FAM110B Gene
protein-coding GIFtS : 46
GCID: GC08 P058907
family with sequence similarity 110, member B (Previous name: chromosome 8 open reading frame 72 ) (Previous symbol: C8orf72 )
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Aliasesfor FAM110B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 110, Member B 1 2 C8orf721 2 3 MGC393251 Chromosome 8 Open Reading Frame 721 Protein FAM110B2
Export aliases for FAM110B gene to outside databases Previous GC identifers: GC08P059072 GC08P054394
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Summariesfor FAM110B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: F110B_HUMAN, Q8TC76 Function : May be involved in tumor progression
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Genomic Viewsfor FAM110B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_008183.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM110B gene promoter: TBP AML1a POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 Gfi-1 N-Myc FOXJ2 (long isoform) PPAR-gamma2 FOXJ2 Other transcription factors Search SABiosciences Chromatin IP Primers for FAM110B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM110B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q12.1 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q12.1 FAM110B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08P058907: view genomic region
(about GC identifiers )
Start:
58,907,068 bp from pter
End:
59,116,838 bp from pter
Size:
209,771 bases
Orientation:
plus strand
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Proteinsfor FAM110B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F110B_HUMAN, Q8TC76 (See
protein sequence )Recommended Name: Protein FAM110B Size : 370 amino acids; 40728 Da
Subcellular location : Cytoplasm. Cytoplasm, cytoskeleton, centrosome
Sequence caution : Sequence=AAB50224.1; Type=Erroneous initiation;
Secondary accessions : Q5BM08 Q9Y4K2Explore the universe of human proteins at neXtProt for FAM110B: NX_Q8TC76 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TC76 FAM110B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_671722.1 ENSEMBL proteins: ENSP00000355204 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
FAM110B for ontologies About GeneDecksing FAM110B Antibody Products: Assay Products for FAM110B:
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Protein
Domains / Familiesfor FAM110B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM110B for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TC76 ProtoNet protein and cluster: Q8TC76
UniProtKB/Swiss-Prot: F110B_HUMAN, Q8TC76 Similarity : Belongs to the FAM110 family
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Functionfor FAM110B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: F110B_HUMAN, Q8TC76 Function : May be involved in tumor progression
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM110B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM110BOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM110B (NM_147189 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM110B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM110B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM110B
2 GenomeRNAi human phenotypes for FAM110B :
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Pathways & Interactionsfor FAM110B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM110B STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)2 Interacting proteins for FAM110B (Q8TC76 3 ENSP00000355204 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor FAM110B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM110B Search CenterWatch for drugs/clinical trials and news about FAM110B / F110B
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Transcriptsfor FAM110B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM110B gene: NM_147189.2 Unigene Cluster for FAM110B:
Family with sequence similarity 110, member B Hs.154652 [show with all ESTs ] Unigene Representative Sequence: NM_147189 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000519262 ENST00000361488 (uc003xtj.1 ) ENST00000520369 ENST00000522059 ENST00000518427 ENST00000523486 ENST00000521413 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM110B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM110BOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FAM110B (NM_147189 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM110B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM110B
Additional cDNA sequence: AK023658.1 AK026141.1 AK092221.1 AY937246.1 BC024294.1 DQ431182.1 U79298.1
7 DOTS entries : DT.114705 DT.120649614
DT.100751741 DT.86847353 DT.75102455 DT.120649618 DT.97807443 24/104 AceView cDNA sequences (see all 104 ):
AI674445 Z39084 BQ575864 T63413 AK092221 BU738872 AI369859 AI769877 CA419003 U79298 AI823875 AW518627 BE672278 AI433783 AA860751 AW772164 AI367242 R84272 AI621055 AW470732 CD366236 BE794537 BM468492 AI050799 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM110B About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c SP1 :         -           SP2 :       -   -           SP3 :                  
ECgene alternative splicing isoforms for FAM110B
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Expression for FAM110B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM110B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image FAM110B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor W10 (Embryonic Progenitor Cell)Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM110B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM110B SOURCE GeneReport for Unigene cluster: Hs.154652 UniProtKB/Swiss-Prot: F110B_HUMAN, Q8TC76 Tissue specificity : Detected in thyroid, spleen and testis, and at lower levels in stomach, spinal cord, lymph node,trachea, adrenal gland, prostate, ovary and intestine SABiosciences Custom PCR Arrays for FAM110B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM110BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM110B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM110B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM110B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM110B
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Orthologsfor FAM110B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for FAM110B gene from 5/12 species (see all 12 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Fam110b1 , 5
family with sequence similarity 110, member B1, 5
89.62(n) 1 96.17(a) 1
 
4 (2.62 cM) 5 242297 1 NM_173426.2 1 NP_775602.1 1 5644090 5
chicken (Gallus gallus)
Aves
FAM110B1
family with sequence similarity 110, member B
82.07(n) 92.97(a)
 
421134 XM_419215.3 XP_419215.2
lizard (Anolis carolinensis)
Reptilia
FAM110B6
--
92(a)
1 ↔ 1
4(27490188-27491300)
African clawed frog (Xenopus laevis)
Amphibia
BX848615.12
--
75.22(n)
 
BX848615.1
zebrafish (Danio rerio)
Actinopterygii
fam110b1
family with sequence similarity 110, member B
66.49(n) 70.92(a)
 
573995 NM_001025174.1 NP_001020345.1
ENSEMBL Gene Tree for FAM110B (if available)TreeFam Gene Tree for FAM110B (if available)
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Paralogsfor FAM110B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM110B gene FAM110A 2 FAM110D 2 FAM110C 2 1 SIMAP similar gene for FAM110B using alignment to 1 protein entry: F110B_HUMAN :FAM110A
FAM110B for paralogs About GeneDecksing
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Genomic Variantsfor FAM110B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 8 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM110B (58907068 - 59116838 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FAM110B: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM110B
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Disorders
/ Diseasesfor FAM110B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM110B for disorders About GeneDecksing
OMIM gene information: 611394
OMIM disorders : --4 diseases for FAM110B : About MalaCards bipolar disorder schizophrenia thyroiditis prostatitis Human Genome Epidemiology (HuGE) Navigator: FAM110B (2 documents) Export disorders for FAM110B gene to outside databases
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Publicationsfor FAM110B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM110B gene, integrated from 9 sources (see all 18 ): (articles sorted by number of sources associating them with FAM110B) Utopia : connect your pdf to the dynamic world of online information
Characterization of the FAM110 gene family. (PubMed id 17499476) 1 , 2 , 3 Hauge H.... Aasheim H.-C. (2007) Large-scale concatenation cDNA sequencing. (PubMed id 9110174) 1 , 2 , 3 Yu W.... Gibbs R.A. (1997) A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474) 1 , 3 Andersson B.... Gibbs R.A. (1996) Integrative genomic, transcriptomic, and RNAi analysis indicates a potential oncogenic role for FAM110B in castration-resistant prosta te cancer. (PubMed id 21919029) 1 Vainio P....Kallioniemi O. (2012) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) A genome-wide meta-analysis identifies novel loci ass ociated with schizophrenia and bipolar disorder. (PubMed id 20889312) 1 Wang K.S....Aragam N. (2010) Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068) 1 Hutchins J.R....Peters J.M. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061) 1 Trynka G....Wijmenga C. (2009)
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External Searches for FAM110B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM110B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM110B gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM110B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM110B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM110B gene: Search GeneIP for patents involving FAM110B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM110B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM110B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM110B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM110B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM110B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM110B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM110B
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FAM110B Proteins, Antibodies, CLIAs, and ELISAs
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Aliases for FAM110B
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Disorders / Diseases for FAM110B
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Expression for FAM110B
Function for FAM110B
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