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Aliases for FAM110B Gene

Aliases for FAM110B Gene

  • Family With Sequence Similarity 110 Member B 2 3 5
  • C8orf72 3 4
  • Family With Sequence Similarity 110, Member B 2
  • Chromosome 8 Open Reading Frame 72 2
  • Protein FAM110B 3

External Ids for FAM110B Gene

Previous HGNC Symbols for FAM110B Gene

  • C8orf72

Previous GeneCards Identifiers for FAM110B Gene

  • GC08P059072
  • GC08P058907
  • GC08P054394

Summaries for FAM110B Gene

GeneCards Summary for FAM110B Gene

FAM110B (Family With Sequence Similarity 110 Member B) is a Protein Coding gene. An important paralog of this gene is FAM110A.

UniProtKB/Swiss-Prot for FAM110B Gene

  • May be involved in tumor progression.

Additional gene information for FAM110B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM110B Gene

Genomics for FAM110B Gene

GeneHancer (GH) Regulatory Elements for FAM110B Gene

Promoters and enhancers for FAM110B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I057993 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563.4 +1.7 1689 4.6 ELF3 PKNOX1 ARID4B ZNF2 RAD21 ZNF143 FOS BCLAF1 RUNX3 MIXL1 FAM110B GC08P057996 ENSG00000253523 GC08M057799
GH08I058077 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.2 +83.2 83191 0.1 FAM110B ENSG00000253116 ENSG00000253523 GC08M057799
GH08I057994 Enhancer 0.5 ENCODE 550.8 -1.3 -1272 0.2 PKNOX1 ZNF362 ZBTB48 SP2 PRDM10 ZNF18 FAM110B GC08P057996 GC08M057799
GH08I058066 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.3 +74.2 74218 4.3 FOXA2 MLX ZFP64 ARID4B FEZF1 TCF12 FOS SP5 MIER2 ZNF488 FAM110B ENSG00000253523 ENSG00000253116 GC08M057799
GH08I058377 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.1 +384.0 384020 1.3 FOXA2 MAX CEBPG RAD21 YY1 ZNF316 RUNX3 MAFK RXRA CEBPB FAM110B UBXN2B GC08P058299
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM110B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM110B gene promoter:

Genomic Locations for FAM110B Gene

Genomic Locations for FAM110B Gene
chr8:57,994,509-58,204,279
(GRCh38/hg38)
Size:
209,771 bases
Orientation:
Plus strand
chr8:58,907,068-59,116,838
(GRCh37/hg19)

Genomic View for FAM110B Gene

Genes around FAM110B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM110B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM110B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110B Gene

Proteins for FAM110B Gene

  • Protein details for FAM110B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC76-F110B_HUMAN
    Recommended name:
    Protein FAM110B
    Protein Accession:
    Q8TC76
    Secondary Accessions:
    • Q5BM08
    • Q9Y4K2

    Protein attributes for FAM110B Gene

    Size:
    370 amino acids
    Molecular mass:
    40728 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB50224.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM110B Gene

Post-translational modifications for FAM110B Gene

No Post-translational modifications

Other Protein References for FAM110B Gene

No data available for DME Specific Peptides for FAM110B Gene

Domains & Families for FAM110B Gene

Gene Families for FAM110B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM110B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM110B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TC76

UniProtKB/Swiss-Prot:

F110B_HUMAN :
  • Belongs to the FAM110 family.
Family:
  • Belongs to the FAM110 family.
genes like me logo Genes that share domains with FAM110B: view

Function for FAM110B Gene

Molecular function for FAM110B Gene

UniProtKB/Swiss-Prot Function:
May be involved in tumor progression.

Phenotypes From GWAS Catalog for FAM110B Gene

genes like me logo Genes that share phenotypes with FAM110B: view

Animal Models for FAM110B Gene

MGI Knock Outs for FAM110B:

Animal Model Products

miRNA for FAM110B Gene

miRTarBase miRNAs that target FAM110B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM110B Gene

Localization for FAM110B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110B Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM110B gene
Compartment Confidence
mitochondrion 5
cytosol 5
cytoskeleton 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Mitochondria (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM110B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FAM110B: view

Pathways & Interactions for FAM110B Gene

SuperPathways for FAM110B Gene

No Data Available

Interacting Proteins for FAM110B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355204%0d%0a9606.ENSP00000334499%0d%0a
Selected Interacting proteins: Q8TC76-F110B_HUMAN ENSP00000355204 for FAM110B Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for FAM110B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM110B Gene

Drugs & Compounds for FAM110B Gene

No Compound Related Data Available

Transcripts for FAM110B Gene

Unigene Clusters for FAM110B Gene

Family with sequence similarity 110, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:

Relevant External Links for FAM110B Gene

GeneLoc Exon Structure for
FAM110B
ECgene alternative splicing isoforms for
FAM110B

Expression for FAM110B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM110B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM110B Gene

This gene is overexpressed in Fetal Brain (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM110B Gene



Protein tissue co-expression partners for FAM110B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM110B Gene:

FAM110B

SOURCE GeneReport for Unigene cluster for FAM110B Gene:

Hs.154652

mRNA Expression by UniProt/SwissProt for FAM110B Gene:

Q8TC76-F110B_HUMAN
Tissue specificity: Detected in thyroid, spleen and testis, and at lower levels in stomach, spinal cord, lymph node, trachea, adrenal gland, prostate, ovary and intestine.

Evidence on tissue expression from TISSUES for FAM110B Gene

  • Nervous system(4.6)
  • Spleen(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with FAM110B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM110B Gene

Orthologs for FAM110B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM110B 33 34
  • 99.82 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM110B 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam110b 33 16 34
  • 89.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM110B 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam110b 33
  • 88.8 (n)
dog
(Canis familiaris)
Mammalia FAM110B 33 34
  • 85.32 (n)
cow
(Bos Taurus)
Mammalia FAM110B 33 34
  • 82.34 (n)
chicken
(Gallus gallus)
Aves FAM110B 33 34
  • 82.07 (n)
lizard
(Anolis carolinensis)
Reptilia FAM110B 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam110b 33
  • 75.77 (n)
zebrafish
(Danio rerio)
Actinopterygii fam110b 33 34
  • 66.67 (n)
Species where no ortholog for FAM110B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM110B Gene

ENSEMBL:
Gene Tree for FAM110B (if available)
TreeFam:
Gene Tree for FAM110B (if available)

Paralogs for FAM110B Gene

Paralogs for FAM110B Gene

(1) SIMAP similar genes for FAM110B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM110B: view

Variants for FAM110B Gene

Sequence variations from dbSNP and Humsavar for FAM110B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
VAR_036319 A colorectal cancer sample p.Ala214Ser
rs1000031517 -- 58,011,916(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000035111 -- 58,148,673(+) G/A 3_prime_UTR_variant
rs1000054138 -- 58,103,428(+) T/C intron_variant
rs1000061400 -- 58,085,385(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM110B Gene

Variant ID Type Subtype PubMed ID
esv2737039 CNV deletion 23290073
esv3617333 CNV loss 21293372
nsv1075139 CNV deletion 25765185
nsv1119181 CNV deletion 24896259
nsv831324 CNV loss 17160897

Variation tolerance for FAM110B Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM110B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM110B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM110B Gene

Disorders for FAM110B Gene

Additional Disease Information for FAM110B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM110B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM110B Gene

Publications for FAM110B Gene

  1. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H … Aasheim HC (Genomics 2007) 2 3 4 58
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58

Products for FAM110B Gene

Sources for FAM110B Gene

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