FAM108B1 Gene
protein-coding GIFtS : 41
GCID: GC09 M074477
family with sequence similarity 108, member B1 (Previous name: chromosome 9 open reading frame 77 ) (Previous symbol: C9orf77 )
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Aliasesfor FAM108B1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 108, Member B1 1 2 RP11-409O11.22 C9orf771 2 3 Abhydrolase Domain-Containing Protein FAM108B12 CGI-671 EC 3.-.-.-3 Chromosome 9 Open Reading Frame 771
Export aliases for FAM108B1 gene to outside databases Previous GC identifers: GC09M073668 GC09M044300
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Summariesfor FAM108B1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor FAM108B1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008470.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM108B1 gene promoter: Max1 USF1 Pax-2 USF-1:USF-2 Pax-2a Evi-1 C/EBPalpha FOXL1 CHOP-10 Cart-1 Other transcription factors Search SABiosciences Chromatin IP Primers for FAM108B1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM108B1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q21.13 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q21.2 FAM108B1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M074477: view genomic region
(about GC identifiers )
Start:
74,477,368 bp from pter
End:
74,526,148 bp from pter
Size:
48,781 bases
Orientation:
minus strand
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Proteinsfor FAM108B1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F108B_HUMAN, Q5VST6 (See
protein sequence )Recommended Name: Abhydrolase domain-containing protein FAM108B1 precursor Size : 288 amino acids; 32215 Da
Subcellular location : Secreted (Potential)
Secondary accessions : A8KAJ5 Q5VST7 Q86YB6 Q8IY03 Q9Y377Alternative splicing : 2 isoforms : Q5VST6-1 Q5VST6-2 Explore the universe of human proteins at neXtProt for FAM108B1: NX_Q5VST6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5VST6 FAM108B1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001020951.1 NP_057098.2 ENSEMBL proteins: ENSP00000366240 ENSP00000330222 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
FAM108B1 for ontologies About GeneDecksing FAM108B1 Antibody Products: Assay Products for FAM108B1:
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Protein
Domains / Familiesfor FAM108B1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q5VST6
UniProtKB/Swiss-Prot: F108B_HUMAN, Q5VST6 Similarity : Belongs to the AB hydrolase superfamily. FAM108 family
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Functionfor FAM108B1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Enzyme Number (IUBMB): EC 3.-.-.- 1 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM108B1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM108B1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): FAM108B1 (NM_016014 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM108B1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM108B1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM108B1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016787 hydrolase activity
IEA --
FAM108B1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for FAM108B1 :Animal Models: 1 MGI phenotypic allele for Fam108b (no phenotypes)
FAM108B1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor FAM108B1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM108B1 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for FAM108B1 (ENSP00000366240 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor FAM108B1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM108B1 Search CenterWatch for drugs/clinical trials and news about FAM108B1 / F108B
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Transcriptsfor FAM108B1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM108B1 gene (2 alternative transcripts): NM_001025780.1 NM_016014.2 Unigene Cluster for FAM108B1:
Family with sequence similarity 108, member B1 Hs.380389 [show with all ESTs ] Unigene Representative Sequence: NM_001025780 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000377041 (uc004ail.3 ) ENST00000333421 (uc004aim.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM108B1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM108B1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): FAM108B1 (NM_016014 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM108B1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM108B1
Additional cDNA sequence: AF151825.1 AK293060.1 BC038390.1 BC044576.1
4 DOTS entries : DT.210039 DT.100777581
DT.121146158 DT.100777580 24/79 AceView cDNA sequences (see all 79 ):
T33207 AI564777 F10401 AW236586 BU158754 BE048356 AI568420 BG654437 AI492609 BC038390 AI245208 BQ441913 BF439335 AW518161 AA897035 N63781 CD523210 Z45181 AW003505 AI041696 BG257758 CD237437 F12793 AI284388 GeneLoc Exon Structure
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Expression for FAM108B1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM108B1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GATTCACTCC
About this image FAM108B1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)Bone, Cartilage, Limb Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FAM108B1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM108B1 SOURCE GeneReport for Unigene cluster: Hs.380389 SABiosciences Custom PCR Arrays for FAM108B1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM108B1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM108B1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM108B1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM108B1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM108B1
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Orthologsfor FAM108B1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for FAM108B1 gene from 8/26 species (see all 26 ) About this table
ENSEMBL Gene Tree for FAM108B1 (if available)TreeFam Gene Tree for FAM108B1 (if available)
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Paralogsfor FAM108B1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM108B1 gene FAM108C1 2 FAM108A1 2 ABHD13 2 2 SIMAP similar genes for FAM108B1 using alignment to 1 protein entry: F108B_HUMAN :FAM108C1 FAM108A1
FAM108B1 for paralogs About GeneDecksing
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Genomic Variantsfor FAM108B1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM108B1 (74477368 - 74526148 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FAM108B1 1 CNV : 100661
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM108B1
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Disorders
/ Diseasesfor FAM108B1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM108B1 for disorders About GeneDecksing 3 diseases for FAM108B1 : About MalaCards tuberculosis malaria mycobacterium tuberculosis Export disorders for FAM108B1 gene to outside databases
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Publicationsfor FAM108B1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM108B1 gene integrated from 9 sources : (articles sorted by number of sources associating them with FAM108B1) Utopia : connect your pdf to the dynamic world of online information
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093) 1 , 2 , 3 Lai C.H....Lin W. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 1 , 2 Humphray S.J.... Dunham I. (2004) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for FAM108B1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM108B1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM108B1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM108B1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM108B1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM108B1 gene: Search GeneIP for patents involving FAM108B1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM108B1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM108B1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM108B1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM108B1 OriGene Protein Over-expression Lysate for FAM108B1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM108B1 OriGene 3'-UTR Clone for FAM108B1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM108B1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM108B1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for FAM108B1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM108B1 OriGene Custom Protein Services for FAM108B1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM108B1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM108B1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM108B1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM108B1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM108B1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM108B1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM108B1
Search ThermoFisher Antibodies for FAM108B1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM108B1
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Aliases for FAM108B1
Databases for FAM108B1
Disorders / Diseases for FAM108B1
Domains / Families for FAM108B1
Drugs / Compounds for FAM108B1
Expression for FAM108B1
Function for FAM108B1
Genomic Views for FAM108B1
Intellectual Property for FAM108B1
Orthologs for FAM108B1
Paralogs for FAM108B1
Pathways / Interactions for FAM108B1
Products for FAM108B1
Proteins for FAM108B1
Publications for FAM108B1
Search Box for FAM108B1
Summaries for FAM108B1
Transcripts for FAM108B1
Variants for FAM108B1
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