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Aliases for FAM110A Gene

Aliases for FAM110A Gene

  • Family With Sequence Similarity 110 Member A 2 3 5
  • C20orf55 3 4
  • F10 3 4
  • Family With Sequence Similarity 110, Member A 2
  • Chromosome 20 Open Reading Frame 55 2
  • Protein FAM110A 3
  • BA371L19.3 3

External Ids for FAM110A Gene

Previous HGNC Symbols for FAM110A Gene

  • C20orf55

Previous GeneCards Identifiers for FAM110A Gene

  • GC20P000762

Summaries for FAM110A Gene

GeneCards Summary for FAM110A Gene

FAM110A (Family With Sequence Similarity 110 Member A) is a Protein Coding gene. An important paralog of this gene is FAM110B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM110A Gene

Genomics for FAM110A Gene

Regulatory Elements for FAM110A Gene

Enhancers for FAM110A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F000828 1.4 FANTOM5 Ensembl ENCODE 29.7 -3.8 -3808 2.2 PKNOX1 ATF1 ARNT GATA2 NCOA1 REST MBD2 SMARCA4 PBX2 MYNN FAM110A SDCBP2 SRXN1 GC20P000795
GH20F000840 1.2 FANTOM5 ENCODE 27 +10.9 10924 7.5 ATF1 PKNOX1 ARNT SIN3A ZNF766 GLIS2 ELK1 SP3 NCOA1 ZHX2 FAM110A ANGPT4 RSPO4 RPS10P5 PIR36894
GH20F000833 0.6 ENCODE 15.3 +0.2 214 2.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 SLC30A9 ZNF207 FOS ZNF263 SP3 FAM110A RPS10P5
GH20F001174 0.5 FANTOM5 12.4 +340.6 340645 0.3 ZIC2 FAM110A SDCBP2 SIRPB2 SIRPB1 LOC105372495 ACTG1P3
GH20F000854 1.3 Ensembl ENCODE 12.3 +22.3 22298 2.4 PKNOX1 ARNT RAD21 GLIS2 ZNF366 RCOR1 FOS EGR2 SMARCA5 CEBPB FAM110A ANGPT4 GC20M000856 PIR34196 GC20M000847
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM110A on UCSC Golden Path with GeneCards custom track

Promoters for FAM110A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001834696 203 1801 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF207 ZNF263 SP3
ENSR00000007828 1503 401 ELF3 DRAP1 CTCF ZNF792 RAD21 TEAD3 ZNF366 ZNF143 NR2F6 TFE3

Genomic Location for FAM110A Gene

833,697 bp from pter
857,463 bp from pter
23,767 bases
Plus strand

Genomic View for FAM110A Gene

Genes around FAM110A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM110A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM110A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110A Gene

Proteins for FAM110A Gene

  • Protein details for FAM110A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM110A
    Protein Accession:
    Secondary Accessions:
    • D3DVW2
    • Q5R1M7

    Protein attributes for FAM110A Gene

    295 amino acids
    Molecular mass:
    31271 Da
    Quaternary structure:
    • May interact with CSPP1.

neXtProt entry for FAM110A Gene

Post-translational modifications for FAM110A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM110A Gene

Domains & Families for FAM110A Gene

Protein Domains for FAM110A Gene


Suggested Antigen Peptide Sequences for FAM110A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM110 family.
  • Belongs to the FAM110 family.
genes like me logo Genes that share domains with FAM110A: view

No data available for Gene Families for FAM110A Gene

Function for FAM110A Gene

Molecular function for FAM110A Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated in stimulated lymphocytes.

Gene Ontology (GO) - Molecular Function for FAM110A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with FAM110A: view

Phenotypes for FAM110A Gene

GenomeRNAi human phenotypes for FAM110A:
genes like me logo Genes that share phenotypes with FAM110A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM110A Gene

Localization for FAM110A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110A Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles.

Subcellular locations from

Jensen Localization Image for FAM110A Gene COMPARTMENTS Subcellular localization image for FAM110A gene
Compartment Confidence
cytoskeleton 3
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAM110A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FAM110A: view

Pathways & Interactions for FAM110A Gene

SuperPathways for FAM110A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM110A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM110A Gene

Transcripts for FAM110A Gene

Unigene Clusters for FAM110A Gene

Family with sequence similarity 110, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110A Gene

No ASD Table

Relevant External Links for FAM110A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM110A Gene

mRNA expression in normal human tissues for FAM110A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM110A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.8), Skin - Not Sun Exposed (Suprapubic) (x6.0), Whole Blood (x5.8), and Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for FAM110A Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM110A Gene

Protein tissue co-expression partners for FAM110A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM110A Gene:


SOURCE GeneReport for Unigene cluster for FAM110A Gene:


mRNA Expression by UniProt/SwissProt for FAM110A Gene:

Tissue specificity: Detected in thyroid, lymph node, trachea, adrenal gland, bone marrow, spleen, thymus, prostate, and peripheral blood leukocyte. Detected at lower levels in stomach, testis and spinal cord.
genes like me logo Genes that share expression patterns with FAM110A: view

Primer Products

Orthologs for FAM110A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM110A 34 35
  • 97.63 (n)
(Canis familiaris)
Mammalia FAM110A 34 35
  • 86.67 (n)
(Bos Taurus)
Mammalia FAM110A 34 35
  • 85.49 (n)
(Mus musculus)
Mammalia Fam110a 34 16 35
  • 81.13 (n)
(Rattus norvegicus)
Mammalia Fam110a 34
  • 80.9 (n)
(Gallus gallus)
Aves FAM110A 34 35
  • 66.55 (n)
(Anolis carolinensis)
Reptilia FAM110A 35
  • 45 (a)
(Danio rerio)
Actinopterygii wu:fa11c10 34
  • 61.8 (n)
fam110a 35
  • 38 (a)
Species where no ortholog for FAM110A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM110A Gene

Gene Tree for FAM110A (if available)
Gene Tree for FAM110A (if available)

Paralogs for FAM110A Gene

Paralogs for FAM110A Gene

(1) SIMAP similar genes for FAM110A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM110A: view

Variants for FAM110A Gene

Sequence variations from dbSNP and Humsavar for FAM110A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1045410 -- 846,023(+) CAAGG(G/T)ATCTC utr-variant-3-prime
rs1045412 -- 846,067(+) CCTTC(C/T)TTCCT utr-variant-3-prime
rs10693381 -- 838,522(+) TAGAT(-/AA)AAGAG intron-variant
rs111358892 -- 836,553(+) TTATG(A/G)CGGAA intron-variant
rs111412543 -- 842,212(+) AGGCC(A/G)GCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM110A Gene

Variant ID Type Subtype PubMed ID
esv3644952 CNV gain 21293372
nsv1062082 CNV gain 25217958
nsv1067424 CNV gain 25217958
nsv510778 CNV deletion 20534489
nsv585191 CNV gain 21841781
nsv585193 CNV gain 21841781
nsv979409 CNV duplication 23825009

Variation tolerance for FAM110A Gene

Gene Damage Index Score: 2.49; 43.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM110A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM110A Gene

Disorders for FAM110A Gene

Relevant External Links for FAM110A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM110A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM110A Gene

Publications for FAM110A Gene

  1. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H. … Aasheim H.-C. (Genomics 2007) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3 64

Products for FAM110A Gene

Sources for FAM110A Gene

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