V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

FAM109A Gene

protein-coding GIFtS: 43

GC12M110262

family with sequence similarity 109, member A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ32356 ^¹, ²

Descriptions
family with sequence similarity 109, member A ^²
hypothetical protein LOC144717 ^²

External Ids
HGNC: 26509¹
Entrez Gene: 144717²
UniProtKB: Q8N4B1³
Ensembl: ENSG00000198324⁷

Search outside databases for aliases for FAM109A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FAM109A gene

Entrez Gene cytogenetic band: 12q24.12 Ensembl cytogenetic band: 12q24.12 HGNC cytogenetic band: 12q24.12

FAM109A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M110262: (about GC identifiers)

Start:	110,282,866 bp from pter
End:	110,291,308 bp from pter
Size:	8,443 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: F109A_HUMAN, Q8N4B1 (See protein sequence)

Recommended Name: Protein FAM109A

Size: 249 amino acids; 27215 Da

Secondary accessions: Q6PJL9 Q96MH8

Alternative splicing: 3 isoforms: Q8N4B1-1 Q8N4B1-2 Q8N4B1-3

REFSEQ proteins: NP_653272.2

ENSEMBL proteins:

ENSP00000376426 ENSP00000354461

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: FAM109A

Antibodies for FAM109A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM109A

Assays for FAM109A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8N4B1

ProtoNet protein and cluster: Q8N4B1

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: F109A_HUMAN, Q8N4B1

Similarity: Belongs to the FAM109 family

Similarity: Contains 1 PH domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM109A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_144671

Applied Biosystems Silencer® siRNAs for FAM109A

Sigma-Aldrich siRNA for FAM109A

Sigma-Aldrich shRNA for FAM109A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FAM109A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_144671
Myc/DDK tagged cDNA clone in CMV expression vector: NM_144671
untagged cDNA clone in CMV expression vector: NM_144671

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_144671

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Interacting proteins for FAM109A (ENSP00000354461³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CUX2	ENSP00000261726³	STRING (score=.918)
SLC6A4	ENSP00000261707³	STRING (score=.799)
CLU	ENSP00000369812³	STRING (score=.79)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM109A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM109A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_144671

Sigma-Aldrich siRNA for FAM109A

Sigma-Aldrich shRNA for FAM109A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_144671

REFSEQ mRNAs for FAM109A gene:

NM_144671.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_144671

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_144671
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_144671
                                 untagged cDNA clone in CMV expression vector: NM_144671

Additional cDNA sequence:

AK056918.1 AK093052.1 AK299344.1 BC014091.2 BC018996.2 BC034809.1

8 DOTS entries:

DT.101980216 DT.100021898 DT.208220 DT.121142082 DT.121142093 DT.121142088 DT.121142092 DT.95157198

24/53 AceView cDNA sequences (see all 53 ):

BF873344 BF869986 AW016521 BU741613 CB306616 BU501318 NM_144671 BU507932

BF224390 AK056918 BM558949 AA007367 BM558909 BC034809 BC018996 BG820145

BX442117 BF436293 AX747887 BE885200 AI565386 BC014091 AK093052 BX435432

highest scoring ESTs for FAM109A:

AA007367 BC014091 BC018996 BC034809 BF971961 BG913211 AA007463 AA582307 AA604701 AA745289

Unigene Cluster for FAM109A:

Family with sequence similarity 109, member A

Hs.173088 [show with all ESTs]

Unigene Representative Sequence: NM_144671

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM109A (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	·	6g	·	6h
SP1:							-										-		-		-		-
SP2:							-										-		-		-
SP3:							-						-		-		-		-		-		-
SP4:							-								-		-		-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for FAM109A

2 Ensembl transcripts including schematic representations:

ENST00000392658 ENST00000361483

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM109A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM109A

¹ / ² / ³

3 probe-sets matching FAM109A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
77540_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AA007367	0.80	1.00	0.91	1
229690_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA007367	0.80	1.00	0.91	1
229690_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGAGGGGTTC

SOURCE GeneReport for Unigene cluster: Hs.173088

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM109A gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC486268¹	--	similar to CG12393-PA, isoform A	75.04(n) 72.04(a)	486268 XM_543394.2 XP_543394.2
chimpanzee (Pan troglodytes)	LOC467132¹	--	similar to Family with sequence similarity 109, member more	98.8(n) 99.2(a)	467132 XM_001145142.1 XP_001145142.1
cow (Bos taurus)	LOC785809¹	--	similar to CG12393 CG12393-PA	84.37(n) 85.65(a)	785809 XM_001253702.1 XP_001253703.1
mouse (Mus musculus)	Fam109a^{1, 5}	5⁵	family with sequence similarity 109, member A^{1, 5}	75.48(n)¹ 75(a)¹	231717¹ NM_175474.3¹ NP_780683.1¹ AK033618⁵ AK039192⁵ (see all 13)
chicken (Gallus gallus)	LOC427697¹	--	similar to Family with sequence similarity 109, member more	70.52(n) 65.78(a)	427697 XM_425271.2 XP_425271.2

About this table Species with no ortholog for FAM109A

ENSEMBL Gene Tree for FAM109A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/29 NCBI SNPs in FAM109A are shown (see all 29 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 21)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs10849938^1,2	A,C,F,H	110284442(+)	`AGGCCC/TGGTCA`	1	--	ut3¹ ese³		4		EU EA WA	412
	rs3742004^1,2	A,C,F,H	110282936(+)	`CACCCG/AACCCA`	1	--	ut3¹		4		EU EA WA	420
	rs874286^1,2	A,C,F	110284064(+)	`AGGCCT/CAGGGG`	1	--	ut3¹ ese³		2		EA	180
	rs3809272^1,2	A,C,F	110284641(+)	`GTGACG/ATTCCC`	1	--	ut3¹ ese³		7		EA NA	1702
	rs3809273^1,2	C,H	110284966(+)	`GGGCCC/TGTGGG`	1	G/R	mis¹ ese³		4		EU EA WA	382
	rs1058706^1,2	C	110283224(-)	`CAAGCC/TCTGCT`	1	--	ut3¹		1		MN	184
	rs12581656^1,2	H	110288306(+)	`TCTCAG/AGCCAC`	1	--	ut5¹ ese³		3		EU EA	296
--	rs7399251^1,2	A,C	110287063(+)	`tcagcC/Tgagat`	1	--	int¹		0	--	--	--	--
--	rs1814246^1,2	A,C	110286334(+)	`ggtcgA/Tccagc`	1	--	int¹		0	--	--	--	--
--	rs2159335^1,2	C	110288978(+)	`CCTTAG/TGCAGG`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for FAM109A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for FAM109A gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 144717	HGNC: 26509	AceView: FLJ32356	Ensembl:ENSG00000198324	euGenes: HUgn144717
ECgene: FAM109A	H-InvDB: FAM109A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FAM109A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FAM109A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM109A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM109A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FAM109A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for FAM109A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM109A

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FAM109A Gene at Home site.
Version 2.41.1
server5.xennexinc.com

FAM109A Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for FAM109A

Summaries
for FAM109A

Genomic Location
for FAM109A

Proteins
for FAM109A

Protein Domains/
Families
for FAM109A

Gene Function
for FAM109A

Pathways & Interactions
for FAM109A

Drugs & Compounds
for FAM109A

Transcripts
for FAM109A

Expression
for FAM109A

Orthologs
for FAM109A

Paralogs
for FAM109A

SNPs/Variants
for FAM109A

Disorders & Mutations
for FAM109A

Medical News
for FAM109A

Publications
for FAM109A

Search for FAM109A

Genome Databases showing FAM109A

Other Databases showing FAM109A

Specialized Databases showing FAM109A

Licensable Technologies
for FAM109A

Services
for FAM109A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM109A Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor FAM109A

Summariesfor FAM109A

Genomic Locationfor FAM109A

Proteinsfor FAM109A

Protein Domains/Familiesfor FAM109A

Gene Functionfor FAM109A

Pathways & Interactionsfor FAM109A

Drugs & Compoundsfor FAM109A

Transcriptsfor FAM109A

Expression for FAM109A

Orthologsfor FAM109A

Paralogsfor FAM109A

SNPs/Variantsfor FAM109A

Disorders & Mutationsfor FAM109A

Medical Newsfor FAM109A

Publicationsfor FAM109A

Search for FAM109A

Genome Databases showing FAM109A

Other Databases showing FAM109A

Specialized Databases showing FAM109A

Licensable Technologiesfor FAM109A

Servicesfor FAM109A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM109A

Summaries
for FAM109A

Genomic Location
for FAM109A

Proteins
for FAM109A

Protein Domains/
Families
for FAM109A

Gene Function
for FAM109A

Pathways & Interactions
for FAM109A

Drugs & Compounds
for FAM109A

Transcripts
for FAM109A

Expression
for FAM109A

Orthologs
for FAM109A

Paralogs
for FAM109A

SNPs/Variants
for FAM109A

Disorders & Mutations
for FAM109A

Medical News
for FAM109A

Publications
for FAM109A

Licensable Technologies
for FAM109A

Services
for FAM109A