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FAM109B Gene

protein-coding   GIFtS: 44

GC22P040795
family with sequence similarity 109, member B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp686J07229 1, 2
MGC125831 2
MGC125832 2
OTTHUMP00000028569 2
Descriptions
family with sequence similarity 109, member B 2
hypothetical protein LOC150368 2
External Ids
HGNC: 271611
Entrez Gene: 1503682
UniProtKB: Q6ICB43
Ensembl: ENSG000001770967
Search outside databases for aliases for FAM109B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FAM109B gene  

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

FAM109B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P040795:     (about GC identifiers)

Start:
40,800,201 bp from pter
End:
40,805,388 bp from pter
Size:
5,188 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000022.9  NT_011520.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F109B_HUMAN, Q6ICB4 (See protein sequence)
Recommended Name: Protein FAM109B  
Size: 259 amino acids; 28338 Da
Secondary accessions: Q3SXQ3 Q8N6L9

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001002034.2  

    ENSEMBL proteins: 
    ENSP00000312753 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (FAM109B)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005739 mitochondrion IDA18029348
    About this table

    Antibodies for FAM109B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for FAM109B
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for FAM109B

    Assays for FAM109B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR011993 PH_type
     IPR001849 Pleckstrin_homology


       GeneDecks  FAM109B for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6ICB4

    ProtoNet protein and cluster: Q6ICB4

    1 Blocks protein family: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: F109B_HUMAN, Q6ICB4
    Similarity: Belongs to the FAM109 family
    Similarity: Contains 1 PH domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAM109B)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001002034

                  Applied Biosystems Silencer® siRNAs for FAM109B

                  Sigma-Aldrich siRNA for FAM109B  
                         Sigma-Aldrich shRNA for FAM109B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FAM109B
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001002034
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001002034
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001002034 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001002034

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FAM109B

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAM109B)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001002034

                  Sigma-Aldrich siRNA for FAM109B  
                         Sigma-Aldrich shRNA for FAM109B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001002034  

    REFSEQ mRNAs for FAM109B gene: 

    NM_001002034.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001002034  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001002034
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001002034
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001002034 

    Additional cDNA sequence: 

    BC029776.1 BC104175.1 BC104176.1 BX648402.1 CR456454.1 CR600979.1 CR605425.1 

    2 DOTS entries:

    DT.101970206  DT.100781341 

    24/110 AceView cDNA sequences (see all 110 ):

    AI143091 AW075393 BQ067666 BU622835 BX110542 CN481747 BM716594 AI269068 
    BX371152 AI869422 CR600979 BU069299 AI673098 CN482518 CA433435 CR605425 
    BU727322 AA308225 BC029776 BI768260 CN482624 BX348070 BI761027 CA432036 

    highest scoring ESTs for FAM109B:

    AA022772 AA040222 AA290695 AA349264 AA522720 AI752048 BC029776 BI761027 BM503822 BM509967 

    Unigene Cluster for FAM109B:

    Family with sequence similarity 109, member B
    Hs.368312  [show with all ESTs]
    Unigene Representative Sequence: BX648402


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000321753  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FAM109B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FAM109B

    1 / 2 / 3

    3 probe-sets matching FAM109B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    51091_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA522720 0.80 1.00 0.91 1

    226504_at2, 3 U133-B 1 1.00 1.00 -- -- AA522720 0.80 1.00 0.91 1

    226504_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FAM109B for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGTTCTCTCC

    SOURCE GeneReport for Unigene cluster: Hs.368312
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FAM109B gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4812251   -- similar to CG12393-PA, isoform A 83.4(n)
    79.22(a)
    481225  XM_538346.2  XP_538346.2 
    chimpanzee
    (Pan troglodytes)
    LOC7467091   -- similar to dJ186O1.2 98.97(n)
    98.46(a)
    746709  XM_001154643.1  XP_001154643.1 
    cow
    (Bos taurus)
    FAM109B1   -- family with sequence similarity 109, member B 86.36(n)
    84.17(a)
    506148  NM_001045936.1  NP_001039401.1 
    rat
    (Rattus norvegicus)
    Fam109b1   -- family with sequence similarity 109, member B 81.6(n)
    79.15(a)
    688685  XM_001067895.1  XP_001067895.1 
    mouse
    (Mus musculus)
    Fam109b1, 5 155
    family with sequence similarity 109, member B1, 5 80.57(n)1
    78.38(a)1
    3383681  NM_177391.31  NP_796365.11 
     AK0833255  AK0900605  (see all 7)
    About this table        Species with no ortholog for FAM109B

    ENSEMBL Gene Tree for FAM109B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/17 NCBI SNPs in FAM109B are shown (see all 17 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 53)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 22 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs1333801,2
    A,C,F,H40798856(+) catctT/Cgcctg 1 -- ng516Minor allele frequency- C:0.45MN EU EA WA 776
    --
    rs130570941,2
    C40800263(+) CCCTCC/TTGGGC 1 -- ut510--------
    rs1333831,2
    A,C40803549(+) CTGGCC/TGCAGA 1 A/A syn1 ese30--------
    rs24136671,2
    A,C,F,H40802183(+) TGTACA/CCTGGA 1 -- int18Minor allele frequency- C:0.10EU EA WA 838
    --
    rs1333821,2
    A,C,F40801720(+) gacagT/Ctggac 1 -- int11Minor allele frequency- C:0.16EA 170
    rs1333811,2
    A,F40800554(+) AGGCCC/GGGTGT 1 -- int14Minor allele frequency- G:0.44EA NA MN 246
    rs48220881,2
    A40800535(+) AGACGC/GTGGGG 1 -- int10--------
    --
    rs360847831,2
    --40800237(+) GGCGC-/TGGGAT 1 -- ut510--------
    --
    rs57512101,2
    --40800020(+) GTCCGA/TGGGGG 1 -- ng510--------
    rs617360391,2
    --40803532(+) GAGTGC/TGCCCA 1 R/C mis10--------
    About this table

    HapMap Linkage Disequilibrium images for FAM109B (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    5 PubMed articles for FAM109B gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 150368 HGNC: 27161 AceView: LOC150368 Ensembl:ENSG00000177096 euGenes: HUgn150368
    ECgene: FAM109B H-InvDB: FAM109B
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FAM109B:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FAM109B-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for FAM109B Antibodies for FAM109B
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FAM109B Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for FAM109B

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