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Aliases for FAM110C Gene

Aliases for FAM110C Gene

  • Family With Sequence Similarity 110, Member C 2 3

External Ids for FAM110C Gene

Summaries for FAM110C Gene

GeneCards Summary for FAM110C Gene

FAM110C (Family With Sequence Similarity 110, Member C) is a Protein Coding gene. GO annotations related to this gene include alpha-tubulin binding. An important paralog of this gene is FAM110A.

UniProtKB/Swiss-Prot for FAM110C Gene

  • May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM110C Gene

Genomics for FAM110C Gene

Regulatory Elements for FAM110C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM110C Gene

Start:
38,814 bp from pter
End:
46,870 bp from pter
Size:
8,057 bases
Orientation:
Minus strand

Genomic View for FAM110C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM110C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110C Gene

Proteins for FAM110C Gene

  • Protein details for FAM110C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1W6H9-F110C_HUMAN
    Recommended name:
    Protein FAM110C
    Protein Accession:
    Q1W6H9
    Secondary Accessions:

    Protein attributes for FAM110C Gene

    Size:
    321 amino acids
    Molecular mass:
    33863 Da
    Quaternary structure:
    • Interacts with AKT1; the interaction is transient and follows AKT1 activation. Interacts with PPP2CA and alpha-tubulin.

neXtProt entry for FAM110C Gene

Proteomics data for FAM110C Gene at MOPED

Post-translational modifications for FAM110C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM110C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FAM110C Gene

Domains for FAM110C Gene

Protein Domains for FAM110C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM110C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1W6H9

UniProtKB/Swiss-Prot:

F110C_HUMAN :
  • Q1W6H9
Family:
  • Belongs to the FAM110 family.
genes like me logo Genes that share domains with FAM110C: view

No data available for Gene Families for FAM110C Gene

Function for FAM110C Gene

Molecular function for FAM110C Gene

UniProtKB/Swiss-Prot Function:
May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.

Gene Ontology (GO) - Molecular Function for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19698782
GO:0043014 alpha-tubulin binding IDA 19698782
genes like me logo Genes that share ontologies with FAM110C: view

Phenotypes for FAM110C Gene

GenomeRNAi human phenotypes for FAM110C:
genes like me logo Genes that share phenotypes with FAM110C: view

Animal Model Products

CRISPR Products

miRNA for FAM110C Gene

miRTarBase miRNAs that target FAM110C

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM110C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM110C Gene

Localization for FAM110C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110C Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with microtubules during interphase. Detected at the mitotic spindle poles. Colocalizes with AKT1 at the cell cortex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM110C Gene COMPARTMENTS Subcellular localization image for FAM110C gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with FAM110C: view

Pathways for FAM110C Gene

SuperPathways for FAM110C Gene

No Data Available

Interacting Proteins for FAM110C Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328347%0d%0a9606.ENSP00000352929%0d%0a9606.ENSP00000270202%0d%0a
Selected Interacting proteins: ENSP00000328347 Q1W6H9-F110C_HUMAN for FAM110C Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IMP 19698782
GO:0051897 positive regulation of protein kinase B signaling IMP 19698782
GO:0060491 regulation of cell projection assembly IMP 19698782
genes like me logo Genes that share ontologies with FAM110C: view

No data available for Pathways by source for FAM110C Gene

Transcripts for FAM110C Gene

mRNA/cDNA for FAM110C Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM110C Gene

Family with sequence similarity 110, member C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM110C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110C Gene

No ASD Table

Relevant External Links for FAM110C Gene

GeneLoc Exon Structure for
FAM110C
ECgene alternative splicing isoforms for
FAM110C

Expression for FAM110C Gene

mRNA expression in normal human tissues for FAM110C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM110C Gene

This gene is overexpressed in Esophagus - Mucosa (7.2).

Protein differential expression in normal tissues for FAM110C Gene

This gene is overexpressed in Heart (59.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM110C Gene

SOURCE GeneReport for Unigene cluster for FAM110C Gene Hs.8379

mRNA Expression by UniProt/SwissProt for FAM110C Gene

Q1W6H9-F110C_HUMAN
Tissue specificity: Detected in stomach, thyroid, trachea, adrenal gland and testis, and at low levels in prostate, ovary, intestine, colon, spinal cord and lymph node.
genes like me logo Genes that share expressions with FAM110C: view

Expression partners for FAM110C Gene

In Situ Assay Products

Orthologs for FAM110C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100337320 35
  • 80.49 (n)
  • 72.82 (a)
mouse
(Mus musculus)
Mammalia Fam110c 35
  • 71.92 (n)
  • 69.96 (a)
Fam110c 16
Fam110c 36
  • 43 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM110C 35
  • 98.86 (n)
  • 98.75 (a)
FAM110C 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam110c 35
  • 67.64 (n)
  • 62.87 (a)
dog
(Canis familiaris)
Mammalia FAM110C 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM110C 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM110C 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM110C 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM110C 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FAM110C 36
  • 29 (a)
OneToOne
Species with no ortholog for FAM110C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM110C Gene

ENSEMBL:
Gene Tree for FAM110C (if available)
TreeFam:
Gene Tree for FAM110C (if available)

Paralogs for FAM110C Gene

Paralogs for FAM110C Gene

genes like me logo Genes that share paralogs with FAM110C: view

Variants for FAM110C Gene

Sequence variations from dbSNP and Humsavar for FAM110C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4241318 -- 45,895(+) CGGGG(A/G)TTGCG missense, reference, nc-transcript-variant
rs4430979 -- 47,208(+) GACTC(G/T)CAGTG upstream-variant-2KB
rs4530399 -- 39,340(+) CTGCA(A/G)CCTTG utr-variant-3-prime
rs6731388 -- 40,569(+) CATTA(C/T)AGCCG utr-variant-3-prime
rs6751912 -- 41,509(+) ATGCT(A/G)CATTC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM110C Gene

Variant ID Type Subtype PubMed ID
dgv4033n71 CNV Gain 21882294
esv2751887 CNV Loss 17911159
nsv873521 CNV Gain 21882294

Relevant External Links for FAM110C Gene

HapMap Linkage Disequilibrium report
FAM110C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM110C Gene

Disorders for FAM110C Gene

Relevant External Links for FAM110C

Genetic Association Database (GAD)
FAM110C

No disorders were found for FAM110C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FAM110C Gene

Publications for FAM110C Gene

  1. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H. … Aasheim H.-C. (Genomics 2007) 2 3 4
  2. Evidence for the involvement of FAM110C protein in cell spreading and migration. (PMID: 19698782) Hauge H. … Aasheim H.C. (Cell. Signal. 2009) 2 3 4
  3. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3 48
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for FAM110C Gene

Sources for FAM110C Gene

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