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FAM110A Gene

protein-coding GIFtS: 38

GC20P000762

family with sequence similarity 110, member A
(Previous name: chromosome 20 open reading frame 55 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C20orf55)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C20orf55 ^², ³
F10 ^², ³
MGC2450 ^²
MGC4675 ^²
OTTHUMP00000029942 ^²
OTTHUMP00000029943 ^²
OTTHUMP00000029944 ^²
OTTHUMP00000029945 ^²
bA371L19.3 ^¹, ²

Descriptions
chromosome 20 open reading frame 55 ^¹
family with sequence similarity 110, member A ^²
hypothetical protein LOC83541 ^²

External Ids
HGNC: 16188¹
Entrez Gene: 83541²
UniProtKB: Q9BQ89³
Ensembl: ENSG00000125898⁷

Search outside databases for aliases for FAM110A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

FAM110A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P000762: (about GC identifiers)

Start:	762,356 bp from pter
End:	774,922 bp from pter
Size:	12,567 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011387.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F110A_HUMAN, Q9BQ89 (See protein sequence)

Recommended Name: Protein FAM110A

Size: 295 amino acids; 31271 Da

Subunit: May interact with CSPP1 (Potential)

Subcellular location: Cytoplasm. Centrosome. Note=Distributed throughout the cytoplasm during

mitosis, accumulating at spindle poles

Developmental stage: During the cell cycle, expression is increased during S phase and G2/M phase

Secondary accessions: Q5R1M7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001035812.1 NP_113612.1 NP_997004.1

ENSEMBL proteins:

ENSP00000246100 ENSP00000371365 ENSP00000354163 ENSP00000371367

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: FAM110A

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IEA	--

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Antibodies for FAM110A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM110A

Assays for FAM110A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9BQ89

UniProtKB/Swiss-Prot: F110A_HUMAN, Q9BQ89

Similarity: Belongs to the FAM110 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM110A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001042353

Applied Biosystems Silencer® siRNAs for FAM110A

Sigma-Aldrich siRNA for FAM110A

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FAM110A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001042353
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001042353
untagged cDNA clones in CMV expression vector (see all 3): NM_001042353

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_207121

UniProtKB/Swiss-Prot: F110A_HUMAN, Q9BQ89

Induction: Up-regulated in stimulated lymphocytes

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17474147

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Interacting proteins for FAM110A (ENSP00000354163³ Q9BQ89¹) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	EBI-1752811, EBI-375543
FYN	P06241¹	EBI-1752811, EBI-515315
GRB2	P62993¹	EBI-1752811, EBI-401755
NCK1	P16333¹	EBI-1752811, EBI-389883
--	ENSP00000373693³	STRING (score=.952)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM110A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM110A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001042353

Sigma-Aldrich siRNA for FAM110A

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001042353 NM_031424 NM_207121

REFSEQ mRNAs for FAM110A gene (3 alternative transcripts):

NM_001042353.1 NM_031424.4 NM_207121.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001042353 NM_031424 NM_207121

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001042353
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001042353
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001042353

Additional cDNA sequence:

AB196290.1 AJ293411.1 AK314165.1 BC004222.2 BC012800.2 BC022238.1 CR590220.1 CR593574.1

CR599968.1 CR613912.1 CR614477.1 CR623946.1 DQ431181.1

12 DOTS entries:

DT.211076 DT.91745633 DT.95075452 DT.100041886 DT.100784276 DT.92029805 DT.100007999 DT.100649071

DT.100694425 DT.95278295 DT.100728409 DT.91723867

24/119 AceView cDNA sequences (see all 119 ):

CR593574 CR599968 BQ053386 CR590220 CR623946 CR613912 CR615581 AA362478

AA830101 AA552147 AI491808 CR614477 AI799589 BC004222 BM843846 AI818675

AL522437 NM_031424 BU542855 BI910519 AL555617 BC022238 NM_207121 BQ933404

Unigene Cluster for FAM110A:

Family with sequence similarity 110, member A

Hs.574822 [show with all ESTs]

Unigene Representative Sequence: NM_001042353

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000246100 ENST00000381939 ENST00000304189 ENST00000381941

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM110A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM110A

¹ / ²

7 probe-sets matching FAM110A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
59113_at²	U95-B	1	1.00	1.00	1.00	1.00	--	--	--	--	--
226584_s_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
214001_x_at²	U133-A	1	0.27	1.00	--	--	--	--	--	--	--
226584_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214001_x_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--
1565947_a_at*²	U133Plus2	5	0.46	0.25	--	--	--	--	--	--	--
1565949_x_at*²	U133Plus2	5	0.36	0.27	--	--	--	--	--	--	--

GeneDecks FAM110A for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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CGAP SAGE TAG: AGTGTACTCC

SOURCE GeneReport for Unigene cluster: Hs.574822
UniProtKB/Swiss-Prot: F110A_HUMAN, Q9BQ89
Tissue specificity: Detected in thyroid, lymph node, trachea, adrenal gland, bone marrow, spleen,
thymus, prostate, and peripheral blood leukocyte. Detected at lower levels in stomach, testis and
spinal cord

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM110A gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC609631¹	--	similar to Protein C20orf55 homolog	86.78(n) 91.19(a)	609631 XM_846925.1 XP_852018.1
chimpanzee (Pan troglodytes)	LOC749312¹	--	similar to C20orf55	97.51(n) 98.31(a)	749312 XM_001167595.1 XP_001167595.1
cow (Bos taurus)	FAM110A¹	--	family with sequence similarity 110, member A	85.6(n) 91.5(a)	540118 NM_001014961.1 NP_001014961.1
rat (Rattus norvegicus)	Fam110a¹	--	family with sequence similarity 110, member A	80.9(n) 85.76(a)	311535 NM_001014050.1 NP_001014072.1
mouse (Mus musculus)	Fam110a^{1, 5}	2⁵	family with sequence similarity 110, member A^{1, 5}	81.24(n)¹ 85.76(a)¹	73847¹ NM_146127.1¹ NP_666239.1¹ AA014820⁵ AI747080⁵ (see all 20)

About this table Species with no ortholog for FAM110A

ENSEMBL Gene Tree for FAM110A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FAM110A gene

GRRP1² FAM110C² FAM110B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/136 NCBI SNPs in FAM110A are shown (see all 136 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 67)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs685119^1,2	A,C,F,H,O	761751(+)	`CAAGAG/CTTGTT`	1	--	ng5¹		9		EU EA WA NA	742
	rs1045410^1,2	A,C,F,H	774666(+)	`CAAGGG/TATCTC`	3	--	ut3¹		5		EA EU WA	1910
	rs2282051^1,2	C,F,H	774513(+)	`CTCTCC/GAAGGG`	3	--	ut3¹ ese³		14		EA NS EU WA	2438
--	rs2282050^1,2	A,C,F	774492(+)	`GCATTG/CTTGGG`	3	--	ut3¹		1		MN	184
	rs552367^1,2	C,F,H	771504(+)	`CCTGAT/GCACCC`	3	--	int¹ ng5¹		4		EU EA WA	420
--	rs7271234^1,2	A,C,F	764394(+)	`AGGGCC/TTGGTG`	2	--	ng5¹ int¹		3		NA	140
--	rs1045412^1,2	A,C,F	774710(+)	`CCTTCT/CTTCCT`	3	--	ut3¹ trp³		2		EA MN	1666
	rs636681^1,2	C,F,H	772422(+)	`GACCAC/AGTAGA`	3	--	int¹ ng5¹		4		EU EA WA	418
	rs576384^1,2	F,H	762381(+)	`CCCCAG/CGGACT`	1	--	ut5¹ ese³		4		EU EA WA	416
--	rs6086133^1,2	A,C	763901(+)	`tatgtA/Gtgtgt`	2	--	int¹ ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for FAM110A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 611393

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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6 PubMed articles for FAM110A gene:

Characterization of the FAM110 gene family. (PubMed id 17499476)^{2, 3, 4} Hauge H....Aasheim H.C. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)³ Wu C....Li S.S. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 83541	HGNC: 16188	AceView: C20orf55	Ensembl:ENSG00000125898	euGenes: HUgn83541
ECgene: FAM110A	H-InvDB: FAM110A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for FAM110A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FAM110A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM110A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM110A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for FAM110A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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FAM110A Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for FAM110A

Summaries
for FAM110A

Genomic Location
for FAM110A

Proteins
for FAM110A

Protein Domains/
Families
for FAM110A

Gene Function
for FAM110A

Pathways & Interactions
for FAM110A

Drugs & Compounds
for FAM110A

Transcripts
for FAM110A

Expression
for FAM110A

Orthologs
for FAM110A

Paralogs
for FAM110A

SNPs/Variants
for FAM110A

Disorders & Mutations
for FAM110A

Medical News
for FAM110A

Publications
for FAM110A

Search for FAM110A

Genome Databases showing FAM110A

Other Databases showing FAM110A

Specialized Databases showing FAM110A

Licensable Technologies
for FAM110A

Services
for FAM110A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM110A Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor FAM110A

Summariesfor FAM110A

Genomic Locationfor FAM110A

Proteinsfor FAM110A

Protein Domains/Familiesfor FAM110A

Gene Functionfor FAM110A

Pathways & Interactionsfor FAM110A

Drugs & Compoundsfor FAM110A

Transcriptsfor FAM110A

Expression for FAM110A

Orthologsfor FAM110A

Paralogsfor FAM110A

SNPs/Variantsfor FAM110A

Disorders & Mutationsfor FAM110A

Medical Newsfor FAM110A

Publicationsfor FAM110A

Search for FAM110A

Genome Databases showing FAM110A

Other Databases showing FAM110A

Specialized Databases showing FAM110A

Licensable Technologiesfor FAM110A

Servicesfor FAM110A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM110A

Summaries
for FAM110A

Genomic Location
for FAM110A

Proteins
for FAM110A

Protein Domains/
Families
for FAM110A

Gene Function
for FAM110A

Pathways & Interactions
for FAM110A

Drugs & Compounds
for FAM110A

Transcripts
for FAM110A

Expression
for FAM110A

Orthologs
for FAM110A

Paralogs
for FAM110A

SNPs/Variants
for FAM110A

Disorders & Mutations
for FAM110A

Medical News
for FAM110A

Publications
for FAM110A

Licensable Technologies
for FAM110A

Services
for FAM110A