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Aliases for FAM110B Gene

Aliases for FAM110B Gene

  • Family With Sequence Similarity 110 Member B 2 3 5
  • C8orf72 3 4
  • Family With Sequence Similarity 110, Member B 2
  • Chromosome 8 Open Reading Frame 72 2
  • Protein FAM110B 3

External Ids for FAM110B Gene

Previous HGNC Symbols for FAM110B Gene

  • C8orf72

Previous GeneCards Identifiers for FAM110B Gene

  • GC08P059072
  • GC08P058907
  • GC08P054394

Summaries for FAM110B Gene

GeneCards Summary for FAM110B Gene

FAM110B (Family With Sequence Similarity 110 Member B) is a Protein Coding gene. An important paralog of this gene is FAM110A.

UniProtKB/Swiss-Prot for FAM110B Gene

  • May be involved in tumor progression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM110B Gene

Genomics for FAM110B Gene

Regulatory Elements for FAM110B Gene

Enhancers for FAM110B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAM110B on UCSC Golden Path with GeneCards custom track

Promoters for FAM110B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM110B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM110B Gene

57,994,509 bp from pter
58,204,279 bp from pter
209,771 bases
Plus strand

Genomic View for FAM110B Gene

Genes around FAM110B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM110B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM110B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110B Gene

Proteins for FAM110B Gene

  • Protein details for FAM110B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM110B
    Protein Accession:
    Secondary Accessions:
    • Q5BM08
    • Q9Y4K2

    Protein attributes for FAM110B Gene

    370 amino acids
    Molecular mass:
    40728 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB50224.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM110B Gene

Post-translational modifications for FAM110B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM110B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM110B Gene

Domains & Families for FAM110B Gene

Protein Domains for FAM110B Gene


Suggested Antigen Peptide Sequences for FAM110B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM110 family.
  • Belongs to the FAM110 family.
genes like me logo Genes that share domains with FAM110B: view

No data available for Gene Families for FAM110B Gene

Function for FAM110B Gene

Molecular function for FAM110B Gene

UniProtKB/Swiss-Prot Function:
May be involved in tumor progression.
genes like me logo Genes that share phenotypes with FAM110B: view

Animal Models for FAM110B Gene

MGI Knock Outs for FAM110B:

Animal Model Products

CRISPR Products

miRNA for FAM110B Gene

miRTarBase miRNAs that target FAM110B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM110B Gene

Localization for FAM110B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110B Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Jensen Localization Image for FAM110B Gene COMPARTMENTS Subcellular localization image for FAM110B gene
Compartment Confidence
mitochondrion 5
cytoskeleton 3
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM110B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with FAM110B: view

Pathways & Interactions for FAM110B Gene

SuperPathways for FAM110B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM110B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM110B Gene

Drugs & Compounds for FAM110B Gene

No Compound Related Data Available

Transcripts for FAM110B Gene

Unigene Clusters for FAM110B Gene

Family with sequence similarity 110, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -

Relevant External Links for FAM110B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM110B Gene

mRNA expression in normal human tissues for FAM110B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM110B Gene

This gene is overexpressed in Fetal Brain (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM110B Gene

Protein tissue co-expression partners for FAM110B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM110B Gene:


SOURCE GeneReport for Unigene cluster for FAM110B Gene:


mRNA Expression by UniProt/SwissProt for FAM110B Gene:

Tissue specificity: Detected in thyroid, spleen and testis, and at lower levels in stomach, spinal cord, lymph node, trachea, adrenal gland, prostate, ovary and intestine.
genes like me logo Genes that share expression patterns with FAM110B: view

Primer Products

No data available for mRNA differential expression in normal tissues for FAM110B Gene

Orthologs for FAM110B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM110B 34
  • 82.34 (n)
  • 86.49 (a)
FAM110B 35
  • 90 (a)
(Canis familiaris)
Mammalia FAM110B 34
  • 85.32 (n)
  • 87.57 (a)
FAM110B 35
  • 89 (a)
(Mus musculus)
Mammalia Fam110b 34
  • 89.62 (n)
  • 96.17 (a)
Fam110b 16
Fam110b 35
  • 96 (a)
(Pan troglodytes)
Mammalia FAM110B 34
  • 99.82 (n)
  • 99.73 (a)
FAM110B 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam110b 34
  • 88.8 (n)
  • 96.17 (a)
(Monodelphis domestica)
Mammalia FAM110B 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia FAM110B 35
  • 89 (a)
(Gallus gallus)
Aves FAM110B 34
  • 82.07 (n)
  • 92.97 (a)
FAM110B 35
  • 93 (a)
(Anolis carolinensis)
Reptilia FAM110B 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam110b 34
  • 75.77 (n)
  • 86.22 (a)
(Danio rerio)
Actinopterygii fam110b 34
  • 66.67 (n)
  • 71.2 (a)
fam110b 35
  • 60 (a)
Species where no ortholog for FAM110B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM110B Gene

Gene Tree for FAM110B (if available)
Gene Tree for FAM110B (if available)

Paralogs for FAM110B Gene

Paralogs for FAM110B Gene

(1) SIMAP similar genes for FAM110B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM110B: view

Variants for FAM110B Gene

Sequence variations from dbSNP and Humsavar for FAM110B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_036319 A colorectal cancer sample
rs954172 -- 58,050,901(+) TTAAA(A/C)TGCTT intron-variant
rs1032951 -- 58,049,923(-) CTGTA(C/T)ACAGG intron-variant
rs1047103 -- 58,146,407(+) AAGGC(A/C)AAGTA reference, synonymous-codon
rs1105302 -- 58,042,104(+) TGACT(A/G)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM110B Gene

Variant ID Type Subtype PubMed ID
esv2737039 CNV deletion 23290073
esv3617333 CNV loss 21293372
nsv1075139 CNV deletion 25765185
nsv1119181 CNV deletion 24896259
nsv831324 CNV loss 17160897

Variation tolerance for FAM110B Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM110B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM110B Gene

Disorders for FAM110B Gene

Relevant External Links for FAM110B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM110B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM110B Gene

Publications for FAM110B Gene

  1. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H. … Aasheim H.-C. (Genomics 2007) 2 3 4 65
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 4 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 65
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 65

Products for FAM110B Gene

Sources for FAM110B Gene