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FAM109A Gene

protein-coding   GIFtS: 47
GCID: GC12M111798

Family With Sequence Similarity 109, Member A

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 109, Member A1 2     Protein FAM109A2
IPIP27A2 3 5     sesquipedalian-12
27 KDa Inositol Polyphosphate Phosphatase-Interacting Protein A2 3     Ses13
SES12 5     

External Ids:    HGNC: 265091   Entrez Gene: 1447172   Ensembl: ENSG000001983247   OMIM: 6142395   UniProtKB: Q8N4B13   

Export aliases for FAM109A gene to outside databases

Previous GC identifers: GC12M110262 GC12M108813


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAM109A Gene:
This gene encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate
5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for FAM109A Gene:
FAM109A (family with sequence similarity 109, member A) is a protein-coding gene. Diseases associated with FAM109A include malaria. GO annotations related to this gene include phospholipid binding and protein homodimerization activity. An important paralog of this gene is FAM109B.

UniProtKB/Swiss-Prot: SESQ1_HUMAN, Q8N4B1
Function: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the
trans-Golgi network and the plasma membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM109A gene promoter:
         p53   AML1a   Egr-1   HSF1 (long)   CREB   deltaCREB   FOXO4   HSF1short   c-Myb   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM109A promoter sequence
   Search Chromatin IP Primers for FAM109A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM109A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.12   Ensembl cytogenetic band:  12q24.12   HGNC cytogenetic band: 12q24.12

FAM109A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM109A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M111798:  view genomic region     (about GC identifiers)

Start:
111,798,455 bp from pter      End:
111,806,925 bp from pter
Size:
8,471 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SESQ1_HUMAN, Q8N4B1 (See protein sequence)
Recommended Name: Sesquipedalian-1  
Size: 249 amino acids; 27215 Da
Subunit: Forms homodimers and heterodimers with FAM109B. Interacts with OCRL and INPP5B
Miscellaneous: Was named after 'sesquipedalian', an unnecessarily long description of a simple thing
(PubMed:20133602)
1 PDB 3D structure from and Proteopedia for FAM109A:
3QIS (3D)    
Secondary accessions: J3KP50 Q6PJL9 Q96MH8
Alternative splicing: 4 isoforms:  Q8N4B1-1   Q8N4B1-2   Q8N4B1-3   Q8N4B1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM109A: NX_Q8N4B1

Explore proteomics data for FAM109A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM109A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171467.1  NP_001171468.1  NP_653272.2  

    ENSEMBL proteins: 
     ENSP00000354461   ENSP00000447353   ENSP00000449994   ENSP00000447349   ENSP00000447539  
     ENSP00000390552   ENSP00000376426  

    FAM109A Human Recombinant Protein Products:

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    Novus Biologicals FAM109A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8N4B1

    ProtoNet protein and cluster: Q8N4B1

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: SESQ1_HUMAN, Q8N4B1
    Domain: The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is
    essential for binding to OCRL and INPP5B (PubMed:21666675)
    Similarity: Belongs to the sesquipedalian family
    Similarity: Contains 1 PH domain


    FAM109A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SESQ1_HUMAN, Q8N4B1
    Function: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the
    trans-Golgi network and the plasma membrane

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0042803protein homodimerization activity IPI--
         
    FAM109A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM109A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM109A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM109A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM109A

    miRNA
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    miRTarBase miRNAs that target FAM109A:
    hsa-mir-615-3p (MIRT040229)

    Block miRNA regulation of human, mouse, rat FAM109A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM109A (see all 13):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4318 hsa-miR-3065-3p hsa-miR-30d hsa-miR-218 hsa-miR-1224-5p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFAM109A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM109A

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    GenScript: all cDNA clones in your preferred vector (see all 3): FAM109A (NM_144671)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM109A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM109A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM109A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SESQ1_HUMAN, Q8N4B1: Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic
    vesicle, clathrin-coated vesicle. Note=Interaction with OCRL may be crucial for targeting to endosome and to the
    trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    golgi apparatus3
    nucleus2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA--
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IDA--
    GO:0030136clathrin-coated vesicle IDA--
    GO:0055037recycling endosome IDA--

    FAM109A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM109A
    Interactions:

        Search GeneGlobe Interaction Network for FAM109A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for FAM109A (Q8N4B12, 3 ENSP000003544614) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLEKHJ1Q9NW612, 3, ENSP000003180754MINT-8266755 I2D: score=2 STRING: ENSP00000318075
    OCRLQ019683, ENSP000003601544I2D: score=1 STRING: ENSP00000360154
    BOLLENSP000003147924STRING: ENSP00000314792
    BVESENSP000003131724STRING: ENSP00000313172
    CCNCENSP000003582224STRING: ENSP00000358222
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001881receptor recycling IMP--
    GO:0007032endosome organization IMP--
    GO:0042147retrograde transport, endosome to Golgi IMP--

    FAM109A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM109A (SESQ1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM109A gene (3 alternative transcripts): 
    NM_001177996.1  NM_001177997.1  NM_144671.4  

    Unigene Cluster for FAM109A:

    Family with sequence similarity 109, member A
    Hs.173088  [show with all ESTs]
    Unigene Representative Sequence: NM_001177996
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361483(uc021rdy.1 uc001tsd.4 uc009zvu.3) ENST00000547838(uc001tsc.3)
    ENST00000548163 ENST00000547710 ENST00000549321 ENST00000450786 ENST00000392658

    miRNA
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    Block miRNA regulation of human, mouse, rat FAM109A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM109A (see all 13):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4318 hsa-miR-3065-3p hsa-miR-30d hsa-miR-218 hsa-miR-1224-5p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFAM109A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM109A
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAM109A (NM_144671)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM109A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM109A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM109A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM109A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM109A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM109A
      QuantiFast Probe-based Assays in human, mouse, rat FAM109A

    Additional mRNA sequence: 

    AK056918.1 AK093052.1 AK299344.1 BC014091.2 BC018996.2 BC034809.1 

    9 DOTS entries:

    DT.101980216  DT.100021898  DT.208220  DT.121142082  DT.121142093  DT.121142083  DT.121142088  DT.121142092 
    DT.95157198 

    Selected AceView cDNA sequences (see all 53):

    BU507932 BF224390 BU741613 BC034809 AK056918 AW016521 NM_144671 AA007367 
    BM558949 BF873344 CB306616 BF869986 BM558909 BU501318 CD671724 BF435061 
    BX442117 BF514876 BF971961 BF436293 BG820145 AX747887 BM724337 BC014091 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM109A (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
    SP1:                    -                             -     -     -     -                                             
    SP2:                    -                             -     -     -                                                   
    SP3:                    -                 -     -     -     -     -     -                                             
    SP4:                    -                       -     -     -     -     -                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for FAM109A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM109A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGGTTC
    FAM109A Expression
    About this image

    FAM109A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM109A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.173088
        Custom PCR Arrays for FAM109A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM109A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM109A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam109a1 , 5 family with sequence similarity 109, member A1, 5 74.84(n)1
    73.56(a)1
      5 (62.01 cM)5
    2317171  NM_175474.31  NP_780683.11 
     1218490285 
    chicken
    (Gallus gallus)
    Aves FAM109A1 family with sequence similarity 109, member A 67.11(n)
    60.89(a)
      101748488  XM_004945584.1  XP_004945641.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM109A6
    family with sequence similarity 109, member A
    49(a)
    1 ↔ 1
    GL343423.1(665191-665979)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004885601 sesquipedalian-1-like 49.49(n)
    48.9(a)
      100488560  XM_004913796.1  XP_004913853.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-193c2.21 si:ch211-193c2.2 69.21(n)
    69.47(a)
      565272  XM_005162464.1  XP_005162521.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG123936
    --
    23(a)
    1 → many
    2L(6047999-6050474)


    ENSEMBL Gene Tree for FAM109A (if available)
    TreeFam Gene Tree for FAM109A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM109A gene
    FAM109B2  
    Selected SIMAP similar genes for FAM109A using alignment to 4 protein entries:     SESQ1_HUMAN (see all proteins) (see all similar genes):
    CYTH4    CYTH3    CYTH1    CYTH2    PLEKHA4    PLEKHH2
    FAM109B    PLEKHH1    SWAP70    ARHGAP24    PLEK2    ANLN
    ARHGAP22    ARHGAP25    RASGRF1    DAPP1    RASGRF2    PLEKHA5

    FAM109A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAM109A
    PGOHUM00000261222


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM109A (see all 207)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399417011,2
    --111594602(+) CATCCC/TGATCA 3 -- ds50010--------
    rs747941261,2
    C--111594705(+) GAACTT/CTGGGC 3 -- ds50012Minor allele frequency- C:0.10CSA WA 120
    rs1807817981,2
    --111594743(+) GACTCC/TGTCCT 3 -- ds50010--------
    rs1417505401,2
    C--111594832(+) GAGCC-/TGTT  
            
    TGTTT
    3 -- ds50010--------
    rs1114728211,2
    C,F--111594884(+) AGAACG/ATGCCT 3 -- ds50012Minor allele frequency- A:0.10CSA WA 120
    rs1851815801,2
    --111594894(+) TGGCAC/GGGCAC 3 -- ds50010--------
    rs1453664631,2
    --111594932(+) CTGCCC/TTTGCA 3 -- ds50010--------
    rs1900877771,2
    --111594988(+) TGGGGA/GAAAAA 3 -- ut310--------
    rs37420041,2
    C,F,A,H--111595081(+) CACCCA/GACCCA 3 -- ut3122Minor allele frequency- G:0.49NS EA NA WA CSA 2351
    rs10587061,2
    C,F,H--111595369(-) CAAGCC/TCTGCT 3 -- ut3112Minor allele frequency- T:0.03MN NS NA WA 1760

    HapMap Linkage Disequilibrium report for FAM109A (111798455 - 111806925 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FAM109A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899520CNV Loss21882294
    nsv516920CNV Loss19592680
    nsv899519CNV Gain21882294
    nsv832513CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614239    OMIM disorders: --

    1 disease for FAM109A:    
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    malaria


    FAM109A for disorders           About GeneDecksing


    Export disorders for FAM109A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM109A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM109A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway. (PubMed id 21233288)1, 2 Noakes C.J.... Lowe M. (Mol. Biol. Cell 2011)
    2. Two closely related endocytic proteins that share a common OCRL- binding motif with APPL1. (PubMed id 20133602)1, 2 Swan L.E.... De Camilli P. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Recognition of the F&H motif by the Lowe syndrome protein OCRL. (PubMed id 21666675)2 Pirruccello M.... De Camilli P. (Nat. Struct. Mol. Biol. 2011)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144717 HGNC: 26509 AceView: FLJ32356 Ensembl:ENSG00000198324 euGenes: HUgn144717
    ECgene: FAM109A H-InvDB: FAM109A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM109A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM109A gene:
    Search GeneIP for patents involving FAM109A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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