V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

FAM108B1 Gene

protein-coding   GIFtS: 41

GC09M073668
family with sequence similarity 108, member B1
(Previous name: chromosome 9 open reading frame 77 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C9orf77)
Services    

Aliases &
Descriptions
for FAM108B1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
C9orf77 2, 3
CGI-67 1, 2
EC 3.-.-.- 3
OTTHUMP00000021455 2
OTTHUMP00000021456 2
RP11-409O11.2 2
Descriptions
chromosome 9 open reading frame 77 1
family with sequence similarity 108, member B1 2
External Ids
HGNC: 242781
Entrez Gene: 511042
UniProtKB: Q5VST63
Ensembl: ENSG000001073627
Search outside databases for aliases for FAM108B1 gene

Summaries
for FAM108B1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for FAM108B1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.2

FAM108B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M073668:     (about GC identifiers)

Start:
 73,667,188 bp from pter
End:
 73,715,968 bp from pter
Size:
 48,781 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000009.10  NT_023935.17  

Proteins
for FAM108B1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: F108B_HUMAN, Q5VST6 (See protein sequence)
Recommended Name: Abhydrolase domain-containing protein FAM108B1 precursor  
Size: 288 amino acids; 32215 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q5VST7 Q86YB6 Q8IY03 Q9Y377
Alternative splicing: 2 isoforms:  Q5VST6-1   Q5VST6-2   

REFSEQ proteins (2 alternative transcripts): 
NP_001020951.1  NP_057098.2  


ENSEMBL proteins: 
ENSP00000330222 ENSP00000366240 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (FAM108B1)
Human Recombinant Proteins from Abnova (C9orf77)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
About this table

Antibodies for FAM108B1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (FAM108B1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (C9orf77)
Novus Biologicals Antibody for FAM108B1

Assays for FAM108B1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for FAM108B1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR000073 AB_hydrolase_1


   GeneDecks  FAM108B1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q5VST6

ProtoNet protein and cluster: Q5VST6

UniProtKB/Swiss-Prot: F108B_HUMAN, Q5VST6
Similarity: Belongs to the AB hydrolase superfamily. FAM108 family

Gene Function
for FAM108B1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (FAM108B1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016014

              Applied Biosystems Silencer® siRNAs for FAM108B1

              Sigma-Aldrich siRNA for FAM108B1  
                     Sigma-Aldrich shRNA for FAM108B1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for FAM108B1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001025780
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001025780
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001025780 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_016014

1 MGI phenotypic allele for Fam108b (no phenotypes)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016787 hydrolase activity IEA--
About this table

Pathways & Interactions
for FAM108B1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for FAM108B1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM108B1

Transcripts
for FAM108B1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (FAM108B1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016014

              Sigma-Aldrich siRNA for FAM108B1  
                     Sigma-Aldrich shRNA for FAM108B1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001025780  NM_016014  

REFSEQ mRNAs for FAM108B1 gene (2 alternative transcripts): 

NM_001025780.1   NM_016014.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001025780  NM_016014  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001025780
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001025780
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001025780 

Additional cDNA sequence: 

AF151825.1 AK293060.1 BC038390.1 BC044576.1 

4 DOTS entries:

DT.210039  DT.100777581  DT.121146158  DT.100777580 

24/79 AceView cDNA sequences (see all 79 ):

AI492609 AI564777 BE048356 N63781 F10401 BF439335 BC038390 AI245208 
AA897035 AW518161 AI568420 BQ441913 BU158754 BG654437 AW236586 T33207 
N92693 BG720713 BG677298 CD638834 AI866136 AV717849 BG502747 CD512632 

Unigene Cluster for FAM108B1:

Family with sequence similarity 108, member B1
Hs.380389  [show with all ESTs]
Unigene Representative Sequence: NM_001025780


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000333421  ENST00000377041  

Expression
for FAM108B1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM108B1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for FAM108B1

1 / 2

6 probe-sets matching FAM108B1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

47164_at2 U95-B 1 1.00 1.00 0.56 1.28 -- -- -- -- --
53478_r_at2 U95-C 2 1.00 0.97 0.89 0.73 -- -- -- -- --

227551_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

220285_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

227551_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

220285_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  FAM108B1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GATTCACTCC

SOURCE GeneReport for Unigene cluster: Hs.380389

Orthologs
for FAM108B1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for FAM108B1 gene from 5/12 species (see all 12 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC4841701   -- similar to chromosome 9 open reading frame 77 isoform more 95.6(n)
100(a)		 484170  XM_541286.2  XP_541286.2 
chimpanzee
(Pan troglodytes)		 LOC4645241   -- similar to C9orf77 protein 100(n)
100(a)		 464524  XM_520071.2  XP_520071.2 
cow
(Bos taurus)		 FAM108B11   -- family with sequence similarity 108, member B1 95.14(n)
100(a)		 781153  XM_001249436.1  XP_001249437.1 
rat
(Rattus norvegicus)		 Fam108b11   -- family with sequence similarity 108, member B1 91.78(n)
99.65(a)		 309399  NM_001014028.1  NP_001014050.1 
mouse
(Mus musculus)		 Fam108b1, 5 195
 family with sequence similarity 108, member B1, 5 90.97(n)1
99.65(a)1		 2260161  NM_146096.31  NP_666208.21 
 AK0508795  AK1528075  (see all 11)
About this table        Species with no ortholog for FAM108B1

ENSEMBL Gene Tree for FAM108B1

Paralogs
for FAM108B1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for FAM108B1 gene
FAM108A62  FAM108C12  FAM108A42  ABHD132  FAM108A32  FAM108A22  

SNPs/Variants
for FAM108B1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/210 NCBI SNPs in FAM108B1 are shown (see all 210 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 77)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs101222591,2
A,C,F,H73667002(+) GTCTGC/TGGCTA 1 -- ng517Minor allele frequency- T:0.07EU EA WA NA 562
rs107810461,2
A,F,H73666857(+) TAAATA/TGCCTA 1 -- ng514Minor allele frequency- T:0.15EU EA WA 414
--
rs20307011,2
A,C73670521(-) CTCCCA/GGGATC 2 -- int1 ut31 ese30--------
rs125519331,2
H73679600(+) ACTGGT/GTCTAG 2 P/T mis1 ese34Minor allele frequency- G:0.00EU EA WA 416
--
rs20307001,2
C73670543(-) CTTGAC/TTCACT 2 -- ut31 int1 ese30--------
rs123803801,2
H73679356(+) TTGTCC/TTAAGA 2 R/K mis1 ese34Minor allele frequency- T:0.00EU EA WA 404
rs18803271,2
A,C,F,H,O73676622(-) AACTCA/GGGGCC 2 -- int19Minor allele frequency- G:0.18NA EU EA WA 740
rs15243811,2
A,C,F,H,O73675105(-) AAATGA/GATTAG 2 -- int110Minor allele frequency- G:0.07EA NA EU WA 620
rs18518801,2
A,C,F,H,O73675377(-) CTGAAT/CGGAAA 2 -- int112Minor allele frequency- C:0.08NS EU EA WA NA 668
rs101231591,2
A,C,F,H73707335(+) AAGCTG/CGGAAG 2 -- int17Minor allele frequency- C:0.17NA EU EA WA 560
About this table

HapMap Linkage Disequilibrium images for FAM108B1 (up to first 250kb)

Disorders & Mutations
for FAM108B1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for FAM108B1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for FAM108B1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for FAM108B1 gene:

Search for FAM108B1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing FAM108B1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 51104 HGNC: 24278 AceView: C9orf77 Ensembl:ENSG00000107362 euGenes: HUgn51104
ECgene: FAM108B1 H-InvDB: FAM108B1

Other Databases showing FAM108B1

(According to HUGE)
About This Section

   --

Specialized Databases showing FAM108B1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for FAM108B1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for FAM108B1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for FAM108B1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FAM108B1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for FAM108B1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for FAM108B1 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (C9orf77)
 Antibodies (C9orf77)
 Search for Chimera RNAi
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(FAM108B1)
 Antibodies (FAM108B1)
 Search OriGene for FAM108B1
 Search Tocris compounds for FAM108B1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for FAM108B1

GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FAM108B1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com