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Aliases for FAM110C Gene

Aliases for FAM110C Gene

  • Family With Sequence Similarity 110 Member C 2 3 5
  • Family With Sequence Similarity 110, Member C 2

External Ids for FAM110C Gene

Summaries for FAM110C Gene

GeneCards Summary for FAM110C Gene

FAM110C (Family With Sequence Similarity 110 Member C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include alpha-tubulin binding. An important paralog of this gene is FAM110B.

UniProtKB/Swiss-Prot for FAM110C Gene

  • May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.

Additional gene information for FAM110C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM110C Gene

Genomics for FAM110C Gene

GeneHancer (GH) Regulatory Elements for FAM110C Gene

Promoters and enhancers for FAM110C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I000043 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.6 1612 5 ELF3 RAD21 RARA ETS1 SLC30A9 ZNF335 GLIS2 SCRT2 ELK4 SP3 FAM110C SH3YL1
GH02I000048 Enhancer 0.6 ENCODE dbSUPER 550.8 -0.9 -916 0 HNF4A EZH2 FAM110C GC02P000061
GH02I000033 Enhancer 1 ENCODE dbSUPER 5.9 +10.9 10859 6.5 ELF3 PKNOX1 NFIB NEUROD1 SIN3A BMI1 RFX5 HSF1 SCRT2 FOS LOC101927262 ALKAL2 FAM110C LOC105373346 SH3YL1
GH02I000040 Enhancer 0.6 dbSUPER 0.4 +6.5 6480 0.6 RXRA JUN CEBPB FEZF1 ATF2 YY1 JUND ATF3 HNF4G CREB1 FAM110C
GH02I000023 Enhancer 0.8 ENCODE dbSUPER 0.3 +22.7 22748 1.6 FOXA2 MAX REST FOXA1 YY1 JUND ATF3 HNF4A ZBTB33 FAM110C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM110C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM110C gene promoter:

Genomic Locations for FAM110C Gene

Genomic Locations for FAM110C Gene
8,302 bases
Minus strand

Genomic View for FAM110C Gene

Genes around FAM110C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM110C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM110C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110C Gene

Proteins for FAM110C Gene

  • Protein details for FAM110C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM110C
    Protein Accession:

    Protein attributes for FAM110C Gene

    321 amino acids
    Molecular mass:
    33863 Da
    Quaternary structure:
    • Interacts with AKT1; the interaction is transient and follows AKT1 activation. Interacts with PPP2CA and alpha-tubulin.

neXtProt entry for FAM110C Gene

Post-translational modifications for FAM110C Gene

No Post-translational modifications

Other Protein References for FAM110C Gene

No data available for DME Specific Peptides for FAM110C Gene

Domains & Families for FAM110C Gene

Gene Families for FAM110C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM110C Gene


Suggested Antigen Peptide Sequences for FAM110C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM110 family.
  • Belongs to the FAM110 family.
genes like me logo Genes that share domains with FAM110C: view

Function for FAM110C Gene

Molecular function for FAM110C Gene

UniProtKB/Swiss-Prot Function:
May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.

Phenotypes From GWAS Catalog for FAM110C Gene

Gene Ontology (GO) - Molecular Function for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19698782
GO:0043014 alpha-tubulin binding IDA 19698782
genes like me logo Genes that share ontologies with FAM110C: view
genes like me logo Genes that share phenotypes with FAM110C: view

Animal Model Products

miRNA for FAM110C Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM110C Gene

Localization for FAM110C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110C Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with microtubules during interphase (PubMed:17499476). Detected at the mitotic spindle poles (PubMed:17499476). Colocalizes with AKT1 at the cell cortex (PubMed:19698782). {ECO:0000269 PubMed:17499476, ECO:0000269 PubMed:19698782}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM110C gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FAM110C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM110C Gene

Pathways & Interactions for FAM110C Gene

SuperPathways for FAM110C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IMP 19698782
GO:0051897 positive regulation of protein kinase B signaling IMP 19698782
GO:0060491 regulation of cell projection assembly IMP 19698782
genes like me logo Genes that share ontologies with FAM110C: view

No data available for Pathways by source and SIGNOR curated interactions for FAM110C Gene

Drugs & Compounds for FAM110C Gene

No Compound Related Data Available

Transcripts for FAM110C Gene

mRNA/cDNA for FAM110C Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM110C Gene

Family with sequence similarity 110, member C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110C Gene

No ASD Table

Relevant External Links for FAM110C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM110C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM110C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM110C Gene

This gene is overexpressed in Esophagus - Mucosa (x7.2).

Protein differential expression in normal tissues from HIPED for FAM110C Gene

This gene is overexpressed in Heart (59.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM110C Gene

Protein tissue co-expression partners for FAM110C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM110C Gene:


SOURCE GeneReport for Unigene cluster for FAM110C Gene:


mRNA Expression by UniProt/SwissProt for FAM110C Gene:

Tissue specificity: Detected in stomach, thyroid, trachea, adrenal gland and testis, and at low levels in prostate, ovary, intestine, colon, spinal cord and lymph node.
genes like me logo Genes that share expression patterns with FAM110C: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM110C Gene

Orthologs for FAM110C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM110C 33 34
  • 98.86 (n)
(Bos Taurus)
Mammalia LOC100337320 33
  • 80.49 (n)
(Mus musculus)
Mammalia Fam110c 33 16 34
  • 71.92 (n)
(Rattus norvegicus)
Mammalia Fam110c 33
  • 67.64 (n)
(Canis familiaris)
Mammalia FAM110C 34
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia FAM110C 34
  • 48 (a)
(Monodelphis domestica)
Mammalia FAM110C 34
  • 38 (a)
(Gallus gallus)
Aves FAM110C 34
  • 39 (a)
(Anolis carolinensis)
Reptilia FAM110C 34
  • 39 (a)
(Danio rerio)
Actinopterygii FAM110C 34
  • 29 (a)
Species where no ortholog for FAM110C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM110C Gene

Gene Tree for FAM110C (if available)
Gene Tree for FAM110C (if available)

Paralogs for FAM110C Gene

Paralogs for FAM110C Gene

genes like me logo Genes that share paralogs with FAM110C: view

Variants for FAM110C Gene

Sequence variations from dbSNP and Humsavar for FAM110C Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000044716 -- 48,034(-) G/A upstream_transcript_variant
rs1000087901 -- 38,881(-) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000103119 -- 39,517(-) G/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000564777 -- 43,537(-) G/C intron_variant
rs1000603237 -- 42,263(-) GG/G genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM110C Gene

Variant ID Type Subtype PubMed ID
dgv3689n100 CNV gain 25217958
dgv3690n100 CNV gain+loss 25217958
dgv3691n100 CNV gain 25217958
dgv3692n100 CNV gain 25217958
dgv3693n100 CNV gain 25217958
dgv3694n100 CNV loss 25217958
dgv3695n100 CNV gain 25217958
esv2751887 CNV loss 17911159
esv3589587 CNV gain 21293372
esv3589589 CNV gain 21293372
nsv1010002 CNV loss 25217958
nsv1011864 CNV loss 25217958
nsv1013177 CNV gain 25217958

Variation tolerance for FAM110C Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM110C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM110C Gene

Disorders for FAM110C Gene

Additional Disease Information for FAM110C

No disorders were found for FAM110C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM110C Gene

Publications for FAM110C Gene

  1. Evidence for the involvement of FAM110C protein in cell spreading and migration. (PMID: 19698782) Hauge H … Aasheim HC (Cellular signalling 2009) 2 3 4 58
  2. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H … Aasheim HC (Genomics 2007) 2 3 4 58
  3. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M … Deary IJ (Biological psychology 2011) 3 44 58
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. (PMID: 25468996) Guo Z … Zaidel-Bar R (Science signaling 2014) 3 58
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M … Superti-Furga G (Nature methods 2013) 3 58

Products for FAM110C Gene

Sources for FAM110C Gene

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