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Aliases for FAM109B Gene

Aliases for FAM109B Gene

  • Family With Sequence Similarity 109, Member B 2 3
  • IPIP27B 3 4 6
  • Ses2 3 4 6
  • 27 KDa Inositol Polyphosphate Phosphatase Interacting Protein B 3 4
  • Sesquipedalian-2 3

External Ids for FAM109B Gene

Previous GeneCards Identifiers for FAM109B Gene

  • GC22P040795
  • GC22P042470
  • GC22P025436

Summaries for FAM109B Gene

GeneCards Summary for FAM109B Gene

FAM109B (Family With Sequence Similarity 109, Member B) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and phospholipid binding. An important paralog of this gene is FAM109A.

UniProtKB/Swiss-Prot for FAM109B Gene

  • Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM109B Gene

Genomics for FAM109B Gene

Regulatory Elements for FAM109B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM109B Gene

42,074,251 bp from pter
42,079,441 bp from pter
5,191 bases
Plus strand

Genomic View for FAM109B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM109B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM109B Gene

Proteins for FAM109B Gene

  • Protein details for FAM109B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q3SXQ3
    • Q8N6L9

    Protein attributes for FAM109B Gene

    259 amino acids
    Molecular mass:
    28338 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with FAM109A. Interacts with OCRL and INPP5B.
    • Was named after sesquipedalian, an unnecessarily long description of a simple thing.

neXtProt entry for FAM109B Gene

Proteomics data for FAM109B Gene at MOPED

Post-translational modifications for FAM109B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM109B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM109B Gene

Domains for FAM109B Gene

Gene Families for FAM109B Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for FAM109B Gene


Suggested Antigen Peptide Sequences for FAM109B Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6ICB4
  • The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B
  • Contains 1 PH domain.
  • Belongs to the sesquipedalian family.
genes like me logo Genes that share domains with FAM109B: view

Function for FAM109B Gene

Molecular function for FAM109B Gene

UniProtKB/Swiss-Prot Function: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.

Gene Ontology (GO) - Molecular Function for FAM109B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21233288
GO:0042803 protein homodimerization activity IPI 21233288
genes like me logo Genes that share ontologies with FAM109B: view

Animal Model Products

CRISPR Products

miRNA for FAM109B Gene

miRTarBase miRNAs that target FAM109B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM109B Gene

Localization for FAM109B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM109B Gene

Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.

Subcellular locations from

Jensen Localization Image for FAM109B Gene COMPARTMENTS Subcellular localization image for FAM109B gene
Compartment Confidence
endosome 5
cytosol 3
golgi apparatus 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM109B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 21233288
GO:0005802 trans-Golgi network IDA 21233288
GO:0030136 clathrin-coated vesicle IDA 21233288
GO:0055037 recycling endosome IDA 21233288
genes like me logo Genes that share ontologies with FAM109B: view

Pathways for FAM109B Gene

SuperPathways for FAM109B Gene

No Data Available

Interacting Proteins for FAM109B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000312753 Q6ICB4-SESQ2_HUMAN for FAM109B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM109B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling IMP 21233288
GO:0007032 endosome organization IMP 21233288
GO:0042147 retrograde transport, endosome to Golgi IMP 21233288
genes like me logo Genes that share ontologies with FAM109B: view

No data available for Pathways by source for FAM109B Gene

Transcripts for FAM109B Gene

mRNA/cDNA for FAM109B Gene

Unigene Clusters for FAM109B Gene

Family with sequence similarity 109, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM109B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FAM109B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM109B Gene

No ASD Table

Relevant External Links for FAM109B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM109B Gene

mRNA expression in normal human tissues for FAM109B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM109B Gene

SOURCE GeneReport for Unigene cluster for FAM109B Gene Hs.368312

genes like me logo Genes that share expressions with FAM109B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM109B Gene

Orthologs for FAM109B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM109B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM109B 35
  • 98.97 (n)
  • 98.46 (a)
FAM109B 36
  • 98 (a)
(Bos Taurus)
Mammalia FAM109B 35
  • 86.36 (n)
  • 84.17 (a)
FAM109B 36
  • 84 (a)
(Canis familiaris)
Mammalia FAM109B 35
  • 83.4 (n)
  • 79.22 (a)
FAM109B 36
  • 81 (a)
(Mus musculus)
Mammalia Fam109b 35
  • 80.57 (n)
  • 78.38 (a)
Fam109b 16
Fam109b 36
  • 78 (a)
(Monodelphis domestica)
Mammalia FAM109B 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia FAM109B 36
  • 53 (a)
(Rattus norvegicus)
Mammalia Fam109b 35
  • 81.6 (n)
  • 79.15 (a)
(Gallus gallus)
Aves FAM109B 36
  • 49 (a)
(Anolis carolinensis)
Reptilia FAM109B 36
  • 49 (a)
(Danio rerio)
Actinopterygii zgc:153733 36
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12393 36
  • 20 (a)
Species with no ortholog for FAM109B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM109B Gene

Gene Tree for FAM109B (if available)
Gene Tree for FAM109B (if available)

Paralogs for FAM109B Gene

Paralogs for FAM109B Gene

Selected SIMAP similar genes for FAM109B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM109B: view

Variants for FAM109B Gene

Sequence variations from dbSNP and Humsavar for FAM109B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs133380 -- 42,072,906(+) catct(C/T)gcctg upstream-variant-2KB
rs133381 -- 42,074,604(+) AGGCC(C/G)GGTGT intron-variant
rs133382 -- 42,075,770(+) GACAG(C/T)TGGAC intron-variant
rs133383 -- 42,077,599(+) CTGGC(C/T)GCAGA reference, synonymous-codon
rs1056025 -- 42,075,116(-) TCCCA(G/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM109B Gene

Variant ID Type Subtype PubMed ID
nsv508737 CNV Insertion 20534489
nsv834210 CNV Loss 17160897
nsv915161 CNV Loss 21882294
dgv4981n71 CNV Loss 21882294

Relevant External Links for FAM109B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM109B Gene

Disorders for FAM109B Gene

No disorders were found for FAM109B Gene.

No data available for UniProtKB/Swiss-Prot for FAM109B Gene

Publications for FAM109B Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Two closely related endocytic proteins that share a common OCRL- binding motif with APPL1. (PMID: 20133602) Swan L.E. … De Camilli P. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4

Products for FAM109B Gene

Sources for FAM109B Gene

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