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Aliases for FAM109A Gene

Aliases for FAM109A Gene

  • Family With Sequence Similarity 109, Member A 2 3
  • IPIP27A 3 4 6
  • SES1 3 4 6
  • 27 KDa Inositol Polyphosphate Phosphatase-Interacting Protein A 3 4
  • Sesquipedalian-1 3
  • Protein FAM109A 3

External Ids for FAM109A Gene

Previous GeneCards Identifiers for FAM109A Gene

  • GC12M110262
  • GC12M111798
  • GC12M108813

Summaries for FAM109A Gene

Entrez Gene Summary for FAM109A Gene

  • This gene encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate 5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for FAM109A Gene

FAM109A (Family With Sequence Similarity 109, Member A) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and phospholipid binding. An important paralog of this gene is FAM109B.

UniProtKB/Swiss-Prot for FAM109A Gene

  • Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM109A Gene

Genomics for FAM109A Gene

Regulatory Elements for FAM109A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM109A Gene

111,360,651 bp from pter
111,369,121 bp from pter
8,471 bases
Minus strand

Genomic View for FAM109A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM109A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM109A Gene

Proteins for FAM109A Gene

  • Protein details for FAM109A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • J3KP50
    • Q6PJL9
    • Q96MH8

    Protein attributes for FAM109A Gene

    249 amino acids
    Molecular mass:
    27215 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with FAM109B. Interacts with OCRL and INPP5B.
    • Was named after sesquipedalian, an unnecessarily long description of a simple thing.

    Three dimensional structures from OCA and Proteopedia for FAM109A Gene

    Alternative splice isoforms for FAM109A Gene


neXtProt entry for FAM109A Gene

Proteomics data for FAM109A Gene at MOPED

Post-translational modifications for FAM109A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM109A Gene

No data available for DME Specific Peptides for FAM109A Gene

Domains for FAM109A Gene

Gene Families for FAM109A Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for FAM109A Gene


Suggested Antigen Peptide Sequences for FAM109A Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8N4B1
  • The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.
  • Contains 1 PH domain.
  • Belongs to the sesquipedalian family.
genes like me logo Genes that share domains with FAM109A: view

Function for FAM109A Gene

Molecular function for FAM109A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.

Gene Ontology (GO) - Molecular Function for FAM109A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21233288
GO:0042803 protein homodimerization activity IPI 21233288
genes like me logo Genes that share ontologies with FAM109A: view

Animal Model Products

CRISPR Products

miRNA for FAM109A Gene

miRTarBase miRNAs that target FAM109A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM109A Gene

Localization for FAM109A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM109A Gene

Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.

Subcellular locations from

Jensen Localization Image for FAM109A Gene COMPARTMENTS Subcellular localization image for FAM109A gene
Compartment Confidence
endosome 5
cytosol 3
golgi apparatus 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM109A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 21233288
GO:0005802 trans-Golgi network IDA 21233288
GO:0030136 clathrin-coated vesicle IDA 21233288
GO:0055037 recycling endosome IDA 21233288
genes like me logo Genes that share ontologies with FAM109A: view

Pathways for FAM109A Gene

SuperPathways for FAM109A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM109A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling IMP 21233288
GO:0007032 endosome organization IMP 21233288
GO:0042147 retrograde transport, endosome to Golgi IMP 21233288
genes like me logo Genes that share ontologies with FAM109A: view

No data available for Pathways by source for FAM109A Gene

Transcripts for FAM109A Gene

Unigene Clusters for FAM109A Gene

Family with sequence similarity 109, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM109A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM109A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP6: - - - - - - - - -
SP7: - -
SP8: -

Relevant External Links for FAM109A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM109A Gene

mRNA expression in normal human tissues for FAM109A Gene

Protein differential expression in normal tissues for FAM109A Gene

This gene is overexpressed in Testis (38.7), Ovary (23.7), and Placenta (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM109A Gene

SOURCE GeneReport for Unigene cluster for FAM109A Gene Hs.173088

genes like me logo Genes that share expressions with FAM109A: view

Expression partners for FAM109A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM109A Gene

Orthologs for FAM109A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM109A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM109A 35
  • 83.73 (n)
  • 84.69 (a)
FAM109A 36
  • 69 (a)
(Canis familiaris)
Mammalia FAM109A 35
  • 82.87 (n)
  • 81.4 (a)
FAM109A 36
  • 68 (a)
(Mus musculus)
Mammalia Fam109a 35
  • 74.84 (n)
  • 73.56 (a)
Fam109a 16
Fam109a 36
  • 54 (a)
(Pan troglodytes)
Mammalia FAM109A 35
  • 98.85 (n)
  • 99.23 (a)
FAM109A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam109a 35
  • 73.95 (n)
  • 73.3 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
(Gallus gallus)
Aves FAM109A 35
  • 67.11 (n)
  • 60.89 (a)
FAM109A 36
  • 56 (a)
(Anolis carolinensis)
Reptilia FAM109A 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488560 35
  • 49.49 (n)
  • 48.9 (a)
(Danio rerio)
Actinopterygii si:ch211-193c2.2 35
  • 69.21 (n)
  • 69.47 (a)
FAM109A 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12393 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6697 36
  • 24 (a)
Species with no ortholog for FAM109A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM109A Gene

Gene Tree for FAM109A (if available)
Gene Tree for FAM109A (if available)

Paralogs for FAM109A Gene

Paralogs for FAM109A Gene Pseudogenes for FAM109A Gene

genes like me logo Genes that share paralogs with FAM109A: view

Variants for FAM109A Gene

Sequence variations from dbSNP and Humsavar for FAM109A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs874286 -- 111,361,877(+) AGGCC(C/T)AGGGG utr-variant-3-prime
rs884626 -- 111,370,586(-) ttgct(C/T)acttg upstream-variant-2KB
rs933398 -- 111,369,447(+) TGAGC(C/G)TAGTA upstream-variant-2KB
rs933399 -- 111,369,695(+) GAGAG(A/G)AAGTT upstream-variant-2KB
rs1058706 -- 111,361,037(-) CAAGC(C/T)CTGCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM109A Gene

Variant ID Type Subtype PubMed ID
nsv832513 CNV Gain 17160897
nsv899519 CNV Gain 21882294
nsv899520 CNV Loss 21882294
nsv516920 CNV Loss 19592680

Relevant External Links for FAM109A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM109A Gene

Disorders for FAM109A Gene

No disorders were found for FAM109A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM109A Gene

Publications for FAM109A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Two closely related endocytic proteins that share a common OCRL- binding motif with APPL1. (PMID: 20133602) Swan L.E. … De Camilli P. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4
  5. The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway. (PMID: 21233288) Noakes C.J. … Lowe M. (Mol. Biol. Cell 2011) 3 4

Products for FAM109A Gene

Sources for FAM109A Gene

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