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FAM108C1 Gene

protein-coding GIFtS: 37

GC15P078774

family with sequence similarity 108, member C1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 3.-.-.- ^³
FLJ34461 ^²
MGC131546 ^²

Descriptions
family with sequence similarity 108, member C1 ^²
hypothetical protein LOC58489 ^²

External Ids
HGNC: 26925¹
Entrez Gene: 58489²
UniProtKB: Q6PCB6³
Ensembl: ENSG00000136379⁷

Search outside databases for aliases for FAM108C1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q25.1

FAM108C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P078774: (about GC identifiers)

Start:	78,774,707 bp from pter
End:	78,835,017 bp from pter
Size:	60,311 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F108C_HUMAN, Q6PCB6 (See protein sequence)

Recommended Name: Abhydrolase domain-containing protein FAM108C1

Size: 329 amino acids; 35831 Da

Secondary accessions: Q1RMD6 Q9NPM1

Alternative splicing: 2 isoforms: Q6PCB6-1 Q6PCB6-2

REFSEQ proteins: NP_067037.1

ENSEMBL proteins:

ENSP00000258884

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for FAM108C1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM108C1

Assays for FAM108C1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6PCB6

UniProtKB/Swiss-Prot: F108C_HUMAN, Q6PCB6

Similarity: Belongs to the AB hydrolase superfamily. FAM108 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM108C1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_021214

Applied Biosystems Silencer® siRNAs for FAM108C1

Sigma-Aldrich siRNA for FAM108C1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021214
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021214
untagged cDNA clones in CMV expression vector (see all 2): NM_021214

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021214

1 MGI phenotypic allele

for Fam108c (no phenotypes)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM108C1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM108C1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_021214

Sigma-Aldrich siRNA for FAM108C1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021214

REFSEQ mRNAs for FAM108C1 gene:

NM_021214.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021214

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021214
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021214
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_021214

Additional cDNA sequence:

AK092758.1 AK298606.1 AL390079.1 BC059401.1 BC115003.1

8 DOTS entries:

DT.453665 DT.99986644 DT.100769359 DT.100020918 DT.100776440 DT.121079096 DT.95376098 DT.100732217

24/138 AceView cDNA sequences (see all 138 ):

AI090396 AI278568 BQ287782 BM769385 BM831165 BG576122 AI096844 N39886

BI222421 AW272569 BI756247 AA308535 CB216663 BM822399 BU729397 AA133234

BF969702 BM818920 AA486504 BM823654 AA488692 N68052 AI278953 BM837169

Unigene Cluster for FAM108C1:

Family with sequence similarity 108, member C1

Hs.459072 [show with all ESTs]

Unigene Representative Sequence: AK092758

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM108C1

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c
SP1:
SP2:							-		-
SP3:					-		-		-
SP4:					-		-		-

About this scheme

ECgene alternative splicing isoforms for FAM108C1

1 Ensembl transcript including schematic representation:

ENST00000258884

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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FAM108C1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM108C1

¹ / ²

3 probe-sets matching FAM108C1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44115_at²	U95-B	1	1.00	1.00	1.00	1.00	--	--	--	--	--
225436_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
225436_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FAM108C1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATCAGAAAA

SOURCE GeneReport for Unigene cluster: Hs.459072

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM108C1 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	Fam108c1¹	--	family with sequence similarity 108, member C1	89.9(n) 97.5(a)	361601 XM_341879.3 XP_341880.3
mouse (Mus musculus)	Fam108c^{1, 5}	7⁵	family with sequence similarity 108, member C^{1, 5}	90.84(n)¹ 97.44(a)¹	70178¹ NM_133722.1¹ NP_598483.1¹ AI835482⁵ AK008906⁵ (see all 12)
chicken (Gallus gallus)	FAM108C1¹	--	family with sequence similarity 108, member C1	84.3(n) 94.84(a)	415479 NM_001007826.1 NP_001007827.1
zebrafish (Danio rerio)	zgc55468²	--	hypothetical protein MGC55468	82.34(n)	393126 BC045350.1
fruit fly (Drosophila melanogaster)	CG33096¹	--	CG33096	68.43(n) 71.02(a)	326251 NM_176560.1 NP_788737.1

About this table Species with no ortholog for FAM108C1

ENSEMBL Gene Tree for FAM108C1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FAM108C1 gene

FAM108A6² FAM108A4² FAM108B1² ABHD13² FAM108A3² FAM108A2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/378 NCBI SNPs in FAM108C1 are shown (see all 378 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 155)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7166728^1,2	A,C,F,H	78834058(+)	`AGCCTC/TGCATC`	1	--	ut3¹ ese³		12		EU EA WA	1258
	rs11072940^1,2	A,C,F,H	78834884(+)	`TTCCAC/AATTTA`	1	--	ut3¹		7		NA EU EA WA	560
	rs1046417^1,2	C,F,H,O	78834459(+)	`CTGACT/CTTCCT`	1	--	ut3¹ ese³ trp³		7		MN EU EA WA NA	784
	rs3825793^1,2	C,F,H	78834952(+)	`GCCAGT/ATTGTG`	1	--	ut3¹		8		EA NA EU WA	2062
	rs11632439^1,2	A,C	78774067(+)	`CACACA/GCGAGA`	1	--	ng5¹		0	--	--	--	--
	rs2046389^1,2	A,C,F,H,O	78820355(-)	`TTTTCA/GTCAGA`	1	--	int¹		20		EU EA WA NA	1836
	rs2627316^1,2	A,C,F,H,O	78829871(-)	`AGGTTT/CTTTTA`	1	--	int¹		11		EU EA WA NA	978
	rs2245049^1,2	A,C,F,H,O	78784252(-)	`TCACCA/GCTCTA`	1	--	int¹		7		EU EA WA NA	544
	rs2170881^1,2	A,C,F,H,O	78794319(-)	`acataT/Catcaa`	1	--	int¹		16		EU EA WA NA	1474
	rs958091^1,2	A,C,F,H,O	78811422(+)	`ACATTT/AAAAGT`	1	--	int¹		22		NS EA NA EU WA	1686

About this table

HapMap Linkage Disequilibrium images for FAM108C1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for FAM108C1 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 58489	HGNC: 26925	AceView: LOC58489	Ensembl:ENSG00000136379	euGenes: HUgn58489
ECgene: FAM108C1	H-InvDB: FAM108C1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for FAM108C1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FAM108C1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM108C1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM108C1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for FAM108C1

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM108C1

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FAM108C1 Gene

protein-coding GIFtS: 37

Aliases &
Descriptions
for FAM108C1

Summaries
for FAM108C1

Genomic Location
for FAM108C1

Proteins
for FAM108C1

Protein Domains/
Families
for FAM108C1

Gene Function
for FAM108C1

Pathways & Interactions
for FAM108C1

Drugs & Compounds
for FAM108C1

Transcripts
for FAM108C1

Expression
for FAM108C1

Orthologs
for FAM108C1

Paralogs
for FAM108C1

SNPs/Variants
for FAM108C1

Disorders & Mutations
for FAM108C1

Medical News
for FAM108C1

Publications
for FAM108C1

Search for FAM108C1

Genome Databases showing FAM108C1

Other Databases showing FAM108C1

Specialized Databases showing FAM108C1

Licensable Technologies
for FAM108C1

Services
for FAM108C1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM108C1 Gene

protein-coding GIFtS: 37

Aliases & Descriptionsfor FAM108C1

Summariesfor FAM108C1

Genomic Locationfor FAM108C1

Proteinsfor FAM108C1

Protein Domains/Familiesfor FAM108C1

Gene Functionfor FAM108C1

Pathways & Interactionsfor FAM108C1

Drugs & Compoundsfor FAM108C1

Transcriptsfor FAM108C1

Expression for FAM108C1

Orthologsfor FAM108C1

Paralogsfor FAM108C1

SNPs/Variantsfor FAM108C1

Disorders & Mutationsfor FAM108C1

Medical Newsfor FAM108C1

Publicationsfor FAM108C1

Search for FAM108C1

Genome Databases showing FAM108C1

Other Databases showing FAM108C1

Specialized Databases showing FAM108C1

Licensable Technologiesfor FAM108C1

Servicesfor FAM108C1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM108C1

Summaries
for FAM108C1

Genomic Location
for FAM108C1

Proteins
for FAM108C1

Protein Domains/
Families
for FAM108C1

Gene Function
for FAM108C1

Pathways & Interactions
for FAM108C1

Drugs & Compounds
for FAM108C1

Transcripts
for FAM108C1

Expression
for FAM108C1

Orthologs
for FAM108C1

Paralogs
for FAM108C1

SNPs/Variants
for FAM108C1

Disorders & Mutations
for FAM108C1

Medical News
for FAM108C1

Publications
for FAM108C1

Licensable Technologies
for FAM108C1

Services
for FAM108C1