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Aliases for FAM110C Gene

Aliases for FAM110C Gene

  • Family With Sequence Similarity 110 Member C 2 3 5
  • Family With Sequence Similarity 110, Member C 2

External Ids for FAM110C Gene

Summaries for FAM110C Gene

GeneCards Summary for FAM110C Gene

FAM110C (Family With Sequence Similarity 110 Member C) is a Protein Coding gene. GO annotations related to this gene include alpha-tubulin binding. An important paralog of this gene is FAM110B.

UniProtKB/Swiss-Prot for FAM110C Gene

  • May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM110C Gene

Genomics for FAM110C Gene

Regulatory Elements for FAM110C Gene

Enhancers for FAM110C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F000033 1.1 Ensembl ENCODE 5.9 +10.9 10859 6.5 ELF3 TBP PKNOX1 SIN3A RAD21 SLC30A9 SCRT2 FOS RCOR1 DEK FAM150B LOC101927262 FAM110C LOC105373346 SH3YL1 LOC102724983 LOC102725018
GH02F000043 1.2 Ensembl ENCODE 0.8 +1.6 1613 5.0 ELF3 ARID4B DMAP1 RAD21 ZNF48 ETS1 RARA ZNF335 SLC30A9 GLIS2 SH3YL1 FAM110C LOC102724983
GH02F000048 0.2 ENCODE 0.8 -0.9 -917 0.0 FAM110C GC02P000061
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM110C on UCSC Golden Path with GeneCards custom track

Promoters for FAM110C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001538819 1114 2800 ELF3 ARID4B DMAP1 RAD21 ZNF48 ETS1 RARA ZNF335 SLC30A9 GLIS2

Genomic Location for FAM110C Gene

Chromosome:
2
Start:
38,814 bp from pter
End:
47,115 bp from pter
Size:
8,302 bases
Orientation:
Minus strand

Genomic View for FAM110C Gene

Genes around FAM110C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM110C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM110C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110C Gene

Proteins for FAM110C Gene

  • Protein details for FAM110C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1W6H9-F110C_HUMAN
    Recommended name:
    Protein FAM110C
    Protein Accession:
    Q1W6H9

    Protein attributes for FAM110C Gene

    Size:
    321 amino acids
    Molecular mass:
    33863 Da
    Quaternary structure:
    • Interacts with AKT1; the interaction is transient and follows AKT1 activation. Interacts with PPP2CA and alpha-tubulin.

neXtProt entry for FAM110C Gene

Post-translational modifications for FAM110C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM110C Gene

No data available for DME Specific Peptides for FAM110C Gene

Domains & Families for FAM110C Gene

Protein Domains for FAM110C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM110C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1W6H9

UniProtKB/Swiss-Prot:

F110C_HUMAN :
  • Belongs to the FAM110 family.
Family:
  • Belongs to the FAM110 family.
genes like me logo Genes that share domains with FAM110C: view

No data available for Gene Families for FAM110C Gene

Function for FAM110C Gene

Molecular function for FAM110C Gene

UniProtKB/Swiss-Prot Function:
May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.

Gene Ontology (GO) - Molecular Function for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19698782
GO:0043014 alpha-tubulin binding IDA 19698782
genes like me logo Genes that share ontologies with FAM110C: view
genes like me logo Genes that share phenotypes with FAM110C: view

Animal Model Products

miRNA for FAM110C Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM110C Gene

Localization for FAM110C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110C Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with microtubules during interphase (PubMed:17499476). Detected at the mitotic spindle poles (PubMed:17499476). Colocalizes with AKT1 at the cell cortex (PubMed:19698782). {ECO:0000269 PubMed:17499476, ECO:0000269 PubMed:19698782}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM110C gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with FAM110C: view

Pathways & Interactions for FAM110C Gene

SuperPathways for FAM110C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IMP 19698782
GO:0051897 positive regulation of protein kinase B signaling IMP 19698782
GO:0060491 regulation of cell projection assembly IMP 19698782
genes like me logo Genes that share ontologies with FAM110C: view

No data available for Pathways by source and SIGNOR curated interactions for FAM110C Gene

Transcripts for FAM110C Gene

mRNA/cDNA for FAM110C Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM110C Gene

Family with sequence similarity 110, member C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110C Gene

No ASD Table

Relevant External Links for FAM110C Gene

GeneLoc Exon Structure for
FAM110C
ECgene alternative splicing isoforms for
FAM110C

Expression for FAM110C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM110C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM110C Gene

This gene is overexpressed in Esophagus - Mucosa (x7.2).

Protein differential expression in normal tissues from HIPED for FAM110C Gene

This gene is overexpressed in Heart (59.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM110C Gene



Protein tissue co-expression partners for FAM110C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM110C Gene:

FAM110C

SOURCE GeneReport for Unigene cluster for FAM110C Gene:

Hs.8379

mRNA Expression by UniProt/SwissProt for FAM110C Gene:

Q1W6H9-F110C_HUMAN
Tissue specificity: Detected in stomach, thyroid, trachea, adrenal gland and testis, and at low levels in prostate, ovary, intestine, colon, spinal cord and lymph node.
genes like me logo Genes that share expression patterns with FAM110C: view

Primer Products

Orthologs for FAM110C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM110C 34 35
  • 98.86 (n)
cow
(Bos Taurus)
Mammalia LOC100337320 34
  • 80.49 (n)
mouse
(Mus musculus)
Mammalia Fam110c 34 16 35
  • 71.92 (n)
rat
(Rattus norvegicus)
Mammalia Fam110c 34
  • 67.64 (n)
dog
(Canis familiaris)
Mammalia FAM110C 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM110C 35
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM110C 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM110C 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM110C 35
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FAM110C 35
  • 29 (a)
OneToOne
Species where no ortholog for FAM110C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM110C Gene

ENSEMBL:
Gene Tree for FAM110C (if available)
TreeFam:
Gene Tree for FAM110C (if available)

Paralogs for FAM110C Gene

Paralogs for FAM110C Gene

genes like me logo Genes that share paralogs with FAM110C: view

Variants for FAM110C Gene

Sequence variations from dbSNP and Humsavar for FAM110C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10172032 -- 43,210(+) TAGGG(A/T)AGTAC intron-variant
rs10173732 -- 41,404(+) CTCTT(A/G)GAGTT nc-transcript-variant, utr-variant-3-prime
rs10179984 -- 43,092(+) GTTCC(A/G)GTGAT intron-variant
rs10180278 -- 43,362(+) CAAAC(A/G)GGATT intron-variant
rs10209856 -- 44,613(+) CAAGA(C/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM110C Gene

Variant ID Type Subtype PubMed ID
nsv1013177 CNV gain 25217958
nsv1011864 CNV loss 25217958
nsv1010002 CNV loss 25217958
esv3589589 CNV gain 21293372
esv3589587 CNV gain 21293372
esv2751887 CNV loss 17911159
dgv3695n100 CNV gain 25217958
dgv3694n100 CNV loss 25217958
dgv3693n100 CNV gain 25217958
dgv3692n100 CNV gain 25217958
dgv3691n100 CNV gain 25217958
dgv3690n100 CNV gain+loss 25217958
dgv3689n100 CNV gain 25217958

Variation tolerance for FAM110C Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM110C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM110C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM110C Gene

Disorders for FAM110C Gene

Relevant External Links for FAM110C

Genetic Association Database (GAD)
FAM110C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM110C

No disorders were found for FAM110C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM110C Gene

Publications for FAM110C Gene

  1. Evidence for the involvement of FAM110C protein in cell spreading and migration. (PMID: 19698782) Hauge H. … Aasheim H.C. (Cell. Signal. 2009) 2 3 4 64
  2. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H. … Aasheim H.-C. (Genomics 2007) 2 3 4 64
  3. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3 46 64
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for FAM110C Gene

Sources for FAM110C Gene

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