    CA941170 AL575427 AU146093 BI757690 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM110D expression in normal human tissues (normalized intensities)      FAM110D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAAGTGCC
    FAM110D Expression
    About this image


    FAM110D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Interzone Cells Stylopod Synovial Joint
             Stylopod Synovial Joint
             limb/hindlimb/leg   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod Long Bone
             skeleton/cranium/viscerocranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Interzone Cells Stylopod Synovial Joint
             skeleton/cranium/viscerocranium   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             skeleton/cranium/viscerocranium   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

    See FAM110D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM110D

    SOURCE GeneReport for Unigene cluster: Hs.694119
        SABiosciences Custom PCR Arrays for FAM110D
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM110D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM110D gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grrp11 , 5 glycine/arginine rich protein 11, 5 86.47(n)1
    87.08(a)1
      4 (66.50 cM)5
    726901  NM_001099296.11  NP_001092766.11 
     1342511105 
    chicken
    (Gallus gallus)
    Aves GRRP11 glycine/arginine rich protein 1 61.2(n)
    59.02(a)
      419603  XM_417749.2  XP_417749.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM110D6
    Uncharacterized protein
    43(a)
    1 ↔ 1
    GL343480.1(353083-353985)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-107n13.11 si:ch211-107n13.1 55.66(n)
    51.16(a)
      798535  NM_001082926.1  NP_001076395.1 


    ENSEMBL Gene Tree for FAM110D (if available)
    TreeFam Gene Tree for FAM110D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM110D gene
    FAM110A2  FAM110B2  FAM110C2  

    FAM110D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/104 SNPs in FAM110D are shown (see all 104)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130416961,2
    C,F--26483560(+) TGCAGC/GTTTGT 1 -- us2k13Minor allele frequency- G:0.07CSA WA 121
    rs1837012211,2
    --26483774(+) CGGCCC/TGCCTT 1 -- us2k10--------
    rs94385421,2
    C,F--26483823(+) tcgccC/Tggccc 1 -- us2k12Minor allele frequency- T:0.11WA 120
    rs1887620891,2
    --26483884(+) ATGTGA/TGGTAC 1 -- us2k10--------
    rs726663381,2
    C,F--26483905(+) CCCTAA/TCATAT 1 -- us2k14Minor allele frequency- T:0.29NA EA 244
    rs1916542261,2
    C--26484103(+) TACTCA/GGGAGG 1 -- us2k10--------
    rs27837091,2
    C,F--26484166(-) gtgacG/Atgatc 1 -- us2k1 tfbs31Minor allele frequency- A:0.50WA 2
    rs49924991,2
    C,F,H--26484201(+) TTTGGA/C/TGAGCT 1 -- us2k118NS EA NA CSA WA 2331
    rs1181365521,2
    C,F--26484234(+) TGAGCC/ATCAGT 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1472898791,2
    --26484295(+) ATGGGG/TATTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM110D (26485511 - 26489119 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM110D: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM110D
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM110D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM110D gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM110D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79927 HGNC: 25860 AceView: FLJ14050 Ensembl:ENSG00000197245 euGenes: HUgn79927
    ECgene: FAM110D H-InvDB: FAM110D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM110D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM110D gene:
    Search GeneIP for patents involving FAM110D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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