FAM108A1 Gene
protein-coding GIFtS: 43
GCID: GC19M001878
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family with sequence similarity 108, member A1(Previous name: chromosome 19 open reading frame 27 )
(Previous symbol: C19orf27)
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Aliases
for FAM108A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 108, Member A11 2 | | C19orf271 2 3 | | MGC52441 | | Chromosome 19 Open Reading Frame 271 | | Abhydrolase Domain-Containing Protein FAM108A12 | | EC 3.-.-.-3 |
Export aliases for FAM108A1 gene to outside databasesPrevious GC identifer: GC19M001830 |
Summaries
for FAM108A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM108A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM108A1 gene promoter:
AhR ATF-2 Pax-2 Pax-2a C/EBPalpha CHOP-10 CREB Ik-2 deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM108A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM108A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3FAM108A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M001878: view genomic region
(about GC identifiers)
Start:
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1,876,809 bp from pter |
End:
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1,885,546 bp from pter |
Size:
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8,738 bases |
Orientation:
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minus strand |
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Proteins
for FAM108A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F18A1_HUMAN, Q96GS6 (See
protein sequence)Recommended Name: Abhydrolase domain-containing protein FAM108A1 precursor Size: 310 amino acids; 33990 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=BAB15709.1; Type=Erroneous initiation; Sequence=BAB84869.1; Type=Erroneous initiation;Sequence=BAC03419.1; Type=Erroneous initiation;
Secondary accessions: A8K0G8 D6W5Z9 Q6PJU2 Q8WUH9 Q9BWL0 Q9H7Q9Alternative splicing: 4 isoforms: Q96GS6-1 Q96GS6-2 Q96GS6-3 Q96GS6-4 (Ref.4 (AAH20512) sequence is in conflict in position: 144:K->E)Explore the universe of human proteins at neXtProt for FAM108A1: NX_Q96GS6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GS6
FAM108A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001123583.1 NP_112490.3
ENSEMBL proteins: ENSP00000292577 ENSP00000250974 ENSP00000468272 ENSP00000467638 ENSP00000466977
Human Recombinant Protein Products for FAM108A1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
FAM108A1 for ontologies About GeneDecksing
FAM108A1 Antibody Products:
Assay Products for FAM108A1: |
Protein
Domains /
Families
for FAM108A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96GS6 UniProtKB/Swiss-Prot: F18A1_HUMAN, Q96GS6Similarity: Belongs to the AB hydrolase superfamily. FAM108 family |
Function
for FAM108A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.-.-.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0016787 | hydrolase activity |
IEA | -- |
FAM108A1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for FAM108A1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM108A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM108A1 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM108A1 (NM_031213) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM108A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM108A1 |
|
Pathways & Interactions
for FAM108A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM108A1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/16 Interacting proteins for FAM108A1 (Q96GS61, 3 ENSP000002509744) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
|
Drugs & Compounds
for FAM108A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM108A1
Search CenterWatch for drugs/clinical trials and news about FAM108A1 / F18A1
|
Transcripts
for FAM108A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM108A1 gene (2 alternative transcripts): NM_001130111.1 NM_031213.3 Unigene Clusters for FAM108A1: Family with sequence similarity 108, member A1 Hs.465542 [show with all ESTs], Hs.653679 [show with all ESTs]Unigene Representative Sequences: AK074043, AK0904386 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000292577(uc002lug.3) ENST00000250974(uc002lud.3 uc002lue.3 uc002luf.3)
ENST00000588598 ENST00000591351 ENST00000590661 ENST00000592757
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM108A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM108A1 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM108A1 (NM_031213) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM108A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM108A1 |
Additional cDNA sequence: AK024419.1 AK090438.1 BC050605.1 23 DOTS entries: DT.99930417 DT.100840721 DT.86840938 DT.121445496 DT.121445498 DT.100886371 DT.100030077 DT.433520 DT.100716668 DT.91984938 DT.100690979 DT.100717195 DT.448823 DT.100665501 DT.100715983 DT.121445086 DT.99987381 DT.100839038 DT.100886368 DT.95262469 DT.100698128 DT.100771895 DT.121445526 24/448 AceView cDNA sequences (see all 448): BM460637 AI888664 AI961022 CR603226 BQ071876 AI468236 BE504907 BM972864 BM271767 BF432160 AA927167 CA312759 AI140274 BC035961 BC071644 AI148394 CR593932 BM272090 AI934362 BC000158 AI564957 BX387170 BE673498 AA458547
GeneLoc Exon Structure
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Expression
for FAM108A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM108A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGACCCCCC
About this image
See FAM108A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM108A1
SOURCE GeneReport for Unigene clusters: Hs.465542 Hs.653679
SABiosciences Custom PCR Arrays for FAM108A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM108A1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM108A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM108A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM108A1 |
Orthologs
for FAM108A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FAM108A1 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for FAM108A1 (if available)
TreeFam Gene Tree for FAM108A1 (if available) |
Paralogs
for FAM108A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM108A1 gene
- FAM108C12 FAM108B12 ABHD132
2 SIMAP similar genes for FAM108A1 using alignment to 3 protein entries: F18A1_HUMAN (see all proteins):FAM108C1 FAM108B1
FAM108A1 for paralogs About GeneDecksing
5/10 Pseudogenes.org Pseudogenes for FAM108A1 (see all 10)
PGOHUM00000246686 PGOHUM00000248826 PGOHUM00000249073 PGOHUM00000249086 PGOHUM00000237299
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Genomic Variants
for FAM108A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM108A1 (1876809 - 1885546 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM108A1
2 CNVs: 30062 7191 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM108A1 |
|
Disorders
/ Diseases
for FAM108A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM108A1 for disorders About GeneDecksing
3  diseases for FAM108A1: About MalaCardstuberculosis malaria mycobacterium tuberculosis
Export disorders for FAM108A1 gene to outside databases
|
Publications
for FAM108A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM108A1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM108A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for FAM108A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FAM108A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM108A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM108A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM108A1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM108A1 gene:
Search GeneIP for patents involving FAM108A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM108A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM108A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM108A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM108A1 | | | OriGene Protein Over-expression Lysate for FAM108A1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM108A1 | | OriGene 3'-UTR Clone for FAM108A1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM108A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM108A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM108A1 | | OriGene Custom Protein Services for FAM108A1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM108A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM108A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM108A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM108A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM108A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM108A1 |
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 | | | FAM108A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM108A1 |
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