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FAM108A1 Gene

protein-coding GIFtS: 40

GC19M001830

family with sequence similarity 108, member A1
(Previous name: chromosome 19 open reading frame 27 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C19orf27)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C19orf27 ^², ³
EC 3.-.-.- ^³
MGC5244 ^¹, ²

Descriptions
chromosome 19 open reading frame 27 ^¹
family with sequence similarity 108, member A1 ^²
hypothetical protein LOC81926 ^²

External Ids
HGNC: 28756¹
Entrez Gene: 81926²
UniProtKB: Q96GS6³
Ensembl: ENSG00000129968⁷

Search outside databases for aliases for FAM108A1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FAM108A1 gene

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

FAM108A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M001830: (about GC identifiers)

Start:	1,827,975 bp from pter
End:	1,836,494 bp from pter
Size:	8,520 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F18A1_HUMAN, Q96GS6 (See protein sequence)

Recommended Name: Abhydrolase domain-containing protein FAM108A1 precursor

Size: 310 amino acids; 33990 Da

Subcellular location: Secreted (Potential)

Secondary accessions: A8K0G8 Q6PJU2 Q8WUH9 Q9BWL0 Q9H7Q9

Alternative splicing: 4 isoforms: Q96GS6-1 Q96GS6-2 Q96GS6-3 Q96GS6-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001123583.1 NP_112490.3

ENSEMBL proteins:

ENSP00000250974 ENSP00000292577

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (FAM108A1)

OriGene Purified Recombinant Human Protein: FAM108A1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

About this table

Antibodies for FAM108A1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM108A1

Assays for FAM108A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96GS6

UniProtKB/Swiss-Prot: F18A1_HUMAN, Q96GS6

Similarity: Belongs to the AB hydrolase superfamily. FAM108 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM108A1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031213

Applied Biosystems Silencer® siRNAs for FAM108A1

Sigma-Aldrich siRNA for FAM108A1

Sigma-Aldrich shRNA for FAM108A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FAM108A1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001130111
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001130111
untagged cDNA clones in CMV expression vector (see all 4): NM_001130111

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_031213

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM108A1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM108A1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031213

Sigma-Aldrich siRNA for FAM108A1

Sigma-Aldrich shRNA for FAM108A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001130111 NM_031213

REFSEQ mRNAs for FAM108A1 gene (2 alternative transcripts):

NM_001130111.1 NM_031213.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001130111 NM_031213

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001130111
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001130111
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001130111

Additional cDNA sequence:

AK024419.1 AK090438.1 BC050605.1

24/28 DOTS entries (see all 28 ):

DT.99930417 DT.100840721 DT.86840938 DT.121445496 DT.433520 DT.100886371 DT.121445498 DT.100030077

DT.100716668 DT.91984938 DT.100690979 DT.100717195 DT.448823 DT.100715983 DT.100665501 DT.121445086

DT.99987381 DT.100839038 DT.100886368 DT.121406344 DT.121445518 DT.95295418 DT.100698128 DT.100771895

24/448 AceView cDNA sequences (see all 448 ):

AI972656 AI360152 AI968984 AI148394 CA946860 BM272090 CR615865 AW005298

AI810687 AI392698 BQ637686 BM967088 AI468236 AK074548 BM717395 BM893794

BE551752 BM854124 BU683478 BC035961 BQ675341 BC067908 BM271767 AI457186

highest scoring ESTs for FAM108A1:

AK074548 AW408471 BC009256 BC011667 BC020512 BC033749 BC035961 BC071644 BC071876 BE729241

Unigene Clusters for FAM108A1:

Family with sequence similarity 108, member A1

Hs.465542 [show with all ESTs], Hs.653679 [show with all ESTs]

Unigene Representative Sequences: AK074043, AK090438

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000250974 ENST00000292577

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM108A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM108A1

¹ / ² / ³

6 probe-sets matching FAM108A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65501_s_at²^{, 3}	U95-C	8	1.00	0.18	0.98	1.06	AI810687	0.80	0.79	0.79	1
88256_at²^{, 3}	U95-E	8	1.00	0.14	0.99	0.94	AW051845	0.80	0.78	0.79	1
221267_s_at²^{, 3}	U133-A	8	1.00	0.17	--	--	NM_031213	0.60	1.00	0.82	1
233358_at*²^{, 3}	U133-B	47	1.00	0.02	--	--	AK024373	0.20	0.01	0.14	3
221267_s_at²	U133Plus2	8	1.00	0.17	--	--	--	--	--	--	--
233358_at*²	U133Plus2	47	1.00	0.02	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.465542 Hs.653679

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM108A1 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC747670¹	--	similar to FAM108A1 protein	97.73(n) 98.05(a)	747670 XM_001157870.1 XP_001157870.1
mouse (Mus musculus)	Fam108a⁵	10 (43.00 cM)	family with sequence similarity 108, member A	--	N28108
thale cress (Arabidopsis thaliana)	AT3G01690¹	--	hypothetical protein	54.95(n) 52.97(a)	821094 NM_111035.4 NP_186818.1
rice (Oryza sativa)	Os12g0286600¹	--	hypothetical protein	53.96(n) 51.75(a)	4351997 NM_001073120.1 NP_001066588.1

About this table Species with no ortholog for FAM108A1

ENSEMBL Gene Tree for FAM108A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FAM108A1 gene

FAM108A6² FAM108C1² FAM108B1² ABHD13² FAM108A3² FAM108A2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/61 NCBI SNPs in FAM108A1 are shown (see all 61 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 29)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1866378^1,2	A,C,F,H	1838364(+)	`ACACCG/AAAGGG`	1	--	ng3¹		8		EU EA WA	834
	rs10414308^1,2	A,C,F,H	1827566(+)	`CTCTGG/AGGTCC`	1	--	ng5¹		7		NA EU EA WA	538
--	rs10414095^1,2	A,C	1836948(+)	`acgggC/Gtttcc`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs8113280^1,2	A,C	1837899(+)	`tgagcC/Tgagac`	1	--	ng3¹		0	--	--	--	--
--	rs11880973^1,2	A,C	1838174(+)	`tggcgC/Tgcacc`	1	--	ng3¹		0	--	--	--	--
--	rs10414061^1,2	A,C	1836901(+)	`ccggcA/Gcccac`	1	--	ng3¹		0	--	--	--	--
--	rs8109966^1,2	A,C	1837907(+)	`gaccgC/Tgccac`	1	--	ng3¹		0	--	--	--	--
	rs1866379^1,2	A,C	1838431(+)	`TCTCAC/TATGTG`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs11671347^1,2	A,C	1827654(+)	`GGGCAC/GTCCCG`	1	--	ng5¹		0	--	--	--	--
	rs4807160^1,2	C	1831950(+)	`GCTCTC/TGCCCA`	1	K/E	mis¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for FAM108A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for FAM108A1 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{2, 3, 4} Ota T....Sugano S. (2004)
Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)^{3, 4} Otsuki T....Isogai T. (2005)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 81926	HGNC: 28756	AceView: C19orf27	Ensembl:ENSG00000129968	euGenes: HUgn81926
ECgene: FAM108A1	H-InvDB: FAM108A1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FAM108A1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FAM108A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM108A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM108A1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FAM108A1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for FAM108A1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM108A1

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FAM108A1 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for FAM108A1

Summaries
for FAM108A1

Genomic Location
for FAM108A1

Proteins
for FAM108A1

Protein Domains/
Families
for FAM108A1

Gene Function
for FAM108A1

Pathways & Interactions
for FAM108A1

Drugs & Compounds
for FAM108A1

Transcripts
for FAM108A1

Expression
for FAM108A1

Orthologs
for FAM108A1

Paralogs
for FAM108A1

SNPs/Variants
for FAM108A1

Disorders & Mutations
for FAM108A1

Medical News
for FAM108A1

Publications
for FAM108A1

Search for FAM108A1

Genome Databases showing FAM108A1

Other Databases showing FAM108A1

Specialized Databases showing FAM108A1

Licensable Technologies
for FAM108A1

Services
for FAM108A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM108A1 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor FAM108A1

Summariesfor FAM108A1

Genomic Locationfor FAM108A1

Proteinsfor FAM108A1

Protein Domains/Familiesfor FAM108A1

Gene Functionfor FAM108A1

Pathways & Interactionsfor FAM108A1

Drugs & Compoundsfor FAM108A1

Transcriptsfor FAM108A1

Expression for FAM108A1

Orthologsfor FAM108A1

Paralogsfor FAM108A1

SNPs/Variantsfor FAM108A1

Disorders & Mutationsfor FAM108A1

Medical Newsfor FAM108A1

Publicationsfor FAM108A1

Search for FAM108A1

Genome Databases showing FAM108A1

Other Databases showing FAM108A1

Specialized Databases showing FAM108A1

Licensable Technologiesfor FAM108A1

Servicesfor FAM108A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM108A1

Summaries
for FAM108A1

Genomic Location
for FAM108A1

Proteins
for FAM108A1

Protein Domains/
Families
for FAM108A1

Gene Function
for FAM108A1

Pathways & Interactions
for FAM108A1

Drugs & Compounds
for FAM108A1

Transcripts
for FAM108A1

Expression
for FAM108A1

Orthologs
for FAM108A1

Paralogs
for FAM108A1

SNPs/Variants
for FAM108A1

Disorders & Mutations
for FAM108A1

Medical News
for FAM108A1

Publications
for FAM108A1

Licensable Technologies
for FAM108A1

Services
for FAM108A1