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Aliases for FAM110B Gene

Aliases for FAM110B Gene

  • Family With Sequence Similarity 110, Member B 2 3
  • C8orf72 3 4
  • Chromosome 8 Open Reading Frame 72 2
  • Protein FAM110B 3

External Ids for FAM110B Gene

Previous Symbols for FAM110B Gene

  • C8orf72

Summaries for FAM110B Gene

GeneCards Summary for FAM110B Gene

FAM110B (Family With Sequence Similarity 110, Member B) is a Protein Coding gene. An important paralog of this gene is FAM110A.

UniProtKB/Swiss-Prot for FAM110B Gene

  • May be involved in tumor progression

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM110B Gene

Genomics for FAM110B Gene

Genomic Location for FAM110B Gene

Start:
57,994,509 bp from pter
End:
58,204,279 bp from pter
Size:
209,771 bases
Orientation:
Plus strand

Genomic View for FAM110B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM110B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110B Gene

Proteins for FAM110B Gene

  • Protein details for FAM110B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC76-F110B_HUMAN
    Recommended name:
    Protein FAM110B
    Protein Accession:
    Q8TC76
    Secondary Accessions:
    • Q5BM08
    • Q9Y4K2

    Protein attributes for FAM110B Gene

    Size:
    370 amino acids
    Molecular mass:
    40728 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB50224.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM110B Gene

Proteomics data for FAM110B Gene at MOPED

Post-translational modifications for FAM110B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM110B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM110B Gene

Domains for FAM110B Gene

Protein Domains for FAM110B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

F110B_HUMAN
Family:
  • Belongs to the FAM110 family.:
    • Q8TC76
genes like me logo Genes that share domains with FAM110B: view

No data available for Gene Families for FAM110B Gene

Function for FAM110B Gene

Molecular function for FAM110B Gene

UniProtKB/Swiss-Prot Function: May be involved in tumor progression

Phenotypes for FAM110B Gene

GenomeRNAi human phenotypes for FAM110B:
genes like me logo Genes that share phenotypes with FAM110B: view

miRNA for FAM110B Gene

miRTarBase miRNAs that target FAM110B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM110B Gene

Localization for FAM110B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110B Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM110B Gene COMPARTMENTS Subcellular localization image for FAM110B gene
Compartment Confidence
cytoskeleton 5
mitochondrion 4
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM110B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with FAM110B: view

Pathways for FAM110B Gene

SuperPathways for FAM110B Gene

No Data Available

Interacting Proteins for FAM110B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355204%0d%0a9606.ENSP00000352929%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000334499%0d%0a
Selected Interacting proteins: ENSP00000355204 Q8TC76-F110B_HUMAN for FAM110B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM110B Gene

None

No data available for Pathways by source for FAM110B Gene

Transcripts for FAM110B Gene

Unigene Clusters for FAM110B Gene

Family with sequence similarity 110, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:

Relevant External Links for FAM110B Gene

GeneLoc Exon Structure for
FAM110B
ECgene alternative splicing isoforms for
FAM110B

Expression for FAM110B Gene

mRNA expression in normal human tissues for FAM110B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM110B Gene

SOURCE GeneReport for Unigene cluster for FAM110B Gene Hs.154652

mRNA Expression by UniProt/SwissProt for FAM110B Gene

Q8TC76-F110B_HUMAN
Tissue specificity: Detected in thyroid, spleen and testis, and at lower levels in stomach, spinal cord, lymph node, trachea, adrenal gland, prostate, ovary and intestine.
genes like me logo Genes that share expressions with FAM110B: view

Orthologs for FAM110B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM110B 36
  • 99.82 (n)
  • 99.73 (a)
FAM110B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM110B 36
  • 82.34 (n)
  • 86.49 (a)
FAM110B 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM110B 36
  • 85.32 (n)
  • 87.57 (a)
FAM110B 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam110b 36
  • 89.62 (n)
  • 96.17 (a)
Fam110b 16
Fam110b 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM110B 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM110B 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam110b 36
  • 88.8 (n)
  • 96.17 (a)
chicken
(Gallus gallus)
Aves FAM110B 36
  • 82.07 (n)
  • 92.97 (a)
FAM110B 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM110B 37
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam110b 36
  • 75.77 (n)
  • 86.22 (a)
zebrafish
(Danio rerio)
Actinopterygii fam110b 36
  • 66.67 (n)
  • 71.2 (a)
fam110b 37
  • 60 (a)
OneToOne
Species with no ortholog for FAM110B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM110B Gene

ENSEMBL:
Gene Tree for FAM110B (if available)
TreeFam:
Gene Tree for FAM110B (if available)

Paralogs for FAM110B Gene

Paralogs for FAM110B Gene

Selected SIMAP similar genes for FAM110B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM110B: view

Variants for FAM110B Gene

Sequence variations from dbSNP and Humsavar for FAM110B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs723330 -- 58,150,132(+) AACTA(G/T)CATTT downstream-variant-500B
rs884135 -- 58,066,633(+) TCTTG(A/C)CCCTG intron-variant
rs884136 -- 58,066,734(+) TGACT(A/G)GGGAG intron-variant
rs954172 -- 58,050,901(+) TTAAA(A/C)TGCTT intron-variant
rs1032951 -- 58,049,923(-) CTGTA(C/T)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM110B Gene

Variant ID Type Subtype PubMed ID
nsv831324 CNV Loss 17160897
esv2737039 CNV Deletion 23290073

Relevant External Links for FAM110B Gene

HapMap Linkage Disequilibrium report
FAM110B

Disorders for FAM110B Gene

Relevant External Links for FAM110B

Genetic Association Database (GAD)
FAM110B
Human Genome Epidemiology (HuGE) Navigator
FAM110B
genes like me logo Genes that share disorders with FAM110B: view

No data available for UniProtKB/Swiss-Prot for FAM110B Gene

Publications for FAM110B Gene

  1. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 4
  2. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H. … Aasheim H.-C. (Genomics 2007) 2 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3

Products for FAM110B Gene

Sources for FAM110B Gene

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