Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM110B Gene

Aliases for FAM110B Gene

  • Family With Sequence Similarity 110 Member B 2 3 5
  • C8orf72 3 4
  • Family With Sequence Similarity 110, Member B 2
  • Chromosome 8 Open Reading Frame 72 2
  • Protein FAM110B 3

External Ids for FAM110B Gene

Previous HGNC Symbols for FAM110B Gene

  • C8orf72

Previous GeneCards Identifiers for FAM110B Gene

  • GC08P059072
  • GC08P058907
  • GC08P054394

Summaries for FAM110B Gene

GeneCards Summary for FAM110B Gene

FAM110B (Family With Sequence Similarity 110 Member B) is a Protein Coding gene. An important paralog of this gene is FAM110A.

UniProtKB/Swiss-Prot for FAM110B Gene

  • May be involved in tumor progression.

Additional gene information for FAM110B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM110B Gene

Genomics for FAM110B Gene

Regulatory Elements for FAM110B Gene

Enhancers for FAM110B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H058066 1.5 Ensembl ENCODE dbSUPER 11.3 +74.2 74218 4 FOXA2 MLX ZFP64 ARID4B FEZF1 TCF12 FOS SP5 ZNF488 MIER2 FAM110B ENSG00000253523 ENSG00000253116
GH08H057993 1.1 Ensembl ENCODE 13.4 +1.7 1689 4 ELF3 PKNOX1 ARID4B ZNF2 RAD21 ZNF143 FOS RUNX3 MIXL1 ZNF654 FAM110B ENSG00000253523
GH08H058377 1.2 Ensembl ENCODE dbSUPER 11.1 +384.0 384020 1 FOXA2 MAX CEBPG RAD21 YY1 ZNF316 RUNX3 MAFK CEBPB REST FAM110B UBXN2B GC08P058299
GH08H058037 1 Ensembl ENCODE dbSUPER 11.5 +44.2 44206 2 CTBP1 GATA3 ZBED1 BCL6B ZNF384 FAM110B ENSG00000253523 ENSG00000253116
GH08H058073 0.8 dbSUPER 12.4 +79.8 79780 1 CTCF FEZF1 ZNF2 RAD21 TEAD3 GATA3 GLIS2 SCRT2 SMC3 ZNF143 FAM110B CYP7A1 ENSG00000253116 ENSG00000253523
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM110B on UCSC Golden Path with GeneCards custom track

Promoters for FAM110B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000224869 592 2200 MXI1 SP2 REST ZNF398 RAD21 POLR2A ZFP3 CREB1 PRDM10 FOXP2

Genomic Location for FAM110B Gene

Chromosome:
8
Start:
57,994,509 bp from pter
End:
58,204,279 bp from pter
Size:
209,771 bases
Orientation:
Plus strand

Genomic View for FAM110B Gene

Genes around FAM110B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM110B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM110B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110B Gene

Proteins for FAM110B Gene

  • Protein details for FAM110B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC76-F110B_HUMAN
    Recommended name:
    Protein FAM110B
    Protein Accession:
    Q8TC76
    Secondary Accessions:
    • Q5BM08
    • Q9Y4K2

    Protein attributes for FAM110B Gene

    Size:
    370 amino acids
    Molecular mass:
    40728 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB50224.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM110B Gene

Post-translational modifications for FAM110B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM110B Gene

No data available for DME Specific Peptides for FAM110B Gene

Domains & Families for FAM110B Gene

Gene Families for FAM110B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM110B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM110B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TC76

UniProtKB/Swiss-Prot:

F110B_HUMAN :
  • Belongs to the FAM110 family.
Family:
  • Belongs to the FAM110 family.
genes like me logo Genes that share domains with FAM110B: view

Function for FAM110B Gene

Molecular function for FAM110B Gene

UniProtKB/Swiss-Prot Function:
May be involved in tumor progression.

Phenotypes From GWAS Catalog for FAM110B Gene

genes like me logo Genes that share phenotypes with FAM110B: view

Animal Models for FAM110B Gene

MGI Knock Outs for FAM110B:

Animal Model Products

CRISPR Products

miRNA for FAM110B Gene

miRTarBase miRNAs that target FAM110B

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM110B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM110B Gene

Localization for FAM110B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110B Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM110B gene
Compartment Confidence
mitochondrion 5
cytosol 5
cytoskeleton 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Mitochondria (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM110B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FAM110B: view

Pathways & Interactions for FAM110B Gene

SuperPathways for FAM110B Gene

No Data Available

Interacting Proteins for FAM110B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355204%0d%0a9606.ENSP00000334499%0d%0a
Selected Interacting proteins: Q8TC76-F110B_HUMAN ENSP00000355204 for FAM110B Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for FAM110B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM110B Gene

Drugs & Compounds for FAM110B Gene

No Compound Related Data Available

Transcripts for FAM110B Gene

Unigene Clusters for FAM110B Gene

Family with sequence similarity 110, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM110B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:

Relevant External Links for FAM110B Gene

GeneLoc Exon Structure for
FAM110B
ECgene alternative splicing isoforms for
FAM110B

Expression for FAM110B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM110B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM110B Gene

This gene is overexpressed in Fetal Brain (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM110B Gene



Protein tissue co-expression partners for FAM110B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM110B Gene:

FAM110B

SOURCE GeneReport for Unigene cluster for FAM110B Gene:

Hs.154652

mRNA Expression by UniProt/SwissProt for FAM110B Gene:

Q8TC76-F110B_HUMAN
Tissue specificity: Detected in thyroid, spleen and testis, and at lower levels in stomach, spinal cord, lymph node, trachea, adrenal gland, prostate, ovary and intestine.

Evidence on tissue expression from TISSUES for FAM110B Gene

  • Nervous system(4.6)
  • Spleen(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with FAM110B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM110B Gene

Orthologs for FAM110B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM110B 33 34
  • 99.82 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM110B 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam110b 33 16 34
  • 89.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM110B 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam110b 33
  • 88.8 (n)
dog
(Canis familiaris)
Mammalia FAM110B 33 34
  • 85.32 (n)
cow
(Bos Taurus)
Mammalia FAM110B 33 34
  • 82.34 (n)
chicken
(Gallus gallus)
Aves FAM110B 33 34
  • 82.07 (n)
lizard
(Anolis carolinensis)
Reptilia FAM110B 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam110b 33
  • 75.77 (n)
zebrafish
(Danio rerio)
Actinopterygii fam110b 33 34
  • 66.67 (n)
Species where no ortholog for FAM110B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM110B Gene

ENSEMBL:
Gene Tree for FAM110B (if available)
TreeFam:
Gene Tree for FAM110B (if available)

Paralogs for FAM110B Gene

Paralogs for FAM110B Gene

(1) SIMAP similar genes for FAM110B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM110B: view

Variants for FAM110B Gene

Sequence variations from dbSNP and Humsavar for FAM110B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_036319 A colorectal cancer sample
rs1000031517 -- 58,011,916(+) TCACC(G/T)TCGTG intron-variant
rs1000035111 -- 58,148,673(+) TAATA(A/G)GAAAC utr-variant-3-prime
rs1000054138 -- 58,103,428(+) TTTGG(C/T)TTTTT intron-variant
rs1000061400 -- 58,085,385(+) GCGGG(G/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM110B Gene

Variant ID Type Subtype PubMed ID
esv2737039 CNV deletion 23290073
esv3617333 CNV loss 21293372
nsv1075139 CNV deletion 25765185
nsv1119181 CNV deletion 24896259
nsv831324 CNV loss 17160897

Variation tolerance for FAM110B Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM110B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM110B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM110B Gene

Disorders for FAM110B Gene

Relevant External Links for FAM110B

Genetic Association Database (GAD)
FAM110B
Human Genome Epidemiology (HuGE) Navigator
FAM110B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM110B

No disorders were found for FAM110B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM110B Gene

Publications for FAM110B Gene

  1. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H … Aasheim HC (Genomics 2007) 2 3 4 60
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60

Products for FAM110B Gene

Sources for FAM110B Gene

Content
Loading form....